Journal of prosthodontic research最新文献

{"title":"Leadership support for an intentional interpersonal interactions (I³)-enabled promotion and tenure process.","authors":"Amol V Janorkar","doi":"10.2186/jpr.JPR_D_26_00008","DOIUrl":"https://doi.org/10.2186/jpr.JPR_D_26_00008","url":null,"abstract":"","PeriodicalId":16887,"journal":{"name":"Journal of prosthodontic research","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of post-curing atmosphere and thermal aging on the physico-mechanical properties of a 3D-printed splint material.","authors":"Pei-Wen Peng, Jy-Jiunn Tzeng, Nai-Chia Teng, Siou-Ci Peng, Ya-Ruei Liu, Yi-Jie Lu, Yi-Jia Lin, Wei-Fang Lee","doi":"10.2186/jpr.JPR_D_25_00250","DOIUrl":"https://doi.org/10.2186/jpr.JPR_D_25_00250","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the effects of different post-curing atmospheres and thermal aging on the surface characteristics and mechanical properties of a 3D-printed splint material fabricated using liquid crystal display technology.</p><p><strong>Methods: </strong>The 3D-printed specimens were divided into three groups based on the post-curing atmosphere (air, nitrogen, and vacuum) and subjected to either water storage at 37 °C for 50 h or 10,000 thermal cycles (5-55 °C). The degree of conversion, surface morphology and roughness, and water sorption/solubility of the specimens were evaluated. The surface hardness was measured using the Vickers hardness test, and the flexural strength was assessed using a three-point bending test. Data were analyzed using two-way ANOVA followed by Tukey's post-hoc test (P < 0.05) after confirming the normality and homogeneity of variances using Shapiro-Wilk and Levene's tests, respectively.</p><p><strong>Results: </strong>The nitrogen and vacuum groups exhibited comparable values for degree of conversion, surface roughness, and water sorption/solubility, which were all significantly higher than those of the air group. A significant difference in the surface hardness was observed among the three post-curing atmospheres (P < 0.001); however, the flexural strength was unaffected. After thermal aging, the surface hardnesses and flexural strengths of all the groups significantly decreased.</p><p><strong>Conclusions: </strong>The post-curing atmosphere significantly influenced the degree of conversion, surface roughness, and water sorption/solubility of the additively manufactured specimens, whereas thermal aging degraded their mechanical properties.</p>","PeriodicalId":16887,"journal":{"name":"Journal of prosthodontic research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148218279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Porphyromonas gingivalis lipopolysaccharide promotes peri-implant inflammation through neutrophil activation.","authors":"Li-Tzu Wang, Sin-Ei Juang, Han-Ying Jhuang, Alpdogan Kantarci, Yun-Fei Lin, Meng-Hsun Tsai, Wei-An Chen, Yu-Wen Huang, Yu-Kang Tu, Kevin Sheng-Kai Ma, Yi-Wen Chen","doi":"10.2186/jpr.JPR_D_25_00271","DOIUrl":"https://doi.org/10.2186/jpr.JPR_D_25_00271","url":null,"abstract":"<p><strong>Purpose: </strong>Peri-implant diseases pose significant challenges to the longevity of titanium-based implants, despite their high survival rates. This study investigated how lipopolysaccharide (LPS) from Porphyromonas gingivalis (P. gingivalis) (P. gingivalis-LPS) as a virulence factor affects neutrophil recruitment and activation surrounding titanium implants to elucidate its potential role in the development of peri-implant inflammation.</p><p><strong>Methods: </strong>Using rat and murine models of titanium implantation, we conducted transcriptomic analysis of peri-implant gingival tissues to identify pathways linked neutrophil activity, particularly in the presence of P. gingivalis-LPS. Flow cytometry was used to validate neutrophil recruitment to the peri-implant mucosa in mice. Human neutrophils were also isolated and stimulated with titanium discs and/or P. gingivalis-LPS to assess their activation and apoptosis.</p><p><strong>Results: </strong>Transcriptomic data revealed significant upregulation of genes associated with neutrophil chemotaxis and activation in peri-implant tissues treated with P. gingivalis-LPS relative to those in the controls (P < 0.05). Flow cytometry data confirmed increased neutrophil infiltration of the peri-implant tissues in mice (P < 0.01). In vitro assays demonstrated that P. gingivalis-LPS significantly enhanced neutrophil CD11b expression and reactive oxygen species production in human neutrophils exposed to titanium (P < 0.01) but inhibited apoptosis (P < 0.001).</p><p><strong>Conclusions: </strong>P. gingivalis-derived LPS amplified neutrophil recruitment and prolonged neutrophil activation in the presence of titanium, suggesting a potential mechanism underlying peri-implant inflammation. This highlights the need for targeted strategies to mitigate neutrophil-induced tissue damage in peri-implant diseases.</p>","PeriodicalId":16887,"journal":{"name":"Journal of prosthodontic research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence-driven workflow synchronizing interdisciplinary dentistry: Narrative review.","authors":"Arvin Kadempour, Ploy Wathanapong, Andrew Cantatore, Shahrzad Mirafzali, Ken Haku-Mizuhara, Satoshi Yamaguchi","doi":"10.2186/jpr.JPR_D_25_00287","DOIUrl":"https://doi.org/10.2186/jpr.JPR_D_25_00287","url":null,"abstract":"<p><strong>Purpose: </strong>This narrative review summarizes an artificial intelligence (AI)-integrated digital workflow that enables a seamless, multidisciplinary approach to dental diagnosis and treatment planning, aiming to improve diagnostic coordination, efficiency, and interdisciplinary communication.</p><p><strong>Study selection: </strong>All studies selected for this narrative review were extracted from the PubMed database. Forty studies were selected, of which 24 were used for general information and 16 were used for the statistical analysis of accuracy of AI software within data acquisition, treatment planning, and clinical implementation.</p><p><strong>Results: </strong>The digital workflow was divided into three phases: data acquisition, treatment planning, and AI data analysis for decision support. Six articles reported the accuracy outcomes for AI-integrated data acquisition tools, such as intraoral scanners (IOS), cone-beam computed tomography (CBCT), facial scanners (FS), and jaw motion trackers (JMT); seven reported AI performance in assisting treatment planning; and three assessed the clinician acceptance rate of AI-supported decisions. IOS, CBCT, FS, and JMT achieved 88-97% overall accuracies. The integrated convolutional neural network and recurrent neural network models obtained 87-98% overall accuracy for treatment planning. Finally, the AI-generated treatment plan obtained 75-95% clinician acceptance rate.</p><p><strong>Conclusions: </strong>By integrating the IOS, CBCT, FS, and JMT, a comprehensive virtual patient can be created to facilitate seamless communication and effective treatment planning. This AI-integrated workflow may enhance interdisciplinary coordination and treatment planning. However, prospective clinical studies are required to validate their effects on patient outcomes and satisfaction.</p>","PeriodicalId":16887,"journal":{"name":"Journal of prosthodontic research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between oral frailty and well-being in community-dwelling older adults in Japan.","authors":"Agatha Ravi Vidiasratri, Masanori Iwasaki, Maki Shirobe, Tatsunosuke Gomi, Keiko Motokawa, Takahisa Ohta, Lisdrianto Hanindriyo, Tsuyoshi Okamura, Hiroyuki Sasai, Hirohiko Hirano","doi":"10.2186/jpr.JPR_D_25_00248","DOIUrl":"https://doi.org/10.2186/jpr.JPR_D_25_00248","url":null,"abstract":"<p><strong>Purpose: </strong>The epidemiological mechanisms linking poor oral health and oral function to declining well-being among older adults remain unclear. This study examined the association between oral frailty and well-being among community-dwelling older adults in Japan and explored potential mediating pathways across the physical, psychological, and social domains.</p><p><strong>Methods: </strong>Data were drawn from the 2023 wave of the Itabashi Longitudinal Study on Aging, including participants aged ≥70 years. Oral frailty was assessed using the Oral Frailty 5-item Checklist. Generalized structural equation modeling (GSEM) was used to estimate the indirect effects of oral frailty on well-being, measured using the Philadelphia Geriatric Center Morale Scale (PGCMS) and the Cantril Self-Anchoring Striving Scale (CSASS), through physical frailty, undernutrition, depressive symptoms, cognitive impairment, and social isolation.</p><p><strong>Results: </strong>A total of 849 older adults (503 men and 346 women; mean age = 75.8 years) were analyzed. The prevalence of oral frailty was 40.2%. The PGCMS showed significant indirect associations between oral frailty and two candidate mediators in the GSEM: undernutrition (b = -0.27, 95% confidence interval [CI]: -0.54 to -0.01) and depressive symptoms (b = -1.35, 95% CI: -1.96 to -0.74). Similar findings were observed for the CSASS, with depressive symptoms (b = -0.66, 95% CI: -0.96 to -0.36) and social isolation (b = -0.14, 95% CI: -0.25 to -0.03) emerging as significant mediators.</p><p><strong>Conclusions: </strong>Oral frailty is indirectly associated with poorer well-being in older Japanese adults, with GSEM estimates suggesting biological and social pathways involving nutritional status, mental health, and social engagement.</p>","PeriodicalId":16887,"journal":{"name":"Journal of prosthodontic research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148015961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histological evaluation of the soft tissue response to plasma-activated healing abutments: A prospective controlled clinical trial.","authors":"Luigi Canullo, Paolo Pesce, Ugo Covani, Virginia Cameroni, Valerio Massimo Sora, Yohei Jinno, Ugo Consolo, Paolo Savadori","doi":"10.2186/jpr.JPR_D_25_00207","DOIUrl":"https://doi.org/10.2186/jpr.JPR_D_25_00207","url":null,"abstract":"<p><strong>Purpose: </strong>This prospective clinical trial aimed to histologically evaluate peri-implant soft tissue response to healing abutments treated with a vacuum plasma reactor.</p><p><strong>Methods: </strong>Thirty bone-level implants were placed with machined healing abutments designed to be retrieved using a calibrated mucotome after soft-tissue healing. Test abutments were plasma-activated immediately before placement, whereas control abutments were left untreated. After 3 months, plaque index and bleeding on probing were recorded prior to collecting peri-implant soft-tissue biopsies. The specimens were processed and evaluated clinically and histologically.</p><p><strong>Results: </strong>Thirty patients with 30 implants completed the study. Histological evaluation showed lower inflammation scores in the basal zone around plasma-activated abutments (P = 0.04). Mean inflammation scores in the test group were 2.78 ± 0.7, 2.52 ± 0.5, and 1.72 ± 0.5 in the upper, intermediate, and basal zones, respectively, compared with 3.28 ± 0.8, 2.93 ± 0.6 and 2.36 ± 0.5 in controls. Connective-tissue maturation and epithelial regeneration were comparable between groups (approximately 3.1 and 3.0, respectively). Vascularization was slightly higher in the test group (1.20 ± 0.19 vs. 1.09 ± 0.05). The cornified layer contacting the abutment was significantly thicker in the test group (2.89 ± 0.8 vs. 1.91 ± 0.7, P = 0.008). No significant differences were observed for plaque index, whereas bleeding on probing was lower in the test group.</p><p><strong>Conclusions: </strong>Plasma-activated healing abutments were associated with localized histological differences at the epithelial-abutment interface, particularly in basal inflammation and cornified layer thickness, while most parameters remained comparable between groups.</p>","PeriodicalId":16887,"journal":{"name":"Journal of prosthodontic research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148015903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of dental implant treatment for occlusal reconstruction in a congenital acute myeloid leukemia survivor.","authors":"Ryo Kajihara, Hironori Sakai, Yuki Sakai, Hiroki Otagiri, Daisuke Higuchi, Hiroshi Kurita","doi":"10.2186/jpr.JPR_D_25_00217","DOIUrl":"https://doi.org/10.2186/jpr.JPR_D_25_00217","url":null,"abstract":"<p><strong>Patients: </strong>The patient was an 11-year-old boy with a medical history of congenital acute myeloid leukemia (AML). He received a series of treatments between 1 and 8 months of age, including chemotherapy, total body irradiation, and peripheral blood stem cell transplantation. Although the permanent incisors had erupted, both crown and root formation were incomplete. No tooth buds were observed for the remaining permanent teeth. The deciduous teeth were still present; however, their roots were shortened and showed mobility. At 18 years of age, growth of the upper and lower jaws had ceased; therefore, occlusal rehabilitation was performed using implants. All teeth except the first molars were extracted, and six implants were placed in the jaws. A screw-retained, implant-supported bridge was fitted, and regular follow-up and maintenance were scheduled. Four years and 9 months after placement of the final prosthesis, the occlusion has remained stable.</p><p><strong>Discussion: </strong>This patient had congenital AML and received chemotherapy during early childhood, coinciding with the critical period of tooth development and resulting in root shortening, tooth microdontia, and absence of tooth buds for the permanent teeth. Following completion of maxillofacial growth, occlusal rehabilitation was performed using implants, and the occlusion has remained stable. The findings of the present case suggest that implant-supported prosthetic treatment represents an effective option for full occlusal reconstruction in congenital AML survivors with severe hypodontia.</p><p><strong>Conclusions: </strong>Dental implant treatment for full occlusal reconstruction in a patient with severe hypodontia who had received chemotherapy for AML is described herein.</p>","PeriodicalId":16887,"journal":{"name":"Journal of prosthodontic research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147982414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of anterior CAD-CAM composite-resin crowns: A 5-year retrospective cohort study.","authors":"Yu Takaesu, Yuki Nakamura, Kazuhiko Yamada, Kota Isshi, Yuichiro Yamaguchi, Naoyuki Kaga, Takashi Matsuura","doi":"10.2186/jpr.JPR_D_25_00383","DOIUrl":"https://doi.org/10.2186/jpr.JPR_D_25_00383","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to compare the 5-year cumulative survival and success rates of anterior CAD-CAM composite-resin crowns and identify the risk factors for complications associated with these restorations.</p><p><strong>Methods: </strong>Clinical data were analyzed for consecutive single anterior CAD-CAM composite-resin crowns placed over a 5-year period and post-treatment events recorded during follow-up. Survival curves for the CAD-CAM composite-resin crowns were generated using Kaplan-Meier analysis, and statistical differences between the groups were assessed using the log-rank test. Cox proportional hazards analysis was performed to identify the risk factors for complications.</p><p><strong>Results: </strong>The 5-year cumulative survival and success rates of CAD-CAM composite-resin crowns were 95.6% and 91.5%, respectively. The 5-year cumulative success rate was significantly higher in the buccolingual total occlusal convergence (TOC) < 20° group than in the buccolingual TOC > 20° group (P = 0.021). In addition, the incidence of complications was significantly greater in the buccolingual TOC > 20° group than in the buccolingual TOC < 20° group (P = 0.024; hazard ratio, 22.105).</p><p><strong>Conclusions: </strong>Anterior CAD-CAM composite-resin crowns demonstrated significantly high 5-year survival and success rates. However, a buccolingual TOC > 20° might be associated with an increased risk of complications.</p>","PeriodicalId":16887,"journal":{"name":"Journal of prosthodontic research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147982394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pilot study on the feasibility of using GPT-5.0 for objective esthetic assessment of single-tooth restorations.","authors":"Guanqi Liu, Yuanxiang Liu, Xiaoyan Chen, Yuhan Hou, Jiahui Lin, Runzhong Liu, Runheng Liu","doi":"10.2186/jpr.JPR_D_25_00336","DOIUrl":"https://doi.org/10.2186/jpr.JPR_D_25_00336","url":null,"abstract":"<p><strong>Purpose: </strong>Large language models (LLMs) are increasingly used in dental esthetic assessment, yet evidence of their feasibility and reliability for objective scoring of single-tooth restorations remains limited. This preliminary study explored the potential of GPT-5.0 for esthetic evaluation using established indices and compared its performance with experienced clinicians and senior dental students.</p><p><strong>Methods: </strong>A retrospective dataset of 46 maxillary central incisor restorations with natural adjacent teeth and standardized, high-quality photographs was analyzed. Each case was independently scored using the Pink Esthetic Score (PES) and White Esthetic Score (WES) by three expert prosthodontists, three calibrated senior dental students, and GPT-5.0 guided by a detailed prompt and expert examples. Intra- and inter-group reliability were assessed using intraclass correlation coefficients (ICCs), and group differences were evaluated with repeated-measures analysis of variance.</p><p><strong>Results: </strong>GPT-5.0 showed high internal consistency and strong agreement with human raters, particularly for restorative (WES) parameters. ICCs between GPT-5.0 and expert consensus were 0.944 (total), 0.868 (PES), and 0.943 (WES). Minor but significant differences occurred in certain soft tissue (PES) subitems (P = 0.035), with slightly greater variability than that of the human raters. Reliability was lower for subjective soft tissue parameters, especially the mesial papilla and soft tissue convexity/color/texture subitems; generalizability beyond idealized conditions remains to be established.</p><p><strong>Conclusions: </strong>With detailed guidance, GPT-5.0 can approach expert-level performance for objective scoring of single-tooth restorations in a controlled setting, but reliability is lower for subjective soft tissue parameters, and broader clinical validation is needed before routine implementation.</p>","PeriodicalId":16887,"journal":{"name":"Journal of prosthodontic research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147982433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chlorhexidine-miconazole-loaded iron oxide nanoparticles inhibit denture stomatitis biofilms in vitro.","authors":"Wilmer Ramírez-Carmona, Caio Sampaio, Heitor Ceolin Araujo, Jose Antônio Fernandes Silva, Douglas Henrique Sales, Valdemiro Pereira de Carvalho-Jr, Agda Eunice de Souza, Rosana Leal do Prado, Thayse Yumi Hosida, Alberto Carlos Botazzo Delbem, Juliano Pelim Pessan, Douglas Roberto Monteiro","doi":"10.2186/jpr.JPR_D_25_00220","DOIUrl":"https://doi.org/10.2186/jpr.JPR_D_25_00220","url":null,"abstract":"<p><strong>Purpose: </strong>This study used chitosan (CS)-coated iron oxide nanoparticles (IONPs) to create a dual-nanocarrier consisting of chlorhexidine (CHX) and miconazole (MCZ) and assessed their impact on a denture stomatitis microcosm biofilm.</p><p><strong>Methods: </strong>CHX and MCZ were immobilized on IONPs functionalized with CS and the nanocarriers were characterized by physicochemical tests. Biofilms originating from the saliva of patients with denture stomatitis were formed on acrylic surfaces and were treated with IONPs-CS carrying different concentrations of CHX-MCZ (7.8, 19.5, 39, or 78 µg/mL). Untreated biofilms served as the negative control (NC), whereas IONPs, CS, and CHX-MCZ served as controls. Biomass, metabolism, lactic acid generation, number of cultivable cells, cell viability, and biofilm thickness were assessed. Analysis of Variance (ANOVA) or Kruskal-Wallis tests were used to examine all results, and then the Student-Newman-Keuls post hoc test was applied (α=0.05).</p><p><strong>Results: </strong>The nanocarriers were spherical with a diameter of 6.6 nm. The nanocarrier concentration of 78 µg/mL increased the biomass compared with NC. This nanocarrier compound also reduced metabolism and lactic acid generation, surpassing the effects of CHX-MCZ. For the total microorganism and Streptococcus mutans loads, IONPs-CS-CHX-MCZ behaved similarly to CHX-MCZ, and both led to significant reductions relative to NC. The nanocarrier reduced cell viability and increased biofilm thickness compared with the NC.</p><p><strong>Conclusions: </strong>The dual nanocarriers showed an antibiofilm effect equal to or greater than that of CHX-MCZ, depending on the variable analyzed. Nanotherapy has potential for use in mouthwashes, denture cleaning solutions, or anti-biofilm mucoadhesive coatings.</p>","PeriodicalId":16887,"journal":{"name":"Journal of prosthodontic research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147982370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}