Journal of radiosurgery and SBRT最新文献

Effect of stereotactic body radiotherapy beyond primary target in prostate cancer. 超靶立体定向放射治疗前列腺癌的疗效。

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Journal of radiosurgery and SBRT Pub Date : 2025-01-01

Jay P Sahu, Trinanjan Basu, Shounak J Kamat, Ajinkya Gadekar, Rohith R Menon, Ghazala K Roshan

引用次数: 0

Stereotactic ablative radiation therapy for pulmonary metastases from sarcoma primaries: A systematic review and meta-analysis of safety and efficacy. 立体定向消融放疗治疗原发性肺转移性肉瘤：安全性和有效性的系统回顾和荟萃分析。

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Journal of radiosurgery and SBRT Pub Date : 2025-01-01

Raj Singh, Robert Sierra, Casey Leimbach, Sidharth Iyer, Eric J Lehrer, Haley Perlow, Rituraj Upadhyay, Sung Jun Ma, Austin Sim, Emile Gogineni, Sujith Baliga, Daniel M Trifiletti, Joshua D Palmer, David J Konieczkowski, Jeremy Brownstein, Nicholas G Zaorzky

{"title":"Stereotactic ablative radiation therapy for pulmonary metastases from sarcoma primaries: A systematic review and meta-analysis of safety and efficacy.","authors":"Raj Singh, Robert Sierra, Casey Leimbach, Sidharth Iyer, Eric J Lehrer, Haley Perlow, Rituraj Upadhyay, Sung Jun Ma, Austin Sim, Emile Gogineni, Sujith Baliga, Daniel M Trifiletti, Joshua D Palmer, David J Konieczkowski, Jeremy Brownstein, Nicholas G Zaorzky","doi":"","DOIUrl":"","url":null,"abstract":"Background: Though promising retrospective and prospective studies have reported on stereotactic ablative radiation therapy(SABR) for management of lung metastases from sarcoma primaries, they are limited by small patient numbers.Methods: The primary outcomes of interest were 1-year and 2-year local control (LC) and Grade 3-5 toxicities. Secondary outcomes were 1-year overall survival (OS) and 2-year OS. Weighted random effects meta-analyses using the DerSimonian and Laird methods were performed to calculate effect sizes.Results: Thirteen studies were identified with 533 patients and 940 lung metastases. The median prescription dose was 50 Gy (range: 48-60 Gy) in 5 fractions (range: 4-10). Following SABR, 1- and 2-year pooled LC rates were 97% (95% CI: 95-98%) and 91% (95% CI: 88-95%), respectively. Pooled 1- and 2-year OS rates were 85% (95% CI: 80-90%) and 68% (95% CI: 57-80%), respectively. The estimated incidence of Grade 3-5 toxicities following SABR was 0.1% (95% CI: 0-0.5%).Conclusion: SABR for sarcoma pulmonary metastases resulted in excellent LC with minimal toxicities.","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"9 3","pages":"215-226"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of non-invasive genetic surgery. 非侵入性基因手术的发展。

IF 0.7

Journal of radiosurgery and SBRT Pub Date : 2025-01-01

Antonio A F De Salles

引用次数: 0

Tumor-targeted Gamma Knife radiosurgery in patients with trigeminal neuralgia secondary to benign tumors. 肿瘤靶向伽玛刀放射治疗良性肿瘤继发三叉神经痛。

IF 0.7

Journal of radiosurgery and SBRT Pub Date : 2025-01-01

Roger Murayi, Jordan C Petitt, Robert D Winkelman, Pablo F Recinos, Samuel T Chao, Erin S Murphy, Pranay Soni, Gene H Barnett, John H Suh, Varun R Kshettry

{"title":"Tumor-targeted Gamma Knife radiosurgery in patients with trigeminal neuralgia secondary to benign tumors.","authors":"Roger Murayi, Jordan C Petitt, Robert D Winkelman, Pablo F Recinos, Samuel T Chao, Erin S Murphy, Pranay Soni, Gene H Barnett, John H Suh, Varun R Kshettry","doi":"","DOIUrl":"","url":null,"abstract":"Background: Secondary trigeminal neuralgia (TN) is often associated with benign meningiomas and schwannomas. For patients who are unable to undergo surgical resection, Gamma Knife radiosurgery (GKRS) is a well-established alternative for tumor control. There is limited data on the pain outcomes in these patients undergoing tumor-targeted GKRS.Methods: Patients receiving tumor-targeted GKRS for a benign tumor causing secondary TN between 2005 and 2021 were identified. The Barrow Neurological Institute (BNI) pain score was documented at baseline and over the course of clinical follow-up. The study endpoint was defined as either last documented follow-up or date of additional pain procedure.Results: Seventeen patients were identified with 12 meningiomas (71%), 4 vestibular schwannomas (24%), and 1 trigeminal schwannoma (6%). Patients received either a single fraction of 12-13 Gy in 14 patients (82%) or 25 Gy in 5 fractions for 3 patients (18%). At a mean time to study endpoint of 29.5 months, 6 patients (35%) were pain free. Median time to BNI pain improvement was 4.6 months post-GKRS. One patient (6%) experienced new onset facial numbness. After the study endpoint, five patients (29%) underwent at least one subsequent balloon compression procedure for pain control. Mean total follow-up time was 61.9 months.Conclusion: For patients with secondary TN due to benign lesions who are poor candidates for surgical resection, tumor-targeted GKRS has a modest effect on pain outcomes. Complication rates are also comparatively very low.","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"9 3","pages":"227-235"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stereotactic ablative radiation therapy for extracranial metastases from malignant melanoma: An international multi-institutional analysis. 立体定向消融放射治疗颅内外转移恶性黑色素瘤：一项国际多机构分析。

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Journal of radiosurgery and SBRT Pub Date : 2025-01-01

Raj Singh, Sophia Bishop, Jan Jenkins, Joanne Davis, Eric J Lehrer, Sujith Baliga, Joshua D Palmer, John A Vargo, Christopher M McLaughlin, Emile Gogineni, Sanjeev Sharma

{"title":"Stereotactic ablative radiation therapy for extracranial metastases from malignant melanoma: An international multi-institutional analysis.","authors":"Raj Singh, Sophia Bishop, Jan Jenkins, Joanne Davis, Eric J Lehrer, Sujith Baliga, Joshua D Palmer, John A Vargo, Christopher M McLaughlin, Emile Gogineni, Sanjeev Sharma","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To report on local control (LC), toxicity, and overall survival (OS) following stereotactic ablative radiation therapy (SABR) for extracranial metastases from malignant melanoma.Methods: The RSSearch® Patient Registry was searched for patients with extracranial melanoma metastases treated with SABR. LC was defined as the time from completion of SABR to the date of last radiographic follow-up with either stability or decrease in size of the treated metastasis or the date at which lesion growth was radiographically confirmed per RECIST criteria. Kaplan-Meier analyses were utilized to evaluate potential prognostic factors on univariate analyses (UVA) with log-rank tests followed by use of a Cox proportional hazards multivariate (MVA) model.Results: There were 45 patients with 52 extracranial melanoma metastases treated with SABR. One- and 2-year LC rates were both 85.3% (95% CI: 67.9-93.7%) following SABR. On UVA, BED10 < 60 Gy was associated with poorer 1-year and 2-year LC (96% vs. 61.9%), which remained significant on MVA (hazard ratio [HR] = 7.06; p = 0.03). On UVA, pulmonary vs. non-pulmonary metastases were correlated with 1-year OS (84.5% vs. 57.4%; p = 0.05) and non-spinal vs. spinal metastases (74.3% vs. 56.3%; p = 0.02), though neither were significant on MVA. The incidence of treatment-related toxicity was 18.9%, all Grade 1-2.Conclusion: We recommend dose/fractionation schedules that meet or exceed BED10 ≥ 60 Gy when treating extracranial melanoma metastases with SABR.","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"9 3","pages":"199-205"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Convolution-based Gamma Knife planning from ICON CBCT: Three-level stepwise electron density assignment versus Hounsfield Unit curve. 基于卷积的ICON CBCT伽玛刀规划：三能级逐步电子密度分配与Hounsfield单位曲线。

IF 0.7

Journal of radiosurgery and SBRT Pub Date : 2025-01-01

Peter B Fallows, Gavin Wright

{"title":"Convolution-based Gamma Knife planning from ICON CBCT: Three-level stepwise electron density assignment versus Hounsfield Unit curve.","authors":"Peter B Fallows, Gavin Wright","doi":"","DOIUrl":"","url":null,"abstract":"Aims: To assess the suitability of CBCT images for dose calculation using the convolution algorithm.Methods: A CT to electron density curve was produced for the Gamma Knife ICON CBCT scanner. A three-level stepwise curve with fixed electron densities for air, brain tissue and bone was also produced. For 10 patients, the beam on time for shots in 11 locations within the brain was calculated using each of these curves and compared to beam on times calculated using the TMR10 algorithm, and the convolution algorithm with CT images.Results: The ratios of the average beam on time for convolution versus TMR10 were 1.058, 1.216 and 1.052 for CT images, CBCT images (Hounsfield unit electron density curve) and CBCT images (three-level stepwise curve with fixed electron densities) respectively.Conclusions: Using ICON CBCT images for dose calculation can result in an underestimation of the dose compared to convolution using CT images. However, using CBCT images along with a three-level stepwise electron density curve with fixed electron densities can provide good agreement with doses calculated using convolution with CT images.","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"9 3","pages":"245-252"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term follow-up after stereotactic radiosurgery for recurrent subependymoma. 复发性室管膜下瘤立体定向放射治疗后的长期随访。

IF 0.7

Journal of radiosurgery and SBRT Pub Date : 2025-01-01

Claire M Lanier, Atilio E Palma, Michael D Chan, Stephen B Tatter

引用次数: 0

PACE A and PACE B trial - What a radiation oncologist needs to know. PACE A和PACE B试验-放射肿瘤学家需要知道的事情。

IF 0.7

Journal of radiosurgery and SBRT Pub Date : 2025-01-01

Shounak J Kamat, Trinanjan Basu, Jay P Sahu, Rohith R Menon, Ajinkya Gadekar, Ghazala K Roshan, Durva A Kurkure, Rohit Kabre, Riddhijyoti Talukdar

引用次数: 0

Evaluating the efficacy of stereotactic radiotherapy for metastatic colorectal cancer: A retrospective review of clinical outcomes. 评价立体定向放疗治疗转移性结直肠癌的疗效：临床结果的回顾性回顾。

IF 0.7

Journal of radiosurgery and SBRT Pub Date : 2025-01-01

Beini Chen, Justin Smith, Revadhi Chelvarajah, Alexandra Knesl, Parushka Moodley, David Pryor, Mark B Pinkham, G Tao Mai, Howard Y Liu, Yoo Young Lee

{"title":"Evaluating the efficacy of stereotactic radiotherapy for metastatic colorectal cancer: A retrospective review of clinical outcomes.","authors":"Beini Chen, Justin Smith, Revadhi Chelvarajah, Alexandra Knesl, Parushka Moodley, David Pryor, Mark B Pinkham, G Tao Mai, Howard Y Liu, Yoo Young Lee","doi":"","DOIUrl":"","url":null,"abstract":"Background: Despite advances in systemic therapy, survival in metastatic colorectal cancer (mCRC) remains poor. The utility of stereotactic body radiotherapy (SBRT) and stereotactic radiosurgery (SRS), allowing dose escalation to achieve improved local control has risen in the treatment of mCRC. However, local control (LC) and overall survival (OS) varies widely between studies, and prognostic factors are not well defined.Methods: We retrospectively assessed LC and OS in patients with mCRC treated with SBRT/SRS between 2014 and 2022.Results: 124 Patients were treated during the study period. Median follow up was 16.4 months (0.2-93.1 months). There were 310 lesions treated with 53% located in the brain, 22% lung, 16% liver, 4% bone, 4% nodal and 1% other. Biologically effective dose (BED10) ranged from 33.6 to 151.2 Gy.LC was 75% (95% CI 67-81%) at 1 year and 65% (95%CI 56-73%) 2 years. On multivariable analysis (MVA), older age (HR 1.04, p = 0.001) and tumour volume >2.5 cc (HR 3.13, p < 0.001) were associated with worse LC.OS from first course of SBRT/SRS was 68% at 1 year (95%CI 58-76%), and 48% at 2 years (95%CI 38-58%). On MVA, ≥2 or more lines of systemic therapy (HR 3.04, p < 0.001) and brain metastases (HR 4.24, p = 0.001) were associated with shorter OS. Living long enough to receive ≥2 courses of SBRT/SRS (HR 0.20, p = 0.004) was associated with longer OS.Conclusion: This study demonstrates that SBRT and SRS offer effective local control, and LC is associated with tumour volume.","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"9 3","pages":"237-243"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stereotactic body radiotherapy for unresectable or locally recurrent pancreatic cancer: A single centre experience. 立体定向放射治疗不可切除或局部复发的胰腺癌：单中心经验。

IF 0.7

Journal of radiosurgery and SBRT Pub Date : 2025-01-01

Draghini Lorena, Tebala Giovanni Domenico, Casale Michelina, Marzo Alessandro Di, Desiderio Jacopo, Trippa Fabio

{"title":"Stereotactic body radiotherapy for unresectable or locally recurrent pancreatic cancer: A single centre experience.","authors":"Draghini Lorena, Tebala Giovanni Domenico, Casale Michelina, Marzo Alessandro Di, Desiderio Jacopo, Trippa Fabio","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: To refer our experience with stereotactic body radiotherapy (SBRT) in patients with pancreatic cancer.Materials and methods: 45 Patients with unresectable or locally recurrent pancreatic cancer after primary surgery, were submitted to SBRT. Toxicities were graded according to CTCAE version 5. Statistical analysis was performed by the Kaplan-Meier method.Results: The characteristics of the patients were median age 70 years (range, 46-84 years), median KPS 90% (range, 80-90%). Six patients had recurrent cancer after surgery, the other 39 patients were unresectable. Median radiation dose was 35 Gy (range, 27-40 Gy) delivered in 5 fractions. Simultaneous integrated boost with median dose of 35 Gy (range, 30-45 Gy) was given in 7 patients.After median follow-up of 10 months (range, 3-61 months) median local control was 10 months (range,5-15 months) and 49% (±8%) at 1-year. Median overall survival (OS) was 10 months (range,7-14 months), 38 % (±7%) at 1 year. Type of radiological response statistically significant influenced LC and OS, stage only LC in non-significant way. Clinical response was obtained in 12 of 36 (33%) cases. Median Numeric Rating Scale (NRS) was 7 (range, 4-8) before radiotherapy and 1 (range, 0-5) post SBRT. Acute G1-2 gastrointestinal toxicities were registered in 15% of patients, no late toxicities were found.Conclusion: In our series we obtained a good local palliation with SBRT that is a safe and effective treatment option. Higher doses could be administered in selected patients to obtain better response to treatment that is correlated with LC and OS.","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"9 3","pages":"207-213"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0