Journal of Research in Pharmacy最新文献_第10页

PLANT PHENOLICS AND THEIR SYNTHETIC DERIVATIVES AS INHIBITORS OF HELICOBACTER PYLORI: SUGGESTION FOR A NEW MECHANISM OF ACTION 植物酚类物质及其合成衍生物作为幽门螺杆菌抑制剂:一种新的作用机制的建议

IF 0.8

Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.388

Simone Carradori

引用次数: 0

Patient experience in community pharmacies from an experiential marketing perspective: structural equation model 体验营销视角下的社区药房患者体验:结构方程模型

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Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.391

Demet AKALGAN AKLAR, G. Ozcelikay

{"title":"Patient experience in community pharmacies from an experiential marketing perspective: structural equation model","authors":"Demet AKALGAN AKLAR, G. Ozcelikay","doi":"10.29228/jrp.391","DOIUrl":"https://doi.org/10.29228/jrp.391","url":null,"abstract":": The main objective of this study was to model patient experience (PX) in community pharmacies as experimental marketing parameters via structural equation modeling (SEM). Our findings show that peace of mind, trust, pharmacy, customer engagement, interaction quality with the pharmacist and personnel, and atmosphere or periphery experience quality is the important component for a patient to re-visit the same pharmacy. The patient's journey to the pharmacy starts before entering the pharmacy, continues at the pharmacy, and then leaves the pharmacy. It is important to understand the touchpoint of the patient journey at a community pharmacy and the needs of the patients as well as other health services. Overall, whether it is patient experience or customer experience, both focus on people and understanding their needs as a service sector will add value to service quality. The research was conducted on 414 volunteer patients given informed consent and answered 73 items in Istanbul province. The data obtained from the questionnaire forms were analyzed using the IBM SPSS Statistics 23 package program. Confirmatory factor analysis (CFA) was applied using IBM SPSS AMOS 23 package program in the analysis of trust, pharmacy customer engagement (PCE), word of mouth (WoM), pharmacist interaction quality, personnel interaction quality, periphery experience quality, peace-of-mind (POM), and autobiographical memory parameters. Since the assumption of normality was not provided, the relationships among these items were calculated using Spearman's correlation coefficient. The results were evaluated at the significance level of p <0.05. Finally, a structural equation model was conducted to specify PX items.","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69838724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biosynthesis of Magnesium Oxide Nanoparticles Using Opunita ficus-indica and Their Antifungal Effect Against Aspergillus Niger 榕树开孔菌合成氧化镁纳米颗粒及其对黑曲霉的抑菌作用

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Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.408

Taif Alholy, Walid Khaddam

引用次数: 0

R&D STUDIES IN THE DEVELOPMENT OF TRADITIONAL HERBAL MEDICINAL PRODUCTS 传统草药产品开发的研发研究

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Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.379

Iffet Irem TATLI ÇANKAYA

引用次数: 0

Investigation of Nutraceutical Potential, in vitro Antioxidant and Free Radical Scavenging Activity of Indian Royal Jelly 印度蜂王浆的营养潜力、体外抗氧化和自由基清除活性研究

IF 0.8

Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.417

R. Dubey, L. Sathiyanarayanan, Laxmi Rao, S. Sankaran

{"title":"Investigation of Nutraceutical Potential, in vitro Antioxidant and Free Radical Scavenging Activity of Indian Royal Jelly","authors":"R. Dubey, L. Sathiyanarayanan, Laxmi Rao, S. Sankaran","doi":"10.29228/jrp.417","DOIUrl":"https://doi.org/10.29228/jrp.417","url":null,"abstract":": Apis mellifera , a priceless bee species is known to produce various nutritional products. Royal Jelly (RJ) is one such bee product which has high nutritive value, functional and biological qualities. However factors such as bee species, environment, season, collection technique and larval age affect the composition of RJ at macro and micro levels thus there is a need to evaluate Indian Royal Jelly (IRJ) for its chemical properties. So in the present work IRJ samples collected from Southern, Central and Northern regions of India were evaluated for physicochemical parameters (nature, color, appearance, odor, and solubility,) residual content (moisture content, ash value and pesticide content), chemical attributes (total polyphenol content, total flavonoid content,), nutraceutical potential (total fat, protein, carbohydrate content, and energy), and antioxidant activity (DPPH assay, ABTS assay and reducing power,). The total flavonoid content and total phenolic content were in the range of 0.119-0.321 mg quercetin/g of IRJ and 25.2844-68.203 mg Gallic acid/g, respectively. High energy, protein and low fat value suggested IRJ as a suitable nutraceutical agent. Antioxidant activity (IC 50 ) of IRJ samples was found to be in the order of IRJ II > IRJ IV > IRJ I > IRJ III. Overall, it was observed that the IRJ-II showed better nutritional efficacy, polyphenolic content, and antioxidant properties.","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69839008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response surface methodology-aided maceration method optimization of quercetin-standardized purified extract of shallot skin (Allium cepa L var. aggregatum) 响应面法辅助浸渍法优化槲皮素标准纯化葱皮提取物

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Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.428

Sapri Sapri, F. Riswanto, E. Wulandari

{"title":"Response surface methodology-aided maceration method optimization of quercetin-standardized purified extract of shallot skin (Allium cepa L var. aggregatum)","authors":"Sapri Sapri, F. Riswanto, E. Wulandari","doi":"10.29228/jrp.428","DOIUrl":"https://doi.org/10.29228/jrp.428","url":null,"abstract":": Shallot skin has potential as a medicinal raw material because it contains many quercetin compounds. It is necessary to conduct a study on the optimization of extraction methods and the extracts standardization. The purpose of this study is the standardization of simplicia, optimization of extraction methods and standardization of shallot skin purified extract as standardized on quercetin. This study is aimed to support quality control of simplicia and shallot skin extract as a source of quercetin. The methods of the study include the collection of raw materials, preparation of simplicia, standardization of simplicia, and optimization of extraction methods with Response Surface Methodology (RSM) using Box-Behnken Design (BBD), standardization of standardized quercetin purified extracts. Based on the results obtained, shallot skin simplicia has a moisture content of 7.98 and a total ash content of 9.91%. Based on the analysis, the optimum point of the solvent concentration factor, time, and the solvent ratio on the yield of the purified extract were respectively 60.42%, 1.29 hours, and 24.45 mL/g. The yield average obtained was 5.16 ± 0.1125 % with a content of 5.947 ppm (0.005497 mg/g).","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69839357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does Combination of DNR and Casticin show advantage in favor of apoptosis on AML leukemia stem-like cell lines? A preliminary study 在AML白血病干细胞样细胞系中，DNR和Casticin联合使用是否有促进细胞凋亡的优势?初步研究

IF 0.8

Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.416

Tuğba Erkmen, H. Ateş, A. S. Koçtürk

{"title":"Does Combination of DNR and Casticin show advantage in favor of apoptosis on AML leukemia stem-like cell lines? A preliminary study","authors":"Tuğba Erkmen, H. Ateş, A. S. Koçtürk","doi":"10.29228/jrp.416","DOIUrl":"https://doi.org/10.29228/jrp.416","url":null,"abstract":": Acute myeloid leukemia (AML) is a form of acute leukemia with the highest incidence and the lowest overall survival rates. Insufficiency of targeting leukemia stem cells (LSC) is the main obstacle that causes drug resistance and relapse in AML. Another important problem is chemotherapeutics’ toxicity. Developing a combination, including well-known chemotherapeutics in lower dose and new agent that have capacity to target LSC may be more reliable and practical way to overcome these limitations. Previously, we found that Casticin polyphenol induces apoptosis in AML stem-like (KG1a) and parental (KG1) cell lines without affecting healthy cell. Therefore, for the first time, we aimed to find synergistic combination of Daunorubicin (DNR) and Casticin to target apoptosis in both LSC and leukemic blasts with less toxicity. Synergism of DNR-Casticin combinations on KG1a, KG1, HL-60 cells were determined with MTT viability assay by Chou-Talalay method. The apoptotic/necrotic effects of combinations were evaluated with Annexin V- PI kit by flow cytometry. Synergistic combination of 0.25 µM DNR + 0.0625 µM Casticin (combination index, CI<1) decreased cell viability to 45.3% and 63.2% in KG1a, KG1 cell lines, respectively. However, the combination-induced apoptosis (KG1a: 5 %; KG1: 5.8%) were not higher than 0.25 µM DNR-induced (KG1a: 9.4%; KG1: 8.1%) or 0.0625 µM Casticin-induced (KG1a: 3.8%; KG1: 5.1%) apoptosis (p>0.05). Our study showed that synergistic combination of DNR-Casticin causes important decrease in cell viability. Although we did not detect increase in apoptosis with the combination, we presume that other cell death pathways may be included. The highest apoptosis was obtained by the treatment of 2 µM Casticin alone in KG1a (21.7%), KG1 (26.5%), HL-60 (14.6%). Therefore, we think that Casticin polyphenol might be the possible candidate for new targeted therapy studies for AML.","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69839467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular docking and drug-likeness study of nirmatrelvir as promising drug candidates of dengue virus NS2B-NS3 protease 尼马特利韦作为登革病毒NS2B-NS3蛋白酶候选药物的分子对接及药物相似性研究

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Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.460

A. Moyeenul Huq, M. Roney, S. N. Tajuddin, M. Aluwi

引用次数: 0

Formulation and in vitro evaluation of pramipexole orally disintegrating tablets for pediatric restless leg syndrome 普拉克索口腔崩解片治疗小儿不宁腿综合征的处方及体外评价

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Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.465

Ömer Türkmen, L. Pozharani, Moein Amel

{"title":"Formulation and in vitro evaluation of pramipexole orally disintegrating tablets for pediatric restless leg syndrome","authors":"Ömer Türkmen, L. Pozharani, Moein Amel","doi":"10.29228/jrp.465","DOIUrl":"https://doi.org/10.29228/jrp.465","url":null,"abstract":": In this study, orally disintegrating tablets (ODT) of pramipexole dihydrochloride monohydrate (PPX) was developed with direct compression method by using ready-to-use excipients Parteck ® ODT, Pharmaburst ® 500, Ludiflash ® , F-Melt ® , and Prosolv ® Easytab SP for pediatric restless leg syndrome (RLS). The formulated ODTs were circular in shape with a total weight of around 100 mg, which was appropriate for pediatric use. In spite of very low content of the drug, content uniformity could be obtained successfully in accordance to the pharmacopoeial specification with a satisfactory mechanical strength in terms of hardness and friability. However, formulations based on Parteck ® ODT and Ludiflash® could not achieve a disintegration time <30 s according to in vitro disintegration test, which was also supported by the simulated wetting test. The optimal ODTs based on Pharmaburst ® 500, F-Melt ® and Prosolv ® Easytab SP were further evaluated for in vitro dissolution study. A very fast release of the drug was observed with these formulations that reached a peak value in 10 min., which was superior than that of the reference conventional tablet formulation of PPX. As a result, pediatric orally disintegrating tablets of PPX were successfully formulated with Pharmaburst ® 500, F-Melt ® and Prosolv ® Easytab SP by using direct compression method with suitable characteristics, which can be further studied to use in pediatric RLS.","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69839818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Polyelectrolyte Complex Beads Containing Vancomycin Hydrochloride for Colon-targeted Drug Delivery 用于结肠靶向给药的盐酸万古霉素聚电解质复合物微球的研制

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Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.450

Venkateswarlu Kudipudi, Ravishankar Kakarparthy, Prakash Nathaniel Kumar Sarella, V. R. Kolapalli

{"title":"Development of Polyelectrolyte Complex Beads Containing Vancomycin Hydrochloride for Colon-targeted Drug Delivery","authors":"Venkateswarlu Kudipudi, Ravishankar Kakarparthy, Prakash Nathaniel Kumar Sarella, V. R. Kolapalli","doi":"10.29228/jrp.450","DOIUrl":"https://doi.org/10.29228/jrp.450","url":null,"abstract":": Vancomycin Hydrochloride is a glycopeptide antibiotic used for the treatment of Pseudomembranous colitis. This drug is susceptible to proteolytic degradation in the gastric environment and it is associated with nephrotoxicity. As the therapeutic action of vancomycin hydrochloride is intended in the intestine, colon-targeted drug delivery could help the drug achieve sufficient concentration in the target site. A polyelectrolyte complex using chitosan and hupu gum is used to prepare the beads that control the drug release and minimize the adverse effects. Eudragit S100 is used as an enteric coating material to bypass the gastric environment. The beads thus formed by polyelectrolyte complex were filled into capsules and coated with Eudragit S100. The formulation (CHP3C8) containing chitosan and hupu gum with polyethylene glycol 400 and 8% Eudragit S100 coating has shown a controlled drug release of up to 24 hours with a predetermined lag time. The ex-vivo studies have shown higher drug release in rat cecal content which can be attributed to the degradation of polyelectrolyte complex by intestinal bacteria. The in-vivo studies are carried out using white New Zealand rabbits where the capsules (CHP3C8) and solution of pure drug of vancomycin hydrochloride are administered via the oral route. The peak plasma concentration (C max ) of Vancomycin Hydrochloride from CHP3C8 and the oral solution was found to be 809.53 µ g/ml and 402 µ g/ml respectively. All the results have shown the superiority of Vancomycin Hydrochloride polyelectrolyte beads (CHP3C8) over the pure drug indicating its suitability for colon drug delivery.","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69839839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0