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ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development最新文献

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Anti-allergic and anti-Inflammatory Effects of Cornus officinalis using Zebrafish and IgE-chip Technology 利用斑马鱼和ige芯片技术研究山茱萸的抗过敏和抗炎作用
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.536590
Young Sook Kim, Y. Cho, Hye-Won Lim, I. S. Lee, Yu-Ri Lee
{"title":"Anti-allergic and anti-Inflammatory Effects of Cornus officinalis using Zebrafish and IgE-chip Technology","authors":"Young Sook Kim, Y. Cho, Hye-Won Lim, I. S. Lee, Yu-Ri Lee","doi":"10.1124/jpet.122.536590","DOIUrl":"https://doi.org/10.1124/jpet.122.536590","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"187 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125093513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Selective TRPC3 Antagonist Rescues Neuronal Loss and Facilitates Spatial Learning and Memory in Alzheimer's Model 选择性TRPC3拮抗剂挽救阿尔茨海默病模型中的神经元损失并促进空间学习和记忆
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.142680
Jiaxing Wang, Sicheng Zhang, V. Boda, Zhong-Chi Wu, Wei Li
{"title":"A Selective TRPC3 Antagonist Rescues Neuronal Loss and Facilitates Spatial Learning and Memory in Alzheimer's Model","authors":"Jiaxing Wang, Sicheng Zhang, V. Boda, Zhong-Chi Wu, Wei Li","doi":"10.1124/jpet.122.142680","DOIUrl":"https://doi.org/10.1124/jpet.122.142680","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"426 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113983279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Profiling Context-Dependent Activity of Allosteric Modulators at mGlu7 mGlu7变构调制剂的环境依赖性活性分析
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.153810
Xia Lei, Alice L. Rodriguez, C. Niswender
{"title":"Profiling Context-Dependent Activity of Allosteric Modulators at mGlu7","authors":"Xia Lei, Alice L. Rodriguez, C. Niswender","doi":"10.1124/jpet.122.153810","DOIUrl":"https://doi.org/10.1124/jpet.122.153810","url":null,"abstract":"Abstract","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116975134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel Molecules and Novel Mechanisms: Prevention of Toxic ß-Amyloid42 Oligomerization 新分子和新机制:预防毒性ß-淀粉样蛋白42寡聚化
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.532270
Gary Jones, J. Leavitt, Mary C. Freesh
{"title":"Novel Molecules and Novel Mechanisms: Prevention of Toxic ß-Amyloid42 Oligomerization","authors":"Gary Jones, J. Leavitt, Mary C. Freesh","doi":"10.1124/jpet.122.532270","DOIUrl":"https://doi.org/10.1124/jpet.122.532270","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"135 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123115564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virtual Screening for Potential Hepatitis B Virus Non-Nucleoside Reverse Transcriptase Inhibitors 潜在乙型肝炎病毒非核苷逆转录酶抑制剂的虚拟筛选
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.233090
E. Inmon, Razia Tajwar, Qilan Li, M. Meyers, J. Tavis
{"title":"Virtual Screening for Potential Hepatitis B Virus Non-Nucleoside Reverse Transcriptase Inhibitors","authors":"E. Inmon, Razia Tajwar, Qilan Li, M. Meyers, J. Tavis","doi":"10.1124/jpet.122.233090","DOIUrl":"https://doi.org/10.1124/jpet.122.233090","url":null,"abstract":"ID 23309","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114948336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sustained Release of Nanochelator in Thermosensitive Hydrogel Corrects Iron Overload 纳米螯合剂在热敏水凝胶中的缓释纠正铁超载
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.285910
Linguxe Zeng, Seung Hun Park, Homan Kang, Jonghan Kim
{"title":"Sustained Release of Nanochelator in Thermosensitive Hydrogel Corrects Iron Overload","authors":"Linguxe Zeng, Seung Hun Park, Homan Kang, Jonghan Kim","doi":"10.1124/jpet.122.285910","DOIUrl":"https://doi.org/10.1124/jpet.122.285910","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125768810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preclinical and Phase I Clinical Development of a Novel Multi-target Drug Candidate for Neuropathic Pain 一种治疗神经性疼痛的新型多靶点候选药物的临床前和I期临床开发
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.161660
Z. Helyes, Adam Horvath Horvath, Nikolett Szentes, V. Tékus, S. Pál, T. Kálai, P. Mátyus
{"title":"Preclinical and Phase I Clinical Development of a Novel Multi-target Drug Candidate for Neuropathic Pain","authors":"Z. Helyes, Adam Horvath Horvath, Nikolett Szentes, V. Tékus, S. Pál, T. Kálai, P. Mátyus","doi":"10.1124/jpet.122.161660","DOIUrl":"https://doi.org/10.1124/jpet.122.161660","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"399 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129997631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of Dextromethorphan on Compulsive Behavior Using the Schedule-Induced Polydipsia Paradigm in Rats 右美沙芬对大鼠强迫行为的影响
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.278750
Madeline T. Van Fossen, Alexia G. Dalton, Bethany E. Beavers, Dillon S. Shekoski, Taylor Galaszewski, A. Prus
{"title":"Assessment of Dextromethorphan on Compulsive Behavior Using the Schedule-Induced Polydipsia Paradigm in Rats","authors":"Madeline T. Van Fossen, Alexia G. Dalton, Bethany E. Beavers, Dillon S. Shekoski, Taylor Galaszewski, A. Prus","doi":"10.1124/jpet.122.278750","DOIUrl":"https://doi.org/10.1124/jpet.122.278750","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129449845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and Validation of a High-Throughput Cell-Based AlphaLISA Assay to Identify Small Molecule 20S Proteasome Modulators 基于细胞的高通量AlphaLISA检测小分子20S蛋白酶体调节剂的开发和验证
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.542420
E. Lisabeth, S. Staerz, Evert Njomen, T. Dexheimer, R. Neubig, J. Tepe
{"title":"Development and Validation of a High-Throughput Cell-Based AlphaLISA Assay to Identify Small Molecule 20S Proteasome Modulators","authors":"E. Lisabeth, S. Staerz, Evert Njomen, T. Dexheimer, R. Neubig, J. Tepe","doi":"10.1124/jpet.122.542420","DOIUrl":"https://doi.org/10.1124/jpet.122.542420","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"546 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120975339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Marine Carotenoid Fucoxanthin as a Promising Anticancer Therapeutic Against Triple-Negative Breast Cancer (TNBC) 海洋类胡萝卜素岩藻黄质治疗三阴性乳腺癌的研究进展
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.176370
Shade’ A. Ahmed, Patricia Mendonca, S. Messeha, K. Soliman
{"title":"Marine Carotenoid Fucoxanthin as a Promising Anticancer Therapeutic Against Triple-Negative Breast Cancer (TNBC)","authors":"Shade’ A. Ahmed, Patricia Mendonca, S. Messeha, K. Soliman","doi":"10.1124/jpet.122.176370","DOIUrl":"https://doi.org/10.1124/jpet.122.176370","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127920068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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