Jurnal Respirologi Indonesia最新文献

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The Correlations Between Measurement of Lung Diffusing Capacity for Carbon Monoxide and The Severity Group of Asthma Patients in Persahabatan Hospital Jakarta 雅加达Persahabatan医院哮喘患者肺一氧化碳弥散量测定与病情严重程度的相关性
Jurnal Respirologi Indonesia Pub Date : 2022-01-08 DOI: 10.36497/jri.v42i1.296
Bulkis Natsir, F. Yunus, Triya Damayanti
{"title":"The Correlations Between Measurement of Lung Diffusing Capacity for Carbon Monoxide and The Severity Group of Asthma Patients in Persahabatan Hospital Jakarta","authors":"Bulkis Natsir, F. Yunus, Triya Damayanti","doi":"10.36497/jri.v42i1.296","DOIUrl":"https://doi.org/10.36497/jri.v42i1.296","url":null,"abstract":"Introduction: Airway remodeling in asthma which involve small airway can affect until alveoli and cause abnormalities in the lung parenchyma. This study tries to find lung parenchymal abnormalities in patients with asthma through the examination diffusion capacity with a single breath DLCO method.Methods: A cross-sectional study by dividing asthma based on the degree of severity into two major groups, namely mild asthma (intermittent and mild persistent) and severe (persistent moderate and severe). The amount of each group is 31 subjects and 29 subjects, which are taken consecutively from stable asthma patients without comorbid who are seeking treatment in Persahabatan Hospital in December 2015 - May 2016.Results: The average value of DLCO /predictions in mild asthma group is 92,74 ± 15,70% and decreased in the severe asthma group is 77,45 ± 16,78%. Some spirometry value showed significant positive correlation with the value of DLCO/prediction, namely: FVC/prediction, FEV1 /prediction and FEF25-75 % / prediction with p < 0.05. Correlation analysis showed FVC/prediction could dramatically affect the diffusion capacity of asthmatic patients. There is a significant relationship between abnormalities in lung function (p=0,004) and severity of asthma (p=0.000) with a corresponding decrease DLCO / prediction (DLCO/ prediction ≤75 %).Conclusion: The severity of asthma has a relationship with the diffusion capacity of the lungs, increased severity will decrease the diffusion capacity in asthma patients. Decreasing diffusion capacity showed that abnormalities in asthma not only occur in the respiratory tract but also in the lung parenchyma.","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115109088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Efficacy of Remdesivir in Reducing SARS-CoV-2 Viral Load and Its Safety on COVID-19 Patients: A Systematic Review 瑞德西韦降低SARS-CoV-2病毒载量的疗效及其对COVID-19患者的安全性:一项系统评价
Jurnal Respirologi Indonesia Pub Date : 2022-01-08 DOI: 10.36497/jri.v42i1.211
Afifah Fauziyyah, R. Rahmasari, R. Sauriasari
{"title":"The Efficacy of Remdesivir in Reducing SARS-CoV-2 Viral Load and Its Safety on COVID-19 Patients: A Systematic Review","authors":"Afifah Fauziyyah, R. Rahmasari, R. Sauriasari","doi":"10.36497/jri.v42i1.211","DOIUrl":"https://doi.org/10.36497/jri.v42i1.211","url":null,"abstract":"Background: This study aimed to examine the effectiveness of Remdesivir in reducing Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) viral load and its safety for antiviral therapy in Coronavirus disease 2019 (COVID-19) treatment.Methods: This systematic review used data sources from the PubMed, ProQuest, SpringerLink, and ClinicalTrial.gov databases for relevant observational and interventional studies during August 2020 to August 2021. Studies evaluating Remdesivir in adults hospitalized for COVID-19 were included in this review. This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guidelines.Results This review found 9 studies that were relevant to the study objectives. In total, 1,088 patients participated as subjects. Three studies demonstrated the effect of remdesivir in reducing SARS-CoV-2 viral load in upper and lower respiratory tract specimens. Six studies demonstrated that remdesivir was safe for use in a variety of baseline conditions (patients on hemodialysis and patients receiving kidney transplantation), had no significant hepatotoxicity, did not increase the risk of acute kidney injury, and did not increase eGFR or systemic symptoms in patients taking remdesivir.Conclusion: Remdesivir has been shown to reduce SARS-CoV-2 viral load and was safe for use as antiviral therapy in the treatment of COVID-19, but an assessment of randomized controlled trial for the effect of Remdesivir on viral load reduction was not available yet.","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123962721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes Prediction Using qSOFA, SpO2 / FiO2 and Procalcitonin of Pneumonia Sepsis Patients In Lung Ward at Dr. M.Djamil Padang Hospital 利用qSOFA、SpO2 / FiO2和降钙素原预测Dr. M.Djamil Padang医院肺病房肺炎败血症患者的预后
Jurnal Respirologi Indonesia Pub Date : 2022-01-08 DOI: 10.36497/jri.v42i1.268
E. Irawan, Irvan Medison, Oea Khairsyaf, Fenty Anggraini
{"title":"Outcomes Prediction Using qSOFA, SpO2 / FiO2 and Procalcitonin of Pneumonia Sepsis Patients In Lung Ward at Dr. M.Djamil Padang Hospital","authors":"E. Irawan, Irvan Medison, Oea Khairsyaf, Fenty Anggraini","doi":"10.36497/jri.v42i1.268","DOIUrl":"https://doi.org/10.36497/jri.v42i1.268","url":null,"abstract":"Background: Sepsis is a systemic inflammatory response to severe infections, sepsis is a major cause of morbidity and mortality. This study aims to determine the outcome prediction using qSOFA, SpO2/FiO2 Rasio and Procalcitonin in sepsis pneumonia patients in Lung ward of Dr. M DJamil Padang Hospital. Methods: Cohort study design with correlative analytics for 43 pneumonia sepsis patiens in Lung ward at Dr. M. Djamil Padang Hospital from September 2019 until to Februari 2020. Samples were taken by consecutive sampling method. Results: There were a significant relationship between qSOFA score with procalcitonin (p value = 0.006). There were no significant relationship between SpO2/FiO2 Rasio with procalcitonin (p value = 0.128). There were a significant relationship between qSOFA scores with patient outcomes (p value = 0.036), there were no significant relationship between procalcitonin with patient outcomes (p value = 0.205), and there were a significant relationship betweenSpO2/FiO2 Rasio with patient outcomes (p value = 0.019). Conclusion: qSOFA and SpO2 / FiO2 Rasio can predict the outcomes of patients with sepsis pneumonia ","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122577725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunological Aspects of Latent Tuberculosis Infection in Diabetes Mellitus 糖尿病潜伏性结核感染的免疫学研究
Jurnal Respirologi Indonesia Pub Date : 2021-11-27 DOI: 10.36497/jri.v41i4.219
Y. Arliny
{"title":"Immunological Aspects of Latent Tuberculosis Infection in Diabetes Mellitus","authors":"Y. Arliny","doi":"10.36497/jri.v41i4.219","DOIUrl":"https://doi.org/10.36497/jri.v41i4.219","url":null,"abstract":"AbstractThe interaction of diabetes mellitus (DM) with tuberculosis (TB) is currently a health concern. Diabetes mellitus is one of the main risk factors for TB infection to become latent TB and / or progress to active TB. Immune mechanisms contribute to this increased risk. The disruption of the mycobacteria recognition process, phagocyte activity and cellular activity will affect the disruption of cytokine and chemokine production. Hyperglycemia that occurs will result in delayed adaptive immune response resulting in reduced Th1, Th2, and Th17 cells as well as the cytokines produced by these cells that play a role in macrophage activation and TB inflammatory response. Understanding of the immune mechanisms that underlie the sensitivity of DM to TB infection, especially latent TB, will facilitate the implementation of strategies in screening and therapy to deal with the double burden of both diseases. The purpose of this literature study focuses on the relationship of DM with latent TB infection in terms of immunology.","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126905696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Neutrophil-Lymphocyte Ratio (NLR), Platelet-Lymphocyte Ratio (PLR), and D-Dimer in Predicting the Outcome of Confirmed COVID-19 patients 中性粒细胞-淋巴细胞比率(NLR)、血小板-淋巴细胞比率(PLR)和d -二聚体在预测COVID-19确诊患者预后中的作用
Jurnal Respirologi Indonesia Pub Date : 2021-11-27 DOI: 10.36497/jri.v41i4.215
F. Isbaniah, Tomu Juliani, Triya Damayanti, Dewi Yenita, F. Yunus, Budhi Antariksa, Wahyu Aniwidyaningsih, S. Andarini, D. Handayani
{"title":"The Role of Neutrophil-Lymphocyte Ratio (NLR), Platelet-Lymphocyte Ratio (PLR), and D-Dimer in Predicting the Outcome of Confirmed COVID-19 patients","authors":"F. Isbaniah, Tomu Juliani, Triya Damayanti, Dewi Yenita, F. Yunus, Budhi Antariksa, Wahyu Aniwidyaningsih, S. Andarini, D. Handayani","doi":"10.36497/jri.v41i4.215","DOIUrl":"https://doi.org/10.36497/jri.v41i4.215","url":null,"abstract":"Background: Cytokine storm or hyperinflammation condition in COVID-19 patients could result in fatal outcomes. Inflammation could also result in coagulation disorders. The Neutrophil-Lymphocyte Ratio (NLR) and Platelet-lymphocyte ratio (PLR) have been known as inflammation markers in several diseases. D-dimer value can be used to assess a patient's coagulation status. Further study on thromboinflammation biomarkers in COVID-19 patients is needed. Therefore, we conducted a study to assess the association between NLR, PLR, and d-dimer on the clinical outcome of confirmed COVID-19 patients at Persahabatan Central Hospital.Methods: Observational cohort retrospective analysis was conducted on 214 medical records of confirmed COVID-19 patients who meet the inclusion criteria in Persahabatan Central Hospital from March to July 2020.Results: The mean patient’s age in this study is 54.35 years, dominated by male patients (60.7%). Most of the patients had normal nutritional status (54.7%). The proportion of patients with comorbidities is 65.4%. The most common comorbid is hypertension, followed by diabetes mellitus. 76.1% of patients have severe-critically ill disease, followed by moderate (20.1%) and mild disease (3.7%) The length of hospitalization median were 12 days. Sixty patients (28%) have died during hospitalization. The median of initial value of NLR, PLR, and d-dimer is 5.75 (0.68–81.5), 243.5 (44.7–1607), and 1140 (190–141300) respectively. We found significant associations between NLR (p = 0.000), PLR (p=0.013) and d-dimer (p = 0.032) on clinical outcome. Conclusion: Initial value of NLR, PLR, and D-dimer of confirmed COVID-19 patients at Persahabatan Central Hospital were associated with clinical outcome. ","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130915100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The Differences in Urokinase Plasminogen Activator System in Lung Cancer Patients Before and After Chemotherapy 肺癌患者化疗前后尿激酶纤溶酶原激活剂系统的差异
Jurnal Respirologi Indonesia Pub Date : 2021-11-27 DOI: 10.36497/jri.v41i4.214
Triwahju Astuti, A. Iskandar, Mufidatun Hasanah, Lindayanti Sumali, D. Nugrahenny
{"title":"The Differences in Urokinase Plasminogen Activator System in Lung Cancer Patients Before and After Chemotherapy","authors":"Triwahju Astuti, A. Iskandar, Mufidatun Hasanah, Lindayanti Sumali, D. Nugrahenny","doi":"10.36497/jri.v41i4.214","DOIUrl":"https://doi.org/10.36497/jri.v41i4.214","url":null,"abstract":"Background: Lung cancer is still the leading cause of death for malignancies worldwide. Urokinase plasminogen activator (uPA), its soluble receptor (suPAR), and its inhibitor (PAI-1) play an important role in tumor invasion and metastasis. This study aimed to evaluate the differences in the urokinase plasminogen activator system (uPA, suPAR, and PAI-1) in lung cancer patients before and after chemotherapy.Methods: This research was an observational analytical study with a cross-sectional design. The subjects were 30, consisting of 17 lung cancer patients before chemotherapy and 13 lung cancer patients after chemotherapy for 4 or 6 cycles. The levels of serum uPA, suPAR, and PAI-1 were measured by enzyme-linked immunosorbent assay (ELISA). Results: In lung cancer patients before chemotherapy, there were no significant (p>0.05) differences in levels of serum uPA, suPAR, and PAI-1 between patients with stage III and IV. The highest serum uPA and suPAR levels were found in adenocarcinoma cell types and the highest serum PAI-1 level in adenoepidermoid cell types. After chemotherapy, serum suPAR and PAI-1 were significantly (p < 0.05) decreased in lung cancer patients. However, there were no significant (p>0.05) differences in the levels of serum uPA, suPAR, and PAI-1 between patients with chemotherapy responses for stable and progressive diseases. Conclusion: This study revealed that suPAR and PAI-1 levels were decreased in lung cancer patients who had received chemotherapy. This can occur due to decreased tumor cells activity. ","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"275 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134144504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gender Disparities in Their Effects on Characteristics and Prognostics of Lung Cancer Patients in Pulmonary Ward of Dr. M Djamil Hospital, Padang 巴东Dr. M . Djamil医院肺病房肺癌患者特征及预后的性别差异
Jurnal Respirologi Indonesia Pub Date : 2021-11-27 DOI: 10.36497/jri.v41i4.216
Sabrina Ermayanti, Afriani Afriani, Sari Nikmawati, Russilawati Russilawati, Irvan Medison, Suyastri Suyastri
{"title":"Gender Disparities in Their Effects on Characteristics and Prognostics of Lung Cancer Patients in Pulmonary Ward of Dr. M Djamil Hospital, Padang","authors":"Sabrina Ermayanti, Afriani Afriani, Sari Nikmawati, Russilawati Russilawati, Irvan Medison, Suyastri Suyastri","doi":"10.36497/jri.v41i4.216","DOIUrl":"https://doi.org/10.36497/jri.v41i4.216","url":null,"abstract":"Background: Lung cancer incidence in female tends to increase in many countries. Various studies have reported the characteristics of lung cancer in female are different from male. The purpose of this study was to determine the effect of gender on characteristics of lung cancer at Dr. M Djamil Hospital, Padang.Methods: A retrospective analytic study of lung cancer patients treated in the Pulmonary Ward of Dr. M. Djamil Hospital Padang from January 1, 2004 to December 31, 2017, with recognized cancer cell types. Data were grouped according to gender.Results: This study found that 451 lung cancer patients, male-dominant 77.8%. Female were younger than male (52.97 ± 12.79 years vs. 57.81 ± 11.23 years; p = 0.00). Most of male (94.5%) were smokers and former smokers, while 93.9% of female were non-smokers (p = 0.00). Most female were having prior history of tuberculosis (TB) (21.2% vs 11.0%; p = 0.008) and also prior history of other organs cancer (10.1% vs 3.4%; p = 0.007) than in male. Squamous cells were highest in males (41.1%), while females had adenocarcinoma (55.0%); with p = 0.008. Advanced stage in female more than male (91.8% vs 82.7%; p = 0.027). The mean life expectancy of female was longer than male, respectively 8.74 ± 1.56 and 7.29 ± 0.64 months; (p = 0.95).  Conclusion: There are differences in the epidemiology of lung cancer between male and female in Dr. M. Djamil Hospital Padang in the form of age, cell type and staging. Non-smokers, a previous history of TB and a history of cancer in other organs were more dominant in female.","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114721789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neutrophil To Lymphocyte Ratio as A Marker of COVID-19 Disease Severity in Banda Aceh 中性粒细胞与淋巴细胞比值作为Banda Aceh地区COVID-19疾病严重程度的标志
Jurnal Respirologi Indonesia Pub Date : 2021-11-27 DOI: 10.36497/jri.v41i4.207
D. Efrina, H. Priyanto, N. Andayani, Y. Arliny, B. Yanti
{"title":"Neutrophil To Lymphocyte Ratio as A Marker of COVID-19 Disease Severity in Banda Aceh","authors":"D. Efrina, H. Priyanto, N. Andayani, Y. Arliny, B. Yanti","doi":"10.36497/jri.v41i4.207","DOIUrl":"https://doi.org/10.36497/jri.v41i4.207","url":null,"abstract":"Background: Patients with severe COVID-19 always coincide with high mortality rate, meanwhile, inflammatory immunity parameters in COVID-19 infection such as Neutrophil to Lymphocyte Ratio (NLR) reflect the infection progress. These are used by clinicians for early identification of patients at high risk or to determine when it is a serious disease. This study aims to determine the effectiveness of NLR as a marker of COVID-19 pneumonia severity.Method: This study was conducted using a retrospective cross-sectional analytical design at the Regional General Hospital of DR. Zainoel Abidin Banda Aceh from June to September 2020. Patients' demographic characteristics, comorbidities, clinical manifestations of COVID-19 infection, chest x rays, examination of blood samples at admissions such as leukocytes, lymphocytes, neutrophils and NLR were extracted from medical record data. The patients were divided into four groups according to the disease severity, namely mild, moderate, severe and critical.Result: A total of 105 medical records were collected for COVID19 patients, meanwhile, 51 to 70 years was the largest age group (60.8%) with twice male than female. Moreover, fever, cough, shortness of breath and weakness are the most common symptoms found in treated patients while almost two-thirds of the patients have bilateral pneumonia. Generally, the levels of leukocytes, neutrophils, NLR were found to increase while the levels of lymphocytes decreased, in addition, more than half of the COVID19 patients were severe. There was a strong relationship between an increase in NLR levels and COVID-19 disease severity (95% CI, α: 0.05, p = 0.001)Conclusion: Based on the results, NLR is applicable as an early inflammatory marker which reflects severe and critical COVID19 infection and also suitable as an objective basis for early identification and management of severe COVID-19 pneumonia.","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124352622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Inflammatory Markers upon Admission as Predictors of Outcome in COVID-19 Patients 入院时炎症标志物作为COVID-19患者预后的预测因子
Jurnal Respirologi Indonesia Pub Date : 2021-11-27 DOI: 10.36497/jri.v41i4.185
Budhi Antariksa, E. Burhan, A. Susanto, Mohamad Fahmi Alatas, F. F. Taufik, Dewi Yennita Sari, D. Soehardiman, A. Putra, E. Samoedro, Ibrahim Nur Insan Putra Darmawan, Hera Afidjati, Muhammad Alkaff, Rita Rogayah
{"title":"Inflammatory Markers upon Admission as Predictors of Outcome in COVID-19 Patients","authors":"Budhi Antariksa, E. Burhan, A. Susanto, Mohamad Fahmi Alatas, F. F. Taufik, Dewi Yennita Sari, D. Soehardiman, A. Putra, E. Samoedro, Ibrahim Nur Insan Putra Darmawan, Hera Afidjati, Muhammad Alkaff, Rita Rogayah","doi":"10.36497/jri.v41i4.185","DOIUrl":"https://doi.org/10.36497/jri.v41i4.185","url":null,"abstract":"Background: Coronavirus disease 2019 (COVID-19) may cause dysregulation of the immune system, leading to hyperinflammation. Inflammatory markers can be used to predict in-hospital mortality in COVID-19 patients. This research was aimed to investigate the association between the levels of various inflammatory markers and mortality in COVID-19 patients.Methods: This study was conducted at Persahabatan National Respiratory Referral Hospital, Indonesia. Blood tests were performed upon admission, measuring the C-reactive protein, PCT, leukocyte, differential counts, and platelet count. The outcome measured was the mortality of hospitalized COVID-19 patients. Statistical analysis methods included the Mann–Whitney U test, receiver operating characteristic (ROC) analysis, and area under the curve (AUC) test.Results: Total 110 patients were included, and the laboratory values were analyzed to compare survivors and non-survivors. The non-survivor group had significantly higher leukocyte count, lower lymphocyte count, higher CRP and PCT levels, higher neutrophil-to-lymphocyte ratio (NLR), higher platelet-to-lymphocyte ratio (PLR), and lower lymphocyte-to-CRP ratio. As predictors of mortality, AUC analysis revealed that PCT, CRP, NLR, and PLR had AUCs of 0.867, 0.82, 0.791, and 0.746, respectively.Conclusions: Routine and affordable inflammatory markers tested on admission may be useful as predictors of in-hospital mortality in COVID-19 patients requiring hospitalization.","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129678357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lung Function Impairment Among Firefighter After Forest Fire Disaster in Riau, Sumatra 苏门答腊廖内省森林火灾后消防员肺功能受损
Jurnal Respirologi Indonesia Pub Date : 2021-11-27 DOI: 10.36497/jri.v41i4.210
Rudi Kurniawan, Seira Putri Boru Rambe, Indra Yovie, E. Samoedro, A. Susanto, J. Zaini
{"title":"Lung Function Impairment Among Firefighter After Forest Fire Disaster in Riau, Sumatra","authors":"Rudi Kurniawan, Seira Putri Boru Rambe, Indra Yovie, E. Samoedro, A. Susanto, J. Zaini","doi":"10.36497/jri.v41i4.210","DOIUrl":"https://doi.org/10.36497/jri.v41i4.210","url":null,"abstract":"Background: The 2015 forest fire disaster affected almost 2.6 million hectares of land in Indonesia, and Riau was among the worst. Firefighters were the first responders to deal with the disaster, but a little was known about the influence of extinguishing forest fire activities with their health. This study aimed to evaluate respiratory symptoms and lung function among firefighters 6 months after forest fire exposure.Methods: Interviews were conducted regarding sociodemographic factors, respiratory symptoms, and history of forest fire exposure during the disaster. Spirometry and chest X-ray were also carried out with standard techniques. Statistical analysis was performed based on the existing data. Ninety firefighters participated in this study, most were male with mean age of 33 years old. About 66% were smoker, had been working as firefighters for 2 to 10 years, and had been on extinguishing forest fire duty around 2–5 hours/day during the disaster.Results: All firefighters reported respiratory symptoms after 3 months. Pulmonary function was abnormal in 50% of subjects with mild restrictive characteristic. The analysis showed that body mass index (BMI) and duration of exposure had a significant correlation with pulmonary function abnormality.Conclusion: Pulmonary function was found abnormal in most subjects 6 months after forest fire exposure in Riau.","PeriodicalId":168168,"journal":{"name":"Jurnal Respirologi Indonesia","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133306872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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