Journal of Research in Pharmacy Practice最新文献

{"title":"Efficacy of Adding Oral N acetyl Cysteine Supplement to the Cystic Fibrosis Treatment Regimen: A Randomized Quasi-Experimental Trial.","authors":"Sedigheh Keshavarz, Mohsen Reisi, Majid Keivanfar, Faezeh Rabbani, Ali Mohammad Sabzghabaee","doi":"10.4103/jrpp.jrpp_54_24","DOIUrl":"https://doi.org/10.4103/jrpp.jrpp_54_24","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated the efficacy of adding the oral N-acetyl cysteine (NAC) supplement to the cystic fibrosis (CF) treatment regimen compared to adding a placebo. It also studied the quality of life and respiratory indicators of patients aged 6-18 with mild-to-moderate pulmonary involvement.</p><p><strong>Methods: </strong>This clinical trial was a randomized, quasi-experimental pilot and add-on therapy controlled with a placebo for 3 months. The case group received 200 mg of oral NAC three times a day. In contrast, the control group had a placebo in the same way. From the 2021 fall to the summer of 2022, 38 CF patients referred to Imam Hossein Children's Hospital Clinic were finally examined. They were clinically stable with a forced expiratory volume in the first second (FEV₁) level of more than 50% and no history of underlying cardiovascular and renal diseases.</p><p><strong>Findings: </strong>The differences between the groups were not significant. In the placebo group, key measures remained unchanged, whereas the NAC group had an improvement in the CF Questionnaire-Revised score but no notable changes in other indices. Overall, comparisons of forced vital capacity (FVC) between the groups showed no variation.</p><p><strong>Conclusion: </strong>The indicators of FEV₁, FVC, FEV₁/FVC, <i>forced expiratory flow between 25% and 75% of vital capacity</i>, and the quality of life of the case group were not significantly different from those of the placebo group, and no significant differences were observed between this medicine and placebo.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"13 3","pages":"72-77"},"PeriodicalIF":0.8,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Efficacy of Intravenous Ketamine and Tramadol in Reducing Postspinal Anesthesia Shivering in Urological Surgeries: A Triple-blind Randomized Clinical Trial.","authors":"Shahnam Sedigh Maroufi, Mehrdad Mesbah Kiaei, Siavash Sangi, Maryam Aligholizadeh, Mohsen Abbasi, Parisa Moradimajd, Rezvan Rajabzadeh, Azam Saei","doi":"10.4103/jrpp.jrpp_4_25","DOIUrl":"https://doi.org/10.4103/jrpp.jrpp_4_25","url":null,"abstract":"<p><strong>Objective: </strong>Shivering is one of the most common complications due to disturbances in the thermoregulatory system after regional anesthesia, leading to adverse outcomes and decreased patient satisfaction. Ketamine and tramadol are considered mild analgesics that affect the thermoregulatory center. This triple-blind, randomized clinical trial aims to explore the comparative efficacy of intravenous ketamine and tramadol in reducing postspinal anesthesia shivering in high-risk urological surgeries.</p><p><strong>Methods: </strong>A total of 90 patients undergoing urological surgeries under spinal anesthesia at Shahid Hasheminejad Hospital in Tehran in 2024 were randomized into three groups: ketamine (0.5 mg/kg), tramadol (0.5 mg/kg), and placebo (normal saline). Variables, including ambient temperature, patient demographics, surgery duration, and anesthetic techniques, were meticulously controlled. The primary outcome was the incidence of shivering, measured using the Crossley and Mahajan scale. Data were analyzed using the SPSS software Version 19, employing Chi-square tests, analysis of variance, and logistic regression.</p><p><strong>Findings: </strong>The patients were homogeneous regarding demographic and surgical variables. No significant difference was found in patients' body temperature upon admission. The incidence of shivering was significantly lower in the tramadol group (23.3%) compared to the ketamine group (36.7%) and placebo group (60%) (<i>P</i> = 0.013). Tramadol demonstrated superior efficacy with minimal side effects. Logistic regression analysis confirmed that patients in the tramadol group were significantly less likely to experience shivering (odds ratio = 0.286; 95% confidence interval: 0.098-0.834, <i>P</i> = 0.022). Ketamine, while effective, had a higher incidence of hemodynamic fluctuations and psychotropic effects.</p><p><strong>Conclusion: </strong>The incidence of shivering was significantly lower in the tramadol group compared to the ketamine and placebo groups. Tramadol demonstrated superior efficacy with minimal side effects. While effective, ketamine had a higher incidence of hemodynamic fluctuations and psychotropic effects.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"13 3","pages":"92-99"},"PeriodicalIF":0.8,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Complications Following Acute Methadone Poisoning in Patients with and Without a History of Long-term Methadone Use.","authors":"Gholamali Dorooshi, Mahbod Shirmohammadi, Farzad Gheshlaghi, Arman Otroshi, Shafeajafar Zoofaghari, Nastaran Eizadi-Mood","doi":"10.4103/jrpp.jrpp_49_24","DOIUrl":"https://doi.org/10.4103/jrpp.jrpp_49_24","url":null,"abstract":"<p><strong>Objective: </strong>Given the prevalence of methadone poisoning, this study was conducted to compare the cardiovascular complications following acute methadone poisoning in patients with and without a history of long-term methadone use.</p><p><strong>Methods: </strong>In this retrospective study, information related to patients with acute methadone poisoning hospitalized at Al-Zahra and Khorshid hospitals in Isfahan-Iran was collected from hospital archives and analyzed. Patients were divided into two groups with and without a history of long-term methadone use.</p><p><strong>Findings: </strong>The mean of corrected QT interval (QTc), QRS, and heart rate showed no significant differences between the two groups at three-time points: baseline (upon admission), 12 h, and 24 h after admission (<i>P</i> > 0.05). The mean QT dispersion upon admission and 12 h after admission did not differ significantly between the groups (<i>P</i> > 0.05). However, the observation at 24 h postadmission indicated a significant increase in QT dispersion in the group with a history of long-term methadone use, showing a mean of 47.53 ± 10.62 ms compared to the without a history of long-term use group, with a mean of 26.78 ± 6.75 ms (<i>P</i> = 0.041).</p><p><strong>Conclusion: </strong>The results indicate that among the cardiovascular findings when analyzing the electrocardiograms of patients with acute methadone poisoning, only QT dispersion differed between patients with and without a history of long-term methadone use. Cardiovascular events resulting from methadone poisoning are the significant factors contributing to patient mortality, highlighting the need for the careful management of methadone use in these patients.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"13 2","pages":"58-64"},"PeriodicalIF":0.8,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbapenem-resistant <i>Acinetobacter baumannii</i> and Ventilator-associated Pneumonia; Epidemiology, Risk Factors, and Current Therapeutic Approaches.","authors":"Malihe Kazemi Najafabadi, Rasool Soltani","doi":"10.4103/jrpp.jrpp_50_24","DOIUrl":"10.4103/jrpp.jrpp_50_24","url":null,"abstract":"<p><p><i>Acinetobacter baumannii</i> is one of the primary pathogens responsible for healthcare-associated infections. It is related to high rates of morbidity and mortality globally, mainly because of its high capacity to develop resistance to antimicrobials. Nowadays, carbapenem-resistant <i>A. baumannii</i> (CRAB) has increased and represents a significant concern among carbapenem-resistant organisms. It is also a key pathogen associated with ventilator-associated pneumonia. CRAB was placed on the critical group of the universal priority list of the World Health Organization for antibiotic-resistant bacteria, to mention the importance of research development and the urgency of new antibiotics. Patients with severe CRAB infections currently face significant treatment challenges. Some approaches have been taken to deal with CRAB, such as combination therapy and the synergistic effect of certain antibiotics, but the best antibiotic regimen is still unknown. In this narrative review, we attempt to clarify the issues, including epidemiology, risk factors, and current treatment options for CRAB.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"13 2","pages":"33-40"},"PeriodicalIF":0.8,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Risk Factors of Medication Errors in Enteral Tube Feeding Among ICU Patients: A Comprehensive Cross-Sectional Analysis.","authors":"Mansooreh Asghari-Varzaneh, Shirinsadat Badri, Shadi Farsaei","doi":"10.4103/jrpp.jrpp_47_24","DOIUrl":"10.4103/jrpp.jrpp_47_24","url":null,"abstract":"<p><strong>Objective: </strong>Most of the patients who are admitted to the intensive care unit (ICU) are forced to feed and use nutrition and medicine through an implanted tube. When administering medication through enteral feeding tubes, it is essential to be cautious, as some drugs may not be suitable due to interactions with feeding formulas or adverse effects when crushed. Some errors during drug gavage can lead to feeding tube blockage, reduced drug effectiveness, or drug toxicity. This study aimed to assess medication errors (MEs) in ICU patients using enteral feeding tubes and identify factors that affect ME incidents.</p><p><strong>Methods: </strong>This descriptive and analytical study was conducted for 9 months in the special care department of hospitals affiliated with Isfahan University of Medical Sciences. It involved 257 patients in the ICU receiving oral medication through an implanted gastric tube. The study assessed the method of oral drug administration, verified the correctness of drug prescriptions, investigated errors in drug provision and administration, and monitored patients for possible side effects of these errors. Demographic information and details about the prescribing physician and relevant nurses were also recorded.</p><p><strong>Findings: </strong>Our findings show that not washing the tube before gavage was the most frequent error (99.6%). However, different factors, whether the patient or the nurse, did not affect them. The other most common errors included mixing drugs simultaneously (75.6%) and not cleaning the tube after administering medication (78.6%). These errors were influenced by factors such as the number of drugs received by the patient, the hospital, and specific shifts.</p><p><strong>Conclusion: </strong>In this study, we found that polypharmacy, the multiplicity of underlying diseases, and nurses' gender are the most critical factors that increase the number of MEs during the gavage of drugs in patients hospitalized in ICUs.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"13 2","pages":"47-52"},"PeriodicalIF":0.8,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Evaluation on Five Dimensions of a Mobile Health Application for Patient Counseling in Ambulatory Care Pharmacy: A Single-center Cross-sectional Survey Based on Pediatric Caregiver's Opinion.","authors":"Qing-Qing Liu, Min Wang, Feng Chen, Xing Ji, Jin Xu, Zhi-Yu Wang","doi":"10.4103/jrpp.jrpp_5_24","DOIUrl":"https://doi.org/10.4103/jrpp.jrpp_5_24","url":null,"abstract":"<p><strong>Objective: </strong>Due to high workloads and insufficient counseling time in ambulatory care pharmacy, outpatient pharmacists for pediatric patients in China proposed a mobile health application (mHealth app) that they considered could provide patient counseling more efficiently. To improve it accordingly, we need to design a more specific and multi-dimensional evaluation method to obtain pediatric caregivers' evaluations of a mHealth app.</p><p><strong>Methods: </strong>A cross-sectional survey on five dimensions (transmission, accuracy, accessibility, completeness, and experience) of the mHealth app was conducted using a random questionnaire among outpatient caregivers at a children's hospital.</p><p><strong>Findings: </strong>We received 478 valid questionnaires from 500 caregivers. The Item-Level Content Validity Index (I-CVI) indicated the content validity of the questions (I-CVI =1.000). The Content Validity Index for Scales (S-CVI) confirmed their content validity (S-CVI =1.000). The intraclass correlation coefficients (ICCs) of test-retest reliability were acceptable (0.806≤ ICC ≤0.869). The mean scores for transmission, accuracy, accessibility, and completeness were more than 3.5 when the experience was 2.1. Caregivers of different ages agreed that their accuracy was satisfactory; however, their experience was not. Caregivers aged over 50 years did not recognize its transmission and accessibility, whereas caregivers aged under 29 years and over 50 years were not satisfied with its completeness.</p><p><strong>Conclusion: </strong>The accuracy of the mHealth app is excellent; the transmission and accessibility need to give the silver generation time to accept and adapt, and experience and completeness should be improved. The five-dimensional assessment model can also be used to evaluate other mHealth apps for patient counseling.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"13 2","pages":"41-46"},"PeriodicalIF":0.8,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there a Possible Association between Multiple Myeloma Relapse and Coronavirus Disease 2019 Vaccination? A Case Report.","authors":"Nasrin Shirzad-Yazdi, Nasrin Namdari, Anahid Noorani, Iman Karimzadeh","doi":"10.4103/jrpp.jrpp_21_24","DOIUrl":"10.4103/jrpp.jrpp_21_24","url":null,"abstract":"<p><p>Due to the high morbidity and mortality of the coronavirus disease 2019 (COVID-19) in patients with malignancy, the necessity of vaccination in this group of patients became particularly important. Although a large number of studies have reported the safety of COVID-19 vaccination in multiple myeloma (MM) patients, the effect of the COVID-19 vaccine on MM relapse has not yet been reported. Here, we report a case of a possible association between relapse of MM and COVID-19 vaccination with Sinopharm^®, an inactivated virus vaccine, in a patient with MM who has remained in complete remission for about 4 years. The MM relapse in the patient was diagnosed by both clinical findings and laboratory workup including serum protein electrophoresis, bone marrow aspiration, and biopsy. Despite this possible association between COVID-19 vaccination and MM relapse in the patient, given its importance in reducing mortality and having an acceptable safety profile, the COVID-19 vaccine should be administered to all cancer patients. However, careful monitoring and follow-up are recommended in patients with MM after COVID-19 vaccination.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"13 1","pages":"27-32"},"PeriodicalIF":0.8,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11524571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical Medroxyprogesterone Acetate and Corneal Epithelium Healing after Photorefractive Keratectomy: A Randomized, Double-masked Contralateral Eye Study.","authors":"Alireza Peyman, Mohsen Pourazizi, Matin Irajpour, Pegah Noorshargh, Asieh Aslani","doi":"10.4103/jrpp.jrpp_26_24","DOIUrl":"10.4103/jrpp.jrpp_26_24","url":null,"abstract":"<p><strong>Objective: </strong>The objective of the study was to evaluate the efficacy and safety of topical 1% medroxyprogesterone in corneal epithelial healing after photorefractive keratectomy (PRK).</p><p><strong>Methods: </strong>In this placebo-controlled double-masked randomized contralateral eye study, 66 eyes of 33 patients with myopia and myopia-astigmatism were assigned into two groups to receive either 1% topical medroxyprogesterone (intervention) or artificial tear (placebo) at the end of PRK surgery. The patients were followed up daily for 5 days until epithelial healing was achieved. The time taken for epithelial healing was the main outcome measure.</p><p><strong>Findings: </strong>The mean age of the subjects was 32.97 ± 7.6 years and 46 individuals were female (69.7%). All baseline refractive characteristics were comparable between the groups. There was no significant difference between the two groups in terms of epithelial defect size on Day 1 (<i>P</i>: 0.67). Both groups exhibited a consistent pattern of decreasing epithelial defect size from Day 1 to Day 5, with the control group having slightly worse initial values. There were no significant differences between the groups in the following days. Both groups showed substantial reductions in the epithelial defect size, but the intervention group showed a more prominent decrease on Day 2. The intervention did not show a significant statistical difference compared to the control group, and both groups ended up with a similar outcome.</p><p><strong>Conclusion: </strong>These findings suggest that the topical 1% medroxyprogesterone does not significantly affect the healing of corneal epithelium after PRK.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"13 1","pages":"14-18"},"PeriodicalIF":0.8,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11524572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Critical Role of Ward-Based and Satellite Pharmacists in Improving Pharmaceutical Care in Hospital.","authors":"Fatemeh Afra, Fatemeh Amou Abedi, Faezeh Feizabadi, Amir Ali Mahboobipour, Mansoor Rastegarpanah","doi":"10.4103/jrpp.jrpp_28_24","DOIUrl":"10.4103/jrpp.jrpp_28_24","url":null,"abstract":"<p><strong>Objective: </strong>Medical errors are the third leading cause of death in the U. S., with medication mistakes being a common issue. Medication reconciliation (MR) involves comparing patients' orders with their existing medications to prevent errors. Pharmacists are ideally suited for MR tasks. Effective MR can reduce drug-related rehospitalizations. This study aimed to investigate medication errors among hospitalized patients and to evaluate the impact of ward-based and satellite pharmacists on the quality of drug administration services.</p><p><strong>Methods: </strong>A descriptive cross-sectional study was conducted at Nikan General Hospitals in Tehran, Iran, over 6 months. We assessed the performance of ward-based and satellite pharmacists in various wards. All patient medication activities were meticulously monitored and recorded. Adjusted drug-related problem (DRP) codes were then used to identify medication errors and the corresponding interventions.</p><p><strong>Findings: </strong>The study included 1682 patients, each experiencing at least one DRP. The data revealed a DRP prevalence of 6.44% (95% confidence interval: 6.15%-6.75%). A total of 2173 DRPs were identified, with 650 originating from intensive care units and the remaining 1523 from other wards. Notably, DRPs attributed to nurses (labeled as S2) constituted 18.36%, and those due to drug interactions (classified as D7) accounted for 13.48%. Following intervention, the most common pharmacist recommendations were initiating a medication (14.04%), discontinuing a medication (13.12%), changing a medication (11.38%), and reducing doses (11.09%).</p><p><strong>Conclusion: </strong>Effective MR, supported by comprehensive training of medical staff such as physicians and nurses, can significantly reduce DRPs in hospitalized patients. Clinical pharmacists play a vital role in this context.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"13 1","pages":"19-26"},"PeriodicalIF":0.8,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11524570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Effect of Hyoscine and Dexamethasone on Cervical Preparation in Primigravid Women with Term Pregnancy: A Double-blind Randomized Clinical Trial.","authors":"Sheida Shabanian, Azar Danesh, Saba Najafi","doi":"10.4103/jrpp.jrpp_41_24","DOIUrl":"https://doi.org/10.4103/jrpp.jrpp_41_24","url":null,"abstract":"<p><strong>Objective: </strong>Pregnancy outcomes are an important factor in women's quality of life, and negative experiences have adverse effects on the overall health of the mother and the family. This study was designed and implemented to compare the effects of two drugs, hyoscine and dexamethasone, on cervical ripening and effacement during childbirth.</p><p><strong>Methods: </strong>This study was a double-blind randomized clinical trial of 150 patients divided into three groups. The researchers, in the early stage (latent) of labor, gave 8 mg of dexamethasone intravenously to the first group, 20 mg of hyoscine butyl bromide to the second group, and 8 mg of dexamethasone along with 20 mg of hyoscine butyl bromide to the third group.</p><p><strong>Findings: </strong>Among the quantitative variables studied (length of labor induction, duration of active stage, first stage and second stage of labor, placental expulsion time, 5- and 10-min Apgar and Bishop score), active stage duration (<i>P</i> = 0.000) and 5-min Apgar (<i>P</i> = 0.042) had statistical differences among the three groups. In addition, the type of delivery (<i>P</i> = 0.003) and the percentage of fetal distress (<i>P</i> = 0.001) in the studied groups had a statistically significant difference, and also, in the third group, the cesarean rate was less than the other two groups.</p><p><strong>Conclusion: </strong>Simultaneous injection of hyoscine and dexamethasone in primiparous women can reduce the duration of the active stage of labor without obstetric complications, so its use in the latent stage is suggested.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"12 4","pages":"130-134"},"PeriodicalIF":0.8,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11386062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}