The importance of vitamin D levels in patients with inflammatory bowel disease.

IF 3.7 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Evgenia Koureta, Pantelis Karatzas, Panagiotis Kanellopoulos, Angeliki Papapanagiotou, Vasileios Lekakis, Giorgos Bamias, Andreas Koutsoumpas, George Karamanolis, Jiannis Vlachogiannakos, Athanasios G Papavassiliou, George V Papatheodoridis
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Abstract

The possible role of vitamin D (VD) in the pathogenesis of inflammatory bowel disease (IBD) and the associations between VD levels and IBD activity remain unclarified. We aimed to assess VD levels in IBD patients and their associations with IBD activity. We evaluated VD levels in Greek patients aged 18-75 years old with Crohn's disease (CD) or ulcerative colitis (UC). Patients were ineligible under the following conditions: history of enterectomy/right colectomy, receiving VD or agent(s) interfering with VD metabolism during the last three months and any comorbidities that influence VD levels. Epidemiologic characteristics, clinical course, laboratory investigations, endoscopic and histologic findings were recorded. In total, 122 patients with CD and 71 with UC were included. Most of them had low levels of VD (90% of CD and 91.5% of UC patients). Patients with clinically active CD or UC had lower levels of VD compared to those in remission (p = 0.009 and p = 0.033, respectively).CD patients with low levels of VD had higher CRP and stool calprotectin compared to those with normal levels of VD (P = 0.032 and P = 0.002, respectively). In UC, patients with pancolitis had lower VD levels compared to patients with proctitis (P = 0.036). In conclusion, the majority of Greek IBD patients have low levels of VD. Clinical activity is related to lower levels of VD. Low compared to normal levels of VD in CD patients are associated with higher CRP and calprotectin levels, so VD levels might serve as an activity marker.

维生素D水平对炎症性肠病患者的重要性。
维生素D (VD)在炎症性肠病(IBD)发病机制中的可能作用以及VD水平与IBD活性之间的关系尚不清楚。我们的目的是评估IBD患者的VD水平及其与IBD活动的关系。我们评估了希腊18-75岁克罗恩病(CD)或溃疡性结肠炎(UC)患者的VD水平。以下条件的患者不符合条件:肠切除术/右结肠切除术史,在过去三个月内接受过VD或干扰VD代谢的药物,以及任何影响VD水平的合并症。记录流行病学特征、临床过程、实验室检查、内镜和组织学检查结果。共纳入122例CD患者和71例UC患者。大多数患者VD水平较低(90%的CD患者和91.5%的UC患者)。临床活动性CD或UC患者的VD水平低于缓解期患者(p = 0.009和p = 0.033)。与VD水平正常的CD患者相比,VD水平低的CD患者的CRP和粪便钙保护蛋白水平更高(P = 0.032和P = 0.002)。UC中,与直肠炎患者相比,全结肠炎患者VD水平较低(P = 0.036)。总之,大多数希腊IBD患者的VD水平较低。临床活动与较低的VD水平有关。与正常VD水平相比,CD患者的VD水平较低与较高的CRP和钙保护蛋白水平相关,因此VD水平可能作为活动标志物。
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来源期刊
Journal of physiology and biochemistry
Journal of physiology and biochemistry 生物-生化与分子生物学
CiteScore
6.60
自引率
0.00%
发文量
86
审稿时长
6-12 weeks
期刊介绍: The Journal of Physiology and Biochemistry publishes original research articles and reviews describing relevant new observations on molecular, biochemical and cellular mechanisms involved in human physiology. All areas of the physiology are covered. Special emphasis is placed on the integration of those levels in the whole-organism. The Journal of Physiology and Biochemistry also welcomes articles on molecular nutrition and metabolism studies, and works related to the genomic or proteomic bases of the physiological functions. Descriptive manuscripts about physiological/biochemical processes or clinical manuscripts will not be considered. The journal will not accept manuscripts testing effects of animal or plant extracts.
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