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ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development最新文献

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High brain-blood barrier permeability highlights a new class of neurolysin activators as promising candidates for stroke treatment: a pilot pharmacokinetic study in mice 高脑血屏障渗透性突出了一类新的神经溶解素激活剂作为中风治疗的有希望的候选者:一项小鼠药物动力学的初步研究
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.533120
Yong Zhang, Sejal Sharma, S. H. Esfahani, S. Jonnalagadda, A. Queen, Saeideh Nozohouri, Dhavalkumar Patel, P. Trippier, V. Karamyan, T. Abbruscato
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引用次数: 0
TLR Agonist INI-4001 Improves Efficacy of Heroin Vaccine Intended for Clinical Treatment of Opioid Use Disorder TLR激动剂INI-4001提高用于阿片类药物使用障碍临床治疗的海洛因疫苗的疗效
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.534700
M. Raleigh, K. Siram, D. Burkhart, Jennifer R. Vigliaturo, C. Baehr, Ann Gebo, Scott Winston, M. Pravetoni
{"title":"TLR Agonist INI-4001 Improves Efficacy of Heroin Vaccine Intended for Clinical Treatment of Opioid Use Disorder","authors":"M. Raleigh, K. Siram, D. Burkhart, Jennifer R. Vigliaturo, C. Baehr, Ann Gebo, Scott Winston, M. Pravetoni","doi":"10.1124/jpet.122.534700","DOIUrl":"https://doi.org/10.1124/jpet.122.534700","url":null,"abstract":"ID","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130193009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multi-Target Directed Ligands for the Treatment of Alzheimer’s Disease 多靶点定向配体治疗阿尔茨海默病
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.183150
Ryan J H West, S. Pecic
{"title":"Multi-Target Directed Ligands for the Treatment of Alzheimer’s Disease","authors":"Ryan J H West, S. Pecic","doi":"10.1124/jpet.122.183150","DOIUrl":"https://doi.org/10.1124/jpet.122.183150","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"255 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122557832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of LSD1 Directed Agents is Enhanced with Kinase Signaling Inhibition in Glioblastoma Stem Cells LSD1定向药物在胶质母细胞瘤干细胞中的疗效与激酶信号抑制有关
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.178990
L. Stitzlein, Jack Adams, Matthew Luetzen, Melissa M. Singh, Xiao-hu Su, Yue Lu, R. Ezhilarasan, J. Gumin, F. Lang, E. Sulman, J. Chandra, M. Monje-Deisseroth
{"title":"Efficacy of LSD1 Directed Agents is Enhanced with Kinase Signaling Inhibition in Glioblastoma Stem Cells","authors":"L. Stitzlein, Jack Adams, Matthew Luetzen, Melissa M. Singh, Xiao-hu Su, Yue Lu, R. Ezhilarasan, J. Gumin, F. Lang, E. Sulman, J. Chandra, M. Monje-Deisseroth","doi":"10.1124/jpet.122.178990","DOIUrl":"https://doi.org/10.1124/jpet.122.178990","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123629150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Venglustat Analogues with Enhanced Inhibition for Protein N-Terminal Methyltransferases 1/2 Venglustat类似物对蛋白n端甲基转移酶的抑制作用增强
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.233150
Rong Huang, Youchao Deng, Ying Meng
{"title":"Venglustat Analogues with Enhanced Inhibition for Protein N-Terminal Methyltransferases 1/2","authors":"Rong Huang, Youchao Deng, Ying Meng","doi":"10.1124/jpet.122.233150","DOIUrl":"https://doi.org/10.1124/jpet.122.233150","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128384372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Schizonepeta tenuifolia extract (DKB138) enhances the muscle strength in dexametasone-induced muscle atrophy mice model 荆芥提取物(DKB138)可增强地塞米松致肌肉萎缩小鼠的肌力
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.563210
Young Sook Kim, Dong-Seon Kim, H. Yuk, BongKyun Park, Kyu‐Hyeok Jo, Y. Park, Do Ho Kim, Seung-Hyung Kim
{"title":"Schizonepeta tenuifolia extract (DKB138) enhances the muscle strength in dexametasone-induced muscle atrophy mice model","authors":"Young Sook Kim, Dong-Seon Kim, H. Yuk, BongKyun Park, Kyu‐Hyeok Jo, Y. Park, Do Ho Kim, Seung-Hyung Kim","doi":"10.1124/jpet.122.563210","DOIUrl":"https://doi.org/10.1124/jpet.122.563210","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123390319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-Fentanyl Monoclonal Antibodies: In Vitro Characterization and In Vivo Efficacy in Reversing Apnea in Pigs 抗芬太尼单克隆抗体:体外表征及逆转猪呼吸暂停的体内疗效
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.541560
C. Baehr, Dustin Hicks, A. Guedes, M. Pravetoni
{"title":"Anti-Fentanyl Monoclonal Antibodies: In Vitro Characterization and In Vivo Efficacy in Reversing Apnea in Pigs","authors":"C. Baehr, Dustin Hicks, A. Guedes, M. Pravetoni","doi":"10.1124/jpet.122.541560","DOIUrl":"https://doi.org/10.1124/jpet.122.541560","url":null,"abstract":"Abstract","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126327791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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