Jurnal Respirologi Indonesia最新文献

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Role of Interventional Radiology in the Management of Massive Hemoptysis 介入放射学在大咯血治疗中的作用
Jurnal Respirologi Indonesia Pub Date : 2021-11-27 DOI: 10.36497/jri.v41i4.220
P. Sidipratomo, G. E. Sibarani
{"title":"Role of Interventional Radiology in the Management of Massive Hemoptysis","authors":"P. Sidipratomo, G. E. Sibarani","doi":"10.36497/jri.v41i4.220","DOIUrl":"https://doi.org/10.36497/jri.v41i4.220","url":null,"abstract":"Massive hemoptysis is one of the emergencies in respiratory system, representing hemorrhage of the bronchial or pulmonary vascular system into the respiratory tract. Massive hemoptysis is a life-threatening condition due to high risk of asphyxia it may induce. Bronchial artery embolization (BAE) is an interventional radiology procedure dedicated in the emergency management of massive hemoptysis. BAE is known for its great success rate and low risk of complications. Proper catheterization technique, recognition of bronchial artery variant anatomy and appropriate selection of embolic material agent proves essential in determining the success of this procedure. As a minimally invasive procedure, BAE is highly recommended to be used in cases of massive hemoptysis.","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"300 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133373310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation between Measurement of Lung Diffusion Capacity Using Single Breath Methods (DLCO-SB) and COPD Group in Persahabatan Hospital Jakarta 雅加达Persahabatan医院单次呼吸法肺弥散量测定(DLCO-SB)与COPD组的相关性
Jurnal Respirologi Indonesia Pub Date : 2021-11-27 DOI: 10.36497/jri.v41i4.218
Ef Ismail, F. Yunus, Triya Damayanti
{"title":"Correlation between Measurement of Lung Diffusion Capacity Using Single Breath Methods (DLCO-SB) and COPD Group in Persahabatan Hospital Jakarta","authors":"Ef Ismail, F. Yunus, Triya Damayanti","doi":"10.36497/jri.v41i4.218","DOIUrl":"https://doi.org/10.36497/jri.v41i4.218","url":null,"abstract":"Background: This was a preliminary study to measure DLCO-SB on COPD patients in Persahabatan Hospital to understand the prevalence of DLCO reduction among COPD patients.Methods: This was a cross sectional study of COPD patients who attended COPD-Asthma clinic in Persahabatan Hospital Jakarta. Spirometry and DLCO-SB were performed consecutively during May–July 2015.  Comorbidities were also recorded.Results: Spirometry and DLCO-SB measurements were conducted on 65 COPD subjects of which 10.8% subjects were in COPD Group A, 29.2% Group B, 32.3% Group C and 27.7% Group D. The mean age was 64.15; mean FEV1% was 46.05%, mean DLCO measured was 19.42 ml/min/mmHg and the mean DLCO% was 72.00%. The proportion of DLCO decline among COPD patients was 56.92%.  There were significant correlations between COPD group, GOLD COPD grade, FEV1, BMI and comorbidities with the DLCO value results. There were no significant correlation between DLCO value with sex, age, smoking history, Brinkmann Index, obstructive-restrictive criteria, comorbidities and length of COPD period. Conclusion: The proportion of DLCO decline among COPD patients was 56.92%. There were significant correlations between COPD group, GOLD COPD grade, FEV1, BMI and previous TB history with the results of DLCO.","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"7 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123887356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Specific levels of calcidiol, calcitriol, cathelicidin and interferon gamma in diabetic patients with TB infection in Jakarta, Indonesia; Case control study 印度尼西亚雅加达合并结核感染的糖尿病患者中骨化二醇、骨化三醇、抗菌素和干扰素γ的特定水平病例对照研究
Jurnal Respirologi Indonesia Pub Date : 2021-10-07 DOI: 10.36497/jri.v41i4.221
Y. Arliny, D. Yanifitri, B. Yanti, Diennisa Mursalin
{"title":"Specific levels of calcidiol, calcitriol, cathelicidin and interferon gamma in diabetic patients with TB infection in Jakarta, Indonesia; Case control study","authors":"Y. Arliny, D. Yanifitri, B. Yanti, Diennisa Mursalin","doi":"10.36497/jri.v41i4.221","DOIUrl":"https://doi.org/10.36497/jri.v41i4.221","url":null,"abstract":"Vitamin D plays a role in regulating the immune system via Vitamin D receptors, expressed by T-helper cells (Th). Cathelicidin LL-37 is an antimicrobial peptide that acts as the primary barrier against the Mycobacterium tuberculosis bacterial infection, which is induced by calcitriol, the active form of Vitamin D3. Interferon gamma (IFN-γ) is a cytokine released by Th-1 cells, and is essential for the elimination of M. tuberculosis. This study aims to determine the state of, and correlation between, calcidiol, calcitriol, cathelicidin and IFN-γ levels, as well as other clinical factors among patients with Type 2 Diabetes Mellitus (T2DM) with active TB coinfection. Further analysis is also performed to study the differences between T2DM patients with active tuberculosis, latent TB and without TB infection.","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"198 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122599559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric Hemoptysis 小儿咳血
Jurnal Respirologi Indonesia Pub Date : 2021-07-30 DOI: 10.36497/jri.v41i3.189
H. Faisal, F. Yunus, N. Rahajoe
{"title":"Pediatric Hemoptysis","authors":"H. Faisal, F. Yunus, N. Rahajoe","doi":"10.36497/jri.v41i3.189","DOIUrl":"https://doi.org/10.36497/jri.v41i3.189","url":null,"abstract":"Hemoptysis or expectoration of blood is one of the respiratory symptoms in children, hemoptysis is hard to detect because it is often swallowed. The common causes of hemoptysis in adults include bronchiectasis, tuberculosis, pulmonary mycosis, and lung cancer. On the other hand, hemoptysis in children is often caused by tracheobronchitis, pneumonia, bronchiectasis in cystic fibrosis, and foreign body aspiration. Bleeding of the pulmonary artery or bronchial artery is the cause of hemoptysis. Upper airway examination is important to rule out epistaxis as the cause of hemoptysis. The primary objectives of hemoptysis management are asphyxia management, bleeding cessation, and treatment of the underlying disease. When all other treatments fail to stop the bleeding, surgery is recommended.","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130419585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case Report Tuberculosis of The Prostate: Findings of Post Transurethral Resection of Prostate (TURP) Procedure 前列腺结核病例报告:经尿道前列腺切除术(TURP)后的发现
Jurnal Respirologi Indonesia Pub Date : 2021-07-30 DOI: 10.36497/JRI.V41I3.188
Kadek Dwi Cahyani, N. Yaniswari, Novitasari Novitasari
{"title":"Case Report Tuberculosis of The Prostate: Findings of Post Transurethral Resection of Prostate (TURP) Procedure","authors":"Kadek Dwi Cahyani, N. Yaniswari, Novitasari Novitasari","doi":"10.36497/JRI.V41I3.188","DOIUrl":"https://doi.org/10.36497/JRI.V41I3.188","url":null,"abstract":"Background: Prostate tuberculosis (PTB) is one of extra pulmonary tuberculosis which potentially has more frequent fatal complications and more severe quality of life deterioration. It is a very rare disease, with prevalence of 2.6% of all urogenital tuberculosis (UGTB). Prostate tuberculosis may be a sexually transmitted disease and leads to sexual dysfunction. \u0000Case: Male, 54 years old, with urinary retention, dysuria, flank pain in the last 1-month, recurrent urinary tract infection in the past 1 year and decrease body weight of 8 kg in 1 month. Physical examination demonstrates enlarged prostate. Patient was referred to Wangaya Hospital with benign prostate hyperplasia (BPH) and suspect malignancy. After underwent clinical and supporting examination, patient underwent TURP procedure. Histopathology examination revealed PTB. Patient was then treated with first line anti-tuberculosis drug (ATD). \u0000Discussion: Multiple risk factors are involved in TB disease. PTB spread occur through hematogenous, lymphatic, or direct routes. Clinical features and supporting examinations of PTB are non-specific. Diagnosis often made through incidental histology finding post TURP. Standard ATD regiment administered based on World Health Organization (WHO) guideline. Duration can be prolonged due to suboptimal concentration to prostate tissue. \u0000Conclusion: Multidisciplinary approach for extra pulmonary TB is needed. Thorough history taking, and high index of suspicion are important aspects. PTB diagnosis should be considered in patients with recurrent lower urinary tract symptoms refractory to standard therapy in TB endemic area.","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114692258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation of Ceramic Dust Content in Workplace with Lung Function in Ceramics Industry Workers of X Company, Mabar, Medan 棉兰市马巴尔市X公司陶瓷工业工人工作场所陶瓷粉尘含量与肺功能的相关性
Jurnal Respirologi Indonesia Pub Date : 2021-07-30 DOI: 10.36497/JRI.V41I3.187
Endy Todo Sirait, A. P. Tarigan, N. Nainggolan, P. Eyanoer
{"title":"Correlation of Ceramic Dust Content in Workplace with Lung Function in Ceramics Industry Workers of X Company, Mabar, Medan","authors":"Endy Todo Sirait, A. P. Tarigan, N. Nainggolan, P. Eyanoer","doi":"10.36497/JRI.V41I3.187","DOIUrl":"https://doi.org/10.36497/JRI.V41I3.187","url":null,"abstract":"Background: Workers in the ceramics industry are often exposed to silica content which is unwittingly inhaled and deposited in the lungs. Macrophages will release Interleukin 8 (IL-8), a chemoattractant that causes neutrophil recruitment to the alveoli and releases proteolytic enzymes that damage the lung parenchyma and cause a decrease in lung function. This study aimed to determine whether dust level correlate with IL-8 serum in ceramic industry workers. \u0000Method: This research is an analytic study with a cross-sectional design conducted in March–June 2019 in the X Ceramic Industry in Mabar, Medan. Personal Dust Sampler was used to measure dust level of the study subjects at work sites. Lung function was measured by spirometry. Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS) software. \u0000Results: A total of 35 male workers were divided into 3 working sections, 11 (31.4%) in the pre-compression section, 13 (37.1%) in the compression section and 11 (31.4%) in the sintering section. Dust levels at each working section were 24.8, 29.2, and 6.11, respectively. The lung function examination showed restrictive impairment in 21 subjects (60%). Statistical analysis showed that the higher the level of dust in the workplace, the lower the value of Forced Expiratory Volume 1 (FEV1) and Forced Vital Capacity (FVC) values, although this correlation was not statistically significant (r = -0.03 and -0.22 respectively; p> 0.05). \u0000Conclusion: There was no significant relationship between workplace dust levels and lung function in ceramic workers.","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114979153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk Factors Affecting Respiratory Symptoms and Impaired Lung Function of Palm Oil Mill Workers in the District of Kandis 影响坎迪斯地区棕榈油厂工人呼吸道症状和肺功能受损的危险因素
Jurnal Respirologi Indonesia Pub Date : 2021-07-30 DOI: 10.36497/JRI.V41I3.194
Surya Hajar Fitria Dana, Indi Esha, F. Yunus, Adrianison Adrianison, Azizman Saad, Ridha Restilla
{"title":"Risk Factors Affecting Respiratory Symptoms and Impaired Lung Function of Palm Oil Mill Workers in the District of Kandis","authors":"Surya Hajar Fitria Dana, Indi Esha, F. Yunus, Adrianison Adrianison, Azizman Saad, Ridha Restilla","doi":"10.36497/JRI.V41I3.194","DOIUrl":"https://doi.org/10.36497/JRI.V41I3.194","url":null,"abstract":"Background: Air pollution that exposed to human have been a problem all over the world and caused a variety of lung disease. Gases and particles emitted from industry including sulfur oxide, nitrogen oxide, and particulate matter may lead to decreasing lung function. Sulfur dioxide is one of the highest causes of air pollution at the highest level. Workers exposure to gases were vulnerable to respiratory function abnormality. \u0000Methods: A study on the effect of risk factors and sulfur dioxide exposure on lung function of palm oil workers in the district of Kandis was carried out in December 2019–January 2020. The research aim at describing sulfur dioxide air ambient in palm oil mill as well as respiratory state of palm oil workers and analyzing sulfur dioxide exposure and lung function relationship. \u0000Result: The result showed that sulfur dioxide concentration in outdoor 25.7 µg/Nm3 and indoor 20.6 µg/Nm3. The result of spirometry showed obstruction in 13% of the workers. Breathlessness and productive cough are the most common symptoms. Several factors that correlated with lung function namely as personal protective equipment (p=0.001), length of working (p=0.003), and smoking habit (p=0.004). From multivariate analysis, personal protective equipment has a significant correlation with lung function (p=0.038). \u0000Conclusion: Increasing the concentration of sulfur dioxide may cause decreased of lung function but other factor like personal protective equipment showed a significant correlation with lung function.","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116460540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Covid-19 Patient Condition at Early Pandemic in Jakarta 雅加达Covid-19大流行早期患者状况
Jurnal Respirologi Indonesia Pub Date : 2021-07-30 DOI: 10.36497/JRI.V41I3.193
A. Putra, W. Wiyono, M. F. Alatas, Aulya Fairuz, F. Fransiska, Bettia Bermawi, Ratna Moniqa, H. Koncoro, L. A. Pramono, M. Sulistio, R. Ramzi, R. Sinto, R. Hamonangan, C. Irianti, J. B. E. Sumargono
{"title":"Covid-19 Patient Condition at Early Pandemic in Jakarta","authors":"A. Putra, W. Wiyono, M. F. Alatas, Aulya Fairuz, F. Fransiska, Bettia Bermawi, Ratna Moniqa, H. Koncoro, L. A. Pramono, M. Sulistio, R. Ramzi, R. Sinto, R. Hamonangan, C. Irianti, J. B. E. Sumargono","doi":"10.36497/JRI.V41I3.193","DOIUrl":"https://doi.org/10.36497/JRI.V41I3.193","url":null,"abstract":"Background: COVID-19 is a disease caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) that has become a pandemic. It became apparent that COVID-19 transmitting from person to person. The clinical manifestations and characteristics of COVID-19 encompassing from asymptomatic infection until severe pneumonia and death. This study aimed to describe and compare the characteristics between COVID-19 suspected patients and confirmed patients at an early pandemic in Jakarta, Indonesia. \u0000Methods: A cross-sectional design was used in this study. Data were collected from March to April 2020 using the electronic health record reporting database, initial laboratory tests, and RT-PCR for SARS-CoV-2 results. There were 58 subjects: 43 COVID-19 confirmed patients and 15 COVID-19 suspected patients. \u0000Results: Male was found predominantly in COVID-19 confirmed patients than female. The mean age of confirmed patients was 49,6 years old. Nearly half of the confirmed patients had comorbidities namely hypertension and diabetes mellitus. Fever and cough were the most common presenting symptoms, and they were also found in suspected patients. Confirmed patients tended to have lymphopenia and neutrophilia. Pulmonary infiltrate was the most common feature in both confirmed and suspected patients. \u0000Conclusion: There were no significant differences found between COVID-19 confirmed and suspected cases regarding demographic characteristics, comorbidities, presenting symptoms, physical examination results, laboratory tests, and chest x-ray results. COVID-19 confirmed patients had a history of exposure to COVID-19 confirmed patients.","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"25 7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125976777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Pleura Fluid Leukocyte Levels Test in Establish of Pleura Tuberculosis Effusion in Exudative Pleural Effusion Patients at H. Adam Malik General Hospital Medan in 2018 2018年棉兰Adam Malik总医院渗出性胸腔积液患者胸膜液白细胞水平测定
Jurnal Respirologi Indonesia Pub Date : 2021-07-30 DOI: 10.36497/JRI.V41I3.182
S. Wulandari, Fajrinur Syahrani, Ade Rahmaini, P. Eyanoer
{"title":"Pleura Fluid Leukocyte Levels Test in Establish of Pleura Tuberculosis Effusion in Exudative Pleural Effusion Patients at H. Adam Malik General Hospital Medan in 2018","authors":"S. Wulandari, Fajrinur Syahrani, Ade Rahmaini, P. Eyanoer","doi":"10.36497/JRI.V41I3.182","DOIUrl":"https://doi.org/10.36497/JRI.V41I3.182","url":null,"abstract":"Background: Tuberculous pleural effusion is an accumulation of fluid in the pleural cavity produced by Mycobacterium tuberculosis (MTB). The gold standard of TB pleural effusion diagnosis is to obtain TB bacilli in pleural fluid or pleural tissue. However, this is often constrained due to the low identification level of these bacilli and the slow growth of MTB cultures. This study aimed to assess the pleural fluid leukocyte level in establishing a diagnosis of pleural effusion caused by TB. Methods: This was a diagnostic study conducted on 111 patients with pleural effusion, caused by TB, malignancy or non-TB infections that were assigned by supporting examinations obtained from medical records, which then assessed for pleural fluid leukocytes. Statistical analysis was performed using Kruskal Wallis Test and Receiver Operating Characteristic (ROC) curve to attain the cut-off point of pleural fluid leukocyte level. Results: Pleural fluid leukocyte levels in TB cases were significantly different when compared to pleural effusion caused by malignancy and non-TB infections (P","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130299931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exhaled Carbon Monoxide (eCO) and Serum CC16 Levels in Active Smokers 活跃吸烟者呼出一氧化碳(eCO)和血清CC16水平
Jurnal Respirologi Indonesia Pub Date : 2021-07-30 DOI: 10.36497/JRI.V41I3.181
Fitri Indah Sari, Triwahju Astuti, Teguh R. Sartono, Garinda Alma Duta
{"title":"Exhaled Carbon Monoxide (eCO) and Serum CC16 Levels in Active Smokers","authors":"Fitri Indah Sari, Triwahju Astuti, Teguh R. Sartono, Garinda Alma Duta","doi":"10.36497/JRI.V41I3.181","DOIUrl":"https://doi.org/10.36497/JRI.V41I3.181","url":null,"abstract":"Background: Toxic particles within tobacco smoke are responsible for several respiratory system problems. Among these toxic particles is Carbon Monoxide (CO), produced from environment and Heme Oxygenase induction. Expiratory CO levels can be measured using CO analyzer. CC16 is a pneumoprotein produced by club cells in distal respiratory tract. In acute condition, CC16 level will increase to maintain homeostasis and anti-inflammation. In chronic condition, i.e. in smokers, CC16 will decrease, following destruction of Club cell. This study aims to determine exhaled CO (eCO) levels and serum CC16 levels in active smokers. \u0000Methods: This cross-sectional analytical study design has 40 samples of healthy smokers in Brawijaya University who consents to the research from October 2019 until June 2020. The minimum consumption amount is 1 cigarette per day for at least 1 year. eCO levels are measured using CO analyzer (Smokelyzer), while ELISA is used to measure serum CC16 levels. \u0000Results: Among 40 subjects, mean eCO level is 10.18 ± 7.42 ppm. Mean serum CC16 level is 3.17 ± 1.78 ng/mL, lower than normal value of 6.4 ng/mL (Lomas et al., 2008). \u0000Conclusion: eCO levels increases and serum CC16 level decreases in active smokers, who smokes at least 1 cigarette/day for at least 1 year. This indicates that CO from tobacco smoke could irritate and damage the Club cells in the respiratory system.","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116257666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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