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Journal of physiology and biochemistry最新文献

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Profibrotic macrophage populations and cell communications in pulmonary fibrosis. 肺纤维化中纤维化巨噬细胞群和细胞通讯。
IF 4.3 3区 生物学
Journal of physiology and biochemistry Pub Date : 2026-04-17 DOI: 10.1007/s13105-026-01179-x
Dengfeng Zhang, Wenyue Zhao, Chang Xu, Liqing Du, Qiang Liu
{"title":"Profibrotic macrophage populations and cell communications in pulmonary fibrosis.","authors":"Dengfeng Zhang, Wenyue Zhao, Chang Xu, Liqing Du, Qiang Liu","doi":"10.1007/s13105-026-01179-x","DOIUrl":"https://doi.org/10.1007/s13105-026-01179-x","url":null,"abstract":"","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":"82 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147717098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Rab11-FIP4 interacts with ARF5 to promote cancer stemness in hepatocellular carcinoma. 更正：Rab11-FIP4与ARF5相互作用促进肝细胞癌的癌变。
IF 4.3 3区 生物学
Journal of physiology and biochemistry Pub Date : 2026-04-15 DOI: 10.1007/s13105-026-01169-z
Feifeng Song, Qi Zhang, Xixuan Lu, Tong Xu, Qing Hu, Xiaoping Hu, Weijiao Fan, Yiwen Zhang, Ping Huang
{"title":"Correction: Rab11-FIP4 interacts with ARF5 to promote cancer stemness in hepatocellular carcinoma.","authors":"Feifeng Song, Qi Zhang, Xixuan Lu, Tong Xu, Qing Hu, Xiaoping Hu, Weijiao Fan, Yiwen Zhang, Ping Huang","doi":"10.1007/s13105-026-01169-z","DOIUrl":"https://doi.org/10.1007/s13105-026-01169-z","url":null,"abstract":"","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":"82 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overall survival, clinical significance and biochemical composition of 'white bile' in patients with impaired biliary drainage: a systematic review. 胆道引流受损患者“白胆汁”的总生存率、临床意义和生化组成：一项系统综述
IF 4.3 3区 生物学
Journal of physiology and biochemistry Pub Date : 2026-04-11 DOI: 10.1007/s13105-026-01177-z
María Rullan, Daniel Oyon, Javier Rández-Garbayo, Lucía Zabalza, Luis Carlos Saiz, Leire Leache, Marta Gutiérrez-Valencia, Matías A Ávila, Juan J Vila, Jesús M Urman
{"title":"Overall survival, clinical significance and biochemical composition of 'white bile' in patients with impaired biliary drainage: a systematic review.","authors":"María Rullan, Daniel Oyon, Javier Rández-Garbayo, Lucía Zabalza, Luis Carlos Saiz, Leire Leache, Marta Gutiérrez-Valencia, Matías A Ávila, Juan J Vila, Jesús M Urman","doi":"10.1007/s13105-026-01177-z","DOIUrl":"https://doi.org/10.1007/s13105-026-01177-z","url":null,"abstract":"","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":"82 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of mitochondria-related genes in calcific aortic valve disease by integrated analysis of single-cell and bulk transcriptomic atlases. 通过单细胞和大量转录组图谱的综合分析鉴定钙化主动脉瓣疾病的线粒体相关基因。
IF 4.3 3区 生物学
Journal of physiology and biochemistry Pub Date : 2026-04-10 DOI: 10.1007/s13105-026-01176-0
Ziling Mai, Huijun Du, Yuhan Chen, Yaner Lu, Bingchen Liu, Deqiang Sun
{"title":"Identification of mitochondria-related genes in calcific aortic valve disease by integrated analysis of single-cell and bulk transcriptomic atlases.","authors":"Ziling Mai, Huijun Du, Yuhan Chen, Yaner Lu, Bingchen Liu, Deqiang Sun","doi":"10.1007/s13105-026-01176-0","DOIUrl":"10.1007/s13105-026-01176-0","url":null,"abstract":"","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":"82 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13068690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147645791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The postnatal expression of transcripts and proteins in the corpus callosum, as well as its myelinization, is affected by the congenital absence of AQP4. 先天性AQP4缺失会影响出生后胼胝体中转录本和蛋白质的表达以及髓鞘形成。
IF 4.3 3区 生物学
Journal of physiology and biochemistry Pub Date : 2026-03-31 DOI: 10.1007/s13105-026-01173-3
Francisco Mayo, Lourdes González-Vinceiro, Laura Hiraldo-González, Ismael Torres-Rubio, Claudia Calle-Castillejo, Elaheh Sobh-Doush, Reposo Ramírez-Lorca, Miriam Echevarría
{"title":"The postnatal expression of transcripts and proteins in the corpus callosum, as well as its myelinization, is affected by the congenital absence of AQP4.","authors":"Francisco Mayo, Lourdes González-Vinceiro, Laura Hiraldo-González, Ismael Torres-Rubio, Claudia Calle-Castillejo, Elaheh Sobh-Doush, Reposo Ramírez-Lorca, Miriam Echevarría","doi":"10.1007/s13105-026-01173-3","DOIUrl":"10.1007/s13105-026-01173-3","url":null,"abstract":"","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":"82 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13038659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147581576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of bariatric and metabolic surgery on the levels of circulating growth differentiation factor 15 in humans. 减肥和代谢手术对人体循环生长分化因子15水平的影响。
IF 4.3 3区 生物学
Journal of physiology and biochemistry Pub Date : 2026-03-31 DOI: 10.1007/s13105-026-01160-8
Victor Yassuda, Beatriz Sequeira, Ana Luísa De Sousa-Coelho
{"title":"The impact of bariatric and metabolic surgery on the levels of circulating growth differentiation factor 15 in humans.","authors":"Victor Yassuda, Beatriz Sequeira, Ana Luísa De Sousa-Coelho","doi":"10.1007/s13105-026-01160-8","DOIUrl":"10.1007/s13105-026-01160-8","url":null,"abstract":"","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":"82 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13038775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147581520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Odevixibat ameliorates high-fat diet-induced MASLD in mice by targeting the gut microbiota-metabolite axis and enhancing gut-liver crosstalk. 奥维西巴通过靶向肠道微生物代谢物轴和增强肠-肝串扰改善小鼠高脂肪饮食诱导的MASLD。
IF 4.3 3区 生物学
Journal of physiology and biochemistry Pub Date : 2026-03-31 DOI: 10.1007/s13105-026-01165-3
Xiang Gao, Song Dai, Jiahao Li, Tao Wang, Xulong Sun, Pengzhou Li
{"title":"Odevixibat ameliorates high-fat diet-induced MASLD in mice by targeting the gut microbiota-metabolite axis and enhancing gut-liver crosstalk.","authors":"Xiang Gao, Song Dai, Jiahao Li, Tao Wang, Xulong Sun, Pengzhou Li","doi":"10.1007/s13105-026-01165-3","DOIUrl":"https://doi.org/10.1007/s13105-026-01165-3","url":null,"abstract":"<p><p>Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent metabolic disorder with limited therapeutic options. This study aimed to investigate the therapeutic effects and underlying mechanisms of Bylvay (odevixibat) on high-fat diet (HFD)-induced MASLD in mice, focusing on liver pathology, gut barrier integrity, and the gut-liver axis via 16 S rRNA gene sequencing and untargeted metabolomics. Bylvay Odevixibat significantly ameliorated hepatic steatosis, inflammation, and liver injury markers. It restored gut barrier integrity, notably reversing HFD-induced dysbiosis, including Akkermansia and Desulfovibrio, and normalized key metabolites like LysoPC (20:5) and trichloroethanol glucuronide. Mechanistically, Bylvay treatment promoted the restructuring of the gut microbiota, which correlated with improved metabolic health. The abundance of trichloroethanol glucuronide was negatively correlated with Muribaculaceae and Lactobacillus abundance. The abundance of LysoPC (20:5(5Z,8Z,11Z,14Z,17Z)/0:0) exhibited a positive correlation with the abundance of Muribaculaceae, Alistipes, Lactobacillus, Alloprevotella and Desulfovibrio, and a negative correlation with Akkermansia and Bacteroides abundance. In summary, our findings reveal the therapeutic potential of Bylvay (odevixibat) in MASLD management, emphasizing the critical role of the interplay between gut microbiota, metabolites, and the gut-liver axis.</p>","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":"82 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147581544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut microbiota-derived extracellular vesicles: novel perspectives from host-microbe interactions to therapeutic applications. 肠道微生物衍生的细胞外囊泡：从宿主-微生物相互作用到治疗应用的新视角。
IF 4.3 3区 生物学
Journal of physiology and biochemistry Pub Date : 2026-03-26 DOI: 10.1007/s13105-026-01175-1
Yuwei Han, Yuying Guo, Wenzhe Xu, Yunsha Zhang, Hongying Hao, Yanhong Song, Nanjin Yu, Linna Zhao, Shixin Xu
{"title":"Gut microbiota-derived extracellular vesicles: novel perspectives from host-microbe interactions to therapeutic applications.","authors":"Yuwei Han, Yuying Guo, Wenzhe Xu, Yunsha Zhang, Hongying Hao, Yanhong Song, Nanjin Yu, Linna Zhao, Shixin Xu","doi":"10.1007/s13105-026-01175-1","DOIUrl":"https://doi.org/10.1007/s13105-026-01175-1","url":null,"abstract":"","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":"82 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147512851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction Note: CTRP15 promotes macrophage cholesterol efflux and attenuates atherosclerosis by increasing the expression of ABCA1. 注：CTRP15通过增加ABCA1的表达，促进巨噬细胞胆固醇外排，减轻动脉粥样硬化。
IF 4.3 3区 生物学
Journal of physiology and biochemistry Pub Date : 2026-03-23 DOI: 10.1007/s13105-026-01174-2
Wei-Hua Tan, Zheng-Liang Peng, Ting You, Zhi-Lu Sun
{"title":"Retraction Note: CTRP15 promotes macrophage cholesterol efflux and attenuates atherosclerosis by increasing the expression of ABCA1.","authors":"Wei-Hua Tan, Zheng-Liang Peng, Ting You, Zhi-Lu Sun","doi":"10.1007/s13105-026-01174-2","DOIUrl":"https://doi.org/10.1007/s13105-026-01174-2","url":null,"abstract":"","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":"82 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147504180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the role of metabolic disorders and gut microbiome in immune checkpoint regulation in cancer: PI3K/AKT/mTOR focus. 探索代谢紊乱和肠道微生物组在癌症免疫检查点调节中的作用：PI3K/AKT/mTOR焦点。
IF 4.3 3区 生物学
Journal of physiology and biochemistry Pub Date : 2026-03-20 DOI: 10.1007/s13105-026-01171-5
Azam Abedi, Mehrdad Moosazadeh Moghaddam, Reza Kachuei, Abbas Ali Imani Fooladi
{"title":"Exploring the role of metabolic disorders and gut microbiome in immune checkpoint regulation in cancer: PI3K/AKT/mTOR focus.","authors":"Azam Abedi, Mehrdad Moosazadeh Moghaddam, Reza Kachuei, Abbas Ali Imani Fooladi","doi":"10.1007/s13105-026-01171-5","DOIUrl":"https://doi.org/10.1007/s13105-026-01171-5","url":null,"abstract":"","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":"82 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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