Jurnal Respirologi Indonesia最新文献

{"title":"Accuracy of Inhaler Use in COPD Patients and Factors Affecting It","authors":"Indah Kusumawati Susanti, R. Sauriasari, A. Rozaliyani, D. Sudiana","doi":"10.36497/jri.v43i4.508","DOIUrl":"https://doi.org/10.36497/jri.v43i4.508","url":null,"abstract":"Background: An inhaler is a type of dosage form used in the treatment of chronic obstructive pulmonary disease (COPD). The inhaler has a unique technique for use; however, the percentage of accuracy in inhaler use is still low. Proper inhaler use is expected to improve quality of life and decrease the occurrence of exacerbations. This study aimed to observe the percentage of accuracy in using inhalers and the factors that influence it.Method: This study was conducted with a cross-sectional design on COPD patients in two different hospitals. Primary data were collected using a questionnaire. The accuracy of inhaler use was assessed using a checklist.Results: The total number of patients in this study was 110, with an average age of 62 years. Patients were given single inhaler therapy, which included Dry Powder Inhalers (DPI) for 34 patients with 70.7% accuracy, Pressurized Metered-Dose Inhalers (pMDI) for 9 persons with 45.74% accuracy, and Soft Mist Inhalers (SMI) for one person with 66.67% accuracy. Furthermore, patients who used a combination of pMDI and DPI inhalers had an accuracy value of 68.53%, while a combination of pMDI and SMI had an accuracy value of 72.72%. The stage with the lowest level of accuracy in the pMDI-type inhaler used alone was exhaling before the inhaler was supplied.Conclusion:  According to the findings, the accuracy of inhaler use in COPD patients is still relatively low. Furthermore, gender is a factor that has a statistically significant relationship with inhaler accuracy.","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139307045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Volatile Organic Compounds in the Exhaled Breath of COVID-19 Patients","authors":"T. Effendi, I. N. Chozin, S. Pratiwi, N. Setijowati, Arinto Yudi Ponco Wardoyo","doi":"10.36497/jri.v43i4.394","DOIUrl":"https://doi.org/10.36497/jri.v43i4.394","url":null,"abstract":"Background: It has been more than 2 years since COVID-19’s first cases were reported in 2019. Rapid diagnosis of COVID-19 is necessary to prevent its spread. A sample for COVID-19 testing is collected by naso-oro-pharyngeal swab. This procedure is often uncomfortable and requires a trained examiner. Exhaled breath contains thousands of volatile organic compounds (VOC), which are likely to change during infection. This study aimed to analyze the difference in VOC in the exhaled breath between COVID-19 and healthy subjects.Methods: A cross-sectional study was carried out, recruiting 90 confirmed cases of COVID-19 and 42 healthy subjects. A sample of exhaled breath was collected by using a 500-mL airbag in both groups. The sample was analyzed using an arrayed sensor breath analyzer to quantify the concentration of CO2, C7H8, C6H14, CH2O, NH4, TVOC, NO2, PM1.0, CO, NH3 ­and Acetone.Results: The medians of CO2, NH4, TVOC, NO2, and acetone were significantly lower in COVID-19 patients compared to healthy subjects (respectively 607.3 vs 1175.1; 0.0 vs 1.05; 0.05 vs 146.6; 0.04 vs 1.55; 0.0 vs 0.23) while C7H8, CH2O, CO, and NH3 were significantly higher (respectively 0.92 vs 0.0; 0.55 vs 0.01; 0.24 vs 0.0; 1.99 vs 0.67; all with P-value of <0.05.). Furthermore, we found NH4, acetone, NH3, and CO were positively correlated with the severity of COVID-19, while CO2 and TVOC were negatively correlated.Conclusion: COVID-19 patients emit distinctive VOC profiles in comparison with healthy subjects, and this is related to the severity of the disease.","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139309305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Measurement RV, RV/TLC, and FRC/TLC with Clinical Symptoms in COPD Patients in Persahabatan Hospital","authors":"Derallah Ansusa Lindra, Faisal Yunus, Triya Damayanti","doi":"10.36497/jri.v43i4.571","DOIUrl":"https://doi.org/10.36497/jri.v43i4.571","url":null,"abstract":"Background: This preliminary study to measure lung volume in patients with stable COPD in Persahabatan Central General Hospital Jakarta to determine the prevalence of the increasing value of lung volume in patients with stable COPD.Methods: This study used a cross-sectional study design of outpatients with stable COPD who visited the asthma-COPD clinic at Persahabatan Central General Hospital Jakarta. The Lung volume test using a gas dilution Multiple Breath Nitrogen Washout (MBNW) was taken consecutively from February to March 2016.Results: Tests of spirometry and Lung volumes were performed on 35 subjects. There were 3 subjects (8.6%) in COPD Group A, 9 subjects (25.7%) in COPD Group B, 9 subjects (25.7%) in COPD Group C, and 14 subjects (40%) in COPD Group D. At the age of 60 years, there were subjects (25.7%) and 60 years, 26 subjects (74.6%). Value Residual Volume/Total Lung Capacity (RV/TLC) has a significant relationship with the symptoms and a 6-minute walking test; however, Functional Residual Capacity/Total Lung Capacity (FRC/TLC) is significantly associated with the symptoms, a 6-minute walking test, and exacerbations within one year.Conclusion: Value RV/TLC has a significant relationship with the symptoms and a 6-minute walking test; however, FRC/TLC is significantly associated with the symptoms, a 6-minute walking test, and exacerbations within one year.","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139306896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Inhaled Ipratropium Bromide as a Premedication For Bronchoscopy on Dyspnea, Cough, and Tracheobronchial Secretion","authors":"Safina Mutmainnah, Y. Sutanto, J. Aphridasari, Farih Raharjo","doi":"10.36497/jri.v43i4.256","DOIUrl":"https://doi.org/10.36497/jri.v43i4.256","url":null,"abstract":"Background: Bronchoscopy is a minimally invasive procedure used for diagnostic examination and intervention of the airways. Patient comfort and cooperation during bronchoscopy are very important because they affect the success and outcome. The sympathetic anticholinergic effect of ipratropium bromide can improve procedure tolerance and airway visualization. This study was conducted to analyze the effect of inhaled ipratropium bromide as a bronchoscopy premedication for the assessment of dyspnea, cough, and tracheobronchial secretion.Methods: This was a clinical study with a quasi-experimental pretest-posttest control group design in pulmonary patients who underwent bronchoscopy at Dr. Moewardi General Hospital Surakarta in October 2021 using consecutive sampling. The subjects of the study were divided into an intervention group with inhaled ipratropium bromide and a control group without inhaled ipratropium bromide. The Borg scale of dyspnea and the visual analog scale (VAS) score of cough were assessed before and after bronchoscopy in both groups. The grading of tracheobronchial secretion was assessed during bronchoscopy.Results: Thirty-six pulmonary patients who underwent bronchoscopy were included in this study. The intervention group showed a lower Borg scale (0.28±0.57) and VAS score (3.22±8.54), lower tracheobronchial secretion grading, and there was a significant difference compared to the control (P≤0.05).Conclusion: There was a significant difference in the Borg scale of dyspnea, VAS score of cough, and the grading of tracheobronchial secretion in patients undergoing bronchoscopy as an effect of ipratropium bromide inhalation.","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139308832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chest Radiography and CT scan as Predictor Factors for Long COVID","authors":"Reny Luhur Setyani, Srie Retno Endah, Ana Madjawati, Muhammad Hafiz, Farsida Farsida, Rahma A Larasati, Turwuri Handayani, Khatarina Setyawati","doi":"10.36497/jri.v43i4.539","DOIUrl":"https://doi.org/10.36497/jri.v43i4.539","url":null,"abstract":"Background: Long COVID presents a significant challenge in the management of COVID-19 patients, necessitating risk stratification and early intervention to mitigate its impact.Objective: This retrospective cohort study aimed to establish a predictive link between initial clinical assessments and imaging findings upon COVID-19 diagnosis and the subsequent development of long COVID symptoms at 6-8 weeks post-treatment.Methods: The study analyzed chest radiography images utilizing the Brixia Score and chest CT scans employing the Severity Score at the time of COVID-19 diagnosis. These findings were then compared with the presence of long COVID symptoms.Results: Among 54 study participants, 63% were non-elderly and 37% were elderly, with a nearly equal gender distribution. Notably, 74.1% of patients developed long COVID symptoms. The Brixia Score identified 38.9% as mild, 37% as moderate and 24.1% as severe lung involvement. Correspondingly, the Severity Score from chest CT scans revealed 33.3% with mild, 53.7% with moderate, and 13% with severe lung abnormalities. Statistical analysis confirmed strong correlations between both the Brixia Score (r = 0.553) and the Severity Score (r = 0.733) with the development of long COVID symptoms (p = 0.000).Conclusion: This study underscores the significant predictive value of both the Brixia Score and the Severity Score in identifying COVID-19 patients at risk of developing long COVID. These findings have critical implications for early risk stratification and targeted intervention strategies to prevent long COVID's debilitating effects.","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139306854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Performance of the Aspergillus Western Blot IgG Kit for Serodiagnosis of Chronic Pulmonary Aspergillosis in Post-Tuberculosis Patients","authors":"A. Rozaliyani, Sresta Azahra, F. Setianingrum, Heri Wibowo","doi":"10.36497/jri.v43i4.562","DOIUrl":"https://doi.org/10.36497/jri.v43i4.562","url":null,"abstract":"Background: Chronic pulmonary aspergillosis (CPA) by Aspergillus spp., which causes slowly progressive destruction to lung parenchyma, is a major complication of pulmonary tuberculosis (TB). Clinical and radiological features of CPA are not typical and might resemble TB. Therefore, detecting Aspergillus-specific IgG is critical for diagnosing CPA.Methods: This cross-sectional study was conducted to evaluate the performance of Aspergillus Western Blot (Asp-WB) IgG kit (LDBio Diagnostics, Lyon, France) for CPA diagnosis in 63 post-TB patients. The analysis was performed by comparing Asp-WB with Aspergillus ELISA IgG (Asp-ELISA) and fungal culture as standard method.Results: Of the 63 patients studied, twenty six (41%) met the probable CPA criteria. The Asp-WB results were positive in 13 probable CPA patients and 3 non-CPA patients, with the significant difference of 50% vs. 8% (p< 0.001). The sensitivity and specificity of Asp-WB were 50% and 93%. False negative results of Asp-WB were detected from non-fumigatus CPA that grew Aspergillus niger. CPA patients with mild symptoms (less than 3 months) indicated early progression of CPA might showed positive Asp-WB test result in low sensitivity of Asp-WB test.Conclusion: The Asp-WB has potential to use as confirmatory test to assist diagnosis of CPA in post-TB patients.","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139307023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Correlations Between Clinical Characteristics and Inflammation Markers with Chest X-rays in COVID-19 Patients at Ulin Hospital","authors":"Muhammad Nor, I. Nurrasyidah, M. Mashuri","doi":"10.36497/jri.v43i4.407","DOIUrl":"https://doi.org/10.36497/jri.v43i4.407","url":null,"abstract":"Background: Chest x-ray is one of the parameters used to estimate the severity and prognosis of COVID-19. Arterial oxygen saturation (SaO2), partial pressure of arterial oxygen (PaO2), and respiratory index (PaO­/FiO2) can also predict the disease severity. Other parameters, like inflammation markers, have also been used as predictors for prognosis. Based on those considerations, this study aimed to examine their connection and find their correlation.Methods: This was an analytic observational retrospective study. The samples were moderate-critical COVID-19 patients in Ulin General Hospital Banjarmasin from July to December 2021 who met the inclusion and exclusion criteria. Statistical tests were used to see the relationship between clinical characteristics and inflammation markers with chest X-rays using various scoring systems (Brixia, sRALE, and modified Soetomo score).Results: The total number of subjects was 67. The data analysis found that the severity of the disease had a significant relationship with the severity of the chest x-ray (P<0.001). The PF ratio also had a significant negative correlation (P<0.001) with the severity of the chest x-ray. For inflammation markers, NLR, CRP, and LDH significantly correlated with a chest x-ray. The patient's outcome was also associated with a chest X-ray (P<0.015).Conclusion: There were significant correlations between clinical characteristics and inflammation markers on the chest X-ray severity, and sRALE was a better scoring system to assess chest X-ray severity than other scoring systems.","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"108 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139307599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in C-Reactive Protein Level Based on Clinical Severity and Outcome of COVID-19 Patients at RSUP Dr. M. Djamil Padang","authors":"Isnaniyah Usman, Irvan Medison, Deddy Herman","doi":"10.36497/jri.v43i4.427","DOIUrl":"https://doi.org/10.36497/jri.v43i4.427","url":null,"abstract":"Background: Inflammatory process in COVID-19 can increase inflammatory markers such as C-reactive protein (CRP), procalcitonin (PCT), and interleukin 6 (IL-6). The level of C-reactive protein describes the severity of viral infection. Several studies had been conducted to investigate the link between C-reactive protein level and the severity of COVID-19. The purpose of this study is to identify differences in C-reactive protein levels based on clinical degrees and outcomes of COVID-19 patients treated at RSUP by Dr. M. Jamil Padang.Methods: This is a retrospective cohort study that analyzed all COVID-19 patients treated at RSUP Dr. M. Djamil Padang. This study lasted from December 1st, 2021 and June 1st, 2022. The data was analyzed using univariate, bivariate, and confounding analysis. Bivariate analysis explored differences in C-reactive protein levels in clinical severity and patient outcomes for COVID-19. The Kruskal-Wallis test determined the difference between the CRP level and clinical severity, while the Mann-Whitney test determined the difference between the CRP level and length of stay and final hospitalization status. Confounding test was performed using multiple linear regression tests.Results: Majority of participants were women (51.0%) with range of age between 50–59 years (28.0%) and suffered from hypertension (46.0%). Less than half of them had secondary infection (49.0%). Majority of them had a critical clinical severity (75.0%) and length of stay ≤14 days (77.0%) and more than half were deceased (65.0%). C-reactive protein levels were higher in patients with critical clinical degrees (89.00 mg/L) compared to moderate (37.50 mg/L) and severe (23.00 mg/L), C-reactive protein levels in patients with long hospitalization ≤14 days (97.00 mg/L) was higher than >14 days (88.50 mg/L), and C-reactive protein levels were higher in patients who died (93.00 mg/L) than those who survived (68.00 mg/L).Conclusion: C-reactive protein levels differed significantly based on clinical severity, length of stay and end of stay status of COVID-19 patients.","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"107 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139307919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Chemotherapy Status, Absolute Lymphocyte Count and Neutrophil Lymphocyte Ratio as Biomarkers of Candidiasis in Lung Cancer Patients","authors":"Muhamad Yusuf Musthafa, I. N. Chozin, U. Setyawan, Teguh W Sardjono, Noorhamdani As","doi":"10.36497/jri.v43i3.518","DOIUrl":"https://doi.org/10.36497/jri.v43i3.518","url":null,"abstract":"Background: Gradually, fungal infections are growing and have become a medical concern. Candida species are one of the most common pathogens in immunocompromised patients, such as those with lung cancer causing invasive fungal disease. Early diagnosis of candidiasis is critical for patient care in lung cancer patients. Anti-mannan IgM and IgG biomarkers are used to diagnose candidiasis. This study aims to determine the relationship between chemotherapy status, absolute lymphocyte count, and neutrophil-lymphocyte ratio to antimannan IgM and IgG.Methods: A correlative analytic cross-sectional study was conducted on 37 lung cancer patients with positive candida sputum cultures in Dr. Saiful Anwar Malang Hospital. The 37 patients were examined for total lymphocyte level, neutrophil-lymphocyte ratio, anti-mannan IgM, and IgG. Data analysis used a contingency coefficient to determine the relationship between chemotherapy status, absolute lymphocyte count, and neutrophil-lymphocyte ratio to anti-mannan IgM and IgG.Results: This study showed a positive correlation between chemotherapy status with anti-mannan IgM and IgG, although insignificant (p>0.05). However, there was a significant correlation between total lymphocytes and anti-mannan IgG (p=0.000;α=0.05) and between neutrophil-lymphocyte ratio and antimannan IgM (p=0.004; α=0.05).Conclusion: The study revealed that chemotherapy status, absolute lymphocyte count, and neutrophil-lymphocyte ratio could be a biomarker of candidiasis, so lung cancer patients with a history of chemotherapy, lymphopenia, and increased neutrophil-lymphocyte ratio should consider receiving antifungals earlier. ","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"102 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127214155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Smoking with Carbon Monoxide Level and Peak Expiratory Flow Rate in High School Students Banda Aceh","authors":"Julie Amalliah, S. Dianova, F. Kurniawan, T. Zulfikar, Nurrahmah Yusuf","doi":"10.36497/jri.v43i3.294","DOIUrl":"https://doi.org/10.36497/jri.v43i3.294","url":null,"abstract":"Background: Indonesia has the highest number of adolescent smokers in the world. Carbon monoxide (CO) is a by-product of tobacco smoking and is inhaled into the lungs. A smokerlyzer can monitor its level. Cigarette smoke also causes inflammation that affects airflow in the airways and can be detected by measuring the peak expiratory flow rate (PEFR). This study aims to determine the relationship between smoking and CO levels and PEFR in high school students in Banda Aceh City.Methods: This quantitative study uses an analytical observational approach with a cross-sectional design. This study involved 300 students from five senior high schools in Banda Aceh. The data were analyzed using the Mann-Whitney and Spearman test with a significance value <0.05.Results: CO levels of the smoker students were higher (12.61 ± 3.342 ppm) than nonsmoker students (2.46 ± 0.569 ppm), p=0.000. The average PEFR for smoking students was lower than nonsmokers (61.11 ± 9.163%) than for non-smoking students (78.48 ± 6.804 %), p=0.000. Duration of smoking in smoking students was also strongly associated with CO levels and PEFR (r=+0.749, p=0,000, r=-0.560, p=0.000, respectively).Conclusion: There is a relationship between smoking and CO levels and PEFR in senior high school students in Banda Aceh.","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121495389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}