Journal of physiology and biochemistry最新文献

{"title":"Purinergic receptors in atherosclerosis: implications for pathophysiology and therapeutic strategies.","authors":"Siarhei A Dabravolski, Vasily V Kashtalap, Aleksandra S Utkina, Gulalek A Babayeva, Anastasia O Maksaeva, Vasily N Sukhorukov, Alexander N Orekhov","doi":"10.1007/s13105-025-01108-4","DOIUrl":"https://doi.org/10.1007/s13105-025-01108-4","url":null,"abstract":"<p><p>Atherosclerosis is a complex cardiovascular disease characterised by the accumulation of lipids, inflammatory cells, and fibrous elements within arterial walls, leading to plaque formation and increased risk of cardiovascular events. Recent evidence highlights the pivotal roles of purinergic receptors in mediating the inflammatory and cellular processes associated with atherosclerosis. This review examines the roles of purinergic receptors in the pathophysiology of atherosclerosis, with a particular focus on the P1 subtype (A2A and A3 receptors), the P2X subtype (P2X4 and P2X7 receptors), and the P2Y subtype (P2Y2, P2Y11, and P2Y12 receptors). The A2A and A3 receptors are involved in modulating vascular inflammation, endothelial cell function, and vascular smooth muscle cell calcification. P2X4 has been implicated in the production of pro-inflammatory cytokines and the promotion of plaque inflammation, whereas P2X7 contributes to vascular inflammation, plaque progression, and rupture. The P2Y2 receptor plays critical roles in regulating vascular inflammation and calcification, smooth muscle cell migration, and plaque growth. Furthermore, the P2Y11 receptor has been shown to modulate endothelial cell inflammation, while P2Y12 is associated with lipid accumulation, foam cell formation, vascular smooth muscle cell migration, and plaque development. By synthesising current knowledge on the involvement of purinergic signalling in atherosclerosis, this review discusses potential therapeutic targets for intervention. Specifically, P2Y receptor antagonists present promising avenues for reducing inflammation and improving vascular function in atherosclerotic patients. However, despite the advancements in understanding purinergic receptor functions, challenges remain in translating this knowledge into clinical practice. Further research is essential to unravel the intricate signalling pathways of these receptors and to develop effective biomarker strategies and therapeutic interventions aimed at combatting atherosclerosis and its associated complications.</p>","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-184 in hepatocellular carcinoma: a promising therapeutic target.","authors":"Leila Hosseinzadeh, Fereshteh Jalilian, Mohammad Reza Kalhori, Reza Alibakhshi, Amir Ali Kalhori, Mohsen Karami","doi":"10.1007/s13105-025-01104-8","DOIUrl":"https://doi.org/10.1007/s13105-025-01104-8","url":null,"abstract":"<p><p>Hepatocellular carcinoma is the most prevalent form of liver cancer worldwide and has high mortality rates. miRNAs, particularly miR-184, have been implicated in cancer biology, where they regulate gene expression and influence tumorigenesis. This study explored the role of miR-184 in HCC, revealing its dual function as both an oncogene and a tumor suppressor, depending on the target genes. We highlight the regulatory effects of miR-184 on critical genes such as INPPL1, FOXO3a, MTSS, OSGIN1, and SOX7 and its impact on key signaling pathways, including the Wnt/β-catenin and JAK2/STAT3/AKT pathways. Dysregulation of miR-184 expression in HCC tissues compared with normal liver tissue was linked to increased proliferation, reduced apoptosis, and autophagy inhibition. Furthermore, miR-184 shows promise as a diagnostic and prognostic biomarker in HCC because of its altered expression in cancerous tissues and blood. Its regulation through circRNAs and lncRNAs such as lncRNA UCA1, circ_0004913, circ-0001141, circ-102,166, LINC00205, and SNHG11 adds a layer of complexity, challenging us to delve deeper into the intricate mechanisms of miR-184, positioning it as a crucial target for potential therapeutic intervention.</p>","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of circulating miRNAs for the diagnosis, prognosis, and personalized treatment of MASLD.","authors":"Ana Luz Tobaruela-Resola, Fermín I Milagro, Paola Mogna-Pelaez, María Jesús Moreno-Aliaga, Itziar Abete, María Ángeles Zulet","doi":"10.1007/s13105-025-01110-w","DOIUrl":"https://doi.org/10.1007/s13105-025-01110-w","url":null,"abstract":"<p><strong>Introduction: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly NAFLD, includes a range of conditions from steatosis to hepatocellular carcinoma and poses a significant health and economic burden. Circulating microRNAs (miRNAs) are key regulators of metabolic and inflammatory pathways involved in MASLD. However, their clinical utility as non-invasive biomarkers remain unclear. This review aims to clarify their diagnostic, prognostic, and therapeutic potential, addressing current gaps in the literature.</p><p><strong>Methods: </strong>Following PRISMA guidelines, we conducted a systematic review of 1149 studies from the PubMed and Scopus databases up to 2024, focused on circulating miRNAs in MASLD.</p><p><strong>Results: </strong>The most frequently studied miRNAs included miR-122 (35.56% of studies), miR-21 (18.89%), miR-34 (14.44%), and miR-192-5p (13.33%). Diagnostic accuracy varied among miRNAs, with miR-200 and miR-298 demonstrating AUROCs of 0.96 and 0.98, respectively, for MASLD detection. In MASH, miR-200, miR-298, and miR-342 exhibited near-perfect AUROCs of 0.99, while miR-122 showed values between 0.81 and 1.0. For HCC, miR-214 achieved an AUROC of 0.88, and miR-34a ranged from 0.73 to 0.76. Several miRNA panels demonstrated high diagnostic accuracy, with AUROCs up to 0.99, particularly in distinguishing HCC from other liver conditions. Prognostically, elevated miR-122 levels correlated with disease severity and fibrosis progression, while miR-21 and miR-223 were linked to obesity-associated MASH. Therapeutic interventions, including surgery, dietary modifications, and supplementation, were found to modulate miRNA profiles.</p><p><strong>Conclusions: </strong>MiRNAs exhibit strong potential as minimally invasive biomarkers for MASLD, contributing to improved diagnosis, prognosis, and therapeutic decision-making. Their stability and role in personalized medicine underscore their clinical relevance.</p>","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenolic compounds and epigenetic mechanisms regulating gene expression: effects on human health.","authors":"Silvia Lorente-Cebrián, André G V Costa, J Andrés Castillo-Rivas, Marta Castro, José Miguel Arbonés-Mainar, Saioa Goñi, Sara Remón, Paula Aranaz, Víctor López, Inmaculada Martín-Burriel, Fermín I Milagro","doi":"10.1007/s13105-025-01105-7","DOIUrl":"https://doi.org/10.1007/s13105-025-01105-7","url":null,"abstract":"<p><p>Phenolic compounds are a large class of phytochemicals with relevant physiological effects that are naturally found in plant-origin foods and derived products. Beneficial effects associated with polyphenol consumption are related to their ability to prevent and/or counteract disease features: they exert anti-inflammatory, antioxidant and anticancer effects, as well as protective actions against metabolic diseases. Phenolic compounds and their metabolites can modulate cell function by regulating gene expression. These effects are partially mediated through specific changes in epigenetic mechanisms such as DNA methylation, histone modifications and microRNA (miRNA) expression. Some polyphenols affect DNA methylation and are effective in counteracting deleterious actions induced by inflammatory/pro-oxidant factors, both in in vitro and in vivo settings. Specific mechanisms include modulation of methyl-transferases, whose levels are inhibited upon polyphenols treatment. Some polyphenols are histone deacetylase inhibitors, which prevent transcriptional repression and suppress tumor and inflammation genes by affecting selective regulation of miRNA expression. Their mostly recognized actions as anti-inflammatory and antioxidants seem to be partially mediated through regulation of individual miRNAs. Due to these actions, polyphenols and polyphenol-derived metabolites are under study in clinical and interventional trials for their benefits on inflammation and/or metabolic disorders. In conclusion, phenolic compounds might be an interesting approach to contribute to human homeostasis given their capacity to dynamically regulate epigenetic factors at cellular and systemic level. The present review aims to study available evidence regarding regulatory effects of polyphenols on gene expression, specifically mediated through epigenetic mechanisms.</p>","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial special issue: Frontiers in cancer, obesity and metabolism.","authors":"Ana B Crujeiras, José Ángel Martínez-Climent, Miguel Burgos","doi":"10.1007/s13105-025-01107-5","DOIUrl":"https://doi.org/10.1007/s13105-025-01107-5","url":null,"abstract":"<p><p>This Special Issue contains 7 contributions elaborated in the context of the workshop \"Frontiers in Cancer, Obesity and metabolism\" organized by the Journal of Physiology and Biochemistry (Pamplona, Spain, 2022). It contains basic, translational and epidemiological research that sheds light in our understanding of the molecular mechanisms underlying how the excess of adipose tissue in obesity promotes tumor growth and progression, and highlights the role of nutrition in preventing tumor development and improving treatment outcomes in cancer patients with obesity and related comorbidities. Two review articles and one systematic review are included in this special issue, which describe the effects of nutrient deprivation that potentially enhance cancer immunotherapy, reveal the importance of the glucose transporter GLUT12 in obesity and cancer, and analyze recently described molecular mechanisms that connect obesity and the development of different types of cancer. Additionally, four original articles demonstrate a metabolic inflammatory pathway in patients with obesity in which dysfunctional adipose tissue alters the tumor microenvironment favoring tumor progression, offers mechanistic support for exploring low-fat ketogenic diets as adjuvant therapy in obesity-related breast cancer prevention or therapy by linking nutritional ketosis to epigenetic regulation of cancer‑related genes, indicate the use of genes related to amino acid metabolism as prognostic biomarkers in breast cancer, and associate a moderate adherence to a dietary-based diabetes-risk score to a lower risk of breast cancer among premenopausal women and women with low body mass index. Globally, the articles included in this special issue contribute to better understand the molecular mechanisms beyond nutritional aspects linked to obesity and cancer development.</p>","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of cell junctions in atherosclerosis: implications for inflammation, endothelial dysfunction, and plaque stability.","authors":"Siarhei A Dabravolski, Vasily V Kashtalap, Ulyana V Rozhkova, Anastasia O Maksaeva, Vasily N Sukhorukov, Alexander N Orekhov","doi":"10.1007/s13105-025-01106-6","DOIUrl":"https://doi.org/10.1007/s13105-025-01106-6","url":null,"abstract":"<p><p>Atherosclerosis, a chronic inflammatory disease, involves a complex interplay between endothelial cells, smooth muscle cells, and inflammatory mediators. Cell-to-cell junctions, including adherens junctions (AJs), tight junctions (TJs), and gap junctions (GJs), play a critical role in maintaining vascular integrity and regulating cellular interactions in the vascular wall. This review summarises the molecular mechanisms by which these junctions contribute to atherosclerosis, focusing on key proteins like VE-cadherin (AJs), ZO-1, occludin, and claudins (TJs), and connexins (GJs). Dysregulation of these junctions, driven by factors such as oxidative stress, pro-inflammatory cytokines, atheroprone shear stress (aSS), and lipid-mediated signalling pathways, leads to endothelial dysfunction, increased permeability, monocyte infiltration, and plaque instability. Furthermore, the role of signalling pathways, including NFκB, PI3K/AKT, and Wnt/β-catenin, in the regulation of junctional proteins is explored. Emerging factors, including oxygenated cholesterol, radiation, and various drugs, provide new insights into junctional modulation in atherosclerosis. The potential of targeting junctional proteins and their associated pathways for therapeutic interventions is also discussed. Future studies focusing on the detailed mechanisms of junctional dysregulation in vivo and the clinical translation of these findings are necessary to develop novel therapeutic strategies for atherosclerosis. Clinical trial number Not applicable.</p>","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postnatal overfeeding induces gut microbiota disturbances and impairs GPR43/FIAF/LPL pathway in the rat model of PCOS.","authors":"Nataša Veličković, Miloš Vratarić, Bojana Mićić, Ana Teofilović, Marina Radovanović, Sofija Ignjatović, Uroš Gašić, Ana Djordjevic, Djuro Macut, Danijela Vojnović Milutinović","doi":"10.1007/s13105-025-01103-9","DOIUrl":"https://doi.org/10.1007/s13105-025-01103-9","url":null,"abstract":"<p><p>Women with polycystic ovary syndrome (PCOS) has high incidence of metabolic dysfunction-associated steatotic liver disease (MASLD). The development of PCOS-associated MASLD is accelerated by prepubertal obesity, therefore, we analyzed the impact of postnatal overfeeding-induced obesity on the gut microbiota and hepatic lipid metabolism in the PCOS rat model. Wistar rats were divided into 4 groups, where treatment with 5α-dihydrotestosterone (5α-DHT) stimulated hyperandrogenemia (DHT groups), whereas litter size reduction induced early postnatal overfeeding and obesity (SL groups). The fecal microbiota composition and diversity was analyzed by 16S rRNA sequencing. The bacterial metabolites level was measured by mass spectrometry. Hematoxylin-eosin staining, Western blots, and qRT-PCR were used to analyze hepatic lipid metabolism. Our results show that postnatal overfeeding shifted the microbiota composition towards obesity-associated genera, while hyperandrogenemia led to reduced β-diversity and increased abundance of androgen-regulated genera. Interaction of treatments reduced α- and β-diversity and decreased the abundance of beneficial butyrate-producing genera Roseburia, Oscillospira, and Ruminococcus and butyric acid plasma level. Shift in microbiota composition and activity was accompanied by decreased expression of G-protein coupled receptor (GPR) 43, fasting-induced adipocyte factor (FIAF) and increased expression of lipoprotein lipase (LPL). In accordance with altered GPR43 and FIAF/LPL pathway, increased expression of lipogenic transcription factors was observed in SL-DHT animals, but this did not result in hepatic lipid deposition. Our results demonstrated that postnatal overfeeding contributes to decreased richness and changes in gut microbiota composition in the PCOS animal model that is associated with impaired hepatic lipid metabolism, which may accelerate development of MASLD.</p>","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curcumin ameliorates hepatic steatosis and insulin resistance through the JNK2/FOXO1/Bcl6 axis and regulate the intestinal flora structure.","authors":"Ju Yang, Biaozhang Song, Feng Zhang, Bing Liu, Jiai Yan, Yingyu Wang, Jing Sun, Chengguang Zhao, Dan Li, Hong Cao","doi":"10.1007/s13105-025-01101-x","DOIUrl":"https://doi.org/10.1007/s13105-025-01101-x","url":null,"abstract":"<p><p>Curcumin, a polyphenol extracted from the plant turmeric rhizoma, is well known for its strong antioxidant capacity and beneficial effects on the treatment of obesity induced by a high-fat diet in mice. However, the exact mechanism of action by which it improves obesity remains elusive. The aim of this study was to investigate the effect of curcumin on the biological phenotype of HFD-induced obese mice, to determine the related metabolic pathways and to determine whether the intestinal flora is involved. C57BL/6 mice were fed HFD for 8 weeks and then gavaged with 200 mg/kg curcumin or the same volume of vehicle for 16 weeks. The body weight, blood glucose level, blood lipid level, insulin resistance and oxidative stress level of the mice were detected to determine the effect of the treatment on lipid metabolism. Liver transcriptome analysis combined with qPCR and cell experiments revealed that curcumin improves hepatic steatosis and insulin resistance in mice fed a high-fat diet by downregulating the JNK2/FOXO1/Bcl6 axis. Curcumin treatment can regulate the composition and structure of intestinal flora in high-fat diet-fed mice, and increase the relative abundance of beneficial bacteria such as Coriobacteriaceae, Mailhella, Faecalibaculum, Phocaeicola vulgatus, Parvibacter vulgatus, and Bacteroides intestinalis, which are associated with obesity and metabolic disorders, while reducing the relative abundance of harmful bacteria such as Alistipes, Oscillibacter, Lactobacillus johnsonii, and Acutalibacter muris. In conclusion, curcumin ameliorated hepatic steatosis and insulin resistance in HFD-fed mice by down-regulating hepatic JNK2/FOXO1/Bcl6 axis and altering the composition and structure of intestinal flora.</p>","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-steatotic effect of Opuntia ficus-indica extracts rich in betalains and phenolics from fruit peel and pulp of different varieties in in vitro models.","authors":"Irene Besné-Eseverri, Jenifer Trepiana, Itziar Eseberri, Andrea Gómez-Maqueo, M Pilar Cano, Joao Tomé-Carneiro, Alberto Dávalos, María P Portillo","doi":"10.1007/s13105-025-01097-4","DOIUrl":"10.1007/s13105-025-01097-4","url":null,"abstract":"<p><p>Opuntia ficus-indica exhibits antioxidant, anti-inflammatory and anti-hyperglycemic properties, making it a promising candidate for the prevention and treatment of metabolic dysfunction-associated fatty liver disease. However, its effects on triglyceride accumulation remain largely unexplored. The aim of the present study is to evaluate the anti-steatotic effect of peel and pulp extracts from different varieties of Opuntia ficus-indica fruits (Pelota, Colorada and Sanguinos) in hepatic murine in vitro models, using both AML12 hepatocytes and hepatic organoids. The pulp extracts of Pelota and Colorada varieties, as well as both peel and pulp extracts of Sanguinos, were effective in reducing palmitic acid-induced triglyceride accumulation in AML12 hepatocytes. The doses that caused the greatest triglyceride reduction were 50 µg/mL of the pulp of Pelota and 100 µg/mL for the other extracts. The potential mechanisms underlying these effects seem to be associated, at least in part, with the inhibition of fatty acid uptake and triglyceride assembly. The pulp extract of the Colorada variety was able to prevent triglyceride accumulation also in hepatic organoids, likely due to downregulation of fatty acid transporters. These findings underscore the value of employing diverse in vitro models (e.g., 2D, 3D) to investigate the potential effects of these extracts, and suggest that the pulp extract of the Colorada variety may be effective in preventing steatosis.</p>","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Acute pancreatitis experimental models, advantages and disadvantages.","authors":"Genaro J Rosales-Muñoz, Verónica Souza-Arroyo, Leticia Bucio-Ortiz, Roxana U Miranda-Labra, Luis E Gomez-Quiroz, María Concepción Gutiérrez-Ruiz","doi":"10.1007/s13105-025-01102-w","DOIUrl":"https://doi.org/10.1007/s13105-025-01102-w","url":null,"abstract":"","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}