Journal of Science: Advanced Materials and Devices最新文献

{"title":"Magnetic and pH-Sensitive dual actuation of biohybrid microswimmer of targeted drug release suitable for cancer cell microenvironment","authors":"Richa Chaturvedi ,&nbsp;Yumin Kang ,&nbsp;Yunji Eom,&nbsp;Sri Ramulu Torati ,&nbsp;CheolGi Kim","doi":"10.1016/j.jsamd.2025.100873","DOIUrl":"10.1016/j.jsamd.2025.100873","url":null,"abstract":"<div><div>The chemotherapeutic agents most frequently used in cancer treatment often have limited effectiveness because of their low specificity for tumors and poor therapeutic performance. In addition to the aforementioned therapeutic challenges the drug delivery carriers conjugated with the drug encounter early detection and elimination from the immune system before arriving at the affected area continues to be a significant research focus among researchers. To address this prevalent issue, an effective approach has been developed that leverages the physiological differences between normal and tumor tissue to enhance the efficacy of anticancer drugs. This drug delivery system is designed based on pH-sensitive drug release, ensuring targeted release within cancer cells. In the present study, we have developed a drug carrier called as biohybrid magnetic microswimmer (BMM). The BMM was formed through a three-step process: firstly, bacterial surfaces were functionalized with biotinylated PEG which enables the bacteria to escape the phagocytosis process; secondly, the anticancer drug lenalidomide was PEGylated to enhance solubility; and finally, both complexes were conjugated via streptavidin-biotin interaction. The study investigated bond formation, bacterial viability after drug treatment, pH-dependent release, and cytotoxicity in various cell lines (MCF-7 and THP-1 cells), and the results revealed that the concentration of the drug, released from BMM gradually increased as the pH of the solvent decreased from neutral to acidic, mimicking the surrounding environment of normal cells and cancer cells, respectively, which in turn affects the cancer cell viability negatively. Therefore, BMM shows promise in targeted drug delivery, utilizing magnetic manipulation and pH-triggered release, providing advantages that include bacteria's maneuverability and PEG's stealth properties, enhancing drug efficacy.</div></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":"10 2","pages":"Article 100873"},"PeriodicalIF":6.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corona triode poling of P(VDF-TrFE) nanofibers: Mechanisms and optimization strategies","authors":"Leonardo Gasperini,&nbsp;Giacomo Selleri,&nbsp;Davide Pegoraro,&nbsp;Daniele Mariani,&nbsp;Alberto Rumi,&nbsp;Paolo Seri,&nbsp;Davide Fabiani","doi":"10.1016/j.jsamd.2025.100870","DOIUrl":"10.1016/j.jsamd.2025.100870","url":null,"abstract":"<div><div>The effectiveness of the poling process of poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) nanofibers is essential for their use in engineering applications (i.e., artificial piezoelectric skins, self-sensing composite materials). While traditional contact poling methods present electrical breakdown risks through the highly porous nanofibrous membranes, the corona poling technique offers a non-contact alternative, utilizing ion generation to polarize piezoelectric materials without direct interaction between the high-voltage electrode and the sample. The corona poling process is well-established for P(VDF-TrFE) thin films, but literature lacks a reliable methodology for P(VDF-TrFE) nanofibers. This study addresses this gap by systematically investigating the differences between the corona poling of P(VDF-TrFE) films and nanofibers and aims to disclose the distinct physical mechanisms involved. First, the corona triode setup is optimized for P(VDF-TrFE) films, achieving a piezoelectric strain coefficient <span><math><mrow><msub><mi>d</mi><mn>33</mn></msub></mrow></math></span> of 23 pC N⁻¹. The parameters of the corona setup are then methodically recalibrated for the nanofiber's polarization, with the rationale behind these adjustments discussed and validated through experimental investigations. Such a refined corona poling method leads to a <span><math><mrow><msub><mi>d</mi><mn>33</mn></msub></mrow></math></span> equal to −20.8 pC N⁻¹ for the nanofibers, contemporary allowing for a comprehensive understanding of the physical mechanisms behind the two distinct methods.</div></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":"10 2","pages":"Article 100870"},"PeriodicalIF":6.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Braille recognition based on protein biomimetic skin mechanical sensors","authors":"Nianfeng Zhang ,&nbsp;Ailing Yang ,&nbsp;Andeng Liu ,&nbsp;Guoxi Shao ,&nbsp;Xixi Wang ,&nbsp;Yingjin Luo ,&nbsp;Zhihua Liu ,&nbsp;Yating Shi ,&nbsp;Na Li ,&nbsp;Wenxi Guo ,&nbsp;Wu Qiu ,&nbsp;Dapeng Yang","doi":"10.1016/j.jsamd.2025.100869","DOIUrl":"10.1016/j.jsamd.2025.100869","url":null,"abstract":"<div><div>Tactile perception, dominated by human skin, plays an important role in human-nature interaction, especially when visual perception is limited. The key to mimicking skin tactile perception is to address skin-like properties of materials and integration of biomimetic tactile functions. To be competent in bionic skin, composite silk fibroin (SF) films possessing high tensile properties (159.71 %) and hydrogels with elasticity (54.42 %) were prepared through a mesoscopic reconstruction strategy of SF materials, using fish scale gelatin molecules as mesoscopic templates to regulate the nucleation and crystallization kinetics of SF molecules. In addition, inspired by the mechanoreceptors, a bimodal protein bionic skin (BPBS) was prepared by horizontally integrating a single-electrode triboelectric sensor and a capacitive sensing array, which can work in sliding and pressing modes to mimic the sliding touch and pressing touch of the finger, respectively. The system achieves a 99 % Braille recognition accuracy in sliding mode through a deep learning algorithm, and Bluetooth technology enables real-time wireless Braille recognition in pressing mode, synergistically enhancing the robustness and practicality of BPBS. This research provides novel insights into enhancing human touch perception, human-computer interaction, and the advancement of intelligent prosthetics, marking a significant stride in the development of bionic skins with multimodal sensing capabilities.</div></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":"10 2","pages":"Article 100869"},"PeriodicalIF":6.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143526841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase structure, microstructure, and mechanical properties of FeCoCrNi-based eutectic high-entropy alloys reinforced with MWCNTs and Gr","authors":"Balaji V ,&nbsp;Arivazhagan A ,&nbsp;Anthony Xavior M","doi":"10.1016/j.jsamd.2025.100868","DOIUrl":"10.1016/j.jsamd.2025.100868","url":null,"abstract":"<div><div>This study primarily focuses on the phase structure, microstructure, and mechanical behaviour of Fe₂₅Co₂₅Cr₂₅Ni₂₅ equiatomic EHEAs upon adding 2 wt% of Multi-Walled Carbon Nanotubes (MWCNTs) and Graphene (Gr) as reinforcements. The alloying processes include Mechanical Alloying (MA) and Vacuum Arc Melting (VAM). The as-milled MA powder is irregularly shaped, with an average particle size of 23.5 μm. Samples subjected to MA followed by VAM exhibited a single-phase alloy composition, with a near-equal chemical distribution of major Face-Centered Cubic (FCC) and minor Body-Centered Cubic (BCC) crystal structures, as confirmed by X-ray diffraction (XRD) analysis. The Vickers microhardness values of the Fe₂₅Co₂₅Cr₂₅Ni₂₅ EHEAs samples were 123 ± 7 HV, while the additions of MWCNTs and Gr increased the hardness to 146 ± 6 HV and 155 ± 9 HV, respectively. To further enhance the strengthening behaviour, the EHEAs samples were heat-treated in a Nabertherm furnace at 1100 °C under an argon atmosphere, resulting in hardness values of 134 ± 6 HV, 164 ± 8 HV, and 171 ± 7 HV for the base alloy, MWCNTs addition, and Gr addition. Adding MWCNTs and Gr enhances the thermal stability of the as-milled powder, preventing secondary phase formation and improving the alloy stability of the equiatomic Fe₂₅Co₂₅Cr₂₅Ni₂₅ composition. Specifically, Fe₂₅Co₂₅Cr₂₅Ni₂₅ exhibited thermal stability up to 534 °C, while Fe₂₅Co₂₅Cr₂₅Ni₂₅+MWCNTs achieved 612 °C, and Fe₂₅Co₂₅Cr₂₅Ni₂₅+Gr demonstrated thermal stability up to 713 °C, with no mass loss or phase change observed, as revealed by thermogravimetric analysis (TGA). Furthermore, adding 2 wt% graphene resulted in superior hardness, residual compressive stress, and thermal stability compared to the MWCNTs addition.</div></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":"10 2","pages":"Article 100868"},"PeriodicalIF":6.7,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of a recyclable Y2O3-g-C3N4 as an auspicious nanosorbent for removing malachite green dye","authors":"Zainab M.H. El-Qahtani ,&nbsp;A. Modwi ,&nbsp;Hanadi M. AbdelSalam ,&nbsp;Tahani M. Albogami ,&nbsp;I.A. Osman ,&nbsp;Eida S. Al-Farraj ,&nbsp;Azizah A. Algreiby","doi":"10.1016/j.jsamd.2025.100867","DOIUrl":"10.1016/j.jsamd.2025.100867","url":null,"abstract":"<div><div>The recent development of industrial and agricultural technology has led to severe environmental damage, most notably water pollution, which poses a serious threat to water security, considering population increases and a decrease in global drinking water sources. In this direction, a nanostructure (Y₂O₃-g-C₃N₄) with a BET surface area of 82.14 m². g⁻¹ was employed for the first time as a novel sorbent to remove malachite green (MG) from the aqueous phase. Besides, the SEM, TEM, and EDX data verified the integration of 14.17 nm Y₂O₃ nanoparticles into the g-C₃N₄ nanosheets. The experimental adsorption results confirmed the best fitting to the well-known Langmuir isotherm equation, achieving <em>q</em>_max = 1297 mg g¹ of MG uptake, and the kinetic model calculations revealed a single-step mechanism involving a pseudo-second-order chemical reaction with a rate constant of 0.00134 mg./mg. min, which accounted for the chemisorption of MG dye on the Y₂O₃-g-C₃N₄ nanostructure sample. Due to its ease of manufacture and ecologically acceptable procedure, the Y₂O₃-g-C₃N₄ nanostructure was recognized as a desirable and promising candidate for eradicating tainted organic dyes. The newly synthesized Y₂O₃-g-C₃N₄ nanostructure with a high surface area demonstrated a short contact time, outstanding removal capacity, five times recyclability, and multiple dyes elimination nominating it a potentially valuable nanosorbent for the adsorption of dyes from wastewater.</div></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":"10 2","pages":"Article 100867"},"PeriodicalIF":6.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel pyrochlores in the Bi2O3–MgO–Ta2O5 (BMT) system: Synthesis optimisation, phase equilibria and dielectric properties","authors":"K.B. Tan ,&nbsp;P.Y. Tan ,&nbsp;Y. Feng ,&nbsp;C.C. Khaw ,&nbsp;V. Raman ,&nbsp;H.C. Ananda Murthy ,&nbsp;R. Balachandran ,&nbsp;S.K. Chen ,&nbsp;O.J. Lee ,&nbsp;K.Y. Chan ,&nbsp;D. Zhou ,&nbsp;M. Lu","doi":"10.1016/j.jsamd.2025.100866","DOIUrl":"10.1016/j.jsamd.2025.100866","url":null,"abstract":"<div><div>Investigating the phase equilibria within the Bi₂O₃–MgO–Ta₂O₅ (BMT) system offers critical insights into the formation and stability of pyrochlore phases. This understanding enables the correlation of dielectric properties with phase equilibria data, facilitating the identification of compositions exhibiting optimal performance. Phase equilibria within the BMT system have been investigated across a temperature range of 800–1025 °C. The layouts of compatible triangles, encompassing two-phase, three-phase regions and the single-phase BMT subsolidus solution area, have been determined through qualitative XRD phase analysis of approximately 150 synthesised compositions. The BMT trapezoidal cubic pyrochlore region could be represented by the general formula of Bi_3.56-xMg_1.96-yTa_2.48+_x + yO_{13.50+x+(3/2)y}, 0.00 ≤ x ≤ 0.32; 0.00 ≤ y ≤ 0.20. Two formation mechanisms are proposed: (i) compositions of Bi_3.56-xMg_1.96Ta_2.48+xO_13.50+x at fixed MgO content, involving a one-to-one substitution of Bi³⁺ by Ta⁵⁺ and oxygen non-stoichiometry x Bi³⁺ → x Ta⁵⁺ + x O²⁻ and (ii) Bi_3.56Mg_1.96-yTa_2.48+yO_13.50+(3/2)y at fixed bismuth content, with Mg content reduction proportional to Ta⁵⁺ and O²⁻ substitution, i.e. y Mg²⁺ → y Ta⁵⁺ + 3y/2 O²⁻. Dielectric properties within this extensive subsolidus solution area exhibit variability; specifically, BMT pyrochlores exhibit dielectric constants (ε′) ranging from 70 to 84, dielectric losses (tan <em>δ</em>) in the order of 0.2–9.1 × 10⁻³, negative temperature coefficients of dielectric constants (TCε′) ranging from 130 to 360 ppm/°C and activation energies (Ea) ranging from 1.10 to 1.48 eV.</div></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":"10 2","pages":"Article 100866"},"PeriodicalIF":6.7,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recycling waste for energy: Reusing methyl orange dye-adsorbed polythiophene/Fe3O4 nanorods/reduced graphene oxide nanocomposite as a supercapacitor electrode","authors":"Ahmad Husain ,&nbsp;Asim Ali ,&nbsp;Sara A. Alqarni ,&nbsp;Khalid Ansari ,&nbsp;Mohtaram Danish ,&nbsp;Prem Gunnasegaran ,&nbsp;Mohammad Kanan ,&nbsp;Jayant Giri ,&nbsp;M. Kandasamy ,&nbsp;M.M.A. Khan ,&nbsp;Kyeong Tae Kang","doi":"10.1016/j.jsamd.2025.100865","DOIUrl":"10.1016/j.jsamd.2025.100865","url":null,"abstract":"<div><div>This study presents a sustainable waste-to-wealth approach by repurposing methyl orange (MO) dye-adsorbed polythiophene/iron oxide/reduced graphene oxide nanocomposite (PTh/Fe₃O₄/RGO) for dual functionality in wastewater treatment and energy storage. PTh/Fe₃O₄/RGO nanocomposite was initially employed as an effective adsorbent to remove harmful MO dye from wastewater. After successful adsorption, the dye-saturated PTh/Fe₃O₄/RGO was repurposed as a supercapacitor electrode to investigate its energy storage capabilities. Electrochemical tests before MO adsorption revealed that the pristine PTh/Fe₃O₄/RGO electrode demonstrated promising performance with a specific capacitance of 467.3 Fg⁻¹ at 1 Ag⁻¹ and excellent cyclic stability of 95.3% retention over 5000 Galvanostatic charge-discharge (GCD) cycles. Further, the maximum adsorption of MO by the PTh/Fe₃O₄/RGO was achieved under optimal conditions: pH 3, 2.5 gL⁻¹ dosage, 120 min contact time, and 50 mgL⁻¹ MO concentration. The adsorption behaviour was well-explained by the Langmuir isotherm, pseudo-second-order kinetics, and Dubinin-Radushkevich (D-R) isotherm, indicating a physical adsorption process with a monolayer capacity of 151.34 mgg⁻¹. Thermodynamic analysis, with a positive enthalpy (ΔH°) and negative Gibbs free energy (ΔG°), confirmed that the process is endothermic and spontaneous. Desorption studies showed that 88.72% of the MO could be desorbed in the first cycle, with effective regeneration up to six cycles using NaOH. Post-adsorption, the material still retained significant supercapacitor properties, with a specific capacitance of 380.9 Fg⁻¹ at 1 Ag⁻¹ and 83.2% cyclic stability over 5000 GCD cycles. This study demonstrates a circular, sustainable approach that integrates waste treatment with energy storage, highlighting the potential of reusing materials for multifunctional applications.</div></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":"10 2","pages":"Article 100865"},"PeriodicalIF":6.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development, exploration and optimization of porous titanium and titanium alloys: A review","authors":"Baoguang Zhang,&nbsp;Kun Yang,&nbsp;Lei Shen,&nbsp;Xingyu Duan,&nbsp;Shaoyang Zhao,&nbsp;Wenbin Gao,&nbsp;Chenyang Xu,&nbsp;Jian Wang","doi":"10.1016/j.jsamd.2025.100863","DOIUrl":"10.1016/j.jsamd.2025.100863","url":null,"abstract":"<div><div>As an integrated material of structure and function, porous titanium (Ti) and Ti alloys with a porosity of (10–95%) processes a wide application prospect in many fields. However, they still faced some issues, including the design and optimization of pore structure, the improvement of service performance, and the exploration of unique applications. To provide valuable insights into addressing these issues, the recent advances in porous Ti and Ti alloys have been reviewed systematically. Firstly, the manufacturing technologies for porous Ti and Ti alloys were expounded and objectively evaluated, with a focus on comparing the corresponding pore structures and mechanical properties. Besides, the current applications corresponding mechanisms, and characteristics of porous Ti and Ti alloys were introduced in detail. Finally, as key factors determining the performance and functions of porous Ti and Ti alloys, the design and optimization of pore structure and doping modification were emphatically summarized and discussed.</div></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":"10 2","pages":"Article 100863"},"PeriodicalIF":6.7,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143396028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the role of multi-functional Mg2GeO4:Eu3+, Sm3+ nanophosphors as a luminescent armour against counterfeiting and implementing its practical adaptability","authors":"Akshay Arjun ,&nbsp;G.P. Darshan ,&nbsp;S.C. Sharma ,&nbsp;H. Nagabhushana ,&nbsp;H.B. Premkumar","doi":"10.1016/j.jsamd.2025.100864","DOIUrl":"10.1016/j.jsamd.2025.100864","url":null,"abstract":"<div><div>The escalating threat of counterfeiting poses a significant challenge across the world. Hence, the development of robust anti-counterfeiting measures and their ease of practical implementation are in demand. In this view, the present work establishes the synthesis of Mg₂GeO₄:Eu³⁺ (7 mol %), Sm³⁺ (1–5 mol %) nanophosphors via a solution combustion route. The structural studies of the prepared samples confirmed the pure orthorhombic phase with <em>Pnma</em> space group. The photoluminescence emission spectrum monitored under 393 nm excitation wavelength displayed distinct, sharp peaks at ∼ 579, 589, 610, 659, and 707 nm. Further, the emission spectra showcase luminescence intensity enhancement upon co-doping, which is ascribed to efficient energy transfer between donor (Eu³⁺) and acceptor (Sm³⁺) ions. The quantum efficiency of the optimized nanophosphor reached an impressive 70.23 % and color purity of 95.9 %, which positioned the prepared nanophosphor as a promising candidate for white light-emitting diode applications. Moreover, various anti-counterfeiting patterns were designed, encrypted, and undergone rigorous environmental tolerance tests to assess their practical implications in real-world scenarios. The encrypted patterns exhibit high resistance to extreme temperatures and water, excellent chemicals and oil stability, battle against abrasions, and are exceptionally photo-stable. The obtained results affirm that the developed anti-counterfeiting patterns retained their integrity and functionality throughout the simulated environmental tests. This emphasizes the impending ability of the prepared Mg₂GeO₄:Eu³⁺ (7 mol %), Sm³⁺ (1–5 mol %) nanophosphors to combat counterfeiting.</div></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":"10 2","pages":"Article 100864"},"PeriodicalIF":6.7,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced wound healing with flaxseed extract-loaded polyvinyl alcohol nanofibrous scaffolds: Phytochemical composition, antioxidant activity, and antimicrobial properties","authors":"Ahmed G. Abdelaziz ,&nbsp;Hassan Nageh ,&nbsp;Mohga S. Abdalla ,&nbsp;Sara M. Abdo ,&nbsp;Asmaa A. Amer ,&nbsp;Samah A. Loutfy ,&nbsp;Ali Alsalme ,&nbsp;David Cornu ,&nbsp;Mikhael Bechelany ,&nbsp;Ahmed Barhoum","doi":"10.1016/j.jsamd.2025.100862","DOIUrl":"10.1016/j.jsamd.2025.100862","url":null,"abstract":"<div><div>This study aimed to develop and optimize composite nanofibrous scaffolds for enhanced wound healing and antimicrobial applications. Polyvinyl alcohol (PVA) nanofibers loaded with ethanolic flaxseed extract were fabricated via solution electrospinning. The methodology focused on optimizing key parameters, including polymer-to-extract ratio, swelling ratio, hydrolytic degradation, and nanofiber mean diameter, to achieve superior scaffold properties. The optimized scaffold, with a PVA-to-flaxseed extract weight ratio of 70:30 (PV70:FS30), exhibited bead-free morphology and a mean fiber diameter of 319 nm (compared to 175 nm for pure PVA fibers). PV70:FS30 scaffolds demonstrated significant antimicrobial activity, effectively inhibiting both Gram-negative and Gram-positive bacterial growth. Moreover, human melanocyte (HBF-4) viability and wound healing rates were substantially higher on PV70:FS30 scaffolds than on pure PVA fibers (viability: 122.3% vs. 91.2%; wound closure at 48 h: 97.3% vs. 69.6%, relative to control). However, cell adhesion was lower on PV70:FS30 scaffolds (93 cells/section vs. 183 cells/section for PVA nanofibers) due to increased cross-linking and reduced hydrophilicity from flaxseed extract incorporation. These findings indicate a clear interplay between flaxseed extract concentration and scaffold morphology, highlighting their potential for advancing skin tissue engineering applications. These results provide insights into designing nanofibrous scaffolds for improved wound healing and antimicrobial properties.</div></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":"10 2","pages":"Article 100862"},"PeriodicalIF":6.7,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143403413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}