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ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development最新文献

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Characterization of the pharmacological mechanism of OJT009 as a novel inhibitor of severe acute respiratory syndrome coronavirus 2 OJT009作为新型严重急性呼吸综合征冠状病毒抑制剂的药理机制研究
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.221240
T. Adebusuyi, Manvir Kaur, Anuoluwapo Egbejimi, Idowu A. Kehinde, Omonike A. Olaeye
{"title":"Characterization of the pharmacological mechanism of OJT009 as a novel inhibitor of severe acute respiratory syndrome coronavirus 2","authors":"T. Adebusuyi, Manvir Kaur, Anuoluwapo Egbejimi, Idowu A. Kehinde, Omonike A. Olaeye","doi":"10.1124/jpet.122.221240","DOIUrl":"https://doi.org/10.1124/jpet.122.221240","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124978035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Mass-Action Law Dynamic Theory-based “Top-Down” Approach with Observation/Statistics-based “Bottom-Up” Approach in Biomedical R&D 基于质量-作用定律动力学理论的“自上而下”方法与基于观察/统计的“自下而上”方法在生物医学研发中的比较
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.185320
Ting-chao Chou
{"title":"Comparison of Mass-Action Law Dynamic Theory-based “Top-Down” Approach with Observation/Statistics-based “Bottom-Up” Approach in Biomedical R&D","authors":"Ting-chao Chou","doi":"10.1124/jpet.122.185320","DOIUrl":"https://doi.org/10.1124/jpet.122.185320","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"129 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126969133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary delivery of nanochelators decreases lung iron accumulation and alleviates bleomycin-induced lung fibrosis in rats 肺输送纳米螯合剂减少肺铁积累，减轻博莱霉素诱导的大鼠肺纤维化
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.177590
Mayuri Patwardhan, Wesley R. Stiles, Homan Kang, Haksoo Choi, Jonghan Kim
{"title":"Pulmonary delivery of nanochelators decreases lung iron accumulation and alleviates bleomycin-induced lung fibrosis in rats","authors":"Mayuri Patwardhan, Wesley R. Stiles, Homan Kang, Haksoo Choi, Jonghan Kim","doi":"10.1124/jpet.122.177590","DOIUrl":"https://doi.org/10.1124/jpet.122.177590","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122113098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Directed Mutagenesis Studies Reveal Amino Acid Residues Responsible for A3Adenosine Receptor Positive Allosteric Modulator Function 定向诱变研究揭示了a3腺苷受体阳性变构调节剂功能的氨基酸残基
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.265090
Courtney L Fisher, V. Salmaso, Tina C. Wan, Balaram Pradhan, Kenneth A. Jacobson, J. Auchampach
{"title":"Directed Mutagenesis Studies Reveal Amino Acid Residues Responsible for A3Adenosine Receptor Positive Allosteric Modulator Function","authors":"Courtney L Fisher, V. Salmaso, Tina C. Wan, Balaram Pradhan, Kenneth A. Jacobson, J. Auchampach","doi":"10.1124/jpet.122.265090","DOIUrl":"https://doi.org/10.1124/jpet.122.265090","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130491372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How ligands achieve biased signaling at opioid receptors 配体如何在阿片受体上实现偏置信号
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.274970
Joseph M. Paggi, D. Aydin, Yianni Laloudakis, Carl-Mikael Suomivuori, Tao Che, Ron O. Dror
{"title":"How ligands achieve biased signaling at opioid receptors","authors":"Joseph M. Paggi, D. Aydin, Yianni Laloudakis, Carl-Mikael Suomivuori, Tao Che, Ron O. Dror","doi":"10.1124/jpet.122.274970","DOIUrl":"https://doi.org/10.1124/jpet.122.274970","url":null,"abstract":"Abstract","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124219990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and Structure-Activity Relationship of SAE-14 Analogs as G-Protein Coupled Receptor 183 Antagonists g蛋白偶联受体183拮抗剂SAE-14类似物的合成及构效关系
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.542210
Israel Olayide, Kathryn Braden, D. Salvemini, C. Arnatt
{"title":"Synthesis and Structure-Activity Relationship of SAE-14 Analogs as G-Protein Coupled Receptor 183 Antagonists","authors":"Israel Olayide, Kathryn Braden, D. Salvemini, C. Arnatt","doi":"10.1124/jpet.122.542210","DOIUrl":"https://doi.org/10.1124/jpet.122.542210","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"17 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114006396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structure-activity Exploration of Positive Allosteric Modulators of the Mu-opioid Receptor 阿片受体正变构调节剂的构效研究
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.238420
Mengchu Li, J. Traynor, Sherrice Zhang, Matthew Stanczyk, Xinmin Gan, Andrew White
{"title":"Structure-activity Exploration of Positive Allosteric Modulators of the Mu-opioid Receptor","authors":"Mengchu Li, J. Traynor, Sherrice Zhang, Matthew Stanczyk, Xinmin Gan, Andrew White","doi":"10.1124/jpet.122.238420","DOIUrl":"https://doi.org/10.1124/jpet.122.238420","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"45 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132737926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacological evaluation ofN-hydroxypyridinediones to support optimization as HBV ribonuclease H inhibitors n -羟基吡啶二酮支持优化HBV核糖核酸酶H抑制剂的药理学评价
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.193530
Molly E. Woodson, M. Mottaleb, Grigoris Zoidis, J. Tavis
{"title":"Pharmacological evaluation ofN-hydroxypyridinediones to support optimization as HBV ribonuclease H inhibitors","authors":"Molly E. Woodson, M. Mottaleb, Grigoris Zoidis, J. Tavis","doi":"10.1124/jpet.122.193530","DOIUrl":"https://doi.org/10.1124/jpet.122.193530","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124258769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Small Molecule Anti-Inflammatory TYK2 Inhibitors Attenuate Inflammation and Clinical Symptoms in a Mouse Model of Imiquimod Induced Psoriasis 小分子抗炎TYK2抑制剂在咪喹莫特诱导的银屑病小鼠模型中减轻炎症和临床症状
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.548690
S. Mallik, A. Tandon, Jissy A. Kuriappan, J. S. Kapure, Mahesh B. Halle, A. Iyer
{"title":"Small Molecule Anti-Inflammatory TYK2 Inhibitors Attenuate Inflammation and Clinical Symptoms in a Mouse Model of Imiquimod Induced Psoriasis","authors":"S. Mallik, A. Tandon, Jissy A. Kuriappan, J. S. Kapure, Mahesh B. Halle, A. Iyer","doi":"10.1124/jpet.122.548690","DOIUrl":"https://doi.org/10.1124/jpet.122.548690","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"114 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117202918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dual sEH/FAAH Inhibitors as a Promising Therapeutic Strategy for the Treatment of Chronic Pain 双重sEH/FAAH抑制剂作为治疗慢性疼痛的一种有前途的治疗策略
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.215530
Jeannes Angelia, R. Kandasamy, Xiaohui Weng, S. Pecic
{"title":"Dual sEH/FAAH Inhibitors as a Promising Therapeutic Strategy for the Treatment of Chronic Pain","authors":"Jeannes Angelia, R. Kandasamy, Xiaohui Weng, S. Pecic","doi":"10.1124/jpet.122.215530","DOIUrl":"https://doi.org/10.1124/jpet.122.215530","url":null,"abstract":"","PeriodicalId":173142,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125073999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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