Thomas Klinge, Marc Modat, Jamie R McClelland, Alexis Dimitriadis, Ian Paddick, John W Hopewell, Lee Walton, Jeremy Rowe, Neil Kitchen, Sébastien Ourselin
{"title":"The impact of unscheduled gaps and iso-centre sequencing on the biologically effective dose in Gamma Knife radiosurgery.","authors":"Thomas Klinge, Marc Modat, Jamie R McClelland, Alexis Dimitriadis, Ian Paddick, John W Hopewell, Lee Walton, Jeremy Rowe, Neil Kitchen, Sébastien Ourselin","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>Establish the impact of iso-centre sequencing and unscheduled gaps in Gamma Knife® (GK) radiosurgery on the biologically effective dose (BED).</p><p><strong>Methods: </strong>A BED model was used to study BED values on the prescription iso-surface of patients treated with GK Perfexion™ (Vestibular Schwannoma). The effect of a 15 min gap, simulated at varying points in the treatment delivery, and adjustments to the sequencing of iso-centre delivery, based on average dose-rate, was quantified in terms of the impact on BED.</p><p><strong>Results: </strong>Depending on the position of the gap and the average dose-rate profiles, the mean BED values were decreased by 0.1% to 9.9% of the value in the original plan. A heuristic approach to iso-centre sequencing showed variations in BED of up to 14.2%, relative to the mean BED of the original sequence.</p><p><strong>Conclusion: </strong>The treatment variables, like the iso-centre sequence and unscheduled gaps, should be considered during GK radiosurgery treatments.</p>","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"7 3","pages":"213-221"},"PeriodicalIF":1.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38907775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Kowalchuk, M. Waters, K. Richardson, K. Spencer, J. Larner, J. Sheehan, William H. McAllister, C. Kersh
{"title":"A comparison of stereotactic body radiation therapy for metastases to the sacral spine and treatment of the thoracolumbar spine.","authors":"R. Kowalchuk, M. Waters, K. Richardson, K. Spencer, J. Larner, J. Sheehan, William H. McAllister, C. Kersh","doi":"10.1016/j.ijrobp.2020.07.2055","DOIUrl":"https://doi.org/10.1016/j.ijrobp.2020.07.2055","url":null,"abstract":"","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"7 2 1","pages":"95-103"},"PeriodicalIF":1.2,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijrobp.2020.07.2055","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49141673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guoqiang Cui, Yun Yang, F. Yin, D. Yoo, Grace J. Kim, J. Duan
{"title":"Evaluation of two automated treatment planning techniques for multiple brain metastases using a single isocenter.","authors":"Guoqiang Cui, Yun Yang, F. Yin, D. Yoo, Grace J. Kim, J. Duan","doi":"10.1016/j.ijrobp.2020.07.682","DOIUrl":"https://doi.org/10.1016/j.ijrobp.2020.07.682","url":null,"abstract":"","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"8 1 1","pages":"47-54"},"PeriodicalIF":1.2,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijrobp.2020.07.682","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49663691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Saenz, N. Papanikolaou, E. Zoros, E. Pappas, M. Reiner, Lip Teck Chew, Hooi Yin Lim, S. Hancock, A. Nevelsky, C. Njeh, G. Anagnostopoulos
{"title":"Robustness of single-isocenter multiple-metastasis stereotactic radiosurgery end-to-end testing across institutions","authors":"D. Saenz, N. Papanikolaou, E. Zoros, E. Pappas, M. Reiner, Lip Teck Chew, Hooi Yin Lim, S. Hancock, A. Nevelsky, C. Njeh, G. Anagnostopoulos","doi":"10.21203/rs.3.rs-15983/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-15983/v1","url":null,"abstract":"The accuracy of stereotactic radiosurgery (SRS) to multiple metastases with a single-isocenter using high definition dynamic radiosurgery (HDRS) was evaluated across institutions. An SRS plan was delivered at six HDRS-capable institutions to an anthropomorphic phantom consisting of point, film, and 3D-gel dosimeters. Direct dose comparison and gamma analysis were used to evaluate the accuracy. Point measurements averaged across institutions were within 1.2±0.5%. The average gamma passing rate in the film was 96.6±2.2% (3%/2 mm). For targets within 4 cm of the isocenter, the 3D dosimetric gel gamma passing rate averaged across institutions was >90% (3%/2 mm). The targeting accuracy of high definition dynamic radiosurgery assessed by geometrical offset of the center of dose distributions across multiple institutions in this study was within 1 mm for targets within 4 cm of isocenter. Across variations in clinical practice, comparable dosimetry and localization is possible with this treatment planning and delivery technique.","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"7 1","pages":"223 - 232"},"PeriodicalIF":1.2,"publicationDate":"2020-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47841197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sua Yoo, Jennifer O'Daniel, Rachel Blitzblau, Fang-Fang Yin, Janet K Horton
{"title":"Accuracy and efficiency of image-guided radiation therapy (IGRT) for preoperative partial breast radiosurgery.","authors":"Sua Yoo, Jennifer O'Daniel, Rachel Blitzblau, Fang-Fang Yin, Janet K Horton","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To analyze and evaluate accuracy and efficiency of IGRT process for preoperative partial breast radiosurgery.</p><p><strong>Methods: </strong>Patients were initially setup with skin marks and 5 steps were performed: (1) Initial orthogonal 2D kV images, (2) pre-treatment 3D CBCT images, (3) verification orthogonal 2D kV images, (4) treatment including mid-treatment 2D kV images (for the final 15 patients only), and (5) post-treatment orthogonal 2D kV or 3D CBCT images. Patient position was corrected at each step to align the biopsy clip and to verify surrounding soft tissue positioning.</p><p><strong>Results: </strong>The mean combined vector magnitude shifts and standard deviations at the 5 imaging steps were (1) 0.96 ± 0.69, (2) 0.33 ± 0.40, (3) 0.05 ± 0.12, (4) 0.15 ± 0.17, and (5) 0.27 ± 0.24 in cm. The mean total IGRT time was 40.2 ± 13.2 minutes. Each step was shortened by 2 to 5 minutes with improvements implemented. Overall, improvements in the IGRT process reduced the mean total IGRT time by approximately 20 minutes. Clip visibility was improved by implementing oblique orthogonal images.</p><p><strong>Conclusion: </strong>Multiple imaging steps confirmed accurate patient positioning. Appropriate planning and imaging strategies improved the effectiveness and efficiency of the IGRT process for preoperative partial breast radiosurgery.</p>","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"6 4","pages":"295-301"},"PeriodicalIF":1.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065902/pdf/rsbrt-6-301.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37748233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Timothy D Malouff, Danushka Seneviratne, William C Stross, Stephen Ko, Katherine Tzou, Daniel M Trifiletti, Laura A Vallow
{"title":"Public interest in stereotactic body radiation therapy (SBRT) and stereotactic radiosurgery (SRS) in the United States.","authors":"Timothy D Malouff, Danushka Seneviratne, William C Stross, Stephen Ko, Katherine Tzou, Daniel M Trifiletti, Laura A Vallow","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Stereotactic body radiation therapy (SBRT) and stereotactic radiosurgery have become widely used in both palliative and curative treatments for variety of primary and secondary malignancies. Although the indications and use of stereotactic techniques have increased substantially in the past decades, there been no studies to date analyzing public interest in these techniques. Using Google Trends (Google LLC, Mountain View, CA), four search terms (\"SBRT,\" \"stereotactic radiosurgery,\" \"Gamma Knife\" and \"Cyberknife\") were analyzed in the U.S. from January 2004 to June 2019. Each term was assigned a relative interest score based on frequency of searches. \"SBRT\" is becoming an increasingly popular search term, reaching peak interest in October 2018. Conversely, \"stereotactic radiosurgery\" and \"Gamma Knife\" radiosurgery initially had high interest, before declining over the past decade. \"Cyberknife\" was most popular in the mid-2000s but decreased steadily since that time. These trends were subsequently compared against PubMed publication data over the same time.</p>","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"6 4","pages":"311-315"},"PeriodicalIF":1.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065901/pdf/rsbrt-6-315.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37748235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Case report: Cyberknife radiosurgery for the treatment of disabling pain caused by vertebral body hemangioma.","authors":"Eduardo Gaviolli, John Sinclair, Shawn Malone","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"6 4","pages":"317-319"},"PeriodicalIF":1.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065896/pdf/rsbrt-6-319.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37748236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eric M Anderson, Kenneth Park, Diana J Lu, Nicholas Nissen, Jun Gong, Andrew Hendifar, Alexandra Gangi, Simon Lo, Mitchell Kamrava, Katelyn M Atkins
{"title":"A radiopaque polymer hydrogel as an irreversible electroporation compatible fiducial marker for pancreas stereotactic body radiotherapy.","authors":"Eric M Anderson, Kenneth Park, Diana J Lu, Nicholas Nissen, Jun Gong, Andrew Hendifar, Alexandra Gangi, Simon Lo, Mitchell Kamrava, Katelyn M Atkins","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"7 2","pages":"165-167"},"PeriodicalIF":1.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717092/pdf/rsbrt-7-167.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38679563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nasser Mohammed, Adomas Bunevicius, Eluvathingal Muttikkal Thomas, Jason Druzgal, Jason P Sheehan
{"title":"Gamma Knife radiosurgery associated worsening of superficial siderosis due to a foramen magnum tumor - A case report.","authors":"Nasser Mohammed, Adomas Bunevicius, Eluvathingal Muttikkal Thomas, Jason Druzgal, Jason P Sheehan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Superficial siderosis (SS) of the brain results from a chronic iron toxicity due to repeated microscopic leakage of blood products into the subarachnoid space. We report on Gamma Knife Radiosurgery (GKRS) associated worsening of superficial siderosis in a patient with skull-base tumor. A 73 year-old male patient presented with clumsiness and gait ataxia and was diagnosed with foramen magnum meningioma. He was also noted to have superficial siderosis involving the mainly the infratentorial compartment. After a thorough evaluation of craniospinal axis, no other cause of bleeding was identified. Patient was treated with the GKRS. After GKRS, there was an initial radiological and clinical worsening of SS starting at 6 months and peaking at 2 years. The disease stabilized and showed mild reduction at 3 years. GKRS lead to an initial progression of superficial siderosis. However, over a longer period, tumor control and improvement of the siderosis was observed.</p>","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"7 2","pages":"169-172"},"PeriodicalIF":1.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717088/pdf/rsbrt-7-172.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38679564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohameth Faye, Moussa Diallo, Manal Sghiouar, Elhadji Cheikh Ndiaye Sy, Pierre Yves Borius, Jean-Marie Régis
{"title":"Stereotactic radiosurgery for thalamus arteriovenous malformations.","authors":"Mohameth Faye, Moussa Diallo, Manal Sghiouar, Elhadji Cheikh Ndiaye Sy, Pierre Yves Borius, Jean-Marie Régis","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Cerebral arteriovenous malformations or angiomas are congenital vascular anomalies defined by abnormal arteriovenous shunt.</p><p><strong>Materials and methods: </strong>We conducted a retrospective study between January 1992 and December 2010 at the Timone Hospital radiosurgery unit, 1557 patients were treated by radiosurgery for arteriovenous malformation of which 53 for thalamic localization (3,4%).</p><p><strong>Results: </strong>The mean age was 35.8-/+16.6 years (4-75). 14 patients underwent pre-radiosurgical embolization (26.4%), discovery mode for 47 patients (88.7%) was haemorrhage. The average treatment volume was 1.43 cm<sup>3</sup>. The average RBAS score was 1.36. The average prescription to the 50% isodose envelope delivered was 22.9 +/-2.9 Gy (12-30), the median margin dose was 24 Gy. Our global obliteration rate after one or two procedures 66.7% for an average follow-up period of 56.7 months. We noted 3.9% of mortality, 5.9% of bleeding after procedure and 3.9% of radio-induced neurological deficit.</p><p><strong>Conclusion: </strong>Radiosurgery became indispensable in the treatment of thalamic AVM even when there is a persistent risk of haemorrhage until total recovery.</p>","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"6 4","pages":"269-275"},"PeriodicalIF":0.7,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065894/pdf/rsbrt-6-275.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37748230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}