Journal of photochemistry and photobiology. B, Biology最新文献

{"title":"Optical and random laser properties of the novel multifunctional endoxifen derivative (FLTX3) and its potential for the diagnosis of breast cancer resistance","authors":"Mario Diaz ,&nbsp;Sergio de Armas-Rillo ,&nbsp;Fernando Lobo ,&nbsp;Daniel Pereda de Pablo ,&nbsp;Kevin Soler-Carracedo ,&nbsp;Pablo Delgado ,&nbsp;Mitzi Rodriguez ,&nbsp;Ana Canerina-Amaro ,&nbsp;Catalina Valdes-Baizabal ,&nbsp;Raquel Marín ,&nbsp;Dácil Hernández ,&nbsp;Alicia Boto ,&nbsp;Fernando Lahoz","doi":"10.1016/j.jphotobiol.2025.113345","DOIUrl":"10.1016/j.jphotobiol.2025.113345","url":null,"abstract":"<div><div>Endoxifen is the most powerful metabolite of tamoxifen (TX), the main endocrine therapy administered worldwide for the treatment of estrogen-receptor (ER) positive metastatic breast cancer. Tamoxifen itself is a prodrug with weak affinity for ER, but it is converted into endoxifen, with up to 100-fold higher affinity for ER than TX. In this study, we introduce the first fluorescent endoxifen derivative (FLTX3), formed by covalent attachment of the small fluorophore NBD to the basic side chain of endoxifen. We have characterized the optical properties of FLTX3, demonstrating its ability as a <u>laser dye</u>. FLTX3 is an efficient target-directed <u>fluorescent probe</u> for the cellular labelling of ER in MCF7 breast cancer cell line as well as in uterine tissues. FLTX3 is also endowed with an intrinsic <u>photodynamic</u> effect when irradiated at the optimal excitation wavelength of FLTX3. Further, we show that FLTX3 has an <u>optical gain behaviour</u> that leads to random laser (RL) when the light emitted by the drug is scattered in the cell cultures. Indeed, analyses of coherent spectra by power function Fourier transform revealed a RL dominant cavity in the range of average cell sizes. As one of the main causes for tamoxifen treatment failure is resistance, we explored the potential discriminative value of FLTX3-induced RL between tamoxifen-resistant and tamoxifen-sensitive MCF7 cells. Using multivariate approaches, we unravelled significant differences in the RL signal between tamoxifen-sensitive and tamoxifen-resistant cells. These findings indicate that FLTX3-generated RL might provide a <u>target-directed diagnostic tool</u> for tamoxifen resistance in metastatic ER+ breast cancer.</div></div>","PeriodicalId":16772,"journal":{"name":"Journal of photochemistry and photobiology. B, Biology","volume":"274 ","pages":"Article 113345"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145797082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydroxysafflower yellow a protects against UVA- and UVB-induced skin aging by suppressing cell apoptosis and SASP via targeting JNK and p38 MAPK pathway","authors":"Biao Guo ,&nbsp;Meiyun Wu ,&nbsp;Liying Tong ,&nbsp;Jiahui Yu ,&nbsp;Ruoyun Liu ,&nbsp;Meng Deng ,&nbsp;Yijing Ma ,&nbsp;Hao Li ,&nbsp;Zile Yang ,&nbsp;Xiyun Ye ,&nbsp;Yongyan Dang","doi":"10.1016/j.jphotobiol.2025.113340","DOIUrl":"10.1016/j.jphotobiol.2025.113340","url":null,"abstract":"<div><div>Safflower (<em>Carthamus tinctorius L.</em>) is a traditional Chinese medicinal herb that has long been used to promote blood circulation. Its major active component, hydroxysafflor yellow A (HSYA), exhibits potent antioxidant and anti-photoaging properties. However, the mechanisms underlying HSYA's protective effects against skin photoaging remain largely unclear. This study aimed to elucidate how HSYA mitigates skin aging induced by UVA- and UVB-triggered apoptosis and the senescence-associated secretory phenotype (SASP) in keratinocytes and fibroblasts. Damage models were established by exposing BALB/c nude mice, HaCaT keratinocytes, and HSF fibroblasts to either combined or individual UVA and UVB irradiation. Network pharmacology analysis was subsequently performed to explore the molecular mechanisms underlying the anti-photoaging effects of HSYA. The predicted targets and signaling pathways were validated through both <em>in vitro</em> and <em>in vivo</em> experiments. HSYA reduced apoptosis in UVB-damaged keratinocytes and UVA-damaged fibroblasts by regulating the expression of Bcl-2 and Bax and reducing cleavage of PARP and caspase 3. It also suppressed ROS accumulation in both cell types. Furthermore, HSYA inhibited SASP by downregulating the expression of <em>TNF-α, IL-6, IL-8</em>, and matrix metalloproteinases (MMPs). It significantly enhanced type I procollagen expression of skin fibroblasts and promoted collagen fiber deposition in mouse skin, suggesting a reversal of UV-induced senescence of skin fibroblasts. Mechanistically, HSYA exerted its protective effects by inhibiting the activation of the p38 and JNK pathways. Notably, the inhibitory effects of HSYA on p38 and JNK phosphorylation were comparable to those of specific MAPK inhibitors. These findings identify that HSYA exerts the protective effects against UV-induced skin damage through coordinated regulation of oxidative stress, inflammation, apoptosis, and collagen remodeling, in part by targeting the JNK/p38 MAPK pathway. Thus, HSYA emerges as a promising active ingredient for the development of anti-photoaging and skin-rejuvenation products in the future.</div></div>","PeriodicalId":16772,"journal":{"name":"Journal of photochemistry and photobiology. B, Biology","volume":"274 ","pages":"Article 113340"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145797083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbonic anhydrase modulates photosynthetic responses to UV radiation in diatoms across temperature gradients","authors":"Xiangyu Li ,&nbsp;Yuheng An ,&nbsp;Juntian Xu ,&nbsp;Yaping Wu ,&nbsp;John Beardall","doi":"10.1016/j.jphotobiol.2025.113315","DOIUrl":"10.1016/j.jphotobiol.2025.113315","url":null,"abstract":"<div><div>Diatoms are major contributors to marine primary production and global carbon cycling, while they face increasing physiological stress from climate change–driven shifts in temperature, light regimes, and carbon availability. Carbonic anhydrase (CA) is a key enzyme in diatom carbon-concentrating mechanisms, catalyzing the reversible conversion of CO₂ and HCO₃⁻ to facilitate carbon fixation. Here, we examined how CA inhibition influences the growth and photosynthetic performance of two morphologically distinct diatoms—<em>Skeletonema costatum</em> and <em>Nitzschia</em> sp. (centric vs. pennate)—under ultraviolet radiation (UVR) across three temperatures (15, 20, and 25 °C). Cultures were exposed to photosynthetically active radiation (PAR) or PAR + UVR (PAB), with or without ethoxyzolamide (EZ), a membrane-permeable CA inhibitor. In <em>S. costatum</em>, EZ completely suppressed growth at all temperatures, indicating a strong dependence on CA-mediated CO₂ supply. <em>Nitzschia</em> sp. maintained growth under EZ at 15 and 20 °C but was more affected at 25 °C, suggesting greater resilience through alternative carbon acquisition pathways. Photophysiological measurements showed that CA inhibition substantially reduced maximum relative electron transport rate (rETR_max) and light saturation point (I_k) in <em>S. costatum</em>, with smaller effects in <em>Nitzschia</em>. Under UVR, effective quantum yield (EQY) declined in both species, but the reduction was amplified by CA inhibition, most severely in <em>S. costatum</em>, where UVR-induced EQY inhibition exceeded 75 % at 25 °C. These results highlight that CA plays a critical role in mitigating UVR stress by sustaining CO₂ availability, and that species-specific traits, including differences in cell geometry, carbon uptake systems, and photoprotective capacity, modulate diatom vulnerability to combined warming and UVR. Such species-specific responses could drive shifts in diatom community composition and alter coastal carbon cycling under future climate scenarios.</div></div>","PeriodicalId":16772,"journal":{"name":"Journal of photochemistry and photobiology. B, Biology","volume":"274 ","pages":"Article 113315"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145578733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional PDA–graphene family nanocomposites for antibacterial and anticancer photothermal therapy","authors":"Sepehr Kamalzadeh ,&nbsp;Kowsar Moradi ,&nbsp;Amir Keshavarz Afshar,&nbsp;Matin Mahmoudifard","doi":"10.1016/j.jphotobiol.2025.113310","DOIUrl":"10.1016/j.jphotobiol.2025.113310","url":null,"abstract":"<div><div>The increasing demand for multifunctional, biocompatible nanomaterials has spurred the exploration of hybrid systems with synergistic antimicrobial, anticancer, antioxidant, and regenerative properties. In this study, polydopamine (PDA)-based nanocomposites incorporating graphene oxide (PDA–GO) and graphene quantum dots (PDA–GQD) were synthesized and systematically characterized for their physicochemical and biological functionalities. The nanocomposites raised temperature &gt; 50 °C within 5 min under 808 nm laser irradiation (1.5 W/cm², 250 μg/mL). Both composites showed antibacterial activity against <em>Escherichia coli (E. coli)</em> (Gram-negative) and <em>Staphylococcus aureus</em> (<em>S. aureus)</em> (Gram-positive), achieving &gt;99 % bacterial eradication under 10 min NIR irradiation at 125 μg/mL, indicating a combined photothermal (PT) and oxidative mechanism. In parallel, in vitro cytotoxicity assays revealed selective toxicity toward MCF-7 cancer cells—reducing viability to 95 % viability of normal L929 fibroblasts. Antioxidant assays confirmed &gt;80 % DPPH radical scavenging at 250 μg/mL, supporting their potential in oxidative stress modulation. Furthermore, scratch wound healing assays demonstrated ∼100 % wound closure within 48 h in NIR-irradiated PDA–GO/PDA–GQD groups. Intracellular H₂O₂ generation reached up to 30.5 μM in MCF-7 cells under laser, enabling dual PT–photodynamic (PD) therapy. Altogether, these findings position PDA–GO and PDA–GQD nanocomposites as versatile platforms for integrated antibacterial, anticancer, and wound-healing therapies, highlighting their promise for future biomedical applications beyond conventional monofunctional approaches.</div></div>","PeriodicalId":16772,"journal":{"name":"Journal of photochemistry and photobiology. B, Biology","volume":"274 ","pages":"Article 113310"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LED blue light photobiomodulation induces ferroptosis and apoptosis via ROS-mediated oxidative damage in osteosarcoma cells","authors":"Jiali Yang ,&nbsp;Haokuan Qin ,&nbsp;Xiaojing Miao ,&nbsp;Longfei Huo ,&nbsp;Qiqi Fu ,&nbsp;Hui Jiang ,&nbsp;Jianfeng Niu ,&nbsp;Muqing Liu","doi":"10.1016/j.jphotobiol.2025.113350","DOIUrl":"10.1016/j.jphotobiol.2025.113350","url":null,"abstract":"<div><div>Blue light (400–500 nm) photobiomodulation (PBM), particularly utilizing light-emitting diodes (LEDs), has garnered extensive attention for its therapeutic efficacy across various conditions, including oncology. Nevertheless, its impact on osteosarcoma cells remain inadequately characterized. This study sought to investigate the tumor-suppressive properties and underlying molecular mechanisms of LED blue light PBM in human osteosarcoma cell lines HOS and MG63. The results indicated that blue light PBM effectively suppressed cell proliferation and triggered G2/M phase cell cycle arrest. Moreover, blue light PBM activated apoptosis and ferroptosis, characterized by significant changes in ferroptosis-associated proteins (HO-1, PTGS2, GPX4). Concurrently, ROS accumulation triggered oxidative stress, as demonstrated by increased MDA and LPO levels, well-established markers of ferroptosis. These findings underscore the promising potential of LED blue light PBM as an innovative, non-pharmacological therapeutic strategy for osteosarcoma, warranting further investigation for future clinical applications.</div></div>","PeriodicalId":16772,"journal":{"name":"Journal of photochemistry and photobiology. B, Biology","volume":"274 ","pages":"Article 113350"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145836859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intermittent blue light-dark cycles: A new strategy for enhancing triterpenoid production in medicinal Sanghuangporus vaninii","authors":"Yanjun Ma ,&nbsp;Rong Li ,&nbsp;Jiahui Li ,&nbsp;Zilu Song ,&nbsp;Fawen She ,&nbsp;Xiaoyan Ma ,&nbsp;Xuetai Zhu","doi":"10.1016/j.jphotobiol.2025.113338","DOIUrl":"10.1016/j.jphotobiol.2025.113338","url":null,"abstract":"<div><div>Triterpenoids from medicinal fungi have significant biological activities and industrial potential, but their low yield limits large-scale production. <em>Sanghuangporus vaninii</em>, a widely cultivated medicinal fungus, is a promising source of triterpenoids, yet the regulatory role of light-dark cycles in its triterpenoid biosynthesis remains unclear. In this study, we demonstrated that intermittent intense blue light-dark cycles (IB/D; ∼110 μmol/m²·s, 10 h/14 h) dramatically enhance triterpenoid production in <em>S. vaninii</em> MF5. IB/D treatment increased triterpenoid yield by 154 % compared to dark controls, also outperforming constant light or white light-dark regimens. Mechanistically, IB/D was associated with: (i) hyperbranching morphology (42 % reduced internode length); (ii) membrane remodeling via upregulated fatty acid desaturases and transporters, enhancing permeability 2.88-fold; and (iii) transcriptional activation of the mevalonate pathway, which was accompanied by a dramatic induction of endogenous 3-hydroxy-3-methylglutaryl-CoA synthase (<em>HMGS</em>) expression 4497-fold. Subsequent cloning and characterization of the <em>SvHMGS</em> gene-through sequence homology with known <em>HMGS</em> genes from <em>Sanghuangporus</em> species, identification of conserved HMGS domains, and prediction of its association with the mevalonic acid (MVA) pathway-suggested its potential conserved function in triterpenoid biosynthesis. This photoperiodic strategy represents a paradigm shift from constant light suppression to rhythmic induction, offering a scalable, low-cost approach to boost triterpenoid production in this medicinal fungus.</div></div>","PeriodicalId":16772,"journal":{"name":"Journal of photochemistry and photobiology. B, Biology","volume":"274 ","pages":"Article 113338"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “An oxygen-independent therapeutic nanosystem for fighting against hypoxic and antioxidant microenvironment of tumor” [Journal of Photochemistry and Photobiology B: Biology 268 (2025) 113184]","authors":"Zixuan Wang ,&nbsp;Shuwei Nie ,&nbsp;Manru Wang ,&nbsp;Huina Niu ,&nbsp;Liqi Wei ,&nbsp;Zhiqi Yang ,&nbsp;Xin Liu ,&nbsp;Yining Chen ,&nbsp;Yunan Yang ,&nbsp;Chunjiang Li ,&nbsp;Qin Zhang ,&nbsp;Lina Feng ,&nbsp;Hongxia Ma ,&nbsp;Rui Chen ,&nbsp;Yan Cheng","doi":"10.1016/j.jphotobiol.2025.113332","DOIUrl":"10.1016/j.jphotobiol.2025.113332","url":null,"abstract":"","PeriodicalId":16772,"journal":{"name":"Journal of photochemistry and photobiology. B, Biology","volume":"274 ","pages":"Article 113332"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Priming cancer cells via photobiomodulation at NIR wavelength to enhance photodynamic action: Insights into mechanistic alterations and cellular migration","authors":"Büşra Sirek ,&nbsp;Nermin Topaloğlu","doi":"10.1016/j.jphotobiol.2025.113336","DOIUrl":"10.1016/j.jphotobiol.2025.113336","url":null,"abstract":"<div><div>Photodynamic therapy (PDT) is a successful therapy for cancer treatment, especially for the superficial and easily reachable types, such as prostate cancer. During photodynamic activation, the light-sensitive chemical, which generally does not have a toxic effect on cells, can induce oxidative stress by producing reactive oxygen species (ROS). Nevertheless, the outcome of the therapy may be diminished by certain drawbacks. For this, PDT can be coupled with other therapies. Different light therapies can also serve as effective anticancer strategies. The combination of photobiomodulation (PBM) with PDT has become increasingly popular in cancer management. In the present study, PBM, which lacks anticancer activity, was combined with Chlorin e6 (Ce6)-mediated PDT. Underlying causes of additional deaths were elucidated by various mechanistic analyses, including ROS, nitric oxide (NO), mitochondrial membrane potential (ΔΨm), etc. PBM priming at an energy density of 5 J/cm² resulted in up to 64 % additional cell death, as demonstrated by colorimetric and dual-staining analyses, and nearly a 100 % decrease in cell migration compared to PDT alone. Besides, PBM priming induced an additional 0.5-fold reduction in NO levels, a 19.4 % increase in ROS levels, and a 1.2 % reduction in ΔΨm compared to only PDT applications. Thus, combining PDT with PBM priming can provide a more effective therapeutic approach and significantly diminish the invasiveness of cancer cells.</div></div>","PeriodicalId":16772,"journal":{"name":"Journal of photochemistry and photobiology. B, Biology","volume":"274 ","pages":"Article 113336"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145747531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A sulfonate-modified cyanine-based photoacoustic probe for selective detection of hydroxyl radicals in diabetic liver injury","authors":"Dong-Xia Fan ,&nbsp;Ren-Wei-Yang Zhang ,&nbsp;Jun-Lian Liu ,&nbsp;Lu Fan ,&nbsp;Hong-Xia Xiang ,&nbsp;Zhong-Yuan Cheng ,&nbsp;Kai Wang","doi":"10.1016/j.jphotobiol.2025.113311","DOIUrl":"10.1016/j.jphotobiol.2025.113311","url":null,"abstract":"<div><div>Hydroxyl radicals (•OH) play a critical role in oxidative stress-related diseases, yet their real-time detection <em>in vivo</em> remains challenging. We developed a hydroxyl radical-responsive photoacoustic probe (OHP) by modifying IR780-SO₃H with enhanced hydrophilicity (logP = −1.051) for improved biodistribution. Structural characterization confirmed the selective reduction of the conjugated system, while <em>in vitro</em> studies demonstrated OHP's selective and linear response to •OH with minimal interference from other ROS/RNS. In diabetic mice, OHP enabled dynamic monitoring of hepatic •OH levels, revealing elevated oxidative stress that was attenuated by metformin treatment. <em>Ex vivo</em> fluorescence imaging and histopathology validated the imaging results, showing strong correlation with disease severity. Biosafety assessments confirmed negligible cytotoxicity in cells and mice. OHP represents a sensitive, selective, and biocompatible tool for non-invasive •OH detection, offering potential for studying oxidative stress and therapeutic interventions.</div></div>","PeriodicalId":16772,"journal":{"name":"Journal of photochemistry and photobiology. B, Biology","volume":"274 ","pages":"Article 113311"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145604752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic polydopamine-intercalated MgAl-layered double hydroxide for effective skin photoprotection and photodamage recovery","authors":"Pengqi Zhu ,&nbsp;Xichen Sun ,&nbsp;Ye Cai ,&nbsp;Mingchen Zhao ,&nbsp;Ruiping Zhang ,&nbsp;Jinghua Sun","doi":"10.1016/j.jphotobiol.2025.113314","DOIUrl":"10.1016/j.jphotobiol.2025.113314","url":null,"abstract":"<div><div>Excessive ultraviolet (UV) radiation is harmful to human health, leading to a range of skin issues including photoaging, sunburn, and skin cancer. Using sunscreen can help alleviate or provide temporary protection against the harmful effects of UV radiation. Commercial sunscreens frequently have low effectiveness and raise safety concerns. Therefore, a novel biocompatible polydopamine-intercalated MgAl-layered double hydroxides nanocomposite (PDA-LDH) was synthesized via in situ oxidation of dopamine within the interlayer of LDH at room temperature and without any additives. LDH can serve as an effective base to facilitate the formation of PDA without the need for an additional base, due to the ordered arrangement of basic hydroxyl groups on the surface of the LDH. The intercalation of PDA in the LDH interlayer ensures good biosafety, effective UV shielding, and excellent antioxidative and anti-inflammatory properties of PDA-LDH, making it suitable for skin photoprotection and the repair of photodamaged skin. PDA-LDH is poised to be a promising next-generation biomimetic sunscreen, designed to assist in the photoprotection and repair of photodamaged skin.</div></div>","PeriodicalId":16772,"journal":{"name":"Journal of photochemistry and photobiology. B, Biology","volume":"274 ","pages":"Article 113314"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145622355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}