Journal of radiosurgery and SBRT最新文献_第2页

Status and challenges of MRI-only simulation for stereotactic body radiation therapy. 立体定向放射治疗中mri模拟的现状与挑战。

IF 0.8

Journal of radiosurgery and SBRT Pub Date : 2026-01-01

Kamal Singhrao, Sven Olberg, Evangelia Kaza, Daphne Haas-Kogan, Shu-Hui Hsu, Atchar Sudhyadhom

{"title":"Status and challenges of MRI-only simulation for stereotactic body radiation therapy.","authors":"Kamal Singhrao, Sven Olberg, Evangelia Kaza, Daphne Haas-Kogan, Shu-Hui Hsu, Atchar Sudhyadhom","doi":"","DOIUrl":"","url":null,"abstract":"The implementation of stereotactic body radiation therapy (SBRT) using magnetic resonance imaging (MRI)-only simulation holds much promise for improving clinical efficiency and reducing treatment burden and toxicity. There have been several clinical implementations of SBRT using MRI-only simulation imaging, including treatments of the prostate using X-ray image-guided SBRT, same-day palliative simulation, and SBRT using online adaptive MRI-simulation imaging. Several challenges exist to the widespread implementation of MRI-only simulation for SBRT. General challenges to the clinical implementation of MRI-only simulation with SBRT include contraindications to MRI such the presence of ferromagnetic implants. SBRT-specific challenges include immobilization and motion management challenges, acquisition and optimization of MRI image sequences for SBRT, and quality assurance of synthetic CT (sCT) and SBRT dose calculations using MRI-only simulation. In this review, we summarize published experiences of SBRT with MRI-only simulation, discuss the challenges to the widespread implementation of this technique and summarize the research that is being conducted to address these challenges.","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"10 1-2","pages":"63-73"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic resonance-guided Linac for stereotactic body radiotherapy of spinal metastases. 磁共振引导直线加速器用于脊柱转移瘤立体定向放射治疗。

IF 0.8

Journal of radiosurgery and SBRT Pub Date : 2026-01-01

Yutaka Natsuaki, Benjamin P Ziemer

{"title":"Magnetic resonance-guided Linac for stereotactic body radiotherapy of spinal metastases.","authors":"Yutaka Natsuaki, Benjamin P Ziemer","doi":"","DOIUrl":"","url":null,"abstract":"Spinal metastases are a common and challenging complication in oncology, often leading to significant morbidity. Advances in surgery and radiotherapy for primary cancers have markedly improved overall patient survival leading to increased chances of metastatic disease spread, and thus increasing the need for less invasive, personalized treatment strategies if this arises. Stereotactic body radiotherapy (SBRT) has emerged as a standard-of-care modality, providing durable local control; however, the proximity of tumors to spinal cord and other critical neural structures necessitates exceptional precision in targeting and dose delivery. Linear accelerators guided by magnetic resonance (MR) represent a major technological advancement by combining high-resolution soft tissue imaging with real-time adaptive radiotherapy. These systems enable superior visualization compared to computed tomography scans normally used in radiotherapy, daily plan adaptation, and intra-fraction motion management beyond the capabilities of conventional image guidance. This review explains the clinical rationale for MR-guided SBRT in spinal metastases, the technological foundations of MR-Linac systems, clinical workflows, and early outcome data using this technology. Special attention is given to challenges specific to spinal applications, such as MR imaging artifacts caused by spinal instrumentation. Established MR metal artifact reduction techniques and emerging artifact reduction methods based on artificial intelligence are discussed as potential solutions to improve image quality. While early results are promising, further development is needed in integrating advanced imaging modality technologies, beam delivery, workflow optimization, and clinical validation. MR-Linac SBRT offers a transformative approach to personalized, high-precision radiotherapy and has the potential to refine the standard of care for spinal metastases.","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"10 1-2","pages":"75-84"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transition from passive scattering to pencil beam scanning: Physics commissioning of a proton radiosurgery system. 从被动散射到铅笔束扫描的转变：质子放射外科系统的物理调试。

IF 0.8

Journal of radiosurgery and SBRT Pub Date : 2026-01-01

Juliane Daartz, Joost M Verburg, Nicolas Depauw, Hanne M Kooy, Paul H Chapman, Helen A Shih, Marc R Bussière

{"title":"Transition from passive scattering to pencil beam scanning: Physics commissioning of a proton radiosurgery system.","authors":"Juliane Daartz, Joost M Verburg, Nicolas Depauw, Hanne M Kooy, Paul H Chapman, Helen A Shih, Marc R Bussière","doi":"","DOIUrl":"","url":null,"abstract":"Background: Our institution has provided proton stereotactic radiosurgery (PSRS) since 1961 using passive scattering (PS). A recent transition to pencil beam scanning with a new treatment planning system required extensive validation, particularly for small field applications.Purpose: This study details the clinical adaptation of our PSRS program to pencil beam scanning (PBS), emphasizing small field dosimetry and treatment delivery accuracy.Methods: Patient alignment via implanted fiducials was validated using a head phantom. Test fields were created to span clinically relevant parameters including distal target depth (3.4-17.9 cm), target thickness (1.0-3.0 cm), aperture diameter (0.9-3.0 cm), and aperture aspect ratios (1.0-3.0). Dosimetric validation of the in-house, vendor co-developed planning system included: (1) central axis depth-dose measurements in water with a micro-diamond detector; (2) absolute point dose measurements in solid water; and (3) two-dimensional relative dose distributions with Gafchromic film. Validation was supplemented by a commercial high-resolution ion chamber array.Results: End-to-end alignment using a hidden target approach showed a mean deviation of 0.6 ± 0.3 mm. Agreement with the treatment planning system (TPS) for 90% distal and proximal central axis depths was within 0.1 ± 0.7 mm and 0.7 ± 0.5 mm, respectively. Absolute isocenter dose agreement in water was within 1.6%. Gamma analysis (2%/1 mm, 10% threshold) yielded a 97.6% average pass rate. A patient-specific QA protocol for small fields was established and validated.Conclusions: We successfully transitioned our PSRS program to PBS, achieving high geometric and dosimetric accuracy suitable for small field proton radiosurgery.","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"10 1-2","pages":"85-92"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatially fractionated radiation therapy: A powerful and low-toxicity technique for cancer treatment. 空间分割放射治疗：一种强大的低毒性癌症治疗技术。

IF 0.8

Journal of radiosurgery and SBRT Pub Date : 2026-01-01

Hualin Zhang

{"title":"Spatially fractionated radiation therapy: A powerful and low-toxicity technique for cancer treatment.","authors":"Hualin Zhang","doi":"","DOIUrl":"","url":null,"abstract":"GRID and LATTICE radiation therapy, officially known as spatially fractionated radiation therapy (SFRT), treat tumors by delivering a spatially modulated radiation dose with highly heterogeneous dose distributions. SFRT represents a rapidly evolving frontier in radiation oncology, physics, and tumor biology, attracting significant interest. Increasing clinical experience with SFRT suggests high tumor response and low toxicity, particularly in therapy-refractory and advanced tumors. Meanwhile, preclinical data from cell and animal studies are accumulating rapidly, alongside continuous advancements in SFRT technologies and techniques. These innovations have expanded SFRT applications across various radiation therapy platforms, including synchrotron, proton, carbon, electron, and photon beams. Despite its potential, SFRT remains challenging for many clinicians. The dosing principles are not well known, dose metrics are unfamiliar, and treatment planning techniques can seem daunting, all these factors may hinder the broader and correct adoption of this unique modality. This review article explores the principles of SFRT, conventional dose-rate GRID and LATTICE SFRT techniques, consensus SFRT dose metrics, and approaches for clinical implementation. While the primary focus is on the physics aspects of SFRT, key clinical data are also reviewed.","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"10 1-2","pages":"139-144"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Upright radiation therapy systems: Requirements, performance and benefits. 直立放射治疗系统：要求、性能和益处。

IF 0.8

Journal of radiosurgery and SBRT Pub Date : 2026-01-01

Benjamin P Ziemer, Dante P I Capaldi

{"title":"Upright radiation therapy systems: Requirements, performance and benefits.","authors":"Benjamin P Ziemer, Dante P I Capaldi","doi":"","DOIUrl":"","url":null,"abstract":"Upright radiotherapy treatment, though historically explored, is re-emerging as a viable approach for delivering stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT). While most radiotherapy is administered with patients in a supine or prone position, treating patients in an upright position may offer significant advantages. This includes improved patient comfort, reduced lung motion, and increased accessibility for non-ambulatory or pain-limited patients that would be changed with current supine treatments. Technological advancements in patient simulation, immobilization, and image guidance now allow for safe and effective upright treatment delivery. A major limitation in adopting upright radiotherapy has been the lack of commercially available upright imaging systems needed throughout the radiotherapy process. Recent developments, including the adaptation of existing linear accelerators for upright imaging and the introduction of specialized upright CT and patient positioning systems, have worked to address this challenge. Additionally, innovative solutions for treatment planning, including synthetic imaging techniques and deformable image registration, are enhancing the feasibility of upright treatment workflows. Patient setup and motion management are critical in SRS/SBRT, where precision is paramount. Recent studies have demonstrated sub-millimeter accuracy in upright treatment positioning, comparable to conventional supine techniques. Moreover, upright radiotherapy presents economic benefits by reducing infrastructure costs and enabling more compact treatment centers. This paper explores the technological advancements supporting upright SRS/SBRT, its clinical implications, and the necessary steps for widespread adoption. With ongoing vendor collaborations and further research, upright radiotherapy has the potential to become a standard approach, expanding treatment accessibility while maintaining high precision and efficacy.","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"10 1-2","pages":"131-138"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stereotactic Gamma Knife radiosurgery: Past, present and future. 立体定向伽玛刀放射外科：过去，现在和未来。

IF 0.8

Journal of radiosurgery and SBRT Pub Date : 2026-01-01

Lijun Ma, Eric L Chang

引用次数: 0

Stereotactic ablative radiation therapy for pulmonary metastases from sarcoma primaries: A systematic review and meta-analysis of safety and efficacy. 立体定向消融放疗治疗原发性肺转移性肉瘤：安全性和有效性的系统回顾和荟萃分析。

IF 0.8

Journal of radiosurgery and SBRT Pub Date : 2025-01-01

Raj Singh, Robert Sierra, Casey Leimbach, Sidharth Iyer, Eric J Lehrer, Haley Perlow, Rituraj Upadhyay, Sung Jun Ma, Austin Sim, Emile Gogineni, Sujith Baliga, Daniel M Trifiletti, Joshua D Palmer, David J Konieczkowski, Jeremy Brownstein, Nicholas G Zaorsky

{"title":"Stereotactic ablative radiation therapy for pulmonary metastases from sarcoma primaries: A systematic review and meta-analysis of safety and efficacy.","authors":"Raj Singh, Robert Sierra, Casey Leimbach, Sidharth Iyer, Eric J Lehrer, Haley Perlow, Rituraj Upadhyay, Sung Jun Ma, Austin Sim, Emile Gogineni, Sujith Baliga, Daniel M Trifiletti, Joshua D Palmer, David J Konieczkowski, Jeremy Brownstein, Nicholas G Zaorsky","doi":"","DOIUrl":"","url":null,"abstract":"Background: Though promising retrospective and prospective studies have reported on stereotactic ablative radiation therapy(SABR) for management of lung metastases from sarcoma primaries, they are limited by small patient numbers.Methods: The primary outcomes of interest were 1-year and 2-year local control (LC) and Grade 3-5 toxicities. Secondary outcomes were 1-year overall survival (OS) and 2-year OS. Weighted random effects meta-analyses using the DerSimonian and Laird methods were performed to calculate effect sizes.Results: Thirteen studies were identified with 533 patients and 940 lung metastases. The median prescription dose was 50 Gy (range: 48-60 Gy) in 5 fractions (range: 4-10). Following SABR, 1- and 2-year pooled LC rates were 97% (95% CI: 95-98%) and 91% (95% CI: 88-95%), respectively. Pooled 1- and 2-year OS rates were 85% (95% CI: 80-90%) and 68% (95% CI: 57-80%), respectively. The estimated incidence of Grade 3-5 toxicities following SABR was 0.1% (95% CI: 0-0.5%).Conclusion: SABR for sarcoma pulmonary metastases resulted in excellent LC with minimal toxicities.","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"9 3","pages":"215-226"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of stereotactic body radiotherapy beyond primary target in prostate cancer. 超靶立体定向放射治疗前列腺癌的疗效。

IF 0.8

Journal of radiosurgery and SBRT Pub Date : 2025-01-01

Jay P Sahu, Trinanjan Basu, Shounak J Kamat, Ajinkya Gadekar, Rohith R Menon, Ghazala K Roshan

引用次数: 0

Development of non-invasive genetic surgery. 非侵入性基因手术的发展。

IF 0.8

Journal of radiosurgery and SBRT Pub Date : 2025-01-01

Antonio A F De Salles

引用次数: 0

Tumor-targeted Gamma Knife radiosurgery in patients with trigeminal neuralgia secondary to benign tumors. 肿瘤靶向伽玛刀放射治疗良性肿瘤继发三叉神经痛。

IF 0.8

Journal of radiosurgery and SBRT Pub Date : 2025-01-01

Roger Murayi, Jordan C Petitt, Robert D Winkelman, Pablo F Recinos, Samuel T Chao, Erin S Murphy, Pranay Soni, Gene H Barnett, John H Suh, Varun R Kshettry

{"title":"Tumor-targeted Gamma Knife radiosurgery in patients with trigeminal neuralgia secondary to benign tumors.","authors":"Roger Murayi, Jordan C Petitt, Robert D Winkelman, Pablo F Recinos, Samuel T Chao, Erin S Murphy, Pranay Soni, Gene H Barnett, John H Suh, Varun R Kshettry","doi":"","DOIUrl":"","url":null,"abstract":"Background: Secondary trigeminal neuralgia (TN) is often associated with benign meningiomas and schwannomas. For patients who are unable to undergo surgical resection, Gamma Knife radiosurgery (GKRS) is a well-established alternative for tumor control. There is limited data on the pain outcomes in these patients undergoing tumor-targeted GKRS.Methods: Patients receiving tumor-targeted GKRS for a benign tumor causing secondary TN between 2005 and 2021 were identified. The Barrow Neurological Institute (BNI) pain score was documented at baseline and over the course of clinical follow-up. The study endpoint was defined as either last documented follow-up or date of additional pain procedure.Results: Seventeen patients were identified with 12 meningiomas (71%), 4 vestibular schwannomas (24%), and 1 trigeminal schwannoma (6%). Patients received either a single fraction of 12-13 Gy in 14 patients (82%) or 25 Gy in 5 fractions for 3 patients (18%). At a mean time to study endpoint of 29.5 months, 6 patients (35%) were pain free. Median time to BNI pain improvement was 4.6 months post-GKRS. One patient (6%) experienced new onset facial numbness. After the study endpoint, five patients (29%) underwent at least one subsequent balloon compression procedure for pain control. Mean total follow-up time was 61.9 months.Conclusion: For patients with secondary TN due to benign lesions who are poor candidates for surgical resection, tumor-targeted GKRS has a modest effect on pain outcomes. Complication rates are also comparatively very low.","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"9 3","pages":"227-235"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0