Journal of Research in Pharmacy最新文献

Evaluation of synthesized methoxy chalcones for therapeutic potential through in vitro and in silico methods 体外和硅法评价合成甲氧基查尔酮的治疗潜力

Journal of Research in Pharmacy Pub Date : 2025-07-04 DOI: 10.12991/jrespharm.1734661

Zeynep Erik, İshak Erik, Can Özgür Yalçın, Sıla Özlem Sener, Şengül Alpay Karaoğlu, Gizem Tatar, Nurettin Yaylı, Rezzan Aliyazıcıoğlu

{"title":"Evaluation of synthesized methoxy chalcones for therapeutic potential through in vitro and in silico methods","authors":"Zeynep Erik, İshak Erik, Can Özgür Yalçın, Sıla Özlem Sener, Şengül Alpay Karaoğlu, Gizem Tatar, Nurettin Yaylı, Rezzan Aliyazıcıoğlu","doi":"10.12991/jrespharm.1734661","DOIUrl":"https://doi.org/10.12991/jrespharm.1734661","url":null,"abstract":"Chalcones are the precursors of flavonoids and have a wide range of biological activities. A series of methoxy chalcones (1-12) were synthesized using the Claisen-Schmidt method and identified by NMR analyses. Enzyme inhibition, antimicrobial, and antioxidant activities of all compounds were investigated. The enzyme kinetics and ADMET profile of the compounds were evaluated by in silico methods. The highest inhibition activities for lipase, AChE, BChE, tyrosinase, α-amylase, and α-glucosidase were observed at the following IC50 values (μg/mL): 7 (39.83±1.1216), 2 (60.39±1.24), 1 (39.79±1.29), 2 (40.40±1.01), 1 (98.61±3.17), and 2 (55.91±1.78), respectively. Compounds 1 and 4 exhibited the highest antioxidant activity against FRAP and CUPRAC tests, while 1 and 3 were the most effective in the DPPH method. All compounds showed the best activity against gram (-) bacteria. The top docking scores were compound 1 against α-amylase and BChE, 2 against α-glucosidase, AChE, and tyrosinase, and 7 against lipase. All compounds met the drug-likeness criteria using the SwissADME. All compounds have high bioavailability with lower toxicity profiles using SwissADME and pkCSM. According to the AMES test, compounds 3, 6, 9, and 10 were predicted to be mutagenic. ProTox (v.3.0) predicts that all compounds have an oral LD50 value of 2100 mg/kg bw and are classified as GHS Category V, indicating relatively low acute toxicity. Overall, the study results indicate that compounds 1 and 2 show promise for animal studies targeting Alzheimer's disease and diabetes, while 7 appears promising for obesity.","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"29 4","pages":"1693-1711"},"PeriodicalIF":0.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://dergipark.org.tr/en/download/article-file/5022256","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147890734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Antimicrobial activities of some Verbascum L. species against clinical isolates of Klebsiella pneumoniae causing lower respiratory tract infections 几种荆芥对肺炎克雷伯菌临床分离株的抑菌活性研究

Journal of Research in Pharmacy Pub Date : 2025-05-24 DOI: 10.12991/jrespharm.1694358

Nurnehir Baltacı Bozkurt, Gamze Benli Yardımcı, Elif Ayça Şahin, Murat Özbek, Ekrem Murat Gönülalan, Çiğdem Kahraman

{"title":"Antimicrobial activities of some Verbascum L. species against clinical isolates of Klebsiella pneumoniae causing lower respiratory tract infections","authors":"Nurnehir Baltacı Bozkurt, Gamze Benli Yardımcı, Elif Ayça Şahin, Murat Özbek, Ekrem Murat Gönülalan, Çiğdem Kahraman","doi":"10.12991/jrespharm.1694358","DOIUrl":"https://doi.org/10.12991/jrespharm.1694358","url":null,"abstract":"Increasing antibiotic resistance in Klebsiella pneumoniae has necessitated the development of novel antimicrobial therapies. In recent years, many studies have been conducted on using plants as antimicrobial agents, and many natural compounds have been found to be effective sources of antibacterial agents. In the present study, the antimicrobial activity of K. pneumoniae strains isolated from patients with lower respiratory tract infections (LRTIs) was investigated against some Verbascum L. species. Five K. pneumoniae strains, isolated from bronchoalveolar lavage (BAL) samples of patients with LRTIs, were identified by VITEK MS MALDI-TOF (BioMerieux, France). Then, the antimicrobial activity of 85% ethanol and 2% aqueous extracts of nine Verbascum species (V. ancyritanum Bornm., V. cheiranthifolium Boiss., V. georgicum Benth., V. kastamunicum Murb., V. lasianthum Boiss. ex Benth., V. mucronatum Lam., V. sinuatum L. subsp. sinuatum var. adenosepalum Murb., V. speciosum Schrad., V. uschakense Hub.-Mor.), three of which are endemic to Turkish flora, was investigated by using the microdilution method. Both 85% ethanol and 2% aqueous extracts of Verbascum species showed MIC values between 128 - 256 ƒÊg/mL and MBC in the range of 256 - 1024 ƒÊg/mL. The endemic species, V. ancyritanum presented the most effective antimicrobial activity. In the present study, the antimicrobial activity of endemic species, V. ancyritanum, V. kastamunicum, and V. uschakense, was investigated for the first time. All extracts were found to have moderate antimicrobial activity against the studied bacteria.","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"29 3","pages":"1187-1192"},"PeriodicalIF":0.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147903525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Development and characterization of acemetacin nanosuspension-based oral lyophilisates 阿西美辛纳米悬浮液口腔冻干剂的研制与表征

Journal of Research in Pharmacy Pub Date : 2025-03-28 DOI: 10.12991/jrespharm.1664881

Hussein Al-gharani, Khalid Kadhem Al-Kinani

{"title":"Development and characterization of acemetacin nanosuspension-based oral lyophilisates","authors":"Hussein Al-gharani, Khalid Kadhem Al-Kinani","doi":"10.12991/jrespharm.1664881","DOIUrl":"https://doi.org/10.12991/jrespharm.1664881","url":null,"abstract":"Acemetacin is a non-steroidal anti-inflammatory drug (NSAIDs) which has an analgesic, antipyretic, and anti-inflammatory effect. The aim of the present study was to develop oral lyophilisates containing acemetacin nanosuspensions. The primary goal was to improve tablet disintegration in the mouth, make swallowing easier, and potentially improve patient compliance. Furthermore, formulating acemetacin as a nanosuspension was intended to improve dose-to-dose proportionality compared to using the drug in its naked form. The solvent-anti-solvent technique was used to develop the nanosuspension, and Soluplus® was added to stabilize acemetacin nanoparticles. The nanosuspension was concentrated using a rotary evaporator before other excipients were added. The excipients utilized were gelatin, polyvinyl pyrrolidone K90, glycine, and mannitol. They were dissolved in the concentrated nanosuspension, poured into tablet blister molds, and lyophilized to create acemetacin nanosuspension-based oral lyophilisates. The experiments were developed via a computer-based approach using Design Expert® software. For this purpose, the Box-Behnken design was used to study the effect of different formulation factors on tablet disintegration time and friability values. The selected formula F9 had the highest desirability value (0.913), and its disintegration time and friability values were 26.6 seconds and 0.938%, respectively. The dose-to-dose proportionality has substantially improved, and more than 85% of the formula F9 was released in only 8 minutes compared to the naked acemetacinbased oral lyophilisates, which only gave 24.5% in this time frame. Compatibility studies showed there was no chemical interaction between the tablet components.","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"29 2","pages":"626-638"},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://dergipark.org.tr/en/download/article-file/4722433","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147884536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Preparation and evaluation of transdermal gel loaded with spanlastics containing meloxicam 含美洛昔康的塑料透皮凝胶的制备与评价

Journal of Research in Pharmacy Pub Date : 2024-01-01 DOI: 10.29228/jrp.801

Mohammed KI AL MANSOORI, Lubna A SABRI

{"title":"Preparation and evaluation of transdermal gel loaded with spanlastics containing meloxicam","authors":"Mohammed KI AL MANSOORI, Lubna A SABRI","doi":"10.29228/jrp.801","DOIUrl":"https://doi.org/10.29228/jrp.801","url":null,"abstract":"A transdermal drug delivery system (TDDS) is characterized by the application of medications onto the skin's surface to deliver drugs at a controlled and predefined rate through the skin.Spanlastics, an elastic nanovesicle capable of transporting various pharmacological substances, shows promise as a drug delivery carrier.It offers numerous advantages over traditional vesicular systems applied topically, including enhanced stability, flexibility in penetration, and improved targeting capabilities.This study aims to develop meloxicam (MX)-loaded spanlastics gel as skin delivery carriers and to look into the effects of formulation factors like Tween80, Brij 35, and carbopol concentration on the properties of spanlastics gel, like pH, drug content, extrudability, spreadability diameter, viscosity, and release profiles in addition to Ex vivo skin permeation for optimal formula.The optimal formula of spanlastics gel (GF1) shows acceptable pH (6.2±0.14),excellent extrudability( 92%), drug content (97.1±0.14),spreadability diameter (cm) (10.8±0.28),sustained release 70.7±0.57%for six hours and the steady-state flux of meloxicam through rat skin was increased 83.52fold as a result of spanlastics in comparison to the plain gel.The vesicles produced in this investigation could potentially interact with or merge with the stratum corneum as a result of their elasticity, which may also be the mechanism that increases the penetration into the skin.According to our findings, dermal delivery vehicles for MX may be provided via spanlastics gel.","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"28(4) 28(4)","pages":"1200-1209"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147885712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Artificial Intelligence approach to verify irrationality of FDCs listed by CDSCO 用人工智能方法验证CDSCO列出的fdc的不合理性

IF 0.8

Journal of Research in Pharmacy Pub Date : 2023-09-04 DOI: 10.25081/rip.2023.v13.8464

Ayush Thakur, Anshu Kumari, Shiwank Rana

引用次数: 0

Potential of Impatiens walleriana Hook.f. as medicinal herb and otherwise - An update 凤仙花的潜力。作为草药或其他-最新消息

IF 0.8

Journal of Research in Pharmacy Pub Date : 2023-08-10 DOI: 10.25081/rip.2023.v13.8449

G. Kulkarni

{"title":"Potential of Impatiens walleriana Hook.f. as medicinal herb and otherwise - An update","authors":"G. Kulkarni","doi":"10.25081/rip.2023.v13.8449","DOIUrl":"https://doi.org/10.25081/rip.2023.v13.8449","url":null,"abstract":"The healing potential and usefulness of plants is known since historic times. Impatiens walleriana Hook.f. (Family - Balsaminaceae) is the most cultivated plant from the genus “Impatiens”. It is explored by floriculture and horticulture industries. It has culinary uses with the potential to be researched by the food industry. Many modern medicines are plant-derived and I. walleriana has the potential to be used as medicine as backed by ethnopharmacological data. I. walleriana finds a number of traditional/folk medicinal claims. All parts of the plant and in varied formulations are used traditionally to treat various ailments. The data reviewed shows its safety in uses and its nontoxic nature. Among the Impatiens species I. walleriana is the less researched one. Few studies pertaining to its antioxidant, antimicrobial and antitumor activities are reported. Phytochemical constituents have been identified and reported by some researchers. Following a detailed study of published information and reported activities current review on the one hand summarizes the research work that has been carried out on the other hand gives food for thought for researchers to undertake more work in the direction of finding its usefulness using scientific methodologies and establishing the ethnic claims.","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"14 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81010074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Missing heritability paradox in schizophrenia: hypothesis and plausible clues 精神分裂症的缺失遗传性悖论:假说和可信线索

IF 0.8

Journal of Research in Pharmacy Pub Date : 2023-03-09 DOI: 10.25081/rip.2023.v13.8124

Rama Thyloor, T. S. Nagamani, H. G. Gowtham, H. B. K. Kumar

引用次数: 0

An Egg Shell: A Nutritional Profile and Health Benefits 蛋壳:营养概况和健康益处

IF 0.8

Journal of Research in Pharmacy Pub Date : 2023-02-06 DOI: 10.25081/rip.2023.v13.8054

Pranjal Sachan

{"title":"An Egg Shell: A Nutritional Profile and Health Benefits","authors":"Pranjal Sachan","doi":"10.25081/rip.2023.v13.8054","DOIUrl":"https://doi.org/10.25081/rip.2023.v13.8054","url":null,"abstract":"Calcium is one of the most fundamentally significant and essential component for the human body since it makes up the majority of the skeletal system in humans (98%). The goal of the present review study was to discuss calcium’s importance in everyday life, calcium absorption theories, eggshell (ES) deposition, and its nutritional makeup. There are two phases to ES formation. 5.5 grams of calcium carbonate, or about 95% of the dry ES, are present. One ES contains traces of sodium, potassium, zinc, manganese, iron, and copper as well as 0.3% phosphorus, 0.3% magnesium, and sodium, potassium, zinc, manganese, and iron. Vitamin D is necessary for calcium absorption; hence, calcium bioavailability is influenced by dietary calcium intake as well as vitamin D status. Calcium may reabsorb at a number of places along the nephron. Intestinal acidity (particularly for CaCO3 absorption), oestrogen, vitamin D, and soluble fibre/prebiotics, probiotics, and synbiotics are some of the elements that have been shown to favourably boost calcium absorption. Pulsed electric fields, high-energy milling, and electric discharge-assisted mechanical milling are relevant techniques that have been studied and might be used to extract calcium from ESs. Researchers looked at the health benefits of eggshells and different ways to get the calcium out of eggshells to see if they could be used to make a good calcium supplement.","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"80 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80963232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Modelling of Some Ligands Against Acetylcholinesterase to Treat Alzheimer’s Disease 抗乙酰胆碱酯酶配体治疗阿尔茨海默病的分子模拟

Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.510

Şaban KALAY, Hatice AKKAYA

引用次数: 0

Beyond the heart - Exploring the therapeutic potential of PDE3 inhibitors 超越心脏-探索PDE3抑制剂的治疗潜力

Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.512

Muhammed TRAWALLY

引用次数: 0