Discovery of increased number or interval growth of brain metastases on same-day GammaKnife™ planning MRI: Predicting factors and patient outcomes.

IF 0.7 Q4 SURGERY

Journal of radiosurgery and SBRT Pub Date : 2022-01-01

Todd R Mereniuk, Heather N Burney, Tim Lautenschlaeger, Gordon A Watson, Ryan M Rhome

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引用次数: 0

Abstract

Purpose: To determine factors associated with increased risk of finding new and/or enlarged brain metastases (BM) on GammaKnife™ (GK) MRI and their impact on patient outcomes.

Results: 43.9% of patients showed BM growth, 32.9% had additional brain metastases (aBM), and 18.1 % had both. Initial brain metastasis velocity (iBMV) was associated with finding aBM. Time between diagnostic MRI (dMRI) and GK MRI was associated with interval growth and each day increased this risk by 2%. Prior brain metastasectomy and greater time between either dMRI or latest extracranial RT and GK MRI predicted both aBM and BM growth. aBM and/or BM growth led to management change in 1.8% of cases and were not associated with OS or incidence of distant intracranial failure.

Conclusions: Number of metastases seen on dMRI and iBMV predicted both aBM and/or BM growth, however, these factors did not significantly affect survival or incidence of distant intracranial failure.

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当天GammaKnife™计划MRI发现脑转移瘤数量增加或间隔生长:预测因素和患者预后

目的:确定GammaKnife™(GK) MRI发现新的和/或扩大的脑转移瘤(BM)风险增加的相关因素及其对患者预后的影响。结果:43.9%的患者出现脑转移瘤生长，32.9%的患者伴有脑转移瘤(aBM)， 18.1%的患者两者兼有。初始脑转移速度(iBMV)与发现aBM相关。诊断性MRI (dMRI)和GK MRI之间的时间间隔与间隔增长有关，每天增加2%的风险。既往脑转移切除术和dMRI或最新颅外RT和GK MRI间隔时间较长预测aBM和BM的生长。在1.8%的病例中，基底膜和/或基底膜生长导致治疗改变，与OS或远端颅内功能衰竭发生率无关。结论:dMRI和iBMV上的转移数量可以预测aBM和/或BM的生长，然而，这些因素对远端颅内功能衰竭的生存率或发生率没有显著影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of radiosurgery and SBRT SURGERY-

CiteScore

1.40

自引率

8.30%

发文量