A Short Review of Methods for the Allylic Oxidation of ÃÂ5 SteroidalCompounds to Enones

Abstract

Introduction of α, β-unsaturated ketones to Δ5 steroidal olefins changes the characteristics and biological function of those compounds. Several synthetic methods have been reported to accomplish carbonyl introduction to Δ5 steroidal olefins. Herein, this short review will catalogue many of those oxidative methods, particularly those proceeding through a peroxide intermediate and/or use chromium complexes as reagents.