Journal of Skin and Sexually Transmitted Diseases最新文献

{"title":"Pyoderma gangrenosum with Marfan syndrome and Crohn’s disease: A rare association","authors":"Dhanya Dhanesh, Sabeena Jayapalan, P. Nair, Athira Sudhesan","doi":"10.25259/jsstd_20_2023","DOIUrl":"https://doi.org/10.25259/jsstd_20_2023","url":null,"abstract":"A 22-year-old man presented with multiple, painful ulcers on the thighs, legs, and face of 10-day duration and diarrhea and bleeding per rectum of 2-year duration. The ulcers were tender and had a peripheral violaceous border. General examination revealed tall stature, long extremities, kyphosis, arachnodactyly, and hyperextensible wrist and thumbs. The arm span was more than the height and the thumb sign and wrist sign were positive, diagnostic of Marfan syndrome. Skin biopsy from the edge of the ulcer showed infiltrates of neutrophils and lymphocytes in the dermis and subcutaneous tissue. A detailed evaluation ruled out other causes for skin ulceration and we made a diagnosis of pyoderma gangrenosum. Echocardiogram demonstrated mitral valve prolapse. Computed tomography of abdomen showed segmental mucosal thickening as skip lesions in the colon and rectum. Endoscopy showed chronic colitis with multiple punched out ulcers. Colonic biopsy showed noncaseating granulomas suggestive of Crohn’s disease. Although inflammatory bowel disease is a well-known association of pyoderma gangrenosum, we did not come across any previous reports of coexistence of pyoderma gangrenosum, Crohn’s disease, and Marfan syndrome.","PeriodicalId":17051,"journal":{"name":"Journal of Skin and Sexually Transmitted Diseases","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90657848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change of guard","authors":"S. Sasidharanpillai","doi":"10.25259/jsstd_35_2023","DOIUrl":"https://doi.org/10.25259/jsstd_35_2023","url":null,"abstract":"Dr René Lefeber stayed at the helm of the Leiden Journal of International Law as its Editor-in-Chief for more than four important years (1996–2000), marked by innovation and change in practically every aspect of the Journal. Barely two years after a profound reorganization , the Journal's volume was doubled with three issues per year in 1997, and four issues in 1998. Meanwhile, the number of pages, the quality, and the diversity of published material saw dramatic growth. The section on Hague International Tribunals became a standard feature; a subsection on the International Criminal Court was set up in 1998 to regularly cover ongoing developments in this important institution; an annual specialized bibliography on dispute settlement was introduced; and regular Editorial notes by members of the Board figured in each issue. All in all, a very different Journal than the one handed down four years earlier. During the same period the Journal desired to become a more accessible forum to a younger and much more diversified audience of international law professionals. From the mainstream to the newstream and back, room was created next to established scholars for voices representing a changing discipline of public international law. The representation of a more diverse \" college of international law, \" to use Oscar Schachter's oft-cited phrase, has not only guided the choice of style and themes of the contributions but also the composition of the new Board of Advisory and Consultative Editors, introduced in 2000. The ranks of the Board of Editors itself were affected, now a busy crowd of engaged colleagues from various walks of the discipline. Although the transformation of the Leiden Journal was a collective project, René's vision, resilience, and skill were pivotal in achieving the necessary balance between stability and change. His thoroughness in the management of the Journal affairs and his high expectations have set the standard for the future. René has now taken up a new and challenging senior position at the Dutch Ministry of Foreign Affairs, where we know that he will make his presence felt. We are grateful for his invaluable contribution to the Leiden Journal and wish him the best of luck and success in his future career and projects. The issue in hand introduces some further changes in the content of the Journal and in the composition of the Board of Editors, in a never-ending process of transformation. Seizing this opportunity, we would …","PeriodicalId":17051,"journal":{"name":"Journal of Skin and Sexually Transmitted Diseases","volume":"175 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81624199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scenarios warranting modified treatment regimens in leprosy: A 5-year retrospective study from a tertiary care center","authors":"Celia Hamlet, P. Nair","doi":"10.25259/jsstd_10_2023","DOIUrl":"https://doi.org/10.25259/jsstd_10_2023","url":null,"abstract":"To study the scenarios warranting modified treatment regimens in leprosy.\u0000\u0000\u0000\u0000A 5-year retrospective study was carried out in a tertiary care center by analyzing the data collected from national leprosy eradication program (NLEP) records.\u0000\u0000\u0000\u0000During the 5-year study period, 171 patients received treatment for leprosy from our center. Thirtyone patients (31/171, 18.1%) required substitution of standard multidrug therapy (MDT) with alternate drugs or required alternate treatment regimens. The patients who required modified treatment included 18 men (18/31, 58.1%) and 13 women (41.9%). Male/female ratio was 1.4:1. Indications for treatment modification were adverse drug reactions to standard MDT (ADR) (21/31, 67.7%) and lack of response to standard MDT (10/31, 32.3%). The most common scenario that warranted a modification of standard MDT was dapsone-induced hemolysis (12/31, 38.7%). Seven (7/31, 22.6%) and two (2/31, 6.5%) patients needed a change in treatment due to drug-induced hepatitis and drug-induced maculopapular rash, respectively.\u0000\u0000\u0000\u0000Retrospective study design, study conducted in single tertiary referral center and small sample size were the limitations.\u0000\u0000\u0000\u0000Nearly one-fifth of patients with leprosy required modifications in standard MDT. The most common indication (in two-third of patients who needed a modified treatment) for modification of treatment regimen was adverse drug reactions.","PeriodicalId":17051,"journal":{"name":"Journal of Skin and Sexually Transmitted Diseases","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73331753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatoses in elderly patients attending a private skin clinic in North Kerala: A retrospective chart review","authors":"Kurikkalakathu Feroz","doi":"10.25259/jsstd_18_2023","DOIUrl":"https://doi.org/10.25259/jsstd_18_2023","url":null,"abstract":"","PeriodicalId":17051,"journal":{"name":"Journal of Skin and Sexually Transmitted Diseases","volume":"65 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86383555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant seborrheic keratosis on the external auditory meatus","authors":"P. Nair","doi":"10.25259/jsstd_11_2023","DOIUrl":"https://doi.org/10.25259/jsstd_11_2023","url":null,"abstract":"","PeriodicalId":17051,"journal":{"name":"Journal of Skin and Sexually Transmitted Diseases","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83168195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and bacteriological profile of primary pyoderma: A cross sectional study","authors":"Arya James, Sandhya George, P. Shanimole","doi":"10.25259/jsstd_58_2022","DOIUrl":"https://doi.org/10.25259/jsstd_58_2022","url":null,"abstract":"\u0000\u0000To evaluate the clinical and bacteriological profile and antibiotic susceptibility pattern in primary pyodermas.\u0000\u0000\u0000\u0000A descriptive cross-sectional study was carried out in patients with clinically diagnosed primary pyodermas and who attended the outpatient department of dermatology of a tertiary care center in South India from December 2017 to June 2019.\u0000\u0000\u0000\u0000During the study period, 180 patients received a clinical diagnosis of primary pyoderma. Most common clinical type was impetigo followed by folliculitis. Most common age group affected was children below ten years of age (74 cases, 41.1%). Sixty five patients (36.1%) had lesions confined to lower limbs. Among the study participants, 26 (14.4%) were on prolonged treatment with systemic corticosteroids. Gram stain study helped in the diagnosis in 115 (63.9%) patients. Staphylococcus aureus (S. aureus) was the predominant pathogen (92 cases, 51.1%). A significant proportion of S. aureus isolates showed resistance to penicillin (90/92, 97.8%) and erythromycin (36/92, 39.1%). The pathogen isolated was methicillin resistant S. aureus (MRSA) in 28 cases (28/92, 30.4%). All isolates of Group A Streptococcus were sensitive to penicillins and first generation cephalosporins.\u0000\u0000\u0000\u0000It was a single center study, conducted in a tertiary referral hospital; hence did not reflect the status of the disease in the community. Complete information on prior antibiotic treatment was not available in all patients.\u0000\u0000\u0000\u0000Pyodermas showed a predilection for younger age group. Impetigo was the leading primary pyoderma. Gram stain is a valuable, but an often neglected tool to diagnose a bacterial infection. Many isolates of S. aureus showing resistance to penicillin and erythromycin and identification of MRSA as the pathogen in many patients highlight the need for periodic assessment of pathogens and drug susceptibility patterns in different population groups to ensure judicious use of antibiotics.\u0000","PeriodicalId":17051,"journal":{"name":"Journal of Skin and Sexually Transmitted Diseases","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84909083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extensive and exuberant angiofibromas producing breathing difficulty in a patient with tuberous sclerosis complex","authors":"","doi":"10.25259/jsstd_6_2023","DOIUrl":"https://doi.org/10.25259/jsstd_6_2023","url":null,"abstract":"","PeriodicalId":17051,"journal":{"name":"Journal of Skin and Sexually Transmitted Diseases","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75427479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traumatic anserine folliculosis","authors":"Logamoorthy Ramamoorthy, Sivaelango Rajamani","doi":"10.25259/jsstd_7_2023","DOIUrl":"https://doi.org/10.25259/jsstd_7_2023","url":null,"abstract":"","PeriodicalId":17051,"journal":{"name":"Journal of Skin and Sexually Transmitted Diseases","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77106762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous non-tuberculous mycobacterial infections: An update","authors":"M. George","doi":"10.25259/jsstd_52_2022","DOIUrl":"https://doi.org/10.25259/jsstd_52_2022","url":null,"abstract":"Non-tuberculous mycobacteria (NTM) are increasingly recognized as causes of skin and soft-tissue infections. They include rapid-growing and slow-growing species. Hospital outbreaks related to contaminated water and in association with surgical and cosmetic procedures have been described. Infections are also associated with immunosuppression. NTM infections have a wide spectrum of clinical manifestations, though Mycobacterium marinum and Mycobacterium ulcerans manifest characteristic lesions – swimming pool granuloma and Buruli ulcer, respectively. NTM infection should be suspected when the skin infection (especially those following trauma or invasive procedure or in a patient with immunosuppression) does not respond to antibiotics. NTM are acid fast, but will be negative on cartridge based nucleic acid amplification tests for Mycobacterium tuberculosis. Diagnosis is confirmed by polymerase chain reaction test which is the gold standard. NTM show variable susceptibility to antimicrobials and no clear treatment guidelines are available. Surgical treatment may also be needed in some cases.","PeriodicalId":17051,"journal":{"name":"Journal of Skin and Sexually Transmitted Diseases","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83851132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD30+ primary cutaneous tumoral adult T-cell leukemia/lymphoma successfully treated with zidovudine and interferon","authors":"A. Khader, Hitha Babu, K. Ajithkumar, S. Manakkad","doi":"10.25259/jsstd_35_2022","DOIUrl":"https://doi.org/10.25259/jsstd_35_2022","url":null,"abstract":"Adult T-cell leukemia/lymphoma (ATL) is an aggressive neoplasia of mature peripheral T lymphocytes associated with human T-cell lymphotropic virus type 1 (HTLV-1). The primary cutaneous tumoral (PCT) type of adult T-cell leukemia/lymphoma presents as nodules and tumors without internal organ involvement, but with a bad prognosis. Here, we report a middle aged woman, who manifested a nodular lesion on the right leg. Histopathology showed moderately dense, lymphoid infiltrate of atypical, medium sized cells in the dermis and subcutaneous tissue. The cells were positive for CD3, CD4, CD30, and CD25, and negative for CD8, CD20, and anaplastic lymphoma kinase. The biopsy specimen showed a Ki-67 proliferation index of 90%. Serological testing for HTLV-1 was positive. The patient was diagnosed to have CD30+ PCT type ATL and was treated initially with localized radiation. The lesion regressed, however, there was a recurrence of the disease, which was treated with low dose interferon-alfa (IFN-α) and zidovudine, following which patient attained complete resolution and remained symptom free during the follow up period of 2 years. Our case highlights the usefulness of low dose IFN-α and zidovudine in the management of PCT type of CD30+ ATL.","PeriodicalId":17051,"journal":{"name":"Journal of Skin and Sexually Transmitted Diseases","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85904324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}