Journal of the International Association of Providers of AIDS Care最新文献

{"title":"Oral Abstracts from the 2025 Continuum Conference.","authors":"","doi":"10.1177/23259582251366825","DOIUrl":"10.1177/23259582251366825","url":null,"abstract":"","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"24 ","pages":"23259582251366825"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12480793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Extreme Weather Events and Resource Insecurities With HIV Vulnerabilities and Biomedical HIV Prevention Outcomes Among Adolescent Girls and Young Women in Kenya: A Cross-Sectional Analysis.","authors":"Carmen H Logie, Zerihun Admassu, Aryssa Hasham, Humphres Evelia, Julia Kagunda, Beldine Omondi, Clara Gachoki, Mercy Chege, Lesley Gittings, Caetano Dorea, Janet M Turan, Mumbi Mwangi, Lawrence Mbuagbaw","doi":"10.1177/23259582251362938","DOIUrl":"10.1177/23259582251362938","url":null,"abstract":"<p><p>ObjectivesWe examined associations between extreme weather events (EWE), resource insecurities, and HIV vulnerabilities among a purposive sample of adolescent girls and young women (AGYW) aged 16 to 24 in Nairobi and Kisumu, Kenya.MethodsWe conducted multivariable logistic/linear regression on cross-sectional survey data to assess associations between EWE exposure, food insecurity (FI), water insecurity (WI), and sanitation insecurity (SI) with HIV vulnerabilities (transactional sex [TS], intimate partner violence [IPV], sexual relationship power [SRP], and preexposure prophylaxis [PrEP] awareness and acceptability).ResultsAmong participants (n = 597; mean age: 20.13 years; standard deviation = 2.5), in adjusted analyses, SI and WI were associated with increased TS. Increased cumulative EWEs and eco-anxiety were associated with increased IPV. EWE frequency, FI, and SI were associated with reduced SRP. EWE frequency and SI were associated with reduced, and WI with increased, PrEP awareness. EWE frequency and SI were associated with PrEP acceptability.ConclusionResource scarcities and EWEs were associated with HIV vulnerabilities and PrEP acceptability among AGYW.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"24 ","pages":"23259582251362938"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12461040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of an Antiviral Treatment Regimen for Immunological Nonresponders Through HIV-DNA Resistance Testing: A Case Report.","authors":"Kun He, Xiang Du, Qi Cao, Mingjun Li, Juan Qian, Min Liu","doi":"10.1177/23259582251340143","DOIUrl":"https://doi.org/10.1177/23259582251340143","url":null,"abstract":"<p><p>In August 2012, a 47-year-old male patient was diagnosed with human immunodeficiency virus (HIV) infection, with no other underlying disease or opportunistic infection. Baseline measurements revealed an HIV RNA count of 79 400 copies/mL and a CD4+ T-lymphocyte count of 8 cells/μL. Despite successful viral suppression with HIV RNA levels remaining below the detectable threshold for 9 consecutive years following the initiation of antiretroviral therapy, the patient's CD4+ T lymphocyte count persistently remained below 200 cells/μL. Resistance testing of the viral reservoir (HIV DNA) was conducted, which revealed proviral resistance. Based on these results, the antiviral treatment regimen was adjusted. One year later, the patient's immune function had significantly improved, with the CD4+ T lymphocyte count having increased to 319 cells/μL.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"24 ","pages":"23259582251340143"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in People Living With HIV Attending Centre of Excellence in HIV Care at a Tertiary Level Teaching Hospital in North India-A Pilot Study.","authors":"Ragini Ram, Anuradha Subramanian, Rajeshwari K","doi":"10.1177/23259582241311912","DOIUrl":"10.1177/23259582241311912","url":null,"abstract":"&lt;p&gt;&lt;p&gt;With the availability of free antiretroviral therapy (ART) across India, HIV in adults has become a chronic disease with prolonged survival. The emergence of various non-communicable diseases in these prolonged survivors is a cause of concern. Metabolic dysfunction-associated steatotic liver disease (MASLD) in adults with HIV infection in India has not been explored to date. In this study, we attempted to assess the existence of MASLD in thirty adults registered at the Centre of Excellence in ART Care at a tertiary teaching hospital in New Delhi. This center provides free first-line, second-line, and third-line ART to patients as well as comprehensive HIV care including counseling, nutritional advice, and inpatient admissions for intercurrent illnesses. A total of 30 subjects were enrolled in the study to assess the occurrence of MASLD among people living with HIV (PLHIV) and its risk factors and to assess hepatic fibrosis in the subjects with MASLD using transient elastography and clinical fibrosis scores. The study population included 13 subjects on ART (43.3%) and 17 ART-naïve subjects (56.6%). All the study subjects underwent ultrasonography (USG) for the identification of the development of MASLD in them. Steatosis was identified as an increase in the echogenicity of the liver seen as an increase in the hepatorenal contrast and was further graded into the 3 grades of fatty liver. Out of the 30 subjects, 16.6% (5 out of 30) were found to have MASLD on USG, with grade 1 fatty changes seen in 4 (13.3%) and grade 2 fatty changes seen in 1 out of 30 subjects (3.3%). A majority (40%) of the subjects were underweight (body mass index [BMI] &lt; 18.5). 22.7% of the male subjects included in the study had MASLD whereas none of the females had fatty changes in the liver on USG. Out of the study subjects, MASLD was detected in 17.6% of ART-naïve subjects while it was detected in 15.4% of subjects on ART. Although no statistically significant association was seen with any of these parameters, a few important trends were observed. These might be statistically significant in a higher power study with a larger sample size. Higher BMI (mean difference [MD] = 3.25, &lt;i&gt;P&lt;/i&gt; = .09), waist circumference (MD = 3.84, &lt;i&gt;P&lt;/i&gt; = .15), hip circumference (MD = 4.36, &lt;i&gt;P&lt;/i&gt; = .14), and older age (MD = 6.56, &lt;i&gt;P&lt;/i&gt; = .07) were observed to be associated with MASLD in our study, whereas the biochemical parameters and HIV-related factors were not seen to have any particular trend of association in our study. However, a higher median CD4 count was associated with MASLD as compared to the group without fatty changes on USG. On FibroScan, all 5 subjects with fatty changes in our study were found to have liver stiffness less than 7 kPa which corresponds to F0-F1 stage of fibrosis. Using the nonalcoholic fatty liver disease score, 2 subjects had scores corresponding to F0-F2 stage of fibrosis (as per METAVIR score) while the rest (3 out of 5) had indeterminate values.","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"24 ","pages":"23259582241311912"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and Risk Factors of Zidovudine-Induced Anemia in Patients With HIV Infection Receiving Zidovudine-Containing Antiretroviral Therapy.","authors":"Lakkana Boonyagars, Peerawit Thinpangnga, Warangkana Munsakul","doi":"10.1177/23259582251321577","DOIUrl":"10.1177/23259582251321577","url":null,"abstract":"<p><strong>Background: </strong>Anemia is among the frequently observed conditions among people living with HIV (PLWH). Zidovudine (AZT) is the most common ART that causes anemia. This study aimed to identify the incidence and risk factors of AZT-induced anemia in PLWH receiving AZT-containing regimens.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on nonpregnant PLWH aged >18 years who received AZT-containing regimens for >6 months and had normal baseline hemoglobin levels. Data on medical history, clinical characteristics, and laboratory examination were collected. Cox proportional hazard regression analysis was performed to determine the risk factors of AZT-induced anemia.</p><p><strong>Results: </strong>A total of 401 individuals were included in the study. In total, 71 individuals presented with AZT-induced anemia. The incidence rate of anemia was 1.98 per 100 person-years of observations. Female sex, low-normal baseline hemoglobin level, low recent and low baseline CD4 cell count were independently associated with an increased risk of anemia. However, a higher body mass index was independently associated with a decreased risk of anemia.</p><p><strong>Conclusion: </strong>Routine screening, early detection, and treatment of anemia should be considered in PLWH receiving AZT-containing regimens.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"24 ","pages":"23259582251321577"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavior Change Communication Strategies on Human Immunodeficiency Virus /Acquired Immunodeficiency Syndrome Risk Reduction for Long-Distance Truckers in Kenya.","authors":"Cyrus Mutie, John Gachohi, Kawira Kithuci, Grace Mbuthia","doi":"10.1177/23259582251377224","DOIUrl":"10.1177/23259582251377224","url":null,"abstract":"<p><p>BackgroundLong-distance truckers (LDTs) not only experience heightened risk of human immunodeficiency virus (HIV) infections due to risky sexual networks, but are also hard to reach with consistent risk reduction messages due to their often disruptive work schedules. Besides, evidence of the existing behavior change communication (BCC) strategies to enhance HIV/ acquired immunodeficiency syndrome (AIDS) risk reduction is limited. Thus, the study sought to explore the most effective and preferred BCC strategies for adoption among LDTs in Kenya.Methods and MethodologyNine key informants and 18 in-depth interviews were used to gather qualitative data from purposively sampled participants at Kenya's Busia and Namanga border points. A thematic analysis was conducted using a hybrid of inductive and deductive approaches, through the Qualitative Data Analysis Miner (QDA-Miner) software for QDA.ResultsAlmost half of the key informants (44%) were aged 25-34, whereas half of the in-depth interviewees were 35-44 years old. Media-based communication channels were the most common and accessible. Other BCC strategies included interpersonal communication and healthcare worker service-driven strategies, peer-led open discussions and shared experiences on HIV/AIDS risk reduction, outreach activities to reach more of the underserved LDTs, and non-governmental organization (NGO)-driven approaches to fill gaps left by the public healthcare systems.ConclusionMedia-based communication channels were the most common BCC strategies. However, a combination of interpersonal communication, peer-led services, outreach activities, and NGO-driven approaches played a key role in enhancing the HIV/AIDS risk reduction message reach to the LDTs.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"24 ","pages":"23259582251377224"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12437158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linking Criminal Justice-Involved Individuals to HIV Preexposure Prophylaxis: A Qualitative Analysis of Multiple Stakeholder Perspectives.","authors":"Jessica Lee, Robin T Higashi, Timothy P Hogan, Julia L Marcus, Emily C Repasky, M Brynn Torres, Douglas Krakower, Ank E Nijhawan","doi":"10.1177/23259582251341940","DOIUrl":"https://doi.org/10.1177/23259582251341940","url":null,"abstract":"<p><p>ObjectiveAlthough incarcerated individuals are at disproportionately higher HIV risk compared to the general US population, few jails offer linkage to preexposure prophylaxis (PrEP). We explored stakeholder perspectives about barriers and facilitators to PrEP for justice-involved individuals.MethodsSemi-structured interviews were conducted with three stakeholder groups in Dallas County, Texas: justice-involved individuals (<i>n</i> = 8), County Jail staff (<i>n</i> = 9), and employees of local community organizations that provide PrEP services (<i>n</i> = 9). Transcripts were analyzed using a combined deductive and inductive approach.ResultsBarriers to PrEP linkage included: limited provider knowledge of and capacity for PrEP care, stigma around incarceration and PrEP, and mistrust in healthcare and criminal justice systems among justice-involved individuals. Perceived facilitators included addressing competing priorities, partnering with community organizations, and providers' cultural competency training.ConclusionFuture research should focus on adapting successful implementation strategies to the needs of justice-involved populations to improve HIV prevention and health outcomes in high-burden regions like the Southern USA.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"24 ","pages":"23259582251341940"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Like Someone Is Paying Attention to You, Listening to You, and Guiding You\": Acceptability of a Mental Health Chatbot Among Caregivers of Adolescents Living With HIV.","authors":"Neil Rupani, Diego H Vasquez, Carmen Contreras, Luis Menacho, Lenka Kolevic, Molly F Franke, Jerome T Galea","doi":"10.1177/23259582251327911","DOIUrl":"10.1177/23259582251327911","url":null,"abstract":"<p><p>BackgroundThis study assessed the acceptability, among caregivers, of a mental health chatbot designed for adolescents living with HIV aged 10 to 19 years.MethodsFifteen caregivers interacted with the mental health chatbot. Pre-post assessments and semistructured interviews evaluated acceptability. Data were analyzed using a Framework Analysis approach.ResultsCaregivers aged 31 to 70 years found the chatbot acceptable on individual, interpersonal, and environmental levels. They appreciated the educational content and self-help tools, feeling the chatbot would benefit them personally. Caregivers also saw potential in the chatbot to improve communication with their children, particularly during critical periods like HIV diagnosis. Despite concerns about data costs or internet access, most viewed the chatbot as an accessible supplement to traditional mental health services.ConclusionThis study suggests that a mental health chatbot for Peruvian adolescents living with HIV was acceptable to their caregivers, potentially benefiting caregivers' mental health, enhancing caregiver-adolescent interactions, and fostering better communication.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"24 ","pages":"23259582251327911"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recreational Use of Efavirenz by Young People Living With HIV in Zimbabwe.","authors":"Rhulani Beji-Chauke MSc, Kudzai Hlahla MSc, Katya Govender PhD, Rashida A Ferrand PhD, Victoria Simms PhD","doi":"10.1177/23259582251370550","DOIUrl":"10.1177/23259582251370550","url":null,"abstract":"","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"24 ","pages":"23259582251370550"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12368391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergency Department Strategies to Identify Out-of-Care People Living With HIV: A Critical Step Toward Ending the HIV Epidemic.","authors":"Bijou R Hunt, Douglas A E White, Nancy R Glick","doi":"10.1177/23259582251372446","DOIUrl":"https://doi.org/10.1177/23259582251372446","url":null,"abstract":"<p><p>People with a previous HIV diagnosis (PWHDx) who are out of care (OOC) (PWHDx OOC) represent a significant but often overlooked population in the United States, accounting for nearly half of new HIV transmissions annually. Emergency departments (EDs), frequently accessed by PWHDx OOC for unscheduled care, are uniquely positioned to identify and re-engage these individuals in HIV care. While ED-based HIV efforts have traditionally focused on diagnosing new infections, this paper reviews and evaluates 3 models EDs can implement to identify PWHDx OOC: routine HIV screening, health information exchange, and electronic health record alerts. We describe each model using examples from the literature, assessing their feasibility, scalability, and effectiveness in identifying patients and determining care status. By synthesizing current approaches, this paper highlights practical and policy-relevant pathways for expanding ED-based HIV services beyond diagnosis, offering concrete guidance for healthcare systems aiming to meet the national \"Ending the HIV Epidemic\" goals.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"24 ","pages":"23259582251372446"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12394870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}