Journal of Research in Pharmacy最新文献_第3页

THE POTENTIAL OF CERTAIN PHYTOCHEMICALS AS ESSENTIAL NUTRIENTS 某些植物化学物质作为必需营养素的潜力

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Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.383

L. Ciesla

引用次数: 0

Asian Veterinary Medicines: From the Past to the Future 亚洲兽药:从过去到未来

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Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.419

S. Goyal, Divya Thirumal, E. A. Yapar, Eda Sönmez Gürer, Ashok Kumar V, M. A. Babu, R. Sindhu

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Public knowledge and attitude towards medications and dietary supplements used during COVID-19 self-isolation: a cross sectional survey in Surabaya, Indonesia 公众对COVID-19自我隔离期间使用的药物和膳食补充剂的知识和态度:印度尼西亚泗水的一项横断面调查

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Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.439

Ilil Maidatuz ZULFA, Silfiana Nisa Permatasari

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Development and Validation of Stability-Indicating RPHplc Method for Simultaneous Determination of Canagliflozin and Metformin in Fixed-Dose Combination 同时测定卡格列净和二甲双胍固定剂量联用中含量的稳定性指示RPHplc方法的建立与验证

IF 0.8

Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.412

N. Khan, Aejaz Ahmed, Majaz Qazi, Yaasir Ahmed Ansari, A. Shaikh, Ayyaj A. Badgire, Mohd. Salman, Noosrat Jahan Khan

引用次数: 0

Chemical Profiling and Antimicrobial Activity of Essential Oils from Hypericum adenotrichum Spach. An Endemic Species 桃金娘挥发油的化学特征及抑菌活性研究。特有物种

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Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.449

N. Saltan, Y. Köse, D. Kırcı, Fatih Göger, B. Demirci

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Foot Deodorizing Gel Formulation Having Antimicrobial Activity 具有抗菌活性的足部除臭凝胶配方

IF 0.8

Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.415

Prashant R. PATANKAR, V. Chopade, P. Chaudhari

{"title":"Foot Deodorizing Gel Formulation Having Antimicrobial Activity","authors":"Prashant R. PATANKAR, V. Chopade, P. Chaudhari","doi":"10.29228/jrp.415","DOIUrl":"https://doi.org/10.29228/jrp.415","url":null,"abstract":": Sweaty feet and foot odour are common nowadays. The existence of one or more of Staphylococcus epidermis, Bacillus subtilis and Propionibacterium Acnes on foot surface may trigger the generation of isovaleric and propionic acids, which in turn can cause a distinctive odor of feet. The present study tested susceptibility of Bacillus subtilis and Staphylococcus epidermidis to various oils and oil combinations. The outcome showed that a combination of lemon oil, neem oil and tulsi oil possessed synergistic antibacterial activity. A foot deodorizing gel containing a combination of lemon oil, neem oil, and tulsi oil; a gel base was prepared and tested for stability, organoleptic performance, antibacterial activity, irritation test, and deodorizing performance. The mixture of oils was found to reduce at least 6 logs of the primary populace of B. subtilis and S. epidermidis in 10 min. The lethal effect was found for at least 60 minutes. The gel formulation decreased at least 90% of the initial population of bacteria after 1 hour of contact when checked for days 0, 15, 30 and 60. The gel formulation also showed desired properties such as clarity, pourability, consistency, spreadability, quick absorption post application, non-stickiness and non-dryness, and absence of residue. The foot deodorizing gel formulation demonstrated antibacterial efficiency against the bacteria responsible for producing a strong foot odour.","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69839456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progressive Journey of Phytosomes: Preparation, Characterization, Patents, Clinical trials & Commercial products 磷脂体的进展历程:制备，表征，专利，临床试验和商业产品

IF 0.8

Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.457

Jyotsana Dwivedi, Pranjal Sachan, Pranay Wal, Sourabh Kosey, Mohd Masih Uzzaman Khan

引用次数: 0

IN-SILICO PHARMACOKINETICS PREDICTION OF MAJOR COUMARINS PRESENT IN AEGLE MARMELOS L. 蜜瓜中主要香豆素的计算机药代动力学预测[j]。

IF 0.8

Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.452

Sagarika Dhamne, Pradum Shinde, S. Agrawal

引用次数: 0

Development and evaluation of gastro retentive drug delivery system of monoammonium glycyrrhizinate for the management of gastric ulcer 治疗胃溃疡的甘草酸单铵胃内保留给药系统的研制与评价

IF 0.8

Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.472

V. Patole, Harshad S Kapare, J. Mahore, Rachana Bhimanwar, Devyani Awari, Pranali Jadhav

{"title":"Development and evaluation of gastro retentive drug delivery system of monoammonium glycyrrhizinate for the management of gastric ulcer","authors":"V. Patole, Harshad S Kapare, J. Mahore, Rachana Bhimanwar, Devyani Awari, Pranali Jadhav","doi":"10.29228/jrp.472","DOIUrl":"https://doi.org/10.29228/jrp.472","url":null,"abstract":": Monoammonium glycyrrhizinate (MAG), a salt of glycyrrhizin, is reported for effective treatment of gastric disorders. The work was aimed to design and develop a gastro-retentive drug delivery system for MAG to delay its release in stomach by developing a stable raft with sufficient strength and acid-neutralizing potential. Preliminary, in-silico molecular docking study of MAG with the native ligand (Vonoprazan, a potential proton pump inhibitor) present in the gastric proton pump was performed. Docking studies predicted that MAG could bind to Vonoprazan binding site, indicating its ability to inhibit the gastric proton pump. The most desirable optimal formulation of raft forming tablets of MAG was anticipated with the desirability (0.819). The optimized formulation showed raft strength (8.61 ± 0.06 g), acid neutralizing capacity (11.19 ± 0.03 mEq) and in vitro release of MAG (69.11 ± 0.61% over 8h) indicating its suitability as a potential Gastro-retentive raft forming delivery system. The optimized formulation decreased gastric acid production and elevated gastric pH (p< 0.001.) in pylorus ligation induced gastric ulcers in animal model and demonstrated significant decrease in ulcer index (p< 0.001.) The developed raft-forming tablet of MAG could be a promising alternative to the existing synthetic agents to treat gastric ulcers.","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"141 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69840309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of the compound of longan honey from indonesia using LC-MS/MS and FTIR and the mechanism of inhibition of HEp-2 cells 采用LC-MS/MS和FTIR对印尼龙眼蜂蜜化合物进行了表征，并对HEp-2细胞的抑制机制进行了研究

IF 0.8

Journal of Research in Pharmacy Pub Date : 2023-01-01 DOI: 10.29228/jrp.483

La Ode SUMARLIN, Achmad Tjachja Nugraha, A. Muawanah, Nur Ernita, Nurul Amilia

{"title":"Characterization of the compound of longan honey from indonesia using LC-MS/MS and FTIR and the mechanism of inhibition of HEp-2 cells","authors":"La Ode SUMARLIN, Achmad Tjachja Nugraha, A. Muawanah, Nur Ernita, Nurul Amilia","doi":"10.29228/jrp.483","DOIUrl":"https://doi.org/10.29228/jrp.483","url":null,"abstract":": Indonesian honey contains active compounds that have the potential as antioxidant and anticancer, especially as anticancer of the larynx through inhibition of HEp-2 cells. This study aims to determine the active compounds in longan honey and proposes the mechanism of action in inhibiting HEp-2 cells. The sample was used in the form of longan obtained from honey bee breeders in Central Java. Honey samples were extracted using methanol, and then liquid-liquid partitioning was carried out successively using n-hexane and ethyl acetate. Isolation and characterization of longan honey samples using FTIR and LC-MS/MS showed the presence of the following compounds: Xanthoxol glycosides, Santonin, Octadecanamide, Indole-3 carboxylaldehyde, 3,4-dimethoxycinnamic acid, Dimethyl esculetin, Tryptophan, O-acetyl-L-serine, D-glucose-6-phosphate, Feruloiltyramine, Lauryl diethanolamide, Taurine, 6-mercaptopurine, 3-(2,4-dichlorophenyl)-4-phenylcoumarin, 3',4'-dimethoxy-3-hydroxy-6- methylflavone and D-1-((3-carboxypropyl)amino)-1-deoxyfructose. The compounds in longan honey against HEp-2 cells is quercetin, 3,6-dimethoxycinnamic acid, phenyl coumarin, dimethyl esculetin, santonin, 6-mercaptopurine, and feruloyltyramine. The proposed mechanism of active compound in honey to inhibit HEp-2 cells in s everal ways including via caspase pathway and purine synthesis and other relevant mechanisms . However, this assumption needs to be tested further to obtain more precise information regarding the mechanism of inhibition of HEp-2 cells.","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69840395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0