Journal of steroids & hormonal science最新文献_第3页

Anti-apoptotic and pro-angiogenic properties of thyroid hormone may oppose cancer chemotherapy 甲状腺激素的抗细胞凋亡和促血管生成特性可能对肿瘤化疗有拮抗作用

Journal of steroids & hormonal science Pub Date : 2016-07-15 DOI: 10.4172/2157-7536.C1.004

P. Davis

引用次数: 0

Stabilizing Motor Reflexive Activation and Acute Growth Hormone Response: ASystematic Review 稳定运动反射激活和急性生长激素反应:系统综述

Journal of steroids & hormonal science Pub Date : 2016-07-13 DOI: 10.4172/2157-7536.1000178

J. Jaquish, Henry D. Alkire, Kevin Hoesley

{"title":"Stabilizing Motor Reflexive Activation and Acute Growth Hormone Response: ASystematic Review","authors":"J. Jaquish, Henry D. Alkire, Kevin Hoesley","doi":"10.4172/2157-7536.1000178","DOIUrl":"https://doi.org/10.4172/2157-7536.1000178","url":null,"abstract":"Objective: Evaluating reflexive (Il and Ia afferent) body-stabilizing activity as a possible mechanism regulating hGH levels. \u0000Data Sources: The authors searched MEDLINE, PubMed, Harvard HOLLIS, and EMBASE databases for studies published through 1 January 2016 by using such terms as: vibration, stability, and human growth hormone. \u0000Study Selection: The authors included randomized, controlled trials and randomized pre-post observational trials that compared acute alterations of hGH in humans with both genders spanning from post-pubescence to elderly populations. \u0000Data Extraction: Three authors independently reviewed articles and abstracted data. \u0000Data Synthesis: PRISMA guidelines were followed with 17 articles describing 24 unique study populations meeting the inclusion criteria. A total of 265 participants who engaged in a destabilizing intervention were assayed both against baseline and control (when present). Populations varied in age, with all populations having a mean age of 35.1 [SD, 13.6], and RCTs of 41.6 [SD, 17.2], with the youngest population being 17.8 [SD, 0.88], and the oldest being 70 [SD, 8.8]. Subjects saw acute increases from pre-to-post of 647% [95% CI, 541% to 753%] (P=0.00001). Test group subjects compared to those subjected to control interventions increased hGH levels by 101% [95% CI, 85.7% to 116%] (P=0.006). Statistical analysis excluded one study that altered its blood sample concentrations via centrifuge. \u0000Conclusions: The literature published on randomized, controlled trials and randomized acute evaluations of reflexive stability recruitment of muscle and hGH in multiple populations is limited but suggests that there is an association with whole body stability firing and hGH levels. On the basis of this evidence, interventions that encourage increases in whole body stability firing can be recommended to illicit increases in hGH levels.","PeriodicalId":17132,"journal":{"name":"Journal of steroids & hormonal science","volume":"1 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2016-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89700652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prolonged QT Intervals in Isolated ACTH Deficiency: Case Report and MiniReview of Literature 孤立ACTH缺乏症QT间期延长:病例报告及文献综述

Journal of steroids & hormonal science Pub Date : 2016-06-25 DOI: 10.4172/2157-7536.1000176

Rikako Suzuki, Takeshi Hayashi, H. Asano, Kennosuke Ohashi, Masaya Sakamoto, K. Tojo, K. Utsunomiya

{"title":"Prolonged QT Intervals in Isolated ACTH Deficiency: Case Report and MiniReview of Literature","authors":"Rikako Suzuki, Takeshi Hayashi, H. Asano, Kennosuke Ohashi, Masaya Sakamoto, K. Tojo, K. Utsunomiya","doi":"10.4172/2157-7536.1000176","DOIUrl":"https://doi.org/10.4172/2157-7536.1000176","url":null,"abstract":"Isolated adrenocorticotropic hormone (ACTH) deficiency is a rare disorder, characterized by secondary adrenal insufficiency. We experienced a case of isolated ACTH deficiency presented with prolonged QT intervals which was helpful in diagnosis. Hereby we report our case and review the previous cases. We describe a 77 year-old female whose major complaints were general malaise, anorexia, and depression. On admission, QT intervals of ECG were prolonged. Endocrine tests indicated that she was suffering from isolated ACTH deficiency. After hydrocortisone replacement therapy was started, QT intervals were shortened and all of her complaints were resolved. There are only six reports about isolated ACTH deficiency associated with prolonged QT intervals until now. Prolongation of QT intervals is known to be a risk factor for cardiovascular events such as ventricular fibrillation, but interestingly prolonged QT intervals associated with isolated ACTH deficiency infrequently cause lethal arrhythmia. The initial symptoms of adrenal deficiency in elderly patients are obscure and adrenal deficiency is often misdiagnosed as unidentified clinical syndrome. It is important to consider isolated ACTH deficiency when recognizing unexplained prolonged QT intervals.","PeriodicalId":17132,"journal":{"name":"Journal of steroids & hormonal science","volume":"20 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2016-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91274166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Cortisol Study; Facial Hair and Nails 皮质醇研究;面部毛发和指甲

Journal of steroids & hormonal science Pub Date : 2016-06-25 DOI: 10.4172/2157-7536.1000177

J. G. Nejad, Mostafa Ghaseminezhad, K. Sung, Fatemeh Hoseinzadeh, Jennette B.A. Cabibi, Jongho Lee

{"title":"A Cortisol Study; Facial Hair and Nails","authors":"J. G. Nejad, Mostafa Ghaseminezhad, K. Sung, Fatemeh Hoseinzadeh, Jennette B.A. Cabibi, Jongho Lee","doi":"10.4172/2157-7536.1000177","DOIUrl":"https://doi.org/10.4172/2157-7536.1000177","url":null,"abstract":"Current methods for measuring cortisol levels can be challenging due to the need to take multiple urine, saliva or serum samples. Therefore, it seems necessary to find alternative matrices which can be used as stress indicators in which sample collection methods are non-invasive. Two experiments were conducted to first to test the feasibility of cortisol levels in facial hair and second to find a correlation among facial hair cortisol and cortisol levels in nails. In the first experiment, facial hair from five subjects was analyzed to confirm the presence of cortisol. The results of the assessment of facial hair showed that facial hair may be used to measure cortisol levels over a short period of time. In the second experiment, nineteen university students (males who regularly partake in martial artsaged: 22 ± 3.15) provided fingernail, toenail and facial hair samples at set intervals throughout the school year; 1) The Study Period-during the student's every-day life (minimal stress conditions, baseline), 2) The Exam Periodfollowing student's final exams (mental stress), and 3) The Fighting Period- following intensive martial arts training (physical stress). Cortisol in facial hair, toenails, and fingernails showed higher levels during both the Exam Period and the Fighting Period when compared to the baseline Study Period (p 0.05). A higher correlation in cortisol levels was observed between facial hair samples and toenails (r=0.73) than between fingernails and toenails (r=0.61). Overall, cortisol levels showed significant correlations between fingernails and toenails (p=0.001, r=0.61), fingernails and facial hair (p=0.01, r=0.54), and toenails and facial hair (p=0.001, r=0.73). Further research is needed to understand the relationship between facial hair and nail cortisol and their possible relationship with health disorders.","PeriodicalId":17132,"journal":{"name":"Journal of steroids & hormonal science","volume":"7 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2016-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89674609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

An Update on Subclinical Hypopituitarism 亚临床垂体功能减退症的最新进展

Journal of steroids & hormonal science Pub Date : 2016-06-22 DOI: 10.4172/2157-7536.1000175

P. Andújar-Plata, Eva Fern, ez-Rodriguez, F. Casanueva

引用次数: 1

Autocrine/Paracrine Insulin-like Growth Factor Binding Protein-3 Acts asPro-apoptotic Factor for Leydig cells in the Rat Testis 自分泌/旁分泌胰岛素样生长因子结合蛋白-3在大鼠睾丸间质细胞中作为促凋亡因子

Journal of steroids & hormonal science Pub Date : 2016-06-09 DOI: 10.4172/2157-7536.1000174

E. Colón, C. Carlsson‐Skwirut, K. Svechnikov, O. Söder

{"title":"Autocrine/Paracrine Insulin-like Growth Factor Binding Protein-3 Acts asPro-apoptotic Factor for Leydig cells in the Rat Testis","authors":"E. Colón, C. Carlsson‐Skwirut, K. Svechnikov, O. Söder","doi":"10.4172/2157-7536.1000174","DOIUrl":"https://doi.org/10.4172/2157-7536.1000174","url":null,"abstract":"The secretory insulin-like growth factor-binding protein-3 (IGFBP-3) induces apoptosis via both insulin-like growth factor-I (IGF-I)-dependent and -independent mechanisms. Here, we have examined the effects of IGFBP-3 on Leydig cell apoptosis, proliferation and steroidogenesis. Immunohistochemical analysis of testes of rats at different ages revealed that IGFBP-3 is expressed first after 20 days of postnatal life and is present at a high level in the adult testis. In addition, Western blotting showed that the expression of IGFBP-3 in Leydig cells isolated from 60-day-old rats is higher than in 40-day-old animals. The rate of DNA synthesis (as assessed by incorporation of 3H-thymidine in vitro) in Leydig cells from 40-day-old rats is reduced by IGFBP-3, which also blocks the promotion of cell survival by IGF-I. Moreover, IGFBP-3 induces apoptosis in Leydig cells and, at the same time, attenuates the anti-apoptotic action of IGF-I. Furthermore, IGF-I stimulates secretion of IGFBP-3, -4, and -2 by Leydig cells. The pro-inflammatory cytokine tumor necrosis factor- α induces apoptosis in these same cells and increases their secretion of IGFBP-3 and IGFBP-4. These findings provide the first evidence that IGFBP-3 acts as a pro-apoptotic effector of Leydig cells and can also block the positive effect of IGF-I on cell survival. In addition, IGFBPs appear to modulate interactions between IGF-I and pro-inflammatory cytokines in the testis, suggesting possible participation of these proteins in processes such as testicular inflammation and cancer.","PeriodicalId":17132,"journal":{"name":"Journal of steroids & hormonal science","volume":"23 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2016-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89948940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Steroid Therapy in Oral Lichen Planus 口腔扁平苔藓的类固醇治疗

Journal of steroids & hormonal science Pub Date : 2016-05-31 DOI: 10.4172/2157-7536.1000173

E. Alerraqi

引用次数: 5

Cholesterol-Binding by the Yeast CAP Family Member Pry1 Requires thePresence of an Aliphatic Side Chain on Cholesterol 酵母CAP家族成员Pry1的胆固醇结合需要在胆固醇上存在脂肪侧链

Journal of steroids & hormonal science Pub Date : 2016-05-07 DOI: 10.4172/2157-7536.1000172

Rabih Darwiche, R. Schneiter

{"title":"Cholesterol-Binding by the Yeast CAP Family Member Pry1 Requires thePresence of an Aliphatic Side Chain on Cholesterol","authors":"Rabih Darwiche, R. Schneiter","doi":"10.4172/2157-7536.1000172","DOIUrl":"https://doi.org/10.4172/2157-7536.1000172","url":null,"abstract":"Pathogen-related yeast protein 1 (Pry1) is a Saccharomyces cerevisiae member of the CAP/SCP/TAPS superfamily. Although, CAP proteins have been proposed to be implicated in a number of physiological processes, such as pathogen virulence, sperm maturation andfertilization, host-pathogen interactions and defense mechanisms, the molecular mode of action of these proteins is poorly understood. CAP proteins are mostly secreted and they are stable in the extracellular space over a wide a range of conditions. All members of this superfamily contain a common CAP domain of approximately 150 amino acids, which adopts a unique α-β-α sandwich fold. We have previously shown that the yeast CAP family members act as sterol-binding and -export proteins in vivo and that the Pry proteins bind cholesterol and cholesteryl acetate in vitro. The conserved CAP domain of Pry1 is necessary and sufficient for sterol binding. Based on these observations, it is conceivable that CAP proteins exert their biological function through a common mechanism, such as binding and sequestration of sterols or related small hydrophobic compounds. Here we analyze the ligand specificity of Pry1 in more detail and show that the presence of the aliphatic isooctane side chain of the sterol but not the 3-hydroxyl group is important for binding to Pry1.","PeriodicalId":17132,"journal":{"name":"Journal of steroids & hormonal science","volume":"94 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2016-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86076403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

A Short Review of Methods for the Allylic Oxidation of ÃÂ5 SteroidalCompounds to Enones ÃÂ5甾体化合物烯丙基氧化制烯酮方法综述

Journal of steroids & hormonal science Pub Date : 2016-04-02 DOI: 10.4172/2157-7536.1000171

Wendell Sg, Edwards Jp

引用次数: 4

Shaping ERBB Signalling by Steroid Hormones 类固醇激素塑造ERBB信号传导

Journal of steroids & hormonal science Pub Date : 2016-01-08 DOI: 10.4172/2157-7536.1000.166

M. Lauriola, G. D’Uva

引用次数: 0