Journal of Research in Pharmacy最新文献_第4页

Anabasis oropediorum Maire. as a health-promoting source: Phytochemical content, in vitro antioxidant, antidiabetic, antibacterial, and anti-inflammatory potential 一种叫anabasoropediorum Maire的植物。作为促进健康的来源:植物化学成分，体外抗氧化，降糖，抗菌和抗炎潜力

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Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.474

Noura Gheraissa, A. Chemsa, Nezar Cherrada, Erol Ebru, Eman Ramadan Elsharkawy

{"title":"Anabasis oropediorum Maire. as a health-promoting source: Phytochemical content, in vitro antioxidant, antidiabetic, antibacterial, and anti-inflammatory potential","authors":"Noura Gheraissa, A. Chemsa, Nezar Cherrada, Erol Ebru, Eman Ramadan Elsharkawy","doi":"10.29228/jrp.474","DOIUrl":"https://doi.org/10.29228/jrp.474","url":null,"abstract":": Phytochemicals, which are necessary for plants to adapt to their environment, offer an exciting source of medicinal products. This study focuses on the desert plant Anabasis oropediorum ( Chenopodiaceae ), which is native to calcareous sandy regions in North African countries and Palestine. This investigation is the first to shed light on the therapeutic nature of the methanolic extract of the aerial parts of A. oropediorum . A phytochemical screening analysis was conducted, including a quantitative estimate of the total phenols, flavonoids, flavonols, anthocyanins, hydrolyzable tannins, and condensed tannins. Antioxidant activity was evaluated in vitro using three methods: DPPH • scavenging, β -carotene bleaching, and anti-hemolytic assay. The antidiabetic activity was tested using two assays: non-enzymatic hemoglobin glycosylation and glucose uptake by yeast cells assay. Antibacterial activity was evaluated by the disc diffusion method, and anti-inflammatory activity was evaluated by the protein anti-denaturation method. Phytochemical screening revealed the presence of alkaloids, coumarins, cardiac glycosides, leuco-anthocyanins, mucilage, phenols, saponins, sterols, and terpenes. The quantitative analysis showed that the methanolic extract provided a high level of flavonoids (17.0±0.50 µ g QE/mg) and the total contents of tannins (5.3±0.04 µ g GAE/mg, 7.3±0.14 µ g CE/mg). Chlorogenic acid, p -coumaric acid, quercetin, and rutin were the phenolic compounds detected by RP-HPLC analysis. FTIR spectroscopy confirmed the presence of alkanes, aromatic compounds, and aliphatic amines in the methanolic extract. Biologically, this medicinal plant exhibited medium antioxidant activity, good in vitro antidiabetic activity, antibacterial activity against only Staphylococcus aureus , Listeria innocua , and Escherichia coli , and very good albumin protection activity from heat denaturation","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69840455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Evaluation of Lidocaine Hydrochloride Cubosomes directed by QbD QbD指导下盐酸利多卡因立方体体的研制与评价

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Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.485

Rajani Thoutreddy, Koteswara Rao Gsn, N. Malothu, C. Guntupalli, Pavani Sriram, R. R. Alavala

{"title":"Development and Evaluation of Lidocaine Hydrochloride Cubosomes directed by QbD","authors":"Rajani Thoutreddy, Koteswara Rao Gsn, N. Malothu, C. Guntupalli, Pavani Sriram, R. R. Alavala","doi":"10.29228/jrp.485","DOIUrl":"https://doi.org/10.29228/jrp.485","url":null,"abstract":": Cubosomes, which are modified cubic phase systems, are looking very promising as a method of delivering both hydrophilic and lipophilic drugs. Transdermal delivery of cubosomes is currently gaining more importance over conventional topical delivery of drugs. The proposed study aimed to produce Lidocaine hydrochloride loaded cubosomes. This study was designed to prepare various formulations of Lidocaine nano cubsomal dispersions at different concentrations of lipid and stabilizer using optimization technique. For the purpose of prolonging the duration of the local anaesthetic action, Lidocaine-loaded cubosomes were developed by bottom up method utilizing Glyceryl mono oleate and Poloxamer 407 in various ratios using the \"Quality by Design\" approach, 3 2 factorial design employing statistical software. Within the confidence intervals, the 3 2 statistical design was effective at forecasting the optimized formulation's composition. Surface morphology, particle size, drug content, poly dispersibility index, zeta potential, entrapment efficiency, and in vitro drug release studies were conducted on the prepared formulations. Several mathematical models were used to conduct and assess an in vitro drug release investigation. The maximal entrapment efficiency for the LH8 formulation, which was validated to have optimum cubosomes dispersion, was reported to be 78 % with vesicle size as 150 nm, Zeta potential 21.5 mV and Poly Dispersibility Index as 0.08 along with an in vitro drug release 80.03 % by the end of 24 hours. A stable dispersion with appreciable results of evaluation parameters of cubosomal dispersion was conferred with formulation LH8. Hence from amongst the nine formulations developed, it is concluded that LH8 is selected as the optimized dispersion to be incorporated into a gel formulation.","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69840490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Drying Temperature Impact on Curcumin - Piperine Dissolution and Its Kinetic Release: Application of A Spray Dryer on the Preparation of Solid Dispersion-based Microparticle Containing Curcuma longa and Piper Nigrum Extracts 干燥温度对姜黄素-胡椒碱溶出及其动力学释放的影响——喷雾干燥机在姜黄和胡椒提取物固体分散颗粒制备中的应用

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Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.420

Siska Ayu PURNAMASARI, Dewi Setyaningsih

{"title":"The Drying Temperature Impact on Curcumin - Piperine Dissolution and Its Kinetic Release: Application of A Spray Dryer on the Preparation of Solid Dispersion-based Microparticle Containing Curcuma longa and Piper Nigrum Extracts","authors":"Siska Ayu PURNAMASARI, Dewi Setyaningsih","doi":"10.29228/jrp.420","DOIUrl":"https://doi.org/10.29228/jrp.420","url":null,"abstract":": After oral administration, low water solubility and rapid pre-systemic metabolism contribute to curcumin's poor bioavailability. To solve the bioavailability issue, piperine, a natural bioenhancer, can be coupled with curcumin in a solid dispersion-based microparticle formulation (SD). This study's objective was to understand drying temperature's effect on the yield and dissolution behaviour of curcumin and piperine in the SD containing C.longa and P.nigurm extracts at a weight ratio of 3:1. The SD was prepared on a solvent method and used polyvinylpyrrolidone K30 as a carrier. Spray drying was operated at 105°C, 115°C, and 125°C to evaporate the solvent. The yield and dissolution behaviour of curcumin and piperine were their defining characteristics, and the dissolution efficiency (DE) was used to compare the dissolution profiles. The kinetic release model of curcumin and piperine was determined using DDsolver software. The results demonstrate that the SD's yield increases as inlet temperature increases, from 33.60% at 105°C to 35.75% at 115°C to 39.30% at 125°C. The dissolution of curcumin and piperine from the SD increases along with the rise in drying temperature. Variation in drying temperature provides a different kinetic model of curcumin and piperine release. The Weibull model describes the release kinetic of curcumin and piperine at almost used drying temperatures; however, the release of piperine from the SD prepared at 125°C fits the zero-order model.","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69839071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neusilin US2 based Liquisolid Compact technique for the enhancement of solubility and dissolution rate of Olmesartan: Box-Behnken design approach 基于Neusilin US2的液相致密技术提高奥美沙坦的溶解度和溶出率:Box-Behnken设计方法

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Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.289

A. Kanugo, Anushka Thanvi

引用次数: 0

Formation of N-Oxide metabolites from isoniazid hydrazones of substituted benzaldehydes by hepatic washed pig microsomal preparations 猪肝洗微粒体制剂中取代苯甲醛异烟肼腙形成n -氧化物代谢物的研究

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Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.307

Göknil Pelin COŞKUN, Elif Göksu Algin, Jülide Cansu Karakoç, Başak Türk Erbul, M. Ülgen

引用次数: 0

The extraction and determination of ellagic acid and resveratrol in blueberry species by HPLC-DAD and LC-MS/MS HPLC-DAD和LC-MS/MS法提取和测定蓝莓中鞣花酸和白藜芦醇的含量

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Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.313

S. Seyhan, G. Yalcin, S. Seyhan

引用次数: 0

Antibacterial and antibiofilm activity of Melaleuca alternifolia (tea tree) essential oil against colistin resistant Salmonella enterica serotypes isolated from poultry environmental specimens 互花千层树(茶树)精油对家禽环境标本中耐粘菌素肠炎沙门氏菌血清型的抑菌和抗菌活性研究

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Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.333

Merve Eylul Kiymaci, Merve Savluk, M. Gumustas, Mehmet Uvey, N. Unal

引用次数: 0

Long-term administration of high doses of Hydroxychloroquine poses a risk of seizures 长期服用大剂量羟氯喹有癫痫发作的危险

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Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.323

Y. Panahi, Tannaz Haghgouie

{"title":"Long-term administration of high doses of Hydroxychloroquine poses a risk of seizures","authors":"Y. Panahi, Tannaz Haghgouie","doi":"10.29228/jrp.323","DOIUrl":"https://doi.org/10.29228/jrp.323","url":null,"abstract":"The coronavirus spreading has led to the development of many drugs to prevent and treat it. One of these drugs is hydroxychloroquine, so this study was designed to investigate the potential side effects of the drug when used long-term and at high doses in male rats. Physiologically, 30 male Wistar rats were randomly divided into two groups: control and hydroxychloroquine (10, 50, 100, and 200 mg/kg) (n=6 per group). Hydroxychloroquine was administered orally for seven consecutive days. On the seventh day, 30 minutes after receiving hydroxychloroquine, the animals were anesthetized with a combination of ketamine (70 mg/kg) and xylazine (7 mg/kg), the animal's head was fixed using a stereotaxic device, and an incision 1.5-2 cm long was made in the scalp. Drill the desired point with a perforated dental drill using the Paxinos coordinates (AP =-0.27, ML =-0.14, DV =-0.3). Pentylenetetrazol (80 mg/kg i.p.) was used to induce epileptiform activities. Finally, diazepam (10 mg/kg, i.p.) was given to reduce epileptiform activity. The number of seizure activities was reduced significantly (p<0.001) at dose of 10 mg/kg and significantly (p<0.001) increased at doses of 100 and 200 mg/kg. In contrast, the dose of 50 mg/kg had no discernible effect. Giving male rats high doses of oral hydroxychloroquine for one week has biphasic effects on the number of pentylenetetrazol-induced seizure activities. As a result, it has protective effects in low and stimulant effects in high doses. © 2023 Marmara University Press ISSN: 2630-6344.","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69837110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is it possible to improve antioxidant activity of curcumin with the structure of lipid- based nanocarriers? 脂基纳米载体结构能否提高姜黄素的抗氧化活性?

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Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.338

Gulin Amasya, Omer Yedikaya, Ulya Badilli, N. Ozdemir

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The Role of Endothelin Axis in Cancer Treatment and Its Position in Therapeutic Strategies 内皮素轴在肿瘤治疗中的作用及其在治疗策略中的地位

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Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.330

Nadir Gül

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