Journal of steroids & hormonal science最新文献

{"title":"Editorial Note for Journal of Steroids and Hormonal Science","authors":"Nguyen Minh Nam","doi":"10.4172/2157-7536.1000E118","DOIUrl":"https://doi.org/10.4172/2157-7536.1000E118","url":null,"abstract":"","PeriodicalId":17132,"journal":{"name":"Journal of steroids & hormonal science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81918150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marine Sourced Bioactive Steroidal Compounds as Potential Cytotoxic Agents against Various Cancer Cell Lines","authors":"N. Sisir, Ankita Sharma","doi":"10.24105/2157-7536.10.199","DOIUrl":"https://doi.org/10.24105/2157-7536.10.199","url":null,"abstract":"To exploit the potential of the natural flora and fauna, it is urgent to study and unravel full chemical mysteries hidden in our vast natural diversity. Natural resources consist of large forest areas in diverse climatic zones, and also of the sea coast. Ocean covers 71% of the earth surface. Inspite of that, number of species on land is much higher than the oceans. About 16% of world’s species lives in oceans, 80% on land and remaining lives in fresh water. There is a great need to expand the capabilities in these sea areas to remain globally relevant. More in-depth study, especially on deep-sea natural products, needs to be carried out to solidify the research on the potential for marine organisms to contribute to the future of drug discovery. Many potential drugs and lead compounds are discovered from the marine organisms. The present study is an attempt to summarize current marine sourced bioactive steroidal compounds as potential cytotoxic agents.","PeriodicalId":17132,"journal":{"name":"Journal of steroids & hormonal science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87311971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implications of Androgen Receptor Hyperstimulation by the FKBP51 L119P Mutation: No Evidence for Early Emergence of L119P in Prostate Cancer","authors":"B. Ward, C. Cluning, Ajanthy Arulpragasam, J. Bentel, David C. Ch, Ler, R. Cohen, G. Fischer, Michael R. Epis, P. Leedman, T. Ratajczak","doi":"10.4172/2157-7536.1000197","DOIUrl":"https://doi.org/10.4172/2157-7536.1000197","url":null,"abstract":"Objective: The immunophilin cochaperones, FKBP51 and FKBP52, have a modulating effect on steroid hormone receptors including the androgen receptor (AR). The differential effects seen by these immunophilins can be attributed to amino acid differences in the proline-rich loop; the proline at position 119 conferring AR potentiation capacity on FKBP52 and the leucine at this position in FKBP51 diminishing potentiation. FKBP51 can nevertheless potentiate AR activity in prostate cancer cells leading to accelerated growth. In addition, FKBP51 is regulated by AR, providing a feed-forward mechanism for FKBP51-mediated AR potentiation. These observations suggest that development of the FKBP51-L119P mutation in rostate cancer could lead to increased potentiation of AR and a more aggressive cancer phenotype. We tested this theory by examining the prevalence of FKBP51-L119P in a cohort of primary prostate tumours of increasing grade. Methods: A segment of the FKBP51 gene containing the leucine 119 codon was amplified from tumour DNA by PCR then subjected to digestion with BsmAI, a restriction enzyme having a recognition sequence incorporating the leucine 119 ‘CTC’ codon and occurring once in the amplicon. A subset of the prostate tumours was also examined for T > C conversion within the CTC codon by deep sequencing using the ion torrent system. Results: We were unable to detect the L119P mutation in any of the prostate cancers examined by restrictionenzyme analysis irrespective of tumour grade. In addition we found no evidence from ion torrent sequencing of early clonal development of cells with the L119P mutation in a subset of the tumours. Conclusion: We found no evidence to suggest that the L119P mutation contributes to an increasingly aggressive prostate cancer phenotype. However, tumour outgrowth favouring this mutation might occur in response to the low androgen environment and we propose examination for the L119P mutation in castrate-resistant prostate cancer.","PeriodicalId":17132,"journal":{"name":"Journal of steroids & hormonal science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78312332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testosterone inhibits Human Wild-Type and Chimeric Aldosterone Synthase Activity In-vitro","authors":"C. Fardella, A. Vecchiola, Cristóbal A. Fuentes, Isidora Solar, C. Campino, C. Carvajal, C. Lagos","doi":"10.4172/2157-7536.1000193","DOIUrl":"https://doi.org/10.4172/2157-7536.1000193","url":null,"abstract":"We have recently reported that in vitro, the wild-type (ASWT) and chimeric aldosterone synthase (ASCE) enzymes are inhibited by progesterone and estradiol had no effect. To explore the direct action of testosterone on wild-type and chimeric aldosterone synthase enzymes, we carried out an in vitro assay using HEK-293 cells transiently transfected with vectors containing the full ASWT or ASWT cDNAs. The effect of testosterone on AS enzyme activities was evaluated incubating with deoxycorticosterone (DOC) with or without increasing doses of testosterone. Aldosterone production was measured by HPLC-MS/MS. Docking of testosterone within the active sites of both enzymes was performed. In this system, testosterone inhibited ASWT, (90% inhibition at 5 μM, IC50=1.690 μM) with higher efficacy and potency than the ASCE (80% inhibition at 5 μM, IC50=3.176 μM). Our results show an inhibitory effect of testosterone on aldosteronesynthesis by ASWT or ASCE enzyme. This effect is a novel regulatory mechanism of testosterone action, which could affect the screening and diagnosis of primary aldosteronism.","PeriodicalId":17132,"journal":{"name":"Journal of steroids & hormonal science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89920171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alleviation of Diet-Induced Fat Accumulation by a Small Molecule CMKLR1 Antagonist in Mice","authors":"Jian Zhang, Liang-hao Xiang, Jie Chen, Tianxia Xiao, Pei-Gen Ren, Li Xue, Yan Yu, Fa Zeng, H. Tang","doi":"10.4172/2157-7536.1000191","DOIUrl":"https://doi.org/10.4172/2157-7536.1000191","url":null,"abstract":"Objective: Non-alcoholic Fatty Liver Disease (NAFLD) is believed to be correlated with chemerin and its receptor, Chemokine-like Receptor 1 (CMKLR1). We analyse the role of CMKLR1 in NAFLD by using a novel small molecule CMKLR1 antagonist-NETA (2-naphthoyl ethyl trimethyl ammonium) in vitro and in vivo. Methods: We assessed the effects of -NETA on a mouse model of high-fat-diet-induced fat accumulation in liver and adipose tissue and an analogous cell model established by culturing Hepa 1-6 and 3T3-L1 cells. Results: We found that chemerin and CMKLR1 mRNA were significantly increased in the livers and fat tissue of the mice fed the high fat diet relative to those in mice fed the normal diet. α-NETA administration suppressed serum TC, TG, AST and ALT levels and hepatic TG content as well as inhibited lipid metabolism-associated factors in the livers and fat of high fat diet mice. Furthermore, in the cell model, α-NETA suppressed oleic acid induction of Hepa 1-6 cell steatosis, 3T3-L1 adipogenesis and the expression of mRNAs for related lipid metabolism-associated factors. Conclusions: Chemerin/CMKLR1 signaling plays an important role in the progression of NAFLD.","PeriodicalId":17132,"journal":{"name":"Journal of steroids & hormonal science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79670246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity in Egyptian Children: Influence of Oxidant-Antioxidant Status on Lipid and Glucose Homeostasis","authors":"Fatma Ebeid, Alaa Baioumi, F. Elzaree, F. Ibrahim","doi":"10.4172/2157-7536.1000194","DOIUrl":"https://doi.org/10.4172/2157-7536.1000194","url":null,"abstract":"Aim: We aimed to assess antioxidant status in Egyptian children with obesity and investigate the mutual relationship between oxidative stress markers, body composition, and metabolic pattern. Methods: This cross-sectional study included 52 obese and 20 healthy-weight children. Subjects underwent through clinical assessment. Serum lipid profile, fasting glucose, and serum insulin were measured in plasma. A range of antioxidant activities was tested. Steady state beta cell function (%B), insulin sensitivity (%S), and insulin resistance (IR) were calculated. Results: Children with obesity had high prevalence of family history of obesity, hypertension and type 2 diabetes and 18 of them had hypertension. Sixteen (30.7%) children with obesity had high level (90th percentiles) of lowdensity lipoprotein (LDL-C) and triglycerides and 14 (24.9%) had low level (10th percentiles) of high-density lipoprotein (HDL-C). Plasma malondialdehyde (MDA), glutathione-S-transferase (GST) were significantly higher, whereas catalase, total antioxidant capacity (TAC), and vitamin E were significantly lower in children with obesity. Both MDA and GST correlated positively with anthropometric measures, triglycerides, fasting insulin, and HOMA-IR. Both catalase and TAC correlated negatively with anthropometric measures, and cholesterol. Furthermore, catalase correlated negatively with diastolic blood pressure, triglycerides, LDL, fasting insulin, and HOMA-IR, but positively with age. Conclusion: There is a substantial burden of oxidative stress represented by the high level of oxidants (MDA, GST) and low level of antioxidants (catalase, TAC) in children with obesity necessitating improvement in the management of childhood obesity","PeriodicalId":17132,"journal":{"name":"Journal of steroids & hormonal science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85882504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Steroids and Hormones in Gynecomastia-Factors and Treatments","authors":"Pooja Shree","doi":"10.4172/2157-7536.1000195","DOIUrl":"https://doi.org/10.4172/2157-7536.1000195","url":null,"abstract":"Gynecomastia is an endocrine disorder where the male breast tissue swells and growth in the size abnormally. All men and women have breast glands; however they're no longer significant in males, because they have a tendency to be small and undeveloped. Drugs which include steroids motive 10%-25% of cases of gynecomastia. They throw off the hormonal stability which increases in estrogen (the female sex hormone) and/or a lower in testosterone (the male sex hormone), which reasons the breast tissue to develop. Almost all reasons of gynecomastia may be in a single manner or different much like excess production of the hormone estrogen inside the male frame because of different factors. In this article, we overview the reasons and treatment of gynecomastia.","PeriodicalId":17132,"journal":{"name":"Journal of steroids & hormonal science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77817594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D Status and the Effect of Oral Vitamin D Treatment in Children with Alopecia Areata","authors":"G. Karagüzel, Sakarya Np, S. Bahadır, E. Beyhun, S. Yaman","doi":"10.4172/2157-7536.1000189","DOIUrl":"https://doi.org/10.4172/2157-7536.1000189","url":null,"abstract":"Objectives: Little is known about the association of vitamin D and alopecia areata (AA). Our objectives were to search a relation between 25-hydroxyvitamin D [25(OH)D] levels and the development of AA and the efficacy of oral vitamin D treatment in children with AA and vitamin D deficiency. Methods: Thirty newly diagnosed AA patients and 30 sex- and age-matched controls were included in the study. Levels of 25(OH)D, parathormone, calcium, inorganic phosphate, alkaline phosphatase were measured at baseline and sixth month. Both patients and controls who diagnosed vitamin D deficiency were treated with oral vitamin D for six months. Results: Serum 25(OH) D levels of the patients and controls were 25.3 ± 19.4 ng/ml and 21.3 ± 12.5 ng/ml, respectively (p>0.05). The frequency of vitamin D deficiency was similar in patients and controls. Serum levels of 25(OH)D and calcium were increased significantly after six months of the treatment in both patients and controls with vitamin D deficiency (p<0.05). A higher frequency (47%) of complete improvement was observed in patients with AA and vitamin D deficiency during oral vitamin D treatment. Conclusions: There was no statistically significant difference in 25(OH)D levels between the patients with AA and controls. However, we observed a higher frequency of complete improvement in these patients with an improved vitamin D status. Thus, oral vitamin D treatment can be given only to selected AA patients who are also deficient in vitamin D.","PeriodicalId":17132,"journal":{"name":"Journal of steroids & hormonal science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78901298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Effect of Taurine on Thiopurine-Induced Testicular Atrophy in Male Albino Rats","authors":"B. Ramadan, M. Schaalan, E. Mahmoud","doi":"10.4172/2157-7536.1000192","DOIUrl":"https://doi.org/10.4172/2157-7536.1000192","url":null,"abstract":"Background: Though the use of Azapress (Azathioprine) in cancers and autoimmune diseases has proved therapeutic effectiveness in numerous prospective clinical trials, some cases of testicular toxicity has been reported, that were referred to the evolved oxidative stress and inflammatory milieu. Taurine (TAU) is an amino acid found abundantly in brain, heart, and reproductive organ cells and with reported antioxidant and anti-inflammatory benefits. Objective: The aim of the work was to investigate the protective effects of Taurine against Azapress-induced testicular dysfunction in male albino rats and unravel the contributing mechanisms. Material and methods: Forty adult male albino rats were allocated into four equal groups; (i) normal control rats (Control group), (ii) Azapress group (AZP, 1mg/day for four weeks); (iii) Taurine group(Tau; 100 mg/kg bw/day for 6 weeks), (iv) Taurine and AZP group). Results: AZP caused alterations in sperm parameters, increased DNA damage, and sex hormones disturbance. Moreover, significant decreased levels of superoxide dismutase (SOD) and catalase (CAT) activities, and upregulated levels of the pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-α) and interleukin-1beta (IL-1β), as well as apoptotic markers; Bcl2 and caspase-9 expression it were evident in the testicular tissues. In contrast, taurine pretreatment significantly alleviated these toxic effects that were further evidenced histologically. Conclusion: Our data suggest that oxidative stress and inflammation are involved in AZP-induced destruction in the male reproductive system and that co-administration of taurine exerts a protective effect against AZP-induced male reproductive testicular atrophy. This could open new horizon to its usage as an add-on complementary approach to chemotherapy supportive care.","PeriodicalId":17132,"journal":{"name":"Journal of steroids & hormonal science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81444030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modern Parathyroid Surgery and Intra-Operative Hormone Monitoring; Present Status, Future Concepts","authors":"TE Abdel-Aziz","doi":"10.4172/2157-7536.1000190","DOIUrl":"https://doi.org/10.4172/2157-7536.1000190","url":null,"abstract":"New technologies look for practical applications and complex clinical problems search for innovations able to address them. This convergent course of clinical needs and technological innovation laid foundation for progress and success of modern health care. Our review looks at the present status and future concepts of parathyroid surgery in relation to important technological developments of the last few decades. We focus on describing how parathyroid operations have been transformed by the more accurate imaging and discuss impact of intra-operative PTH monitoring, a “disruptive technology” with a potential to change current clinical paradigm.","PeriodicalId":17132,"journal":{"name":"Journal of steroids & hormonal science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77689990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}