Journal of radiosurgery and SBRT最新文献

Positron emission tomography-guided radiation therapy: An overview of the RefleXion SCINTIX biology-guided platform. 正电子发射断层扫描引导放射治疗：反射SCINTIX生物引导平台的概述。

IF 0.8

Journal of radiosurgery and SBRT Pub Date : 2026-01-01

Dae Yup Han, Huixiao Chen, Weili Zhong, Min-Young Lee, Henry S Park, Yiu-Hsin Chang, Zhe Chen, David J Carlson

{"title":"Positron emission tomography-guided radiation therapy: An overview of the RefleXion SCINTIX biology-guided platform.","authors":"Dae Yup Han, Huixiao Chen, Weili Zhong, Min-Young Lee, Henry S Park, Yiu-Hsin Chang, Zhe Chen, David J Carlson","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: To present an introduction and overview of the RefleXion™ X1 system using SCINTIX, a radiation therapy platform guided by positron emission tomography (PET) designed for biology-guided radiation therapy (BgRT).Methods: The RefleXion X1 system integrates a 6 MV flattening-filter-free linear accelerator, onboard kilovoltage computed tomography (kVCT), and dual PET arcs. The system enables both conventional kVCT-based image-guided radiation therapy (IGRT) and PET-guided treatment with SCINTIX. Compared to the conventional IGRT radiation treatment, the SCINTIX workflow includes a planning PET session prior to treatment planning and a PET pre-scan before each fraction. Fluorodeoxyglucose (FDG) was used as the PET tracer. An activity concentration (AC) ≥5 kBq/ml) and normalized target signal (NTS) ≥2.7 for planning PET session and an NTS ≥2.0 for treatment) are evaluated to decide whether the patient is eligible to treat with the SCINTIX.Results: The RefleXion X1 with SCINTIX treatment system was successfully installed for PET-guided radiation therapy. Detailed SCINTIX and SBRT/IGRT treatment workflows are described. SCINTIX-related shielding design, including uptake room specifications, is presented. Representative clinical cases include lung and rib lesions treated with SCINTIX, and a liver case treated with SBRT.Conclusion: SCINTIX enables PET-guided radiation therapy, offering a novel approach for BgRT. The integration of high-resolution kVCT further supports conventional IGRT workflows. Initial clinical experience demonstrates feasibility, accuracy, and potential for expanded adoption in personalized radiation therapy.","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"10 1-2","pages":"13-21"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Special issue on Contemporary and emerging stereotactic radiosurgery and stereotactic body radiation therapy technology. 当代和新兴立体定向放射外科和立体定向身体放射治疗技术特刊。

IF 0.8

Journal of radiosurgery and SBRT Pub Date : 2026-01-01

Eric L Chang, Lijun Ma, Michael W McDermott

引用次数: 0

CyberKnife stereotactic radiosurgery, stereotactic radiation therapy and stereotactic body radiation therapy: Technical and clinical updates. 射波刀立体定向放射外科，立体定向放射治疗和立体定向身体放射治疗：技术和临床更新。

IF 0.8

Journal of radiosurgery and SBRT Pub Date : 2026-01-01

Ahed H Kattaa, David J Park, Erqi Pollom, Elham Rahimy, Steven D Chang, Lei Wang, John Byun, Scott G Soltys

引用次数: 0

Developing Bragg-peak FLASH proton irradiator using permanent magnet synchrotron. 利用永磁同步加速器研制Bragg-peak FLASH质子辐照体。

IF 0.8

Journal of radiosurgery and SBRT Pub Date : 2026-01-01

Xin Qian, Dejan Trbojevic, Stephen Brooks, Thomas Tsang, Renee Cattell, Jinkoo Kim, Tiezhi Zhang, Samuel Ryu

引用次数: 0

Inter-fraction monitoring of brain metastases resection cavities during fractionated stereotactic radiosurgery on the 0.35 T MRI-Linac. 在0.35 T MRI-Linac上分割立体定向放射手术中脑转移瘤切除腔的分段监测。

IF 0.8

Journal of radiosurgery and SBRT Pub Date : 2026-01-01

Natalia Lutsik, Karen Chin Snyder, Eyub Y Akdemir, Alessandro Valderrama, Gregory A Azzam, Gregory J Kubicek, Rupesh Kotecha, Parag J Parikh, Eric A Mellon

{"title":"Inter-fraction monitoring of brain metastases resection cavities during fractionated stereotactic radiosurgery on the 0.35 T MRI-Linac.","authors":"Natalia Lutsik, Karen Chin Snyder, Eyub Y Akdemir, Alessandro Valderrama, Gregory A Azzam, Gregory J Kubicek, Rupesh Kotecha, Parag J Parikh, Eric A Mellon","doi":"","DOIUrl":"","url":null,"abstract":"Background: Fractionated stereotactic radiosurgery (fSRS) is a standard treatment for brain metastases resection cavities, but changes in cavities sizes during SRS can affect radiation precision. MRI-guided adaptive radiotherapy (RT) offers per-fraction imaging to visualize and address these changes.Materials and methods: We analyzed five patients treated with fSRS on a 0.35 T MRI-Linac at three centers, assessing cavity volume changes across 3-5 treatment fractions. Pre-treatment and fractional MRIs were used to evaluate relative changes in planning target volume (PTV index), brain volume pulled into the PTV (migration volume), and PTV Hausdorff distances.Results: Three of five patients showed >1 ml cavity shrinkage during fSRS. The ranges for PTV index, brain migration volume, and Hausdorff distance were 0.59 to 1.13 (median: 0.85 ± 0.14), -1.57 to 16.53 ml (median: 2.59 ± 4.78 ml), and 2.34 to 9.84 mm (median: 4.30 ± 1.96 mm).Conclusion: MRI-Linac imaging during fSRS allows adaptive adjustments, potentially reducing toxicity for post-surgical brain metastasis treatment.","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"10 1-2","pages":"57-62"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dedicated self-shielded Linac-based intracranial radiosurgery device: The ZAP-X. 专用的基于linac的自屏蔽颅内放射手术装置：ZAP-X。

IF 0.8

Journal of radiosurgery and SBRT Pub Date : 2026-01-01

Georg A Weidlich, Alex E Maslowski, John R Adler

引用次数: 0

Linac-based stereotactic radiosurgery or stereotactic body radiotherapy via online dynamic tracking. 基于直线的立体定向放射外科或通过在线动态跟踪的立体定向全身放疗。

IF 0.8

Journal of radiosurgery and SBRT Pub Date : 2026-01-01

Zhengzheng Xu, Lijun Ma, Eric Chang

{"title":"Linac-based stereotactic radiosurgery or stereotactic body radiotherapy via online dynamic tracking.","authors":"Zhengzheng Xu, Lijun Ma, Eric Chang","doi":"","DOIUrl":"","url":null,"abstract":"Stereotactic body radiotherapy (SBRT) is widely applied to treat patients with medically inoperable peripheral early-stage non-small cell lung cancer (NSCLC) and spine metastases. The tracking technology applied in SBRT has undergone profound changes over the last decades. The dose delivery accuracy has been significantly improved with the implementation of real-time motion management. High delivery accuracy allows higher target dose with sufficient normal tissue sparing which will further improve the tumor control probability. The general principle of the state-of-the art respiratory motion tracking techniques were introduced and discussed including tracking with multi-leaf collimator (MLC), optical imaging, portal X-ray imaging, radio-frequency markers, and positron emission tomography (PET) imaging. Implementation of the real-time tracking includes the application of external or internal imaging to build a correlation between tumor position and marker signals, using a predictive model to provide the tracking details for the linear accelerator (Linac), and control of the Linac to compensate for the respiratory motion. As the tracking technology is involving more advanced imaging modalities, the traditional radiation therapy workflow must be revised to ensure motion tracking efficiency and accuracy.","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"10 1-2","pages":"3-12"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tomotherapy-based stereotactic radiosurgery and stereotactic body radiation therapy. 基于断层治疗的立体定向放射外科和立体定向全身放射治疗。

IF 0.8

Journal of radiosurgery and SBRT Pub Date : 2026-01-01

Zhilei L Shen, Yutaka Natsuaki, Salim Balik, Benjamin P Ziemer

{"title":"Tomotherapy-based stereotactic radiosurgery and stereotactic body radiation therapy.","authors":"Zhilei L Shen, Yutaka Natsuaki, Salim Balik, Benjamin P Ziemer","doi":"","DOIUrl":"","url":null,"abstract":"Tomotherapy is an advanced form of intensity modulated radiation therapy that integrates helical radiation delivery and image-guided radiation therapy into a single platform. Utilizing a rotating linear accelerator combined with megavoltage computed tomography imaging, tomotherapy delivers highly conformal radiation doses to tumors while minimizing exposure to surrounding healthy tissue. This article reviews the technical principles and recent developments in helical tomotherapy (HT) and explores its clinical implementations in stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT). For brain SRS, HT shows similar target conformality as dedicated SRS platforms like Gamma Knife (GK) or CyberKnife (CK), but HT has slightly larger low isodose volumes. These factors should be considered depending on patient and disease characteristics, especially for SRS and SBRT treatments. For spine, lung, and prostate SBRT, HT demonstrates comparable performance to other modalities such as CK and volumetric modulated arc therapy, especially when enhanced with new features such as dynamic jaw technology (TomoEDGE) and real-time motion tracking (Synchrony). Although HT provides excellent tumor coverage and precise dose delivery, it is limited by treatment time and restricted beam angle flexibility due to the absence of couch rotation. Recent advancements in the latest HT system (Radixact), including higher dose rates, kilovoltage CT imaging, real-time motion tracking and correction, have significantly enhanced treatment efficiency and accuracy. These innovations establish tomotherapy as a competitive modality in the field of high precision radiotherapy such as SRS and SBRT.","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"10 1-2","pages":"23-31"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proton-based stereotactic radiosurgery and stereotactic body radiation therapy. 质子立体定向放射外科和立体定向全身放射治疗。

IF 0.8

Journal of radiosurgery and SBRT Pub Date : 2026-01-01

Zhengzheng Xu, Kaley Woods, Lijun Ma, Eric Chang

{"title":"Proton-based stereotactic radiosurgery and stereotactic body radiation therapy.","authors":"Zhengzheng Xu, Kaley Woods, Lijun Ma, Eric Chang","doi":"","DOIUrl":"","url":null,"abstract":"Proton beam radiation has a unique depth-dose distribution with lower surface dose, peaked energy loss at the end of the traveling range, and negligible exit dose compared to photon radiation that allows better sparing of normal tissues and potential dose escalation to the tumor. With advanced proton beam delivery and imaging guidance systems and years of successful proton treatment experience, clinicians are moving forward to implement proton beam in stereotactic body radiation therapy (SBRT). Major challenges in implementing stereotactic body proton therapy (SBPT) still exist such as the proton range uncertainty, radiobiological modeling, and inter-fractional motion management. Recent studies have demonstrated the safety and efficacy of utilizing SBPT in treating central nervous system (CNS), lung, and liver tumors. However, more clinical trials involving large patient cohorts are needed to evaluate the long-term clinical outcomes of SBPT. In addition to the technical challenges, consensus guidelines on treating selected patients with SBPT are needed to ensure treatment quality. Lastly, more effort on SBPT insurance approval is needed to further expand its clinical application. This study introduces the fundamental and new technologies utilized in SBPT and summarizes the current status of SBPT implementation in treating CNS, lung, and liver tumors.","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"10 1-2","pages":"93-100"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging FLASH therapy platforms for stereotactic radiosurgery and body radiotherapy. 用于立体定向放射外科和全身放射治疗的新兴FLASH治疗平台。

IF 0.8

Journal of radiosurgery and SBRT Pub Date : 2026-01-01

Dixin Chen, Joseph B Schulz, Stavros Melemenidis, Lawrie Skinner, Lei Xing, Billy W Loo, M Ramish Ashraf

{"title":"Emerging FLASH therapy platforms for stereotactic radiosurgery and body radiotherapy.","authors":"Dixin Chen, Joseph B Schulz, Stavros Melemenidis, Lawrie Skinner, Lei Xing, Billy W Loo, M Ramish Ashraf","doi":"","DOIUrl":"","url":null,"abstract":"The integration of FLASH radiotherapy with stereotactic techniques presents a promising avenue for improving therapeutic outcomes through normal tissue sparing while maintaining tumor control. However, significant technical challenges must be addressed for successful clinical implementation. This review evaluates emerging platforms and technical requirements for combining FLASH delivery with stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT). While electrons have enabled extensive preclinical FLASH research, their limited penetration depth makes them unsuitable for most stereotactic applications. Photon-based systems face significant engineering challenges in achieving both FLASH dose rates (>40 Gy/s) and the beam characteristics necessary for stereotactic delivery, particularly regarding heat management and multi-angle treatment capabilities. Proton and heavy ion systems offer advantages through the Bragg peak but require substantial development to overcome technical limitations in beam delivery and scanning speeds. We evaluate emerging platforms including novel accelerator designs, beam monitoring systems, and delivery techniques aimed at clinical translation. Critical technical requirements are discussed, including specialized dosimetry systems capable of ultra-high dose rate measurements, quality assurance protocols, treatment planning systems that optimize both spatial and temporal aspects of delivery, and novel image guidance strategies.","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"10 1-2","pages":"101-121"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0