Journal of steroids & hormonal science最新文献_第4页

Commentary on: Injection of Steroids Intralesional in Central Giant Cell Granuloma Cases (Giant Cell Tumor): Is it Free of Systemic Complications or Not? 中央性巨细胞肉芽肿(巨细胞瘤)病灶内注射类固醇:是否无全身并发症?

Journal of steroids & hormonal science Pub Date : 2016-01-01 DOI: 10.4172/2157-7536.1000E117

E. Alerraqi

引用次数: 4

A Short Communication Based on: A Bayesian Network Meta-analysis:Comparing the Clinical Effectiveness of Local Corticosteroid Injections usingDifferent Treatment Strategies for Carpal Tunnel Syndrome 基于贝叶斯网络的meta分析:比较局部皮质类固醇注射不同治疗策略对腕管综合征的临床疗效

Journal of steroids & hormonal science Pub Date : 2016-01-01 DOI: 10.4172/2157-7536.1000168

C. Pc, Chuang Ch, Liang Hf

引用次数: 0

A Case of Ambiguous Genitalia and Unaccustomed Sexual Behavior Depictedfrom the Margin Notes of a Byzantine Monk 从拜占庭僧侣的页边笔记中描绘的暧昧的生殖器和不习惯的性行为

Journal of steroids & hormonal science Pub Date : 2016-01-01 DOI: 10.4172/2157-7536.1000170

Armeni Ak, Vasileiou, Neoklis Ag

引用次数: 0

Polycystic Ovarian Morphology is Associated with Hyperandrogenemia and Insulin Resistance in Women with Polycystic Ovary Syndrome (PCOS) 多囊卵巢形态学与多囊卵巢综合征(PCOS)患者高雄激素血症和胰岛素抵抗相关

Journal of steroids & hormonal science Pub Date : 2016-01-01 DOI: 10.4172/2157-7536.1000169

Neoklis Ag, Anastasia Ka, K. Damianaki, N. Dr, G. Markantes, Papadopoulos, Adonakis Gl, G. Decavalas, D. Panidis

{"title":"Polycystic Ovarian Morphology is Associated with Hyperandrogenemia and Insulin Resistance in Women with Polycystic Ovary Syndrome (PCOS)","authors":"Neoklis Ag, Anastasia Ka, K. Damianaki, N. Dr, G. Markantes, Papadopoulos, Adonakis Gl, G. Decavalas, D. Panidis","doi":"10.4172/2157-7536.1000169","DOIUrl":"https://doi.org/10.4172/2157-7536.1000169","url":null,"abstract":"Objectives: The aim of the present study was to evaluate the impact of polycystic ovarian morphology in the hormonal and metabolic features of the \"classical\" phenotypes of PCOS. Design: The study included 1275 Caucasian women with PCOS with a mean age of 24.25 ± 5.79 years and a mean BMI of 26.80 ± 7.03 kg/m2. Diagnosis of PCOS was based on the 2003 Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus criteria. Two phenotypes, matched for age and BMI were compared: Phenotype I (n=620) which included PCOS women with biochemical hyperandrogenemia and/or clinical hyperandrogenemia, chronic anovulation and polycystic ovarian morphology on ultrasound (PCO). Phenotype II (n=400) which included PCOS women with biochemical hyperandrogenemia and/or clinical hyperandrogenemia and chronic anovulation, without PCO. These phenotypes were further subdivided in normal weight and obese PCOS women. Results: PCOS women of Phenotype I had higher LH/FSH ratio (p<0.001), higher Testosterone (p<0.01), Δ4 Androstenedione (p<0.001) and 17-OH progesterone levels (p<0.001), and higher Free Androgen Index (FAI) values (p<0.01) compared to Phenotype II. With the exception of fasting glucose levels, all other indices of insulin resistance (fasting insulin, fasting glucose/insulin ratio, QUICKI and HOMA2IR) document an association between Phenotype I and greater insulin resistance in overweight/obese PCOS women. Conclusions: In conclusion, in \"classical\" phenotypes of polycystic ovary syndrome (PCOS), polycystic ovarian morphology is associated with more severe hyperandrogenemia and deranged LH/FSH ratio. In overweight/obese PCOS subjects, PCO is positively correlated with insulin resistance.","PeriodicalId":17132,"journal":{"name":"Journal of steroids & hormonal science","volume":"4 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87262907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Synthetic Epoxy-Pregnan Steroids: Effects on Anxiety Behavior in Rats 合成环氧孕激素对大鼠焦虑行为的影响

Journal of steroids & hormonal science Pub Date : 2016-01-01 DOI: 10.4172/2157-7536.1000167

M. Rey, A. Ghini, H. Coirini

{"title":"Synthetic Epoxy-Pregnan Steroids: Effects on Anxiety Behavior in Rats","authors":"M. Rey, A. Ghini, H. Coirini","doi":"10.4172/2157-7536.1000167","DOIUrl":"https://doi.org/10.4172/2157-7536.1000167","url":null,"abstract":"Neurosteroids like 3α-OH-5α-pregnan-20-one (allopregnanolone) and 3α-OH-5β-pregnan-20-one (pregnanolone) modulate the γ-aminobutyric acid-A (GABAA) receptor function and produce several effects that can be considered for therapeutical pruposes like antidepressant and anxiolyticts, in a similar way to benzodiazepines. However, their rapid metabolism is a great disadvantage for medicinal treatments consideration. Synthetic steroid analogues with more bioavailability and stability arise like a solution to overcome these limitations. In previous studies, we evaluated the performance of a synthetic steroid group (Epoxies, similar to allopregnanolone and pregnanolone) throughout different assays in rat cerebral cortex and hippocampus, including neuroprotection and GABAA receptor modulation obtaining promising results. Taking into account the anxiolytic effect of allopregnanolone and pregnanolone, in this work we evaluated the effect of an intracranial administration (in dorsal hippocampus) of two synthetic steroids, Epoxy 1 and Epoxy 2, in an anxiety animal model to provide knowledge about the possible in vivo effects of these steroids. Allopregnanolone and pregnanolone produced increases in vertical and horizontal exploration behaviors, interpreted as anxiolytic-like effects. However, the two Epoxies capable to modulate GABAA receptor binding have no effect on anxiety at the dose evaluated. These features make them suitable for other therapeutical purposes where the anxiogenic behaviors are not involved.","PeriodicalId":17132,"journal":{"name":"Journal of steroids & hormonal science","volume":"18 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90989151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Reversing Hormone Therapy Resistance: A Novel Era of EpigeneticTherapy in Breast and Prostate Cancers 逆转激素治疗抵抗:乳腺癌和前列腺癌表观遗传学治疗的新时代

Journal of steroids & hormonal science Pub Date : 2015-12-31 DOI: 10.4172/2157-7536.1000-E116

Nguyen Minh Nam

引用次数: 3

Endocrine Immune Interactions in the Host-Parasite Relationship: SteroidHormones as Immune Regulators in Parasite Infections 宿主-寄生虫关系中的内分泌免疫相互作用:类固醇激素在寄生虫感染中的免疫调节作用

Journal of steroids & hormonal science Pub Date : 2015-12-18 DOI: 10.4172/2157-7536.1000165

H. Aguilar-Díaz, K. Nava-Castro, Cerbón-Cervantes Ma, Meneses-Ruiz Dm, Ponce-Regalado, J. Morales-Montor

{"title":"Endocrine Immune Interactions in the Host-Parasite Relationship: SteroidHormones as Immune Regulators in Parasite Infections","authors":"H. Aguilar-Díaz, K. Nava-Castro, Cerbón-Cervantes Ma, Meneses-Ruiz Dm, Ponce-Regalado, J. Morales-Montor","doi":"10.4172/2157-7536.1000165","DOIUrl":"https://doi.org/10.4172/2157-7536.1000165","url":null,"abstract":"There is a close relationship between hormones, cytokines, neuropeptides, and neurotransmitters that modulate the host immune response by several effector mechanisms, including both cellular and humoral immunity. Disruption of this communication balance results in disease or in a higher susceptibility to infections. The relationships between parasites and hosts are complex and there is substantial interaction, communication and biochemical co-evolution. The role of certain hormones in parasitic infections has been demonstrated, and there are documented direct effects of hormones on parasites. Many parasites induce the secretion of molecules that influence the physiological and immunological responses in hosts, including intermediaries and vectors. Conversely, the parasites secrete many factors that alter hormone host levels. In some cases, hormones have positive or negative effects on the parasites status. In other cases, effects are mediated indirectly via the host’s immune system. In vertebrates, the parasite presence also has a major influence on the host’s endocrine status and the normal suite of processes governed by hormones. These processes include host development, establishment, metamorphosis, and reproduction. Thus, understanding the mechanisms involved in immunoendocrine modulation and its effects on parasites is essential for developing new drugs, finding vaccine targets and devising new therapies for several infectious diseases.","PeriodicalId":17132,"journal":{"name":"Journal of steroids & hormonal science","volume":"1 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2015-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88602712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Genomic Alterations in Ethanol-Exposed Trophoblast Cell Lines Inducedby Chronic Ethanol Treatment 慢性乙醇处理诱导的乙醇暴露滋养细胞的基因组改变

Journal of steroids & hormonal science Pub Date : 2015-12-10 DOI: 10.4172/2157-7536.1000164

S. Clavé, X. Joya, A. Puiggros, Marta Bódalo, J. Salat-Batlle, M. Salido, B. Espinet, Ó. G. Algar, O. Vall

{"title":"Genomic Alterations in Ethanol-Exposed Trophoblast Cell Lines Inducedby Chronic Ethanol Treatment","authors":"S. Clavé, X. Joya, A. Puiggros, Marta Bódalo, J. Salat-Batlle, M. Salido, B. Espinet, Ó. G. Algar, O. Vall","doi":"10.4172/2157-7536.1000164","DOIUrl":"https://doi.org/10.4172/2157-7536.1000164","url":null,"abstract":"Background: Ethanol consumption during pregnancy results in a broad spectrum of damage, but the knowledge of its mechanism is lacking. Objective: The aim of this study is to determine ethanol-caused genomic alterations in placental cell lines after a repeated ethanol treatment in order to describe new genomic targets of cell damage. Methods: A model of sustained exposure to standard doses of ethanol on two in vitro human choriocarcinoma cell lines, JEG-3 and BeWo, was used. Chromosomic abnormalities and copy number alterations (CNAs) were assessed by G-Banding cytogenetics and oligonucleotide Single Nucleotide Polymorphism-Array analysis (CytoScan, Affymetrix). Results: Chromosomal abnormalities did not change despite ethanol exposure except for the presence of a derivative chromosome 4 [add(4)(p14)] in exposed BeWo cells. Regarding SNP-Array analysis, a total of 21 CNAs were found to be caused by ethanol exposure, 16 in JEG-3 cell line and 5 in BeWo cell line, which were not found in controls. There was no coincidence between JEG-3 and BeWo regions affected by ethanol. Conclusion: Trophoblast cell lines exposed repetitively to ethanol presented genomic instability resulting in CNAs. However, no region has been equally altered in both models to consider it an ethanol exposure target area. So, further studies involving different models and approaches that target gene regulation are required.","PeriodicalId":17132,"journal":{"name":"Journal of steroids & hormonal science","volume":"159 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2015-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87885508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Potential Side-Effects of CSC Systemic Approach CSC系统方法的潜在副作用

Journal of steroids & hormonal science Pub Date : 2015-11-30 DOI: 10.4172/2157-7536.1000162

Nelli Roosipuu, Alina Vijulie, R. Dolz-Marco, R. Gallego-Pinazo

引用次数: 0

Ovariectomy Drives Asynchronous Changes in Serotonin Receptor 2A andTransporter Availability in Rats 卵巢切除术驱动大鼠血清素受体2A和转运体可用性的非同步变化

Journal of steroids & hormonal science Pub Date : 2015-11-30 DOI: 10.4172/2157-7536.1000161

N. Frimer, A. Overgaard, M. Lie, J. Mikkelsen, V. Frokjaer

{"title":"Ovariectomy Drives Asynchronous Changes in Serotonin Receptor 2A andTransporter Availability in Rats","authors":"N. Frimer, A. Overgaard, M. Lie, J. Mikkelsen, V. Frokjaer","doi":"10.4172/2157-7536.1000161","DOIUrl":"https://doi.org/10.4172/2157-7536.1000161","url":null,"abstract":"Ovarian hormones have potent effects on key features of the serotonergic neurotransmission. This includes effects that may counterbalance each other, e.g. postsynaptic receptor changes and change in serotonin transporter (SERT) levels, which regulates synaptic serotonin. Such mechanisms may be implicated in the heightened risk for depressive episodes seen in perimenopause or postpartum. However, to what extent transition to hypogonadism in it-self drives such serotonin related risk mechanism remains elusive. Here we evaluate if ovarian hormone withdrawal affects postsynaptic serotonin receptor 2A (5-HT2A) and presynaptic SERT availability differently across the early withdrawal phase in ovariectomized (OVXed) relative to sham operated rats. Cortical (prefrontal cortex (PFC)) and subcortical (striatum) 5-HT2A receptor and SERT binding were quantified with autoradiography at 8 and 23 days after ovariectomy (OVX). We observed that 8 and 23 days after withdrawal the level of 5-HT2A receptor binding was decreased relative to sham, while SERT binding was unaltered, however, with a weak trend to decrease at day 23. The dataset available is small and the results should be viewed as preliminary. If replicated, these data highlight a potential phase-specific and predominantly early challenge of serotonergic neurotransmission when ovarian hormone levels decline abruptly, which may translate to the risk for psychopathology, e.g. depressive episodes postpartum or during menopausal transition in humans.","PeriodicalId":17132,"journal":{"name":"Journal of steroids & hormonal science","volume":"1 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2015-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77249168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0