Y Sih Ibet Marie, F Torio Erickson, V Bayhon Maurice, D Maala Jonna Mae, M Mariano Manuel, M Casis Rhoderick, G Barredo Carlo, L Mariano Juan Manuel, M Leong Jo-Celine, C Mercado Charlene Mary, M Yanto Jan Rehino, J Magsanoc Juan Martin, P Camacho Angela, C Calaguas Miriam Joy, T Vergara Thomas Vincent, P Rojales Julius Cezar, U Cortez Kathleen Jane, S D Santos Ma Socorro, G Torcuator Roy
{"title":"影响51名菲律宾成人脊柱转移瘤立体定向放射手术患者总体生存的因素。","authors":"Y Sih Ibet Marie, F Torio Erickson, V Bayhon Maurice, D Maala Jonna Mae, M Mariano Manuel, M Casis Rhoderick, G Barredo Carlo, L Mariano Juan Manuel, M Leong Jo-Celine, C Mercado Charlene Mary, M Yanto Jan Rehino, J Magsanoc Juan Martin, P Camacho Angela, C Calaguas Miriam Joy, T Vergara Thomas Vincent, P Rojales Julius Cezar, U Cortez Kathleen Jane, S D Santos Ma Socorro, G Torcuator Roy","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Stereotactic radiosurgery (SRS) is part of the multimodality treatment for patients with cancer. The objective of this study is to determine factors which influence overall survival (OS) of Filipino patients who underwent SRS for metastatic tumors of the spine.</p><p><strong>Methods: </strong>This is a retrospective analysis of a cohort of Filipino patients treated with spine SRS for metastatic tumors in a single institution. Putative predictors were determined by the institution's spine SRS team and described in the cohort. A Cox proportional hazards regression model was utilized to construct a model based on the predictors determined by the institution's spine SRS team.</p><p><strong>Results: </strong>A total of 51 consecutive patients with 68 spine metastases were treated with SRS at our institution. The median OS was 13.1 months (95% CI of 7.1 to 19.1). On multivariate analysis, significant predictors that are associated with OS were visceral tumor origin (adjusted HR: 3.08, 95% CI of 1.24 to 7.64, <i>p</i> = 0.015) and cardiovascular disease (adjusted HR: 2.50, 95% CI of 1.04 to 5.94, p = 0.039) with dose and number of fractions as co-variates [Model Wald χ<sup>2</sup> (5, N = 51) = 11.11 (<i>p</i> = 0.049)].</p><p><strong>Conclusions: </strong>The presence of visceral tumor origins and cardiovascular disease are independent factors that are associated with lower overall survival in Filipino patients with spine metastasis treated with SRS.</p>","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"8 3","pages":"175-180"},"PeriodicalIF":0.7000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970737/pdf/rsbrt-8-175.pdf","citationCount":"0","resultStr":"{\"title\":\"Factors affecting overall survival in 51 adult Filipino patients undergoing stereotactic radiosurgery for spine metastases.\",\"authors\":\"Y Sih Ibet Marie, F Torio Erickson, V Bayhon Maurice, D Maala Jonna Mae, M Mariano Manuel, M Casis Rhoderick, G Barredo Carlo, L Mariano Juan Manuel, M Leong Jo-Celine, C Mercado Charlene Mary, M Yanto Jan Rehino, J Magsanoc Juan Martin, P Camacho Angela, C Calaguas Miriam Joy, T Vergara Thomas Vincent, P Rojales Julius Cezar, U Cortez Kathleen Jane, S D Santos Ma Socorro, G Torcuator Roy\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Stereotactic radiosurgery (SRS) is part of the multimodality treatment for patients with cancer. The objective of this study is to determine factors which influence overall survival (OS) of Filipino patients who underwent SRS for metastatic tumors of the spine.</p><p><strong>Methods: </strong>This is a retrospective analysis of a cohort of Filipino patients treated with spine SRS for metastatic tumors in a single institution. Putative predictors were determined by the institution's spine SRS team and described in the cohort. A Cox proportional hazards regression model was utilized to construct a model based on the predictors determined by the institution's spine SRS team.</p><p><strong>Results: </strong>A total of 51 consecutive patients with 68 spine metastases were treated with SRS at our institution. The median OS was 13.1 months (95% CI of 7.1 to 19.1). On multivariate analysis, significant predictors that are associated with OS were visceral tumor origin (adjusted HR: 3.08, 95% CI of 1.24 to 7.64, <i>p</i> = 0.015) and cardiovascular disease (adjusted HR: 2.50, 95% CI of 1.04 to 5.94, p = 0.039) with dose and number of fractions as co-variates [Model Wald χ<sup>2</sup> (5, N = 51) = 11.11 (<i>p</i> = 0.049)].</p><p><strong>Conclusions: </strong>The presence of visceral tumor origins and cardiovascular disease are independent factors that are associated with lower overall survival in Filipino patients with spine metastasis treated with SRS.</p>\",\"PeriodicalId\":16917,\"journal\":{\"name\":\"Journal of radiosurgery and SBRT\",\"volume\":\"8 3\",\"pages\":\"175-180\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970737/pdf/rsbrt-8-175.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of radiosurgery and SBRT\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"SURGERY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of radiosurgery and SBRT","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"SURGERY","Score":null,"Total":0}
Factors affecting overall survival in 51 adult Filipino patients undergoing stereotactic radiosurgery for spine metastases.
Objectives: Stereotactic radiosurgery (SRS) is part of the multimodality treatment for patients with cancer. The objective of this study is to determine factors which influence overall survival (OS) of Filipino patients who underwent SRS for metastatic tumors of the spine.
Methods: This is a retrospective analysis of a cohort of Filipino patients treated with spine SRS for metastatic tumors in a single institution. Putative predictors were determined by the institution's spine SRS team and described in the cohort. A Cox proportional hazards regression model was utilized to construct a model based on the predictors determined by the institution's spine SRS team.
Results: A total of 51 consecutive patients with 68 spine metastases were treated with SRS at our institution. The median OS was 13.1 months (95% CI of 7.1 to 19.1). On multivariate analysis, significant predictors that are associated with OS were visceral tumor origin (adjusted HR: 3.08, 95% CI of 1.24 to 7.64, p = 0.015) and cardiovascular disease (adjusted HR: 2.50, 95% CI of 1.04 to 5.94, p = 0.039) with dose and number of fractions as co-variates [Model Wald χ2 (5, N = 51) = 11.11 (p = 0.049)].
Conclusions: The presence of visceral tumor origins and cardiovascular disease are independent factors that are associated with lower overall survival in Filipino patients with spine metastasis treated with SRS.
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