Journal of Supercritical Fluids最新文献_第9页

Preparation of hesperetin-polyvinylpyrrolidone sub-microparticles by supercritical anti-solvent technique for improved anti-cancer efficiency 超临界抗溶剂技术制备橙皮苷-聚乙烯吡咯烷酮亚微粒，提高抗癌效果

IF 3.4 3区工程技术

Journal of Supercritical Fluids Pub Date : 2025-01-21 DOI: 10.1016/j.supflu.2025.106523

Xiao-Chang Lu , Biao-Qi Chen , Sheng-Qing Li , Jian-Fei Xu , Ranjith Kumar Kankala , Shi-Bin Wang , Ai-Zheng Chen

{"title":"Preparation of hesperetin-polyvinylpyrrolidone sub-microparticles by supercritical anti-solvent technique for improved anti-cancer efficiency","authors":"Xiao-Chang Lu , Biao-Qi Chen , Sheng-Qing Li , Jian-Fei Xu , Ranjith Kumar Kankala , Shi-Bin Wang , Ai-Zheng Chen","doi":"10.1016/j.supflu.2025.106523","DOIUrl":"10.1016/j.supflu.2025.106523","url":null,"abstract":"<div><div>The poor water solubility of hesperetin (HST) has impeded its relevant medical applications. To address this problem, the supercritical anti-solvent (SAS) technique was used to prepare HST-polyvinylpyrrolidone (HST-PVP) sub-microparticles. Additionally, the Box-Behnken Design was used to optimize three parameters (temperature, total solute concentration, and pressure) to determine the optimal process conditions, which were determined to be 40 ℃, 5 mg/mL, and 100 bar. The physicochemical properties, drug release, and <em>in vitro</em> anti-cancer efficacy of the designed particles under the optimal conditions were systematically investigated. The drug loading of HST in HST-PVP sub-microparticles was quantified at 12.73 %. The dissolution rate of SAS-treated HST-PVP sub-microparticles was significantly enhanced compared to that of pure HST, leading to a higher anti-cancer efficiency of the HST-PVP sub-microparticles than that of pure HST. These findings indicate that the SAS technique holds significant potential for enhancing the bioavailability of hydrophobic drugs.</div></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"219 ","pages":"Article 106523"},"PeriodicalIF":3.4,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143077782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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A new supercritical extraction equipment in the Amazon: Supercritical extractor efficiency upgrade provided by gas booster performance 一种新的超临界萃取设备在亚马逊：超临界萃取效率提升提供了气体助推器性能

IF 3.4 3区工程技术

Journal of Supercritical Fluids Pub Date : 2025-01-17 DOI: 10.1016/j.supflu.2025.106522

Ana Paula de Souza e Silva , Flávia Cristina Seabra Pires , Maria Caroline Rodrigues Ferreira , Maria Eduarda Ferraz de Carvalho , Letícia Maria Martins Siqueira , Fernando de Freitas Maués de Azevedo , Eduardo Gama Ortiz de Menezes , Raul Nunes Carvalho Junior

{"title":"A new supercritical extraction equipment in the Amazon: Supercritical extractor efficiency upgrade provided by gas booster performance","authors":"Ana Paula de Souza e Silva , Flávia Cristina Seabra Pires , Maria Caroline Rodrigues Ferreira , Maria Eduarda Ferraz de Carvalho , Letícia Maria Martins Siqueira , Fernando de Freitas Maués de Azevedo , Eduardo Gama Ortiz de Menezes , Raul Nunes Carvalho Junior","doi":"10.1016/j.supflu.2025.106522","DOIUrl":"10.1016/j.supflu.2025.106522","url":null,"abstract":"<div><div>The Amazon bioeconomy demands technologies that transform raw materials into high-value bioproducts. This work presents the assembly of a supercritical extractor designed for the Amazon, aiming for efficiency and adaptation of the equipment to the local conditions such as humidity and temperature that provide a directly influence in the phase equilibrium in the CO<sub>2</sub> cylinder. Therefore, a gas booster system was developed, eliminating the need for CO<sub>2</sub> liquefaction. This innovation simplified operations, reduced costs, and increased energy efficiency. The unit, tested against Soxhlet and commercial SFE methods, achieved 72 % of extraction efficiency using jambu inflorescences, improving product quality. This equipment promotes the use of sustainable resources and supports the Amazon bioeconomy.</div></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"219 ","pages":"Article 106522"},"PeriodicalIF":3.4,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143168308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Employing supercritical n-butanol to remove the EVA film for the delamination of photovoltaic laminated module 采用超临界正丁醇去除EVA膜，用于光伏叠层组件的分层

IF 3.4 3区工程技术

Journal of Supercritical Fluids Pub Date : 2025-01-16 DOI: 10.1016/j.supflu.2025.106520

Xuwen Wang , Zhifeng Liu , Haoda Ruan , Xinyu Li , Lei Zhang

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Effect of CO2 addition on crocin i extraction from gardenia fruits using CO2-expanded deep eutectic solvent CO2添加量对CO2扩展深度共熔溶剂萃取栀子中藏红花素i的影响

IF 3.4 3区工程技术

Journal of Supercritical Fluids Pub Date : 2025-01-16 DOI: 10.1016/j.supflu.2025.106521

Yiheng Dou, Yoshito Oshima, Makoto Akizuki

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Comparative analysis of supercritical-based and chemical-based decellularization technique for meniscus tissue 半月板组织超临界与化学脱细胞技术的比较分析

IF 3.4 3区工程技术

Journal of Supercritical Fluids Pub Date : 2025-01-15 DOI: 10.1016/j.supflu.2025.106518

Gizem Zihna , Busra Kilic , Bengisu Topuz , Gulcin Gunal , Halil Murat Aydin

{"title":"Comparative analysis of supercritical-based and chemical-based decellularization technique for meniscus tissue","authors":"Gizem Zihna , Busra Kilic , Bengisu Topuz , Gulcin Gunal , Halil Murat Aydin","doi":"10.1016/j.supflu.2025.106518","DOIUrl":"10.1016/j.supflu.2025.106518","url":null,"abstract":"<div><div>The increasing prevalence of meniscus injuries highlights the critical need for the development of effective repair strategies. Currently, there is ongoing exploration of materials possessing microscopic and macroscopic characteristics akin to authentic meniscus tissue. In this study, meniscus tissue was subjected to a comparative evaluation of two different decellularization techniques which one of these involved conventional decellularization technique; one novel approach involved the utilization of supercritical carbon dioxide (scCO₂) technology on meniscus tissue. All decellularized tissues underwent biochemical, histological, microscopic, mechanical and cytotoxic evaluations. The optimized method, combining physical pretreatment, enzymatic agitation with trypsin agent, and chemical agitation with SDS agent, achieved a remarkable reduction of 82 % in genomic DNA content. Physical pre-treatment in scCO₂ decellularization facilitated enhanced penetration depth with trypsin, resulting in optimal group demonstrating a 76 % reduction in DNA content. While histological examinations and biochemical analyses indicated no alteration in collagen quantities, the conventional decellularization group exhibited a 42 % decline in GAG content, whereas the scCO<sub>2</sub> group showed a 58 % decrease. Compressive modulus decreased from 22.8 ± 0.91 MPa in decellularized tissues to 15.26 ± 0.28 MPa in conventionally decellularized scaffold and 14.49 ± 0.48 MPa in scCO<sub>2</sub> decellularized tissue, attributed to GAG destruction. Cytotoxicity assessments of the examined tissues revealed cell viability levels exceeding 75 % in both groups. Both approaches demonstrate potential for producing high-quality biomaterials; nevertheless, further research endeavors may lead to enhancements in the extracellular matrix preservation, mechanical characteristics, and facilitation of biological responses using supercritical fluid-based methodologies.</div></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"219 ","pages":"Article 106518"},"PeriodicalIF":3.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Fluid phase behavior of asymmetric synthetic mixture + gas: Experimental and modeling studies 不对称合成混合物+气体的流体相行为：实验和模型研究

IF 3.4 3区工程技术

Journal of Supercritical Fluids Pub Date : 2025-01-13 DOI: 10.1016/j.supflu.2025.106519

Hugo Andersson Dantas Medeiros , Jean-Patrick Bazile , Filipe Xavier Feitosa , Hosiberto Batista de Sant’Ana , Jean-Luc Daridon

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Monodisperse protein nanoparticles production by supercritical assisted atomization 超临界辅助雾化制备单分散蛋白质纳米颗粒

IF 3.4 3区工程技术

Journal of Supercritical Fluids Pub Date : 2025-01-07 DOI: 10.1016/j.supflu.2025.106517

Hsien-Tsung Wu, Yi-Jia Tu, Yu-Xuan Huang, Kim Hoong Ng

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The role of water in the oxidation of lead and bismuth by high-density water-oxygen fluid 水在高密度水-氧流体氧化铅和铋中的作用

IF 3.4 3区工程技术

Journal of Supercritical Fluids Pub Date : 2025-01-04 DOI: 10.1016/j.supflu.2024.106509

Oxana N. Fedyaeva, Aleksander P. Grebennikov, Anatoly A. Vostrikov

{"title":"The role of water in the oxidation of lead and bismuth by high-density water-oxygen fluid","authors":"Oxana N. Fedyaeva, Aleksander P. Grebennikov, Anatoly A. Vostrikov","doi":"10.1016/j.supflu.2024.106509","DOIUrl":"10.1016/j.supflu.2024.106509","url":null,"abstract":"<div><div>The paper presents the research results on oxidation of liquid lead (Pb)<sup>l</sup> and bismuth (Bi)<sup>l</sup> by high density water-oxygen fluid (ρ<sub>H2O</sub> = 0.91–4.69 and ρ<sub>O2</sub> = 0.75–2.93 mol/dm<sup>3</sup>). Time dependences of the pressure were obtained by the method of H<sub>2</sub>O/O<sub>2</sub> fluid injection into the reactor at different temperatures (623–873 K), from which the dependences of the amount of O<sub>2</sub> in the reaction mixture were calculated and the oxidation kinetics was described. The results revealed a non-monotonic dependence of the (Pb)<sup>l</sup> oxidation rate and mechanisms on temperature and H<sub>2</sub>O/O<sub>2</sub> molar ratio, caused by the transition from kinetic to diffusion modes. The oxidation rate of (Bi)<sup>l</sup> was observed to increase with increasing temperature and is governed by diffusion. The oxidation of (Pb)<sup>l</sup> at 653–723 K and molar ratio H<sub>2</sub>O/O<sub>2</sub> = 1.45–1.70 was found to lead to the formation of a porous oxide layer consisting of polyhedral Pb<sub>3</sub>O<sub>4</sub> crystals. The oxidation of (Bi)<sup>l</sup> gives rise to the synthesis of Bi(OH)<sub>3</sub> and Bi<sub>2</sub>O<sub>3</sub> in the form of plates, ribbons, and rods exhibiting diverse crystal structures. It is shown that H<sub>2</sub>O molecules can participate in oxidation of (Pb)<sup>l</sup> as a catalyst, whereas in the oxidation of (Bi)<sup>l</sup> they act as the reagent. The results obtained may be useful in developing new approaches to the synthesis of oxide particles using supercritical water fluids, evaluating the stability of catalysts based on variable valence metal oxides, and ensuring the safety of power units.</div></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"218 ","pages":"Article 106509"},"PeriodicalIF":3.4,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142968091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Studying the rifampin solubility in supercritical CO2 with/without co-solvent: Experimental data, modeling and machine learning approach 利福平在超临界CO2中的溶解度研究：实验数据、建模和机器学习方法

IF 3.4 3区工程技术

Journal of Supercritical Fluids Pub Date : 2025-01-04 DOI: 10.1016/j.supflu.2024.106510

Hamed Peyrovedin , Seyed Ali Sajadian , Sara Bahmanzade , Kamiar Zomorodian , Mohammad Khorram

{"title":"Studying the rifampin solubility in supercritical CO2 with/without co-solvent: Experimental data, modeling and machine learning approach","authors":"Hamed Peyrovedin , Seyed Ali Sajadian , Sara Bahmanzade , Kamiar Zomorodian , Mohammad Khorram","doi":"10.1016/j.supflu.2024.106510","DOIUrl":"10.1016/j.supflu.2024.106510","url":null,"abstract":"<div><div>Rifampin is an effective tuberculosis drug. This study examines drug solubility in supercritical carbon dioxide at 308 K to 338 K and 12 MPa to 30 MPa. This study investigates Rifampin solubility using ethanol as a co-solvent. The experimental data is then used to develop a solute-solvent system model using semi-empirical correlations, the Peng-Robinson equation of state, and machine learning models. A study showed that the mole fraction of rifampin without a co-solvent ranges from 0.147 × 10<sup>−5</sup> to 1.972 × 10<sup>−5</sup>. Using ethanol as a co-solvent enhances Rifampin mole fraction, resulting in a range of 1.880 × 10<sup>−5</sup> to 1.403 × 10<sup>−4</sup>. This study shows that ethanol can be used in this particular system as a co-solvent. The findings demonstrate that semi-empirical, equation of state-based, and machine learning methods may accurately determine Rifampin solubility. Moreover, the results indicate that the incorporation of a co-solvent enhances solubility and may facilitate the application of SCF-based micronization techniques, particularly the rapid expansion of supercritical solution (RESS) and other SCF-based methods for nanoparticle production. However, the use of a liquid co-solvent can complicate the recovery of a dry drugs powder.</div></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"218 ","pages":"Article 106510"},"PeriodicalIF":3.4,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142990553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Short-term supercritical heat transfer: In memory of Anneke Levelt Sengers 短期超临界传热：纪念安内克液位传感器

IF 3.4 3区工程技术

Journal of Supercritical Fluids Pub Date : 2025-01-03 DOI: 10.1016/j.supflu.2025.106516

Pavel Skripov , Sergey Rutin , Lin Chen

{"title":"Short-term supercritical heat transfer: In memory of Anneke Levelt Sengers","authors":"Pavel Skripov , Sergey Rutin , Lin Chen","doi":"10.1016/j.supflu.2025.106516","DOIUrl":"10.1016/j.supflu.2025.106516","url":null,"abstract":"<div><div>The paper is dedicated to the memory of Anneke Levelt Sengers (Johanna/Anneke/Maria Henrica Levelt, 1929–2024), a world-renowned scientist on liquid-vapor critical phenomena. It summarizes the results of pulse heating experiments performed under conditions of short-term (units of ms) powerful heat release in supercritical-pressure water. The pressure, being the parameter of the experiment, was varied from a near-supercritical value (22.1 MPa) to 100 MPa. Initial temperature was 25 ºC, while its rise in the course of a pulse ranged from 230 ºC up to 680 ºC. Results obtained for pulse heating along the supercritical isobars are based solely on comparison with primary data. The surprising feature of the results is that a threshold drop in the intensity of heat transfer near the critical temperature occurs and becomes deeper, as the pressure approaches the supercritical pressure. The aim of the present paper is to suggest a relatively simple approach to reconciling pulse heating results with well-known peaks of thermophysical properties derived from experiments under stationary conditions. The variant suggested of such approach is based on the hypotheses of suppression of large-scale fluctuations in fast processes and the additional thermal resistance accompanying by the appearance of structural non-uniformity in an initially homogeneous fluid.</div></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"218 ","pages":"Article 106516"},"PeriodicalIF":3.4,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142990545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0