Journal of Research in Pharmacy Practice最新文献

{"title":"Investigating the Effect of Hyoscine and Dexamethasone on Cervical Preparation in Primigravid Women with Term Pregnancy: A Double-blind Randomized Clinical Trial.","authors":"Sheida Shabanian, Azar Danesh, Saba Najafi","doi":"10.4103/jrpp.jrpp_41_24","DOIUrl":"https://doi.org/10.4103/jrpp.jrpp_41_24","url":null,"abstract":"<p><strong>Objective: </strong>Pregnancy outcomes are an important factor in women's quality of life, and negative experiences have adverse effects on the overall health of the mother and the family. This study was designed and implemented to compare the effects of two drugs, hyoscine and dexamethasone, on cervical ripening and effacement during childbirth.</p><p><strong>Methods: </strong>This study was a double-blind randomized clinical trial of 150 patients divided into three groups. The researchers, in the early stage (latent) of labor, gave 8 mg of dexamethasone intravenously to the first group, 20 mg of hyoscine butyl bromide to the second group, and 8 mg of dexamethasone along with 20 mg of hyoscine butyl bromide to the third group.</p><p><strong>Findings: </strong>Among the quantitative variables studied (length of labor induction, duration of active stage, first stage and second stage of labor, placental expulsion time, 5- and 10-min Apgar and Bishop score), active stage duration (<i>P</i> = 0.000) and 5-min Apgar (<i>P</i> = 0.042) had statistical differences among the three groups. In addition, the type of delivery (<i>P</i> = 0.003) and the percentage of fetal distress (<i>P</i> = 0.001) in the studied groups had a statistically significant difference, and also, in the third group, the cesarean rate was less than the other two groups.</p><p><strong>Conclusion: </strong>Simultaneous injection of hyoscine and dexamethasone in primiparous women can reduce the duration of the active stage of labor without obstetric complications, so its use in the latent stage is suggested.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"12 4","pages":"130-134"},"PeriodicalIF":0.8,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11386062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Preoperative Intravenous and Inhalational Dexmedetomidine on the Hemodynamic Response of Laryngoscopy: A Prospective Double-blinded Randomized Study.","authors":"Shivanya Singh, Priyanka Gupta, Mridul Dhar, Arhan Pasha","doi":"10.4103/jrpp.jrpp_12_24","DOIUrl":"https://doi.org/10.4103/jrpp.jrpp_12_24","url":null,"abstract":"<p><strong>Objective: </strong>Laryngoscopy induces potent noxious stimuli causing reflex autonomic activation manifested by an increase in blood pressure and heart rate (HR). Various drugs with different routes have been tried to prevent this response. The literature comparing inhalational dexmedetomidine with intravenous (IV) dexmedetomidine to prevent laryngoscopy response is limited.</p><p><strong>Methods: </strong>A total of 150 American Society of Anesthesiologists Physical Status Class I/II, undergoing elective surgery requiring laryngoscopy and intubation, were included and randomized into two groups. Patients in Group D_INH received nebulized dexmedetomidine (1 μg/kg) and in Group D_IV received IV dexmedetomidine (0.5 μg/kg), 15 min before anesthesia induction. For blinding, nebulized or IV saline was used simultaneously. The primary outcome was to compare the mean arterial pressure (MAP) and HR at laryngoscopy, intubation, and 1, 5, and 10 min after intubation. The secondary outcome was to compare sedation, following the administration of dexmedetomidine, propofol consumption during induction, and any side effects.</p><p><strong>Findings: </strong>There was no significant difference in MAP (mmHg) postlaryngoscopy and intubation (immediate after intubation 78.5 ± 11.3 vs. 82.3 ± 16.0, <i>P</i> = 0.093). The mean HR was clinically similar in both groups postlaryngoscopy and intubation (immediate after intubation, 80.9 ± 12.5 vs. 76.3 ± 10.9). Patients in the D_IV group were more sedated than the D_INH (Ramsay Sedation Scale 3-4 vs. 1-2, <i>P</i> < 0.001). Bradycardia was seen in eight patients of the D_IV group only.</p><p><strong>Conclusion: </strong>Preoperative nebulized dexmedetomidine is as effective as and safer than IV dexmedetomidine in preventing laryngoscopic response among adults.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"12 4","pages":"123-129"},"PeriodicalIF":0.8,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11386063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Drug Interactions in Hospitalized Hematologic Cancer Patients: New Update with New Chemotherapy Regimens.","authors":"Tahereh Gholipourshahraki, Amir Aria, Mehran Sharifi, Ayda Moghadas, Azadeh Moghaddas","doi":"10.4103/jrpp.jrpp_40_24","DOIUrl":"https://doi.org/10.4103/jrpp.jrpp_40_24","url":null,"abstract":"<p><strong>Objective: </strong>This cross-sectional study aimed to assess the frequency of potential drug-drug interactions (DDIs) and demographic correlates of moderate and major DDIs among patients with hematologic cancer at a referral hematology hospital in Iran.</p><p><strong>Methods: </strong>In this study, for 6 months, all patients suffering from hematologic cancers admitted to the tertiary oncology hospital, Omid, Isfahan, were considered. Data from all medications prescribed to patients during hospitalization were analyzed using the online Lexicomp^® drug interaction checker, recording all interactions classified by risk level: C, D, or X.</p><p><strong>Findings: </strong>A total of 674 DDIs were detected in 109 patients. The prevalence of treatments with at least one clinically relevant interaction was 95%, being 57.9% for those at level C and 31.5% for levels D and X. According to the frequency, the main interaction was between aprepitant and corticosteroids, followed by the interaction between aprepitant and vincristine. The most common interaction between antineoplastic agents was between doxorubicin and cyclophosphamide. In terms of mechanism, most of DDIs (54.9%) were pharmacodynamics. Only the number of administered medications was associated with DDI occurrence.</p><p><strong>Conclusion: </strong>Potential DDIs of moderate to major severity are common among patients with hematologic malignancies. This underscores the importance of implementing different strategies to mitigate this clinically significant risk.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"12 4","pages":"115-122"},"PeriodicalIF":0.8,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11386064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Licorice as Adjunctive Therapy in Critically Ill Patients with COVID-19: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial.","authors":"Babak Alikiaie, Seyed Mohammad Hosseinian Shalamzari, Rasool Soltani, Afsaneh Yegdaneh, Sarah Mousavi","doi":"10.4103/jrpp.jrpp_22_24","DOIUrl":"https://doi.org/10.4103/jrpp.jrpp_22_24","url":null,"abstract":"<p><strong>Objective: </strong>There is no definitive pharmacological strategy for COVID-19; thus, medicinal herbs can be an appropriate option for COVID-19 management. We investigated the efficacy of a D-reglis^® tablet (root extract of licorice) as adjuvant therapy in critically ill patients with COVID-19 at intensive care units (ICUs) of Alzahra Teaching Hospital affiliated with Isfahan University of Medical Sciences, Isfahan, Iran.</p><p><strong>Methods: </strong>In the present double-blind, randomized, placebo-controlled clinical trial, critically ill cases with COVID-19 (<i>n</i> = 52) received a D-reglis^® tablet (760 mg) or a placebo tablet for 5 days. The ICU stay length was the primary outcome. The secondary outcome included the changes in oxygen saturation, duration of mechanical ventilation, mortality rate, and Sequential Organ Failure Assessment (SOFA) Score during the study period.</p><p><strong>Findings: </strong>The ICU stay was significantly lower in the licorice group than in the placebo group (<i>P</i> = 0.015). No significant difference was detected between the groups regarding oxygen saturation, SOFA score, duration of mechanical ventilation, and mortality rate.</p><p><strong>Conclusion: </strong>The licorice tablet (D-reglis^®) as an adjuvant treatment showed promising results regarding the ICU stay length in critically ill COVID-19 patients. However, further clinical trials with larger sample sizes, further duration of intervention, measurement of inflammatory markers, and further study about the molecular mechanism of the effect of licorice on COVID-19 should be done to obtain more conclusive findings.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"12 4","pages":"141-147"},"PeriodicalIF":0.8,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11386065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Antimicrobial Resistance Pattern of Nosocomial Infections in Patients Hospitalized in Chamran Heart Educational, Medical, and Research Center of Isfahan.","authors":"Mehrnoush Dianatkhah, Zeinab Sadat Davoodi, Rasool Soltani, Fatemeh Shafiee, Alireza Hosseini","doi":"10.4103/jrpp.jrpp_25_24","DOIUrl":"https://doi.org/10.4103/jrpp.jrpp_25_24","url":null,"abstract":"<p><strong>Objective: </strong>According to the importance of evaluating the antimicrobial resistance pattern in the management of nosocomial infections (NIs), we decided to investigate the prevalence of antimicrobial resistance in Chamran Heart Hospital.</p><p><strong>Methods: </strong>This retrospective cross-sectional observational study was performed for 6 months from February to July 2022 at Shahid Chamran Hospital of Isfahan, Iran. All hospitalized patients with any NIs were eligible for the study. Clinical specimens were obtained from patients with NIs. All specimens underwent microbial culture, and if bacterial growth developed, differential tests were performed. Antibiotic susceptibility testing also was performed per the standards of Clinical and Laboratory Standards Institute, 2022.</p><p><strong>Findings: </strong>Out of 201 examined samples, urinary infection (34.83%), pneumonia (27.86%), and sepsis (13.43%) were reported to be the most prevalent infections. Among Gram-negatives (76.12%), <i>Citrobacter</i> spp. (26.37%), <i>Escherichia coli</i> (24.87%), and <i>Klebsiella</i> spp. (11.44%) were the most common pathogens. About 54.9% of <i>Citrobacter</i> spp., 33.3% of <i>E</i>. <i>coli</i>, and 45.45% of <i>Klebsiella</i> spp. were resistant to carbapenems. About 1.88% and 15% of <i>Citrobacter</i> spp. were identified as pan-drug-resistant bacteria and extensively drug-resistant (XDR), respectively. In addition, 4.34% of <i>Klebsiella</i> spp. were identified as XDR. Among Gram-positives (23.88%), <i>Enterococcus</i> spp. (8.95%) was identified as the most common pathogen, and the prevalence of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) and vancomycin-resistant <i>Enterococcus</i> (VRE) was 11.11% and 61.11%, respectively.</p><p><strong>Conclusion: </strong>In our study, carbapenem-resistant Enterobacteriaceae accounts for about 50% of all NIs. Moreover, despite the low prevalence of MRSA, VRE was reported to be high in our center when compared with other studies.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"12 4","pages":"135-140"},"PeriodicalIF":0.8,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11386061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effectiveness of <i>Perovskia abrotanoides</i> Extract Topical Formulation on the Cutaneous Leishmaniasis: A Randomized Controlled Clinical Trial.","authors":"Maryam Sadat Tayebi, Nazila Poostiyan, Masoud Sadeghi Dinani, Erfaneh Ghassami, Rasool Soltani","doi":"10.4103/jrpp.jrpp_13_24","DOIUrl":"10.4103/jrpp.jrpp_13_24","url":null,"abstract":"<p><strong>Objective: </strong>Despite many attempts to treat leishmaniasis, new approaches are necessary to reduce the burden of disease. <i>Perovskia abrotanoides</i> (Brazambel) has shown significant effects against <i>Leishmania</i> parasites in some studies. This study aimed to investigate the effects of <i>P. abrotanoides</i> extract topical formulation on cutaneous leishmaniasis.</p><p><strong>Methods: </strong>In this randomized controlled clinical trial, patients with cutaneous leishmaniasis were assigned to experimental (<i>n</i> = 18) and control (<i>n</i> = 18) groups. Both groups received intralesional meglumine antimoniate (Glucantime^®). The experimental group also received 5% Brazambel extract ointment once a day. The interventions continued until the complete healing of the lesions (reepithelialization) for a maximum of 8 weeks. The clinical response, defined as complete response (reepithelialization >75%), partial response (reepithelialization 50%-75%), or treatment failure (reepithelialization <50%), was compared between the groups.</p><p><strong>Findings: </strong>The percentage of reepithelialization in the experimental group (4^th week: 64.44 ± 25.13; 8^th week: 83.85 ± 11.54) was higher than the control group (4^th week: 53.97 ± 25.88; 8^th week: 76.27 ± 21.67); however, the differences were not statistically significant (<i>P</i> = 0.252 and 0.494, respectively). Moreover, there was no significant difference between the experimental and control groups regarding the rate of complete healing (88.9% vs. 72.2%, respectively).</p><p><strong>Conclusion: </strong>The use of <i>P. abrotanoides</i> extract 5% topical formulation does not affect the healing of cutaneous leishmaniasis.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"12 3","pages":"104-109"},"PeriodicalIF":1.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11071059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140876667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of an Oral Solution Containing Five Herbal Extracts in the Treatment of Urolithiasis: A Randomized, Single-blind, Placebo-controlled Clinical Trial.","authors":"Sahand Samandarian, Rasool Soltani, Valiollah Hajhashemi, Mehdi Dehghani, Mohammad Matinfar, Mohaddese Mahboubi, Afsaneh Mohsenzadeh","doi":"10.4103/jrpp.jrpp_11_24","DOIUrl":"10.4103/jrpp.jrpp_11_24","url":null,"abstract":"<p><strong>Objective: </strong>The high prevalence of urolithiasis and its recurrence entail the preparation of an efficient drug with the least side effects. <i>Tribulus terrestris</i>, <i>Urtica dioica</i>, <i>Adiantum capillus-veneris</i>, <i>Stigma maydis</i> (corn silk), and <i>Cucumis melo</i> are herbal remedies utilized in traditional medicine for urolithiasis. This study aimed to assess the efficiency of these plants' extracts in treating urolithiasis.</p><p><strong>Methods: </strong>In a randomized, single-blind, placebo-controlled clinical trial, participants meeting inclusion criteria were randomly allocated to the drug (<i>n</i> = 27) and placebo (<i>n</i> = 27) groups to take herbal or placebo solutions, respectively, at a dose of 60 drops 3 times daily for 4 weeks with standard treatment. Before and after the intervention, 24-h urine volume and the quantities of calcium, sodium, citrate, oxalate, urea, creatinine, and uric acid in 24-h urine, and urinary pH were measured. The number and size (diameter in mm) of stones were determined by ultrasonography and recorded for each patient.</p><p><strong>Findings: </strong>Except for 24 h urine volume, other urinary parameters did not alter significantly at the end of the intervention compared to baseline. Furthermore, the two groups had no significant difference regarding these indices. Regarding stone parameters, the stone size decreased significantly in the drug group compared to the placebo group (<i>P</i> = 0.049). The number of cases with complete stone expulsion in the drug group was significantly higher than in the placebo group (12 cases vs. 4 cases, respectively, <i>P</i> = 0.017).</p><p><strong>Conclusion: </strong>Oral consumption of the herbal solution causes stone size reduction and stone expulsion in patients with urolithiasis.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"12 3","pages":"96-103"},"PeriodicalIF":1.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11071061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140876663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Stem Cell Mobilization and CD34+ Cell Collection in a Poor Mobilizer: A Case Report Utilizing a Combination of Recombinant Growth Colony Stimulating Factor, Recombinant Human Growth Factor, and Plerixafor.","authors":"Maliheh Kazemi Najafabadi, Azadeh Moghaddas, Mozhgan Karimifar, Ali Darakhshandeh","doi":"10.4103/jrpp.jrpp_46_23","DOIUrl":"10.4103/jrpp.jrpp_46_23","url":null,"abstract":"<p><p>Diffuse large B-cell lymphoma is the most prevalent form of non-Hodgkin's lymphoma that is usually treated with chemoimmunotherapy. If the disease proves refractory or recurrent, the primary treatment approach involves high-dose chemotherapy with bone marrow transplantation. The collection of peripheral blood stem cells before transplantation plays a vital role in the treatment process, necessitating the mobilization of blood stem cells from the bone marrow to the peripheral blood. Despite using standard methods such as granulocyte colony-stimulating factor (G-CSF), chemotherapy, and plerixafor, some patients cannot collect an optimal count of CD34+ cells for transplantation. Managing these patients with poor mobilization poses significant challenges. In this article, we present a case of a poor mobilizer patient who achieved prosperous mobilization by using recombinant human G-CSF, recombinant human growth hormone, and plerixafor.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"12 3","pages":"110-113"},"PeriodicalIF":1.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11071060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140876666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Follow-up of Methanol-related Visual Defects in a Cohort Study: Initial Severity Predicts Long-term Outcome.","authors":"Farzad Gheshlaghi, Anselm Wong, Rezvan Firuzfar, Keyvan Jenab, Shayan Gheshlaghi, Golnoosh Shahverdi, Nastaran Eizadi-Mood","doi":"10.4103/jrpp.jrpp_80_22","DOIUrl":"10.4103/jrpp.jrpp_80_22","url":null,"abstract":"<p><strong>Objective: </strong>Methanol poisoning can occur either intentionally through the consumption of methanol-containing products or accidentally through ingestion, resulting in visual impairment. We assessed the long-term visual sequelae in patients with methanol poisoning.</p><p><strong>Methods: </strong>This prospective cohort study was conducted at referral centers, Khorshid and Alzahra University Hospitals, affiliated with Isfahan University of Medical Sciences, Isfahan, Iran. The study included patients hospitalized for methanol poisoning from June 22, 2018, to June 21, 2020, with follow-up extended until June 2021. Toxico-clinical and ophthalmologic examination data were collected from patients upon hospital admission, discharge, and during follow-up.</p><p><strong>Findings: </strong>Thirty-nine patients were assessed in this study. The majority of them (94.9%) were male, with an average age of 34 years. Patients who presented with reduced visual acuity (VA) upon admission subsequently showed abnormalities (in acuity and visual fields) during follow-up (<i>n</i> = 13). Among the patients who displayed visual field defects on admission, bilateral optic disc atrophy was observed in follow-up (<i>n</i> = 13). Conversely, patients who reported blurred vision, with or without photophobia upon admission, had normal results in their follow-up eye examinations. Among the 36 patients who underwent dialysis, 14 (38.9%) exhibited visual impairment during follow-up examinations. Additionally, 38 patients received sodium bicarbonate, and 14 of them (36.85%) also presented ocular abnormalities.</p><p><strong>Conclusion: </strong>Patients who demonstrated VA deficits upon admission are more likely to experience long-term VA and visual field defects, as well as optic disc atrophy. Patients who solely complained of blurred vision, with or without photophobia, during admission were less likely to develop long-term visual defects.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"12 3","pages":"88-95"},"PeriodicalIF":1.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11071062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140876664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoglycemic Agents and Anesthetic Techniques to Ameliorate Stress Hyperglycemia in Critically Ill Patients: A Systematic Review.","authors":"Fatemeh Rahimpour, Malihe Nejati, Azadeh Moghaddas, Shadi Farsaei, Awat Feizi","doi":"10.4103/jrpp.jrpp_45_23","DOIUrl":"10.4103/jrpp.jrpp_45_23","url":null,"abstract":"<p><p>The concurrent utilization of hypoglycemic agents and anesthetic techniques has been demonstrated to mitigate stress hyperglycemia in critically ill patients without diabetes, thereby contributing to enhanced patient outcomes. Stress hyperglycemia, characterized by elevated blood glucose levels as a result of acute illness or physiological stress, frequently manifests in patients experiencing critical illness. This condition has been linked to augmented morbidity, protracted hospitalization durations, and elevated mortality rates. This review aims to introduce and critically assess various hypoglycemic agents and anesthetic techniques employed to alleviate stress hyperglycemia, emphasizing the necessity for continued research to comprehensively ascertain the safety and efficacy of these approaches, which will facilitate their broader integration.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"12 3","pages":"69-87"},"PeriodicalIF":1.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11071063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140876665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}