Journal of radiosurgery and SBRT最新文献

{"title":"Paralysis of diaphragm after SBRT of lung cancer.","authors":"Shyam S Bisht, Deepak Gupta, Abhidha Malik, Venkatesan Kaliyaperumal, Susovan Banarjee, Kushal Narang, Manoj Tayal, Nagendra Sharma, Tejinder Kataria","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"8 1","pages":"63-65"},"PeriodicalIF":1.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930052/pdf/rsbrt-8-65.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10807208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gamma Knife radiosurgery for trigeminal neuralgia provides greater pain relief at higher dose rates.","authors":"Andrew I Yang,&nbsp;Kobina G Mensah-Brown,&nbsp;Emily F Shekhtman,&nbsp;Svetlana Kvint,&nbsp;Connor A Wathen,&nbsp;Frederick L Hitti,&nbsp;Michelle Alonso-Basanta,&nbsp;Stephen M Avery,&nbsp;Jay F Dorsey,&nbsp;John Y K Lee","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In Gamma Knife (GK) radiosurgery, dose rate decreases during the life cycle of its radiation source, extending treatment times. Prolonged treatments influence the amount of sublethal radiation injury that is repaired during exposure, and is associated with decreased biologically-equivalent dose (BED). We assessed the impact of treatment times on clinical outcomes following GK of the trigeminal nerve - a rare clinical model to isolate the effects of treatment times. This is a retrospective analysis of 192 patients with facial pain treated across three source exchanges. All patients were treated to 80 Gy with a single isocenter. Treatment time was analyzed in terms of patient anatomy-specific dose rate, as well as BED calculated from individual patient beam-on times. An outcome tool measuring pain in three distinct domains (pain intensity, interference with general and oro-facial activities of daily living), was administered before and after intervention. Multivariate linear regression was performed with dose rate/BED, brainstem dose, sex, age, diagnosis, and prior intervention as predictors. BED was an independent predictor of the degree of improvement in all three dimensions of pain severity. A decrease in dose rate by 1.5 Gy/min corresponded to 31.8% less improvement in the overall severity of pain. Post-radiosurgery incidence of facial numbness was increased for BEDs in the highest quartile. Treatment time is an independent predictor of pain outcomes, suggesting that prescription dose should be customized to ensure iso-effective treatments, while accounting for the possible increase in adverse effects at the highest BEDs.</p>","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"8 2","pages":"117-125"},"PeriodicalIF":1.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489081/pdf/rsbrt-8-117.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10458378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between biologically effective dose and local control after stereotactic body radiotherapy for metastatic sarcoma.","authors":"Eashwar Somasundaram,&nbsp;Timothy D Smile,&nbsp;Ahmed Halima,&nbsp;James B Broughman,&nbsp;Chandana A Reddy,&nbsp;Shireen Parsai,&nbsp;Jacob G Scott,&nbsp;Chirag Shah,&nbsp;Timothy Chan,&nbsp;Shauna Campbell,&nbsp;Lilyana Angelov,&nbsp;Peter M Anderson,&nbsp;Stacy Zahler,&nbsp;Matteo Trucco,&nbsp;Stefanie M Thomas,&nbsp;Shavaughn Johnson,&nbsp;Nathan Mesko,&nbsp;Lukas Nystrom,&nbsp;Dale Shepard,&nbsp;George Thomas Budd,&nbsp;Peng Qi,&nbsp;Anthony Magnelli,&nbsp;Erin S Murphy","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Stereotactic body radiation therapy (SBRT) is increasingly utilized for patients with recurrent and metastatic sarcoma. SBRT affords the potential to overcome the relative radioresistance of sarcomas through delivery of a focused high biological effective dose (BED) as an alternative to invasive surgery. We report local control outcomes after metastatic sarcoma SBRT based on radiation dose and histology.</p><p><strong>Methods: </strong>From our IRB-approved single-institution registry, all patients treated with SBRT for metastatic sarcoma between 2014 and 2020 were identified. Kaplan-Meier analysis was used to estimate local control and overall survival at 1 and 2 years. A receiver operating characteristic (ROC) curve was generated to determine optimal BED using an α/β ratio of 3. Local control was compared by SBRT dose using the BED cut point and evaluated by histology.</p><p><strong>Results: </strong>Forty-two patients with a total of 138 lesions met inclusion criteria. Median imaging follow up was 7.73 months (range 0.5-35.0). Patients were heavily pre-treated with systemic therapy. Median SBRT prescription was 116.70 Gy BED (range 66.70-419.30). Desmoplastic small round cell tumor, Ewing sarcoma, rhabdomyosarcoma, and small round blue cell sarcomas were classified as radiosensitive (<i>n</i> = 63), and all other histologies were classified as radioresistant (<i>n</i> = 75). Local control for all lesions was 66.7% (95% CI, 56.6-78.5) at 1 year and 50.2% (95% CI, 38.2-66.1) at 2 years. Stratifying by histology, 1- and 2-year local control rates were 65.3% and 55.0%, respectively, for radiosensitive, and 68.6% and 44.5%, respectively, for radioresistant histologies (<i>p</i> = 0.49). The ROC cut point for BED was 95 Gy. Local control rates at 1- and 2-years were 75% and 61.6%, respectively, for lesions receiving >95 Gy BED, and 46.2% and 0%, respectively, for lesions receiving <95 Gy BED (<i>p</i> = 0.01). On subgroup analysis, local control by BED > 95 Gy was significant for radiosensitive histologies (p = 0.013), and trended toward significance for radioresistant histologies (<i>p</i> = 0.25).</p><p><strong>Conclusion: </strong>There is a significant local control benefit for sarcoma SBRT when a BED > 95 Gy is used. Further investigation into the dose-response relationship is warranted to maximize the therapeutic index.</p>","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"8 4","pages":"265-273"},"PeriodicalIF":1.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322177/pdf/rsbrt-8-265.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9862184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An observational study on tumour response of portal vein tumour thrombus in hepatocellular carcinoma.","authors":"Prateek Mehra,&nbsp;Tejinder Kataria,&nbsp;Deepak Gupta,&nbsp;Sonal Krishan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>Stereotactic body radiotherapy (SBRT) can sterilize the portal vein tumour thrombus (PVTT) and may make the patient eligible for liver transplant. We assessed the radiological response of PVTT after SBRT and check incidence of radiation induced liver disease (RILD).</p><p><strong>Methods: </strong>PVTT treatment response was measured at 4-6 weeks as per mRECIST criteria, volume of PVTT and its enhancement in arterial phase. Biochemical data and Child-Pugh scoring (CPC) were evaluated to determine RILD incidence.</p><p><strong>Results: </strong>31 Patients were included. Complete response was seen in 5 patients (16.1%), partial response in 13 patients (41.9%), stable disease in 12 patients (38.7%). Mean volume of PVTT was 15.05 cc before SBRT and 7.83 cc afterwards (p = 0.001). The mean enhancement of the lesion was 86.19HU before SBRT vs 58.58HU after SBRT (p = 0.000). Two patients had grade 3 adverse events.</p><p><strong>Conclusion: </strong>Volume, enhancement, and major axis length of PVTT showed statistically significant improvement after SBRT. No case had RILD after SBRT.</p>","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"8 4","pages":"257-264"},"PeriodicalIF":1.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322169/pdf/rsbrt-8-257.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9806513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors affecting overall survival in 51 adult Filipino patients undergoing stereotactic radiosurgery for spine metastases.","authors":"Y Sih Ibet Marie,&nbsp;F Torio Erickson,&nbsp;V Bayhon Maurice,&nbsp;D Maala Jonna Mae,&nbsp;M Mariano Manuel,&nbsp;M Casis Rhoderick,&nbsp;G Barredo Carlo,&nbsp;L Mariano Juan Manuel,&nbsp;M Leong Jo-Celine,&nbsp;C Mercado Charlene Mary,&nbsp;M Yanto Jan Rehino,&nbsp;J Magsanoc Juan Martin,&nbsp;P Camacho Angela,&nbsp;C Calaguas Miriam Joy,&nbsp;T Vergara Thomas Vincent,&nbsp;P Rojales Julius Cezar,&nbsp;U Cortez Kathleen Jane,&nbsp;S D Santos Ma Socorro,&nbsp;G Torcuator Roy","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>Stereotactic radiosurgery (SRS) is part of the multimodality treatment for patients with cancer. The objective of this study is to determine factors which influence overall survival (OS) of Filipino patients who underwent SRS for metastatic tumors of the spine.</p><p><strong>Methods: </strong>This is a retrospective analysis of a cohort of Filipino patients treated with spine SRS for metastatic tumors in a single institution. Putative predictors were determined by the institution's spine SRS team and described in the cohort. A Cox proportional hazards regression model was utilized to construct a model based on the predictors determined by the institution's spine SRS team.</p><p><strong>Results: </strong>A total of 51 consecutive patients with 68 spine metastases were treated with SRS at our institution. The median OS was 13.1 months (95% CI of 7.1 to 19.1). On multivariate analysis, significant predictors that are associated with OS were visceral tumor origin (adjusted HR: 3.08, 95% CI of 1.24 to 7.64, <i>p</i> = 0.015) and cardiovascular disease (adjusted HR: 2.50, 95% CI of 1.04 to 5.94, p = 0.039) with dose and number of fractions as co-variates [Model Wald χ² (5, N = 51) = 11.11 (<i>p</i> = 0.049)].</p><p><strong>Conclusions: </strong>The presence of visceral tumor origins and cardiovascular disease are independent factors that are associated with lower overall survival in Filipino patients with spine metastasis treated with SRS.</p>","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"8 3","pages":"175-180"},"PeriodicalIF":1.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970737/pdf/rsbrt-8-175.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10830193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung stereotactic body radiation therapy using simultaneous integrated BED-escalation for peripherally located non-small cell lung cancer.","authors":"Colton J Ladbury,&nbsp;Sagus Sampath","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>Report the outcomes of patients with non-small cell lung cancer (NSCLC) and peripheral tumors treated with simultaneous integrated biologically equivalent dose (BED)-escalation (SIBE) lung stereotactic body radiation therapy (SBRT) to achieve dose escalation.</p><p><strong>Materials/methods: </strong>Patients with NSCLC within 5 mm of the chest wall treated with a SIBE approach were eligible. Patients received 60 Gy in 5 fractions, with dose decreased to 50 Gy based on proximity to the chest wall. Dosimetry, oncologic outcomes, and toxicity were evaluated.</p><p><strong>Results: </strong>Twenty-four patients met inclusion criteria. Median BED to the PTV was 135.4 Gy. Median chest wall V30 was 18.7 cc. The 3-year LC, OS, and PFS of the non-metastatic cohort was 93%, 35%, and 39%, respectively. The crude rate of chest wall toxicity was 12.5%, with no rib fractures.</p><p><strong>Conclusions: </strong>SIBE lung SBRT appears to be well tolerated and achieves favorable local control rates and survival.</p>","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"8 3","pages":"181-187"},"PeriodicalIF":1.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970741/pdf/rsbrt-8-181.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10830198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of two automated treatment planning techniques for multiple brain metastases using a single isocenter.","authors":"Guoqiang Cui,&nbsp;Yun Yang,&nbsp;Fang-Fang Yin,&nbsp;David Yoo,&nbsp;Grace Kim,&nbsp;Jun Duan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Two automated treatment planning techniques were evaluated for multiple brain metastases using a single isocenter. One technique is knowledge-based planning (KBP) using a stereotactic radiosurgery (SRS) model in Eclipse treatment planning system (TPS); and the other is the Multiple Brain Mets (MBM) SRS technique in Brainlab Elements TPS. Eighteen plans each with 3-10 lesions were used for the study. Plan evaluation metrics included the planning target volume (PTV) coverage, conformity index (CI), total monitor units (MUs), plan optimization time, brain V_12 Gy, V_8 Gy, and V_5 Gy. Both the KBP and MBM planning techniques produced comparable plans to the manually generated clinical plans in terms of PTV coverage and CI. For irregularly shaped lesions, the KBP plans provided more conformal dose distribution to the PTV than the MBM plans. The KBP plans took significantly longer time to plan but have fewer MUs than the MBM plans. The MBM plans spared normal brain tissues better than the KBP plans in terms of V_5 Gy.</p>","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"8 1","pages":"47-54"},"PeriodicalIF":1.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930061/pdf/rsbrt-8-54.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10807210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffusivity metrics alterations three months after GammaKnife radiosurgery for trigeminal neuralgia may predict pain relief.","authors":"Stylianos Pikis,&nbsp;Georgios Mantziaris,&nbsp;Joseph Donahue,&nbsp;Lydia Tian-Jin Ren,&nbsp;Lance Flesch,&nbsp;Karen Lavezzo,&nbsp;Zhiyuan Xu,&nbsp;Jason Sheehan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>Early identification of patients who will experience delayed-onset pain relief after GKRS for trigeminal neuralgia (TN) will allow optimal patient management, and avoidance of unnecessary procedures. A non-invasive tool to identify late responders to GKRS is currently unavailable. We sought to evaluate MRI based diffusivity metrics obtained at the 3-month post-GKRS time point as predictors of treatment response.</p><p><strong>Methods: </strong>Pre-procedural and 3-month post-procedural 3T MRI examinations were obtained in 43 patients with TN. Diffusion tensor metrics including axial diffusivity (AD), radial diffusivity (RD), and fractional anisotropy (FA) were extracted from the bilateral trigeminal nerve intra-pontine fibers, cisternal radiosurgical targets (or corresponding contralateral nerve segments), and non-targeted cisternal nerve segments. A favorable treatment response was defined as pain intensity on the Barrow Neurological Institute (BNI) scale of I-II at last follow-up. Pain relief and treatment response at last follow-up were examined for correlation with the 3-month post-GKRS diffusivity metrics.</p><p><strong>Results: </strong>At a median clinical follow-up of 5 months (range 0.5 to 24.5 months), all patients who did not experience pain relief at last follow-up had significantly reduced cisternal AD values (p=0.04) at the 3-month brain Diffusion Tensor image. In patients with classic TN, reduced mean cisternal AD (p=0.032), RD (p=0.026), and FA (p=0.042) values at the 3-month DTI follow-up were associated with BNI >2 at last follow-up. In addition, decreased mean cisternal AD (p=0.036), RD (p=0.029), and FA (p=0.037) were noted in patients with classic TN that failed to achieve a decrease of 2 points on the BNI scale at last follow-up.</p><p><strong>Conclusion: </strong>Alterations of diffusivity metrics on the treated trigeminal nerve 3 months after GKRS for classic TN significantly correlated with no response to GKRS at last follow-up. Further studies to clarify the value of DTI as a non-invasive tool to predict response to treatment in patients with TN managed with GKRS are warranted.</p>","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"8 4","pages":"241-246"},"PeriodicalIF":1.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322175/pdf/rsbrt-8-241.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9806511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of increased number or interval growth of brain metastases on same-day GammaKnife™ planning MRI: Predicting factors and patient outcomes.","authors":"Todd R Mereniuk,&nbsp;Heather N Burney,&nbsp;Tim Lautenschlaeger,&nbsp;Gordon A Watson,&nbsp;Ryan M Rhome","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To determine factors associated with increased risk of finding new and/or enlarged brain metastases (BM) on GammaKnife™ (GK) MRI and their impact on patient outcomes.</p><p><strong>Results: </strong>43.9% of patients showed BM growth, 32.9% had additional brain metastases (aBM), and 18.1 % had both. Initial brain metastasis velocity (iBMV) was associated with finding aBM. Time between diagnostic MRI (dMRI) and GK MRI was associated with interval growth and each day increased this risk by 2%. Prior brain metastasectomy and greater time between either dMRI or latest extracranial RT and GK MRI predicted both aBM and BM growth. aBM and/or BM growth led to management change in 1.8% of cases and were not associated with OS or incidence of distant intracranial failure.</p><p><strong>Conclusions: </strong>Number of metastases seen on dMRI and iBMV predicted both aBM and/or BM growth, however, these factors did not significantly affect survival or incidence of distant intracranial failure.</p>","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"8 3","pages":"189-199"},"PeriodicalIF":1.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970740/pdf/rsbrt-8-189.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10820815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the dosimetric impact of intra-fraction motion during frameless treatment delivery on GammaKnife® Icon™.","authors":"Hannah Taylor,&nbsp;Peter Fallows,&nbsp;Gavin Wright","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study investigated the impact of patient motion on the dosimetric quality of treatment plans for metastatic patients undergoing frameless GammaKnife^® Icon™ treatments. By quantifying dosimetric robustness at increasing high definition motion management (HDMM) gating tolerances, this study investigated the possibility of increasing the HDMM threshold for patients treated at our centre from our current standard of 1 mm.</p><p><strong>Methods: </strong>Motion was retrospectively simulated by shifting the stereotactic co-ordinates of shots in treatment plans using three motion models. Dosimetric quality indicators of original and shifted plans were compared. Influence of target location and size was determined.</p><p><strong>Results: </strong>Motion models showed median (p-value) absolute changes in target coverage of up to -0.133% (<0.0001), -0.267% (<0.0001) and -0.667% (<0.0001) for HDMM tolerances of 1mm, 1.5mm and 3mm. The greatest median (p-value) absolute changes in Paddick Conformity Index (PCI) and Gradient Index (GI) were -0.008 (0.0032) and 0.017 (0.6893). A reduction in target size correlated weakly with greater changes in target coverage for all models and HDMM tolerances (r² =0.040-0.309). No location dependence was observed.</p><p><strong>Conclusion: </strong>HDMM tolerances up to and including 3mm all resulted in negligible changes in PCI and GI. Target coverage exhibited greater sensitivity to motion, but only at 3mm was the target coverage reduced below local planning aims. Our HDMM tolerance could therefore potentially be increased to 1.5mm, with likely benefits to treatment delivery efficiency.</p>","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"8 3","pages":"217-226"},"PeriodicalIF":1.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970743/pdf/rsbrt-8-217.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10820821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}