S. Chantaratin, Kawita Trimetha, P. Werarak, K. Lapphra, Alan Maleesatharn, S. Rungmaitree, O. Wittawatmongkol, W. Phongsamart, N. Kongstan, Benjawan Khumcha, K. Chokephaibulkit
{"title":"Depression and Anxiety in Youth and Young Adults Living with HIV: Frequency and Associated Factors in Thai Setting","authors":"S. Chantaratin, Kawita Trimetha, P. Werarak, K. Lapphra, Alan Maleesatharn, S. Rungmaitree, O. Wittawatmongkol, W. Phongsamart, N. Kongstan, Benjawan Khumcha, K. Chokephaibulkit","doi":"10.1177/23259582221101811","DOIUrl":"https://doi.org/10.1177/23259582221101811","url":null,"abstract":"Integrative mental health care in HIV patients is an important contributor to successful therapy. This is a cross-sectional study in youth and young adults who attend routine HIV clinic at a tertiary care centre in Bangkok. We recruited 100 youth and 130 young adults living with HIV to evaluate the frequency of depression and anxiety and associated sociodemographic including sexual orientation and health-related behaviours. Overall, about a fifth of the participants had significant depression or anxiety. Interestingly, we found different factors associated with depression in youth and young adults living with HIV. Loss of their father, loss of close relatives or friends, and being unemployed or school exclusion were the factors associate with depression in youth; while dangerous alcohol use, feeling discriminated against and having lipodystrophy were factors in young adults. The understanding of the frequency and different associated factors can inform more effective prevention and treatment strategies.","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49022475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shaimaa Alsulami, Sultan N Alotaibi, Nader Damfu, Doaa M Aljefri, Hadeel Ahmed Altayib, Maher Alharbi
{"title":"Efficacy and Safety of Bictegravir-Based Regimen in Pregnant Women Living with HIV: A Case Report.","authors":"Shaimaa Alsulami, Sultan N Alotaibi, Nader Damfu, Doaa M Aljefri, Hadeel Ahmed Altayib, Maher Alharbi","doi":"10.1177/23259582221146110","DOIUrl":"https://doi.org/10.1177/23259582221146110","url":null,"abstract":"<p><p>Bictegravir (BIC) is included in international guidelines as the first line of therapy for patients living with Human Immunodeficiency Virus (HIV), either as initial therapy or as a replacement for patients with prior antiretroviral therapy (ART). Due to limited efficacy and safety data, BIC is currently not recommended during pregnancy. Data on the safety and efficacy of BIC during pregnancy were unavailable at the time of drug approval. In our case, BIC/TAF/FTC was effective in suppressing viral load (VL) in pregnancy, and there were no reported safety issues for the mother or the baby.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/07/d2/10.1177_23259582221146110.PMC9772963.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10512249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nancy Mwongeli, Anjuli D Wagner, Julia C Dettinger, Jillian Pintye, Susan Brown Trinidad, Merceline Awuor, Grace Kimemia, Kenneth Ngure, Renee A Heffron, Jared M Baeten, Nelly Mugo, Elizabeth A Bukusi, John Kinuthia, Maureen C Kelley, Grace C John-Stewart, Kristin M Beima-Sofie
{"title":"\"<i>PrEP Gives the Woman the Control\":</i> Healthcare Worker Perspectives on Using pre-Exposure Prophylaxis (PrEP) During Pregnancy and Postpartum in Kenya.","authors":"Nancy Mwongeli, Anjuli D Wagner, Julia C Dettinger, Jillian Pintye, Susan Brown Trinidad, Merceline Awuor, Grace Kimemia, Kenneth Ngure, Renee A Heffron, Jared M Baeten, Nelly Mugo, Elizabeth A Bukusi, John Kinuthia, Maureen C Kelley, Grace C John-Stewart, Kristin M Beima-Sofie","doi":"10.1177/23259582221111068","DOIUrl":"https://doi.org/10.1177/23259582221111068","url":null,"abstract":"<p><p><b>Background:</b> Pregnant and postpartum women in high HIV prevalent regions are at increased HIV risk. Oral pre-exposure prophylaxis (PrEP) can decrease HIV incidence reducing infant HIV infections. Understanding healthcare worker (HCW) beliefs about PrEP prior to national roll-out is critical to supporting PrEP scale-up. <b>Methods:</b> We conducted 45 semi-structured interviews among a range of HCW cadres with and without PrEP provision experience purposively recruited from four clinics in Kenya to compare their views on prescribing PrEP during pregnancy and postpartum. Interviews were analysed using a conventional content analysis approach to identify key influences on PrEP acceptability and feasibility. <b>Results:</b> All HCWs perceived PrEP as an acceptable and feasible HIV prevention strategy for pregnant and postpartum women. They believed PrEP meets women's needs as an on-demand, female-controlled prevention strategy that empowers women to take control of their HIV risk. HCWs highlighted their role in PrEP delivery success while acknowledging how their knowledge gaps, concerns and perceived PrEP implementation challenges may hinder optimal PrEP delivery. <b>Conclusion:</b> HCWs supported PrEP provision to pregnant and postpartum women. However, counseling tools to address risk perceptions in this population and strategies to reduce HCW knowledge gaps, concerns and perceived implementation barriers are required.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40469744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Biopsychosocial Impact and Syndemic Effect of COVID-19 on Youth Living with HIV in Kenya.","authors":"Tiffany Chenneville, Kemesha Gabbidon, Bharat Bharat, Zachary Whitney, Scholastic Adeli, Mary Anyango","doi":"10.1177/23259582221112342","DOIUrl":"https://doi.org/10.1177/23259582221112342","url":null,"abstract":"<p><p>COVID-19's rapid emergence as a biological and psychosocial threat has affected people globally. The purpose of this qualitative study, which was guided by syndemic theory and the biopsychosocial framework, was to examine the impact of COVID-19 on youth living with HIV (YLWH) in Kenya. Seven virtual focus groups and two in-depth interviews were conducted with 15 YLWH aged 18-24, 13 youth affected by HIV aged 18-24, and 12 HIV healthcare providers living in Nakuru and Eldoret, two of Kenya's largest cities. Data were analyzed using qualitative content analysis, which was guided by a descriptive phenomenological approach. Findings provided information about the problems and needs of YLWH as well as potential solutions for mitigating COVID-19's biopsychosocial impact and syndemic effect on YLWH in Kenya. A variety of individual, community, healthcare, and government issues were identified including but not limited to concerns about psychosocial functioning; economic stability; access to medical treatment and medication; the availability of goods and services; patient education; and the dissemination of accurate information. These findings have important implications for addressing the ongoing and long-term impact of the pandemic on YLWH in resource-limited settings through research, policy, and practice.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/43/63/10.1177_23259582221112342.PMC9280818.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40493819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Harsha Adnani, Nirav Agrawal, A. Khatri, Jaclyn Vialet, Meng Zhang, J. Cervia
{"title":"Impact of Antiretroviral Therapy on Kidney Disease in HIV Infected Individuals – A Qualitative Systematic Review","authors":"Harsha Adnani, Nirav Agrawal, A. Khatri, Jaclyn Vialet, Meng Zhang, J. Cervia","doi":"10.1177/23259582221089194","DOIUrl":"https://doi.org/10.1177/23259582221089194","url":null,"abstract":"Kidney disease is the fourth most common cause of non-AIDS-related mortality in people living with HIV. Combination antiretroviral therapy (cART) remains the cornerstone of treatment. However, little is known about the impact of cART on disease outcomes in patients with HIV-associated nephropathy (HIVAN) and HIV-immune complex kidney disease (HIVICK). This systematic review evaluates the impact of cART on progression to end-stage kidney disease (ESKD) and other outcomes in HIV-infected individuals. We conducted a literature search utilizing PubMed, and Cochrane database and 11 articles met inclusion criteria for analysis of which nine HIVAN studies showed decreased progression to ESKD or death for subjects when treated with cART versus those untreated. However, two studies showed no survival advantage with cART. Three HIVICK studies showed improvement in delaying ESKD in subjects on cART compared to untreated subjects. cART appeared to reduce the risk to ESKD or death in patients with both HIVAN and HIVICK.","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43637116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mary Spicar Kilapilo, Raphael Zozimus Sangeda, G. Bwire, G. Sambayi, I. Mosha, J. Killewo
{"title":"Adherence to Antiretroviral Therapy and Associated Factors Among People Living With HIV Following the Introduction of Dolutegravir Based Regimens in Dar es Salaam, Tanzania","authors":"Mary Spicar Kilapilo, Raphael Zozimus Sangeda, G. Bwire, G. Sambayi, I. Mosha, J. Killewo","doi":"10.1177/23259582221084543","DOIUrl":"https://doi.org/10.1177/23259582221084543","url":null,"abstract":"Background: Adherence to antiretroviral therapy (ART) is the key determinant of virological suppression in people living with HIV (PLHIV). This study reports factors associated with non-adherence among PLHIV one year after introducing dolutegravir (DTG) based regimens in Tanzania. Methods: A hospital-based cross-sectional study was conducted in two health facilities in Dar es Salaam, Tanzania, in 2020. Results: A total of 406 PLHIV were recruited, where the majority (73.4%) were females, with 94.6% of patients being on DTG based regimens. Factors such as refill interval and sharing of antiretrovirals had significant effects on adherence. Multivariate analysis found that patients attending care and treatment center (CTC) at Temeke Regional Referral Hospital (RRH) were 4.3 times more likely to have non-adherence compared to those attending Amana RRH (aOR [adjusted odds ratio] 4.3, 95% CI [confidence interval]: 2.38 – 7.91, p-value < 0.0001). Conclusions: Sustainable adherence counseling is warranted to overcome non-adherence to ART.","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46935641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Olukemi Adekanmbi, Stephen Ilesanmi, Babatunde Ogunbosi, Dasola Moradeyo, Sulaiman Lakoh
{"title":"Retention in Care among Patients Attending a Large HIV Clinic in Nigeria Who Were Treated for Tuberculosis.","authors":"Olukemi Adekanmbi, Stephen Ilesanmi, Babatunde Ogunbosi, Dasola Moradeyo, Sulaiman Lakoh","doi":"10.1177/23259582221124826","DOIUrl":"https://doi.org/10.1177/23259582221124826","url":null,"abstract":"<p><p>A retrospective study of 2764 patients was conducted at an HIV clinic in Nigeria to evaluate retention in care in patients treated for TB. At 6 and 12 months after commencement of TB treatment, 1842(66.6%) and 1624(58.8%) participants remained in care. Of the 922 and 1140 not in care at 6 and 12 months, 814(88.3%) and 1006(88.2%) respectively were lost to follow-up (LTFU). VL < 1000copies/ml was associated with higher odds of retention in care at 6 and 12 months (OR = 2.351 and 2.393) than VL > 1000 copies/ml. HAART use was associated with high likelihood of being in care at 12 months (OR = 3.980). CD4 counts of 200-350 and >350 cells/mm<sup>3</sup> were associated with increased odds of remaining in care at 12 months compared with CD4 < 200 cells/mm<sup>3</sup> (p = 0.005 and p = 0.001). Targeted interventions such as early HAART and close follow-up for high risk groups are likely to improve retention in care.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/af/25/10.1177_23259582221124826.PMC9465612.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33455539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ritah F Mutagonda, Hamu J Mlyuka, Betty A Maganda, Appolinary A R Kamuhabwa
{"title":"Adherence, Effectiveness and Safety of Dolutegravir Based Antiretroviral Regimens among HIV Infected Children and Adolescents in Tanzania.","authors":"Ritah F Mutagonda, Hamu J Mlyuka, Betty A Maganda, Appolinary A R Kamuhabwa","doi":"10.1177/23259582221109613","DOIUrl":"10.1177/23259582221109613","url":null,"abstract":"<p><p><b>Objectives:</b>This study aimed at assessing adherence, effectiveness, and safety of DTG-based HAART regimens among HIV-infected children and adolescents in Tanzania. <b>Methods:</b> This was a single-center prospective cohort study, conducted at the pediatric HIV Clinic in Mbeya, Tanzania. A binary logistic regression model was used to determine predictors of undetectable viral load at week 24. The results were significant when P-value was <0.05. <b>Results:</b> A total of 200 patients were enrolled with the majority (85.5%) being treatment experienced. High adherence levels (71%) were observed using the pharmacy refill method. At week 24, the overall proportion of patients with undetectable viral load was 70.2%. The predictors of undetectable viral load were age, World Health Organization (WHO) clinical stage, baseline VL and adherence to pharmacy refill. <b>Conclusion:</b> The majority of patients attained undetectable viral load 6 months after using DTG based regimen. DTG-based regimens were generally safe with few ADEs reported.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7f/24/10.1177_23259582221109613.PMC9257168.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40463460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mary Jo Trepka, Melissa K Ward, Robert A Ladner, Diana M Sheehan, Tan Li, Cynthia Ibarra, Semiu O Gbadamosi, Gladys E Ibañez, Michele Jean-Gilles
{"title":"HIV Care Access During the COVID-19 Pandemic as Perceived by Racial/Ethnic Minority Groups Served by the Ryan White Program, Miami-Dade County, Florida.","authors":"Mary Jo Trepka, Melissa K Ward, Robert A Ladner, Diana M Sheehan, Tan Li, Cynthia Ibarra, Semiu O Gbadamosi, Gladys E Ibañez, Michele Jean-Gilles","doi":"10.1177/23259582221084536","DOIUrl":"10.1177/23259582221084536","url":null,"abstract":"<p><p>The Ryan White Program (RWP) in Miami-Dade County, Florida made several modifications to keep HIV care accessible during the COVID-19 Pandemic, including expanding telehealth services, increasing access to HIV medications, and waiving required lab tests for service recertification. We assessed ease of access to medical providers, medical case managers, and antiretroviral medications during the COVID-19 Pandemic among 298 Non-Hispanic Black, Hispanic, and Haitian people with HIV (PWH) served by the RWP Part A, Miami-Dade County, Florida using a telephone-administered survey between October 2020 and January 2021. Overall, most clients reported similar or better access compared to before the Pandemic. Use of videocalls to communicate with HIV medical providers varied by race/ethnicity: Hispanics (49.6%), Non-Hispanic Blacks (37.7%), and Haitian clients (16.0%). Results suggest the modifications helped maintain access to care during an unprecedented health crisis. Permanently adopting many of these modifications should be considered to continue to facilitate access to care.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43517784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Undernutrition and Associated Risk Factors among Adult HIV/AIDS Patients Attending Antiretroviral Therapy at Public Hospitals of Bench Sheko Zone, Southwest Ethiopia.","authors":"Nigusie Shifera, Tewodros Yosef, Rahel Matiyas, Ayechew Kassie, Ashenafi Assefa, Abebaw Molla","doi":"10.1177/23259582221079154","DOIUrl":"https://doi.org/10.1177/23259582221079154","url":null,"abstract":"<p><p>Even though there are advancements in the treatment of patients with HIV, many deaths are related to undernutrition. Despite this fact, the burden of undernutrition and associated factors among adults receiving ART is a significant shortcoming in the study area. A cross-sectional study was done in public hospitals of the Bench-Sheko zone. Face-to-face interviews were used to gather information. Odds ratio with a 95% confidence level was used to identify determinants of undernutrition. The proportion of undernutrition, normal, and overweight were 29.2%, 61.2%, and 9.6% respectively. Food insecurity, poor ART adherence, low CD4 count, and substance use were factors associated with under nutrition among HIV patients. Undernutrition was so high in comparison to other studies in Ethiopia; the local concerned bodies should focus on identified risk factors for improving HIV/AIDS treatment via health education, nutritional assistance and counseling.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/30/21/10.1177_23259582221079154.PMC9099061.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10240173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}