Journal of prosthodontic research最新文献

{"title":"Effects of post-polymerization conditions on the mechanical properties of 3D-printed dental resin nanocomposite.","authors":"Keyu Qi, Tamaki Hada, Xiangyu Ren, Maiko Iwaki, Shunsuke Minakuchi, Manabu Kanazawa","doi":"10.2186/jpr.JPR_D_24_00221","DOIUrl":"https://doi.org/10.2186/jpr.JPR_D_24_00221","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the optimal post-polymerization temperature and time to enhance the mechanical properties of three-dimensional (3D)-printed nanocomposites.</p><p><strong>Methods: </strong>A control group of pure 3D-printed resin was used to fabricate specimens post-polymerized at 40 °C for 15 min (n = 6). Next, 3-wt% functionalized yttria-stabilized zirconia (YSZ) nanoparticles were dispersed in a 3D-printed resin to fabricate YSZ-based nanocomposites for the experimental groups. The post-polymerization conditions of six experimental groups (n = 6) were set as two temperatures (40 °C and 80 °C) and three time periods (30, 60, and 90 min). The degree of conversion (DC), flexural strength, modulus, fractography, and hardness values of each group were evaluated. One-way and two-way analysis of variance were applied to analyze significant differences among the control and experimental groups and interaction effect of temperature and time of post-polymerization, respectively (α = 0.05).</p><p><strong>Results: </strong>Significant reductions in DC values were noted in the experimental groups compared to the control group. The experimental groups demonstrated significantly higher flexural strengths and moduli than those of the control group. At 80 °C, no significant differences were observed for different post-polymerization times. Compared to post-polymerization at 40 °C, the flexural strength, modulus, and hardness were significantly enhanced when the post-polymerization temperature was increased to 80 °C.</p><p><strong>Conclusions: </strong>Optimal mechanical properties of 3D-printed YSZ-based nanocomposites could be achieved under post-polymerization at 80 °C and 30 min.</p>","PeriodicalId":16887,"journal":{"name":"Journal of prosthodontic research","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of restorative materials on biomechanical behavior of endocrown and post-core restorations: A 3-dimensional finite element analysis.","authors":"Filiz Yagci, Emir Esim, Ravza Eraslan, Fehime Alkan Aygor","doi":"10.2186/jpr.JPR_D_24_00096","DOIUrl":"https://doi.org/10.2186/jpr.JPR_D_24_00096","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated biomechanical behavior of endocrown and post-core restorations produced from computer aided design/computer aided manufacturing (CAD/CAM) and traditional materials in severely damaged teeth that lack a ferrule and assessed the associated failure risk of resin cement.</p><p><strong>Methods: </strong>A phantom maxillary central incisor and mandibular second premolar were trimmed 1 mm coronally to the cemento-enamel junction, the root canals were enlarged, and the teeth were scanned. Data were transferred to a solid modeling software. Twenty-two models were constructed, including endocrowns (hybrid ceramic, lithium disilicate, and polyetheretherketone [PEEK]) and post-cores (glass-fiber post/composite core; glass-fiber single-piece post-core; PEEK single-piece post-core; gold single-piece post-core). Hybrid ceramic and lithium disilicate crowns were modeled on the post-cores. Loads of 100 N for the central incisor and 300 N for the premolar were applied in a 45° oblique direction. von Mises stresses were analyzed on both root dentin and restorations, and the failure risks for the resin cement were calculated.</p><p><strong>Results: </strong>The highest stresses were found at the roots of the PEEK endocrown (37.6 MPa) for the central incisor and of the lithium disilicate endocrown for the premolar (40.0 MPa) among endocrown groups. PEEK endocrowns had the lowest stress within the restoration and presented a higher risk of cement failure. The glass-fiber post/composite core groups demonstrated the highest adhesive and cohesive failure risks for post cement.</p><p><strong>Conclusions: </strong>For the central incisor and mandibular premolar, lithium disilicate and PEEK endocrowns, respectively, generated less stress at the root. However, PEEK endocrowns had a higher risk of cement failure.</p>","PeriodicalId":16887,"journal":{"name":"Journal of prosthodontic research","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between denture restoration for tooth loss and cognitive impairment: A systematic review and meta-analysis.","authors":"Xinyi Ma, Yichi Zhang, Jiaying Wang, Chaoming Hu, Xuejia Zhang, Xinhua Hong, Shuomin Chen, Jun Wang, Liang Chen, Yutian Wu, Qinhui Zhang, Yilin Wang, Menghan Wu, Yuge Chen, Shengbin Huang","doi":"10.2186/jpr.JPR_D_24_00060","DOIUrl":"https://doi.org/10.2186/jpr.JPR_D_24_00060","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the association between denture restoration and cognitive impairment through a meta-analysis and to assess the correlation between different degrees of tooth loss.</p><p><strong>Study selection: </strong>Observational studies exploring the association between denture restoration and cognitive function were systematically searched across six databases from January 2000 to January 2024. Two researchers independently searched electronic databases and extracted relevant studies from all articles.</p><p><strong>Results: </strong>This study included 24,252 participants from six observational studies. The risk ratio and 95% confidence interval (CI) were used to compare the risk of cognitive impairment. Participants who experienced tooth loss without dentures had a 1.27-fold (95% CI: 1.20-1.38) higher risk of cognitive impairment, whereas those with dentures had only a 1.01-fold (95% CI: 0.92-1.12) higher risk. In the dose-response analysis, the risk of cognitive impairment in the non-denture group increased by 1.009 times (95% CI: 1.006-1.012) for each tooth lost, whereas the denture restoration group showed a 1.003 times (95% CI: 1.000-1.006) increased risk. The years of follow-up and clinical measurement tools simultaneously explained this heterogeneity.</p><p><strong>Conclusions: </strong>This study provides detailed evidence of a potential association between denture restoration and a reduced risk of cognitive impairment. Furthermore, there was a correlation between denture restoration and a reduced impact of the number of teeth lost on the risk of cognitive impairment. Therefore, timely and reasonable denture restoration may contribute to prevent cognitive impairment.</p>","PeriodicalId":16887,"journal":{"name":"Journal of prosthodontic research","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of build orientation on trueness and adaptation of intaglio surface of maxillary complete denture metal frameworks fabricated by selective laser melting.","authors":"Wenrui Qu, Atsushi Takaichi, Yuka Kajima, Shingo Kamijo, Noriyuki Wakabayashi","doi":"10.2186/jpr.JPR_D_24_00195","DOIUrl":"https://doi.org/10.2186/jpr.JPR_D_24_00195","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to evaluate the trueness and adaptation of the intaglio surfaces of complete denture metal frameworks fabricated using selective laser melting (SLM) with different building orientations (0°, 45°, and 90°).</p><p><strong>Methods: </strong>Cobalt-chromium maxillary complete denture metal frameworks were fabricated at 0°, 45°, and 90° using SLM. Trueness measurements were conducted using the best-fit alignment method of three-dimensional inspection software, and adaptation was evaluated using the silicone replica technique. Nonparametric Kruskal-Wallis and Bonferroni tests were performed to determine differences among the groups (P = 0.05).</p><p><strong>Results: </strong>No significant differences were observed in the root mean square (RMS), positive, and negative deviation values between 0° and 45° group (P > 0.05), and the median, first quartile, and third quartile of each were considered clinically acceptable. For the 90° group, the RMS, positive deviation, and negative deviation values were significantly higher than those of the other groups (P < 0.05). The overall adaptation of the 45° group was better than that of the 0° and 90° groups (P < 0.05), whereas the 0° and 90° groups showed no significant difference (P > 0.05).</p><p><strong>Conclusions: </strong>The trueness and adaptation of the intaglio surface of cobalt-chromium maxillary complete denture metal frameworks were affected by the building orientation through SLM. Considering both trueness and adaptation, 45° is recommended as the most efficient build orientation for clinical applications.</p>","PeriodicalId":16887,"journal":{"name":"Journal of prosthodontic research","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between oral health and multidimensional flourishing: A cross-sectional study from Japan Gerontological Evaluation Study (JAGES).","authors":"Kewei Wang, Shiho Kino, Yusuke Matsuyama, Koichiro Shiba, Atsushi Nakagomi, Katsunori Kondo, Kokoro Shirai, Kenji Fueki, Jun Aida","doi":"10.2186/jpr.JPR_D_24_00009","DOIUrl":"https://doi.org/10.2186/jpr.JPR_D_24_00009","url":null,"abstract":"<p><strong>Purpose: </strong>Human flourishing is a multidimensional concept that encompasses happiness and life satisfaction (happiness), mental and physical health (health), meaning and purpose (purpose), character and virtue (character), and close social relationships (social), which are characterized by comprehensive well-being. This cross-sectional study investigated the association of oral health, number of remaining teeth, and prosthesis use with multidimensional flourishing.</p><p><strong>Methods: </strong>Data was sourced from the 2022 wave of the Japan Gerontological Evaluation Study, a population-based survey of independent individuals aged 65 years or older. This study utilized multilevel linear regression with multiple imputations. The covariates included sex, age, income, education, marital status, smoking status, diabetes history, instrumental activities of daily living, and depressive symptoms.</p><p><strong>Results: </strong>This study included 87,201 participants with a mean age of 74.87 years [standard deviation (SD)=6.30], and mean±SD composite flourishing index of 6.77±1.64. Multilevel multivariable regression showed that individuals with dental prostheses or more teeth had a higher flourishing index. Among individuals without dental prostheses, those with >20 teeth showed a composite flourishing index of 0.34 units higher (95% confidence interval (95% CI): 0.26-0.42, P < 0.001) than those with 0-9 teeth. Among those with 0-9 teeth, individuals with dental prostheses showed 0.21 (95% CI: 0.12-0.29, P < 0.001) higher units compared to those without prostheses. The interaction analysis showed that dental prosthesis use was significantly associated with higher indices, especially among those with fewer teeth.</p><p><strong>Conclusions: </strong>Teeth and prostheses were independently associated with multidimensional flourishing. Using dental prostheses may enhance multidimensional flourishing among individuals with fewer remaining teeth.</p>","PeriodicalId":16887,"journal":{"name":"Journal of prosthodontic research","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anodized and hydrothermally treated titanium with a nanotopographic structure combined with dental pulp stem cells promotes bone formation in a rat calvarial bone defect model.","authors":"Toshiyuki Kobayashi, Masaki Hata, Yoshihiko Sugita, Atsushi Aoyagi, Ryohei Matsukawa, Yuka Imanishi, Takeshi Hagio, Kensuke Kuroda, Hatsuhiko Maeda, Jun Takebe","doi":"10.2186/jpr.JPR_D_24_00176","DOIUrl":"https://doi.org/10.2186/jpr.JPR_D_24_00176","url":null,"abstract":"<p><strong>Purpose: </strong>Spark-discharged anodic oxidation coating on commercially pure titanium (SAc.p.Ti) has been shown to promote bone conduction and bone matrix mineralization during new bone formation. This study hypothesized that the combination of SAc.p.Ti with dental pulp stem cells (DPSCs) would enhance new bone formation. The objective was to evaluate the effect of this combination in a rat bone defect model.</p><p><strong>Methods: </strong>DPSCs were isolated from Sprague-Dawley (SD) rat incisors and cultured. Calvarial bone defects were created in SD rats, followed by transplantation of commercially pure titanium (c.p.Ti), SAc.p.Ti, or SAc.p.Ti combined with DPSCs. Bone formation was assessed using micro-computed tomography (micro-CT). Toluidine blue O staining was employed to evaluate bone-implant contact and the newly formed bone area. Hematoxylin-eosin (HE) staining was performed to identify osteoblast-like cells.</p><p><strong>Results: </strong>Micro-CT analysis revealed hard tissue formation on the surface of SAc.p.Ti. Toluidine blue O staining showed significantly greater bone-implant contact and newly formed bone area in the SAc.p.Ti/DPSC group compared to the c.p.Ti and SAc.p.Ti groups. HE staining confirmed the presence of osteoblast-like cells at the defect margins, with evidence of new bone formation on the surface of SAc.p.Ti and in the SAc.p.Ti/DPSC groups.</p><p><strong>Conclusions: </strong>The combination of SAc.p.Ti and DPSCs presents a promising strategy for promoting new bone formation in rat calvarial defect model.</p>","PeriodicalId":16887,"journal":{"name":"Journal of prosthodontic research","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association among prosthodontic treatment, dietary diversity, and ingestible food profile in older outpatients with missing teeth.","authors":"Kazuki Sakamoto, Aya Kimura-Ono, Yoko Kurosaki, Takuya Mino, Shinsuke Nakagawa, Yuji Shimomura, Kou Omori, Takaharu Higuchi, Eri Koyama, Kumiko Nawachi, Kana Tokumoto, Yuji Tsuchiyama, Tokihiro Fukutoku, Mitsuaki Ono, Takuo Kuboki","doi":"10.2186/jpr.JPR_D_24_00150","DOIUrl":"https://doi.org/10.2186/jpr.JPR_D_24_00150","url":null,"abstract":"<p><strong>Purpose: </strong>In this cross-sectional study, we aimed to investigate the association among dietary diversity, ingestible food profiles, and the type of prosthodontic treatment (i.e., removable partial or complete dentures [RD] vs. implant-supported dentures [ID], including implant-supported fixed prostheses and implant-assisted overdentures) in older Japanese outpatients.</p><p><strong>Methods: </strong>We included 297 patients aged ≥65 years (mean age, 75.3 years) undergoing maintenance therapy for RD or ID. Dietary diversity was assessed using the Dietary Variety Score (DVS) questionnaire. The ingestible food profile, a subjective quantification of the ability to consume foods with high masticatory difficulty, was evaluated using a validated ingestible food questionnaire and assessed using the ingestible food score (IFS). DVS- and IFS-related factors were identified using multiple regression analyses.</p><p><strong>Results: </strong>The median IFS of the ID group (100.0) was significantly higher than that of the RD group (84.5); however, the median DVS showed no statistically significant difference between the two groups. After adjusting for confounding factors, prosthodontic treatment type (RD) and the number of present teeth (≤20) were found to be significantly associated with low IFS, whereas young age and presence of cardiovascular disease were significantly associated with low DVS.</p><p><strong>Conclusions: </strong>Older individuals with ID had a better ingestible food profile than those with RD; however, dietary diversity did not differ significantly between the two groups. RD is a potential risk factor for poor ingestible food profile, whereas the prosthodontic treatment type is not a direct risk factor for low dietary diversity.</p>","PeriodicalId":16887,"journal":{"name":"Journal of prosthodontic research","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular senescence of RANKL⁺ osteoblasts and Th17 cells in severe periodontitis with occlusal trauma.","authors":"Yutian Wang, Masato Nakagawa, Chuyi Luo, Ryuhei Kanda, Yasuhiko Matsushima, Aki Nishiura, Yoshitomo Honda","doi":"10.2186/jpr.JPR_D_24_00294","DOIUrl":"https://doi.org/10.2186/jpr.JPR_D_24_00294","url":null,"abstract":"<p><strong>Purpose: </strong>Excessive occlusal forces resulting from inadequate dental prosthesis, along with periodontal infection (PI), lead to severe periodontitis; however, the roles of senescent cells and their involvement in the mechanisms underlying this process remain unclear. Therefore, this study aimed to elucidate the roles of senescent cells and their cell types in severe periodontitis with excessive force (occlusal trauma [OT]).</p><p><strong>Methods: </strong>To determine whether senescent cells exacerbate alveolar bone resorption, we developed a severe periodontitis rat model by inducing PI and OT and assessed the presence of senescent cells and bone resorption. Senolytics (dasatinib + quercetin [DQ]) were administered to evaluate the changes in the appearance of senescent cells and bone resorption.</p><p><strong>Results: </strong>PI and OT + PI increased senescent cells as well as osteoclasts. Furthermore, p21 and receptor activator of nuclear factor-kappa B ligand (RANKL) co-expressing cells were observed in the OT + PI group rats, suggesting a correlation between bone resorption and senescent cells. Cell type analysis identified osteoblasts and Th17 cells as RANKL⁺ cells expressing p21 or p16. DQ administration reduced senescent cells and osteoclasts, thereby preventing alveolar bone resorption.</p><p><strong>Conclusions: </strong>RANKL⁺ senescent osteoblasts and Th17 cells are involved in osteoclastogenesis and bone resorption. Our findings highlight a new target for the prosthetic treatment of severe periodontitis.</p>","PeriodicalId":16887,"journal":{"name":"Journal of prosthodontic research","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statement on a new list of key points to summarize the standard of care for temporomandibular disorders.","authors":"Ryota Takaoka","doi":"10.2186/jpr.JPR_D_24_00343","DOIUrl":"https://doi.org/10.2186/jpr.JPR_D_24_00343","url":null,"abstract":"","PeriodicalId":16887,"journal":{"name":"Journal of prosthodontic research","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of assistive devices on the precision of digital implant impressions for fully edentulous maxilla: An in vivo study.","authors":"Keisuke Ashida, Minoru Sanda, Shinpei Tanaka, Kazuyoshi Baba","doi":"10.2186/jpr.JPR_D_24_00261","DOIUrl":"https://doi.org/10.2186/jpr.JPR_D_24_00261","url":null,"abstract":"<p><strong>Purpose: </strong>This study examined the effect of assistive device use on the precision of digital impressions for multiple implants placed in a fully edentulous maxilla in vivo.</p><p><strong>Methods: </strong>A total of eight participants with fully edentulous maxillae and four implants at position #15, #12, #22, and #25 were included in the study. The assistive device was made using CAD/CAM technology. Digital impressions were obtained using an intraoral scanner with (AD+) and without (AD-) the assistive device that attached to the scan bodies. Each participant underwent five digital and conventional impressions (verification casts (VC)). Dimensional deviations for each impression method were measured using the least-squares best-fit method to assess precision. Statistical analysis was performed using one-way analysis of variance (ANOVA) with Tukey's post-hoc adjustments for multiple comparisons.</p><p><strong>Results: </strong>The dimensional deviations were as follows: AD- (37.56 ± 7.43 µm), AD+ (16.23 ± 2.56 µm), and VC (26.48 ± 5.13 µm). One-way ANOVA revealed significant differences between the groups (F = 31.04, P < 0.0001), which remained after Tukey adjustment (P < 0.01). The AD+ group exhibited the highest precision, while the AD- group had the lowest.</p><p><strong>Conclusions: </strong>For implants placed in a fully edentulous maxilla in vivo, digital impressions with assistive devices demonstrated superior precision compared with those obtained without assistive devices or conventional impressions obtained with an implant indexing device.</p>","PeriodicalId":16887,"journal":{"name":"Journal of prosthodontic research","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}