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ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development最新文献

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An Elastin-like Polypeptide-fused Peptide Inhibits MMP-2 Activity at nM Concentrations with High Specificity 弹性蛋白样多肽融合肽在nM浓度下具有高特异性抑制MMP-2活性
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.202220
Adesanya A. Akinleye, Richard J Roman, G. Bidwell
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引用次数: 0
Natural Products as a Source of Chemical Diversity in cyclic-AMP dependent Protein Kinase A (PKA) Inhibitor Discovery 天然产物作为环amp依赖性蛋白激酶a (PKA)抑制剂化学多样性的来源
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.521340
Brice A. P. Wilson, Ning Li, J. M. Fiesco, Masoumeh Dalilian, Dongdong Wang, S. Senadeera, Lin Du, Richard W. Fuller, Rohan Shah, Emily A. Smith, E. Goncharova, J. Beutler, T. Grkovic, Ping Zhang, B. O'Keefe
{"title":"Natural Products as a Source of Chemical Diversity in cyclic-AMP dependent Protein Kinase A (PKA) Inhibitor Discovery","authors":"Brice A. P. Wilson, Ning Li, J. M. Fiesco, Masoumeh Dalilian, Dongdong Wang, S. Senadeera, Lin Du, Richard W. Fuller, Rohan Shah, Emily A. Smith, E. Goncharova, J. Beutler, T. Grkovic, Ping Zhang, B. O'Keefe","doi":"10.1124/jpet.122.521340","DOIUrl":"https://doi.org/10.1124/jpet.122.521340","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133143426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Topical Application of cannabis fixed Oil on Imiquimod-Induced Psoriasis-like Lesions in the Thin Skin of Adult Male Albino rabbits 局部应用大麻固定油对吡喹莫德致成年雄性白化兔薄皮肤银屑病样病变的影响
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.236130
Y. Kadil, Hasnaa Bazhar, Ibtihal Segmani, afaf Banid, Fatimaezzahra kabbali, Houda Filali
{"title":"Effect of Topical Application of cannabis fixed Oil on Imiquimod-Induced Psoriasis-like Lesions in the Thin Skin of Adult Male Albino rabbits","authors":"Y. Kadil, Hasnaa Bazhar, Ibtihal Segmani, afaf Banid, Fatimaezzahra kabbali, Houda Filali","doi":"10.1124/jpet.122.236130","DOIUrl":"https://doi.org/10.1124/jpet.122.236130","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123908046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting human melanocortin type 2 receptor (MC2R) with small molecules and designed peptides for the treatment of congenital adrenal hyperplasia 利用小分子和设计肽靶向人黑色素皮质素2型受体(MC2R)治疗先天性肾上腺增生
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.242640
A. Pandey, Shaheena Parween, Shripriya Singh
{"title":"Targeting human melanocortin type 2 receptor (MC2R) with small molecules and designed peptides for the treatment of congenital adrenal hyperplasia","authors":"A. Pandey, Shaheena Parween, Shripriya Singh","doi":"10.1124/jpet.122.242640","DOIUrl":"https://doi.org/10.1124/jpet.122.242640","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127886994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing how Neurodegeneration and Cognitive Impairment can be Ameliorated through the Neuroprotective Effect of Thymoquinone 评估如何通过百里醌的神经保护作用改善神经变性和认知障碍
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.141810
Chukwunonso Chukwuemeka
{"title":"Assessing how Neurodegeneration and Cognitive Impairment can be Ameliorated through the Neuroprotective Effect of Thymoquinone","authors":"Chukwunonso Chukwuemeka","doi":"10.1124/jpet.122.141810","DOIUrl":"https://doi.org/10.1124/jpet.122.141810","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121232594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Marine-Derived Pharmaceuticals in Clinical Trials in 2022 2022年进入临床试验的海洋衍生药物
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.527010
Alejandro M Mayer, Marshall Pierce, Maria Reji, Alex C. Wu, Karolina K. Jekielek, Henry Q. Le, Katelyn Howe, Maryam Butt, Su-Gyeong Seo, D. J. Newman, K. Glaser
{"title":"Marine-Derived Pharmaceuticals in Clinical Trials in 2022","authors":"Alejandro M Mayer, Marshall Pierce, Maria Reji, Alex C. Wu, Karolina K. Jekielek, Henry Q. Le, Katelyn Howe, Maryam Butt, Su-Gyeong Seo, D. J. Newman, K. Glaser","doi":"10.1124/jpet.122.527010","DOIUrl":"https://doi.org/10.1124/jpet.122.527010","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115668821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Identification of Transfer RNA Modification Enzymes That Regulate a Bacterial RNA Chaperone Known as Hfq 调控细菌RNA伴侣蛋白Hfq的转移RNA修饰酶的鉴定
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.522570
Jalisa Nurse, K. Thompson, Joseph I. Aubee, Valerie de Crecy-Legard
{"title":"Identification of Transfer RNA Modification Enzymes That Regulate a Bacterial RNA Chaperone Known as Hfq","authors":"Jalisa Nurse, K. Thompson, Joseph I. Aubee, Valerie de Crecy-Legard","doi":"10.1124/jpet.122.522570","DOIUrl":"https://doi.org/10.1124/jpet.122.522570","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124390536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery of Potent Therapeutics for Treatment of Cryptosporidiosis 隐孢子虫病有效治疗方法的发现
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.245840
M. Meyers, C. Huston
{"title":"Discovery of Potent Therapeutics for Treatment of Cryptosporidiosis","authors":"M. Meyers, C. Huston","doi":"10.1124/jpet.122.245840","DOIUrl":"https://doi.org/10.1124/jpet.122.245840","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124985762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of Mutant-Selective Allosteric EGFR Inhibitors for Drug-Resistant Lung Cancer 耐药肺癌突变选择性变构EGFR抑制剂的研究进展
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.162040
T. Beyett, Ciric To, D. Heppner, T. Gero, N. Gray, David A. Scott, P. Jänne, M. Eck
{"title":"Development of Mutant-Selective Allosteric EGFR Inhibitors for Drug-Resistant Lung Cancer","authors":"T. Beyett, Ciric To, D. Heppner, T. Gero, N. Gray, David A. Scott, P. Jänne, M. Eck","doi":"10.1124/jpet.122.162040","DOIUrl":"https://doi.org/10.1124/jpet.122.162040","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123262824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Herbal microbiomes are plant-specific and rich in immune-stimulating pathogen-associated molecular pattern molecules 草药微生物群是植物特异性的，富含免疫刺激病原体相关的分子模式分子
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.144910
E. Mazzio, A. Barnes, R. Badisa, H. Williams, K. Soliman
{"title":"Herbal microbiomes are plant-specific and rich in immune-stimulating pathogen-associated molecular pattern molecules","authors":"E. Mazzio, A. Barnes, R. Badisa, H. Williams, K. Soliman","doi":"10.1124/jpet.122.144910","DOIUrl":"https://doi.org/10.1124/jpet.122.144910","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130483535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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