Journal of radiosurgery and SBRT最新文献_第5页

Experience of Gamma Knife radiosurgery for treatment of brain metastases in pregnancy with literature review. 伽玛刀放射外科治疗妊娠期脑转移瘤的经验及文献综述。

IF 0.7

Journal of radiosurgery and SBRT Pub Date : 2024-01-01

Beehong Soon, Fuad Ismail, Marfu'ah Nik Ezzamudden, Shahizon Azura Mohamed Mukari, Aida-Widure Mustapha Mohd Mustapha, Aida Hani Mohd Kalok, Norlia Abdullah, Ian Paddick, Ramesh Kumar

{"title":"Experience of Gamma Knife radiosurgery for treatment of brain metastases in pregnancy with literature review.","authors":"Beehong Soon, Fuad Ismail, Marfu'ah Nik Ezzamudden, Shahizon Azura Mohamed Mukari, Aida-Widure Mustapha Mohd Mustapha, Aida Hani Mohd Kalok, Norlia Abdullah, Ian Paddick, Ramesh Kumar","doi":"","DOIUrl":"","url":null,"abstract":"Brain metastases during pregnancy poses complex conundrum in management. Stereotactic radiosurgery (SRS) offers valuable option to clinicians in this scenario. We reviewed and described the safety and effectiveness of Gamma Knife (GK) SRS in treating a solitary cerebellar metastasis in a patient with recurrent breast cancer at 28 weeks of gestation. Following multidisciplinary discussion, she consented for urgent single session GK SRS to the brain metastasis with 2 cycles of 3-weekly paclitaxel chemotherapy prior to planned delivery at term. Prior to the frame-based treatment, a trial run with dosimeters placed on the superior and inferior parts of foam knee support showed radiation exposure of 3.12 mSv and 1.06 mSv respectively. A prescription dose of 16 Gy at the 50% isodose was delivered using 24 isocentres over 39.7' of beam on time. The treatment plan had 98% coverage, 89% selectivity and a gradient index of 2.98. Dosimeters placed near the uterine fundus and suprapubic region (consistent with location of fetal head) during the actual treatment recorded 2.83 mSv and 0.27 mSv, which is lower than the trial dosimeter readings. The patient successfully completed SRS treatment and gave birth to a healthy baby two months later. Follow-up MRI at three months interval showed total resolution of the lesion. GK SRS is known for the lowest extracranial dose compared to other SRS modalities. This report and literature review confirmed that GK is a sharp and effective, yet gentle and safe treatment for pregnant patients with brain metastases.","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"9 2","pages":"171-175"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11288652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141860091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Initial experience and patient tolerance of proton stereotactic body radiotherapy. 质子立体定向体放射治疗的初步经验和患者耐受性。

IF 0.7

Journal of radiosurgery and SBRT Pub Date : 2024-01-01

Naba Ali, Jun Zhou, Bree R Eaton, Jeffrey M Switchenko, Yichun Cao, William A Stokes, Pretesh R Patel, Katja M Langen, Roelf Slopsema, Jeffrey D Bradley, Mark W McDonald

{"title":"Initial experience and patient tolerance of proton stereotactic body radiotherapy.","authors":"Naba Ali, Jun Zhou, Bree R Eaton, Jeffrey M Switchenko, Yichun Cao, William A Stokes, Pretesh R Patel, Katja M Langen, Roelf Slopsema, Jeffrey D Bradley, Mark W McDonald","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: To review our initial experience with proton-based SBRT to evaluate the planning outcomes and initial patient tolerance of treatment.Patients and methods: From Sep. 2019 to Dec. 2020, 52 patients were treated with proton SBRT to 62 lesions. Fractionation varied by indication and site with a median of 5 fractions and median fractional dose of 8 Gy. Planning outcomes, including plan heterogeneity, conformity, and PTV volume receiving 100% of the prescription dose (PTV V100%) were evaluated. Acute toxicities were prospectively recorded, and patient reported outcomes were assessed prior to and at completion of treatment using the MD Anderson Symptom Inventory (MDASI) and EQ-5D5L visual analogue score (VAS).Results: All treated patients completed their course of proton-based SBRT. The mean conformity index was 1.05 (range 0.51-1.48). R50% values were comparable to ideal photon parameters. PTV V100% was 89.9% on average (40.44% - 99.76%). 5 patients (10%) required plan modification due to setup or tumor changes. No patients developed a new grade 3 or greater toxicity during treatment. Comparing pretreatment to end of treatment timepoints, there was a significant improvement in the mean VAS (65 to 75, p = 0.014), with no significant change in the mean MDASI symptom (1.7, 1.8; p = 0.79) or interference (2.3, 2.4; p = 0.452) scores.Conclusion: Proton-based SBRT can achieve dosimetric goals required by major clinical photon trials. It was well-tolerated with no decrement in patient reported outcomes and a mean 10-point improvement in VAS at the conclusion of SBRT. Further follow-up is necessary for tumor control and late effects analysis.","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"9 2","pages":"121-128"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11288653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141860093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive assessment of proton plans with three different beam delivery systems for multiple brain metastases. 采用三种不同的射束传输系统对治疗多发性脑转移瘤的质子计划进行综合评估。

IF 0.8

Journal of radiosurgery and SBRT Pub Date : 2024-01-01

Tara Gray, Anna Maria Kolano, Chieh-Wen Liu, Young-Bin Cho, Jeremy Donaghue, Samuel Chao, John Suh, Ping Xia, Jonathan Farr

{"title":"Comprehensive assessment of proton plans with three different beam delivery systems for multiple brain metastases.","authors":"Tara Gray, Anna Maria Kolano, Chieh-Wen Liu, Young-Bin Cho, Jeremy Donaghue, Samuel Chao, John Suh, Ping Xia, Jonathan Farr","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: To compare plan quality among photon volumetric arc therapy (VMAT), Gamma Knife, and three different proton beam modalities.Methods: Fifty-five brain lesions from 20 patients were planned with three different proton spot size ranges of cyclotron-generated proton beams, CPBs (spot size σ: 2.7-7.0 mm), linear accelerator proton beams, LPBs (σ: 2.9-5.5 mm), and linear accelerator proton minibeams, LPMBs (σ: 0.9-3.9 mm), with and without apertures and compared against photon VMAT and Gamma Knife plans. Dose coverage to each lesion for each proton and photon plan was set to 99% of the GTV receiving the prescription (Rx) dose. All proton plans used ±2 mm setup uncertainty and ±2% range uncertainty in robust evaluation to achieve V100%Rx > 95% of the GTV. Apertures were applied to proton beams irradiating tumors <1 cm3 volume and located <2.5 cm depth. Conformity index (CI), gradient index (GI), V12 Gy, V4.5 Gy, and mean brain dose were compared across all plan types. The Wilcoxon signed rank test was utilized to determine statistical significance of dosimetric results compared between photon and proton plans.Results: When compared to CPB generated plans, average CI and GI were significantly better for the LPB and LPMB plans. Aperture-based IMPT plans showed improvement from Gamma Knife for all dosimetric metrics. Aperture-based IMPT plans also showed improvement in all dosimetric metrics for shallow tumors (d < 2.5 cm) when compared with non-aperture-based plans.Conclusion: The LPB and LPMB stand as excellent alternatives to CPB or photon therapy and significantly increase the preservation of normal tissue.","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"9 2","pages":"145-156"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11288651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141862057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A single center, inter-observer evaluation of vestibular schwannoma stereotactic radiosurgery and its dosimetric impact. 对前庭分裂瘤立体定向放射手术及其剂量影响的单中心观察者间评估。

IF 0.7

Journal of radiosurgery and SBRT Pub Date : 2024-01-01

Maria Jose Perez-Calatayud, Antonio Menéndez, Françoise Lliso, Vicente Carmona, Antonio Conde, Francisco Celada, Mariola Bernisz, Carlos Botella, Jose Perez-Calatayud

引用次数: 0

Intra-fractional corrections and clinical outcomes in frameless image-guided radiosurgery for trigeminal neuralgia. 无框架图像引导放射外科治疗三叉神经痛的点内修正和临床疗效。

IF 0.7

Journal of radiosurgery and SBRT Pub Date : 2024-01-01

Wei-Hsien Hou, Michelle B Chen, Rachel Chou, Allan Y Chen

{"title":"Intra-fractional corrections and clinical outcomes in frameless image-guided radiosurgery for trigeminal neuralgia.","authors":"Wei-Hsien Hou, Michelle B Chen, Rachel Chou, Allan Y Chen","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: Precision targeting is crucial to successful stereotactic radiosurgery for trigeminal neuralgia (TGN). We investigated the impact of intra-fractional 6-dimensional corrections during frameless image-guided radiosurgery (IGRS) for pain outcome in TGN patients.Materials and methods: A total of 41 sets of intra-fractional corrections from 35 patients with TGN treated by frameless IGRS from 2009 to 2013 were retrospectively studied. For each IGRS, the intra-fractional 6-dimensional shifts were conducted at 6 couch angles. Clinical pain outcome was recorded according the Barrow Neurological Institute (BNI) 5-points score. The relationship in 6-dimensional corrections and absolute translational distances between patients with pain relief score points <2 versus ≥2 were analyzed.Results: The absolute mean lateral, longitudinal, and vertical translational shifts were 0.46 ± 0.15 mm, 0.36 ± 0.16 mm and 0.21 ± 0.08 mm, respectively, with 97% of translational shifts being within 0.7 mm. The absolute mean lateral (pitch), longitudinal (roll), and vertical (yaw) rotational corrections are 0.33 ± 0.24°, 0.18 ± 0.09°, and 0.27 ± 0.15°, respectively, with 97% of rotational corrections being within 0.6°. The median follow-up duration for pain outcome was 26 months after IGRS. The average calculated absolute shift for patients with pain relief <2 and ≥2 BNI points, were 0.228 ± 0.008 mm and 0.259 ± 0.007 mm, respectively. There was no statistically significant difference in the translational shifts, rotational corrections or absolute distances between these two patient groups.Conclusions: Our data demonstrate high spatial targeting accuracy of frameless IGRS for TGN with only nominal intra-fraction 6-dimensional corrections.","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"9 2","pages":"135-143"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11288655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141860094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stereotactic body radiation therapy is promising treatment for complex arteriovenous malformation of the neck: A case report. 立体定向体放射疗法是治疗颈部复杂动静脉畸形的有效方法：病例报告。

IF 0.7

Journal of radiosurgery and SBRT Pub Date : 2024-01-01

Evelyn O Ilori, Timothy D Smile, Tom Masaryk, Abraham Levitin, Mark Bain, Sarah Stock, Jonathan Lee, Eric Lamarre, Neil M Woody, Shauna Campbell, Shlomo A Koyfman

引用次数: 0

Credentialing of stereotactic radiosurgery and stereotactic body radiation therapy programs for quality and safety: The Novalis Certified Program. 对立体定向放射外科和立体定向体放射治疗项目进行质量和安全认证：Novalis 认证计划。

IF 0.7

Journal of radiosurgery and SBRT Pub Date : 2024-01-01

Timothy D Solberg, Nzhde Agazaryan, Mark De Ridder, Isabelle Germano, Naren Ramakrishna, James Robar, Ronald Warnick, Reinhard Wurm, Antonia Wurmseher

引用次数: 0

Proton versus photon radiotherapy for hepatocellular carcinoma: Current data and technical considerations. 质子与光子放射治疗肝细胞癌:目前的数据和技术考虑。

IF 1.2

Journal of radiosurgery and SBRT Pub Date : 2023-01-01

Hannah J Roberts, Theodore S Hong

{"title":"Proton versus photon radiotherapy for hepatocellular carcinoma: Current data and technical considerations.","authors":"Hannah J Roberts, Theodore S Hong","doi":"","DOIUrl":"","url":null,"abstract":"Radiation is an accepted standard of care for unresectable hepatocellular carcinoma (HCC), and while photon radiation is the current standard, the use of proton beam radiotherapy (PBT) is an active area of investigation given its ability to better spare uninvolved liver. Patients with HCC typically have background liver disease and many patients die of their underlying liver function in the absence of tumor progression. Early photon-based series showed promising rates of local control however the risk of non-classic radiation induced liver disease (RILD) remains relatively high and may be associated with poorer outcomes. There is a theoretical advantage to PBT in its ability to spare uninvolved liver parenchyma and potentially allow for further dose escalation. There are technical considerations for image guidance, respiratory motion management, and conformality to both PBT and photon radiotherapy that are critical to optimizing each modality. Whether the use of PBT affects clinical outcomes is the subject of the ongoing NRG Oncology GI003 trial, that randomizes patients with HCC to protons or photons. This article reviews the technical differences and literature on individual outcomes for PBT and photon radiation as well as the available comparative data.","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"9 1","pages":"9-16"},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138460589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stereotactic body proton therapy for non-small cell lung cancer: Clinical indications and recommendations. 立体定向体质子治疗非小细胞肺癌:临床适应症和建议。

IF 1.2

Journal of radiosurgery and SBRT Pub Date : 2023-01-01

Matthew T McMillan, Mingle Kang, Annemarie F Shepherd, Wei Liu, Liyong Lin, Haibo Lin, Charles B Simone

{"title":"Stereotactic body proton therapy for non-small cell lung cancer: Clinical indications and recommendations.","authors":"Matthew T McMillan, Mingle Kang, Annemarie F Shepherd, Wei Liu, Liyong Lin, Haibo Lin, Charles B Simone","doi":"","DOIUrl":"","url":null,"abstract":"Stereotactic body radiation therapy (SBRT) has emerged as a standard treatment approach for early-stage lung cancer and intrathoracic oligometastatic or oligoprogressive disease. While local control is often excellent with this modality when delivered with photon therapy, toxicities for select patients can be significant. Proton therapy offers a unique opportunity to widen the therapeutic window when treating patients with thoracic malignancies requiring or benefitting from ultra-high doses per fraction. Thoracic proton SBRT may be particularly beneficial in cases requiring dose escalation, for tumors >5 cm, for central or ultra-central tumors, for reirradiation, in patients with interstitial lung diseases, and when combining radiation with immunotherapy. These clinical indications are detailed, along with supporting literature and clinical recommendations. Other considerations, future directions and potential benefits of proton SBRT, including sparing lymphocytes, when delivered as intensity-modulated proton therapy or as FLASH, and for the treatment of locally advanced non-small cell lung cancer or in patients with homologous recombination repair deficiencies, are also discussed.","PeriodicalId":16917,"journal":{"name":"Journal of radiosurgery and SBRT","volume":"9 1","pages":"17-32"},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138460592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proton stereotactic body radiation therapy as a new treatment regimen: Technical development and limitation with initial clinical experience. 质子立体定向放射治疗作为一种新的治疗方案:技术发展和局限性与初步临床经验。

IF 1.2

Journal of radiosurgery and SBRT Pub Date : 2023-01-01

Liyong Lin, Fang Fang Yin, Kristin A Higgins, Samuel Ryu, Charles B Simone

引用次数: 0