Medicinska istrazivanja最新文献

{"title":"Open aortic aneurysm repair in the endovascular era","authors":"L. Davidovic, David Matejević, Ognjen Kostić","doi":"10.5937/medi55-37621","DOIUrl":"https://doi.org/10.5937/medi55-37621","url":null,"abstract":"Open repair (OR) of aortic aneurysms is still relatively mutilating and risky in older and high-risk patients. Since the introduction of EVAR, a significantly lower perioperative mortality has been noted. Apart from advantages, endovascular treatment has some disadvantages as well, due to which OR still has a very important role in the endovascular era. In a vast majority of the patients younger than 65, with good overall condition, long life expectancy and favorable anatomy, as well as in patients with hostile aneurysm neck anatomy, heritable connective tissue disorders, complete thrombosis of abdominal aortic aneurysm (AAA) and potent accessory renal arteries, OR is the first treatment option in comparison with the endovascular treatment. EVAR is recommended as the first treatment option in patients with inflammatory aneurysms and OR should be considered only in better shaped patients with inflammatory AAA and significant hydronephrosis. Late open surgical conversion (LOSC) is a noted event after endovascular treatment and is associated with a significantly higher perioperative mortality and other serious perioperative complications compared to primary OR. Multicenter randomized controlled trials (RCT) did not find a significant difference regarding 30-day mortality between open and endovascular repair of ruptured AAA. However, not all ruptured AAA are suitable for endovascular repair. In a hemodynamically unstable patients, when there is no time for MDCT angiography, EVAR is not possible, and OR is the only option. The incidence of abdominal compartment syndrome after OR is significantly lower in comparison with EVAR thanks to surgical evacuation and drainage of retroperitoneal hematoma. The improvement of the results of aortic aneurysm treatment largely depends on the volume of yearly aortic operations. Having in mind all the mentioned advantages and disadvantages of OR and endovascular repair, we can conclude that in high volume centers, younger generations of vascular surgeons should be educated in standard and complex open aortic surgery.","PeriodicalId":167411,"journal":{"name":"Medicinska istrazivanja","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134487517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autism and MMR vaccine","authors":"N. Maksimovic, D. Kisić-Tepavčević","doi":"10.5937/medist1801014m","DOIUrl":"https://doi.org/10.5937/medist1801014m","url":null,"abstract":"Autism is a complex neurological developmental disorder with wide range of symptoms. Among them, poor social interaction, limited and repeated behavioral patterns are the most important for diagnosing the disorder. The prevalence of autism is rising constantly. One of the theories drawing the greatest public attention for a long time is a possible association between MMR vaccine and risk of autism. The first study aimed to investigate this association is the one conducted in 1998. As the results supported the theory that MMR vaccine increased the risk of autism, MMR immunization coverage decreased dramatically which further led to measles outbreaks, even in those countries where the disease was almost eradicated. Soon after that publication, new studies denying any association between MMR vaccine and risk of autism were published. Among them, systematic review published in 2012, including 57 epidemiological studies with 14.700.000 children is particularly important. Although the etiology of autism is not completely clarified, there are strong evidence on the presence of neurobiological changes with significant genetic component underlying the etiology. According to recent literature data, morphological changes in brain of children age 6 to 12 months, that is, before the administration of MMR vaccine, precede clinical symptoms of autism.","PeriodicalId":167411,"journal":{"name":"Medicinska istrazivanja","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134382112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience of the Institute of Oncology and Radiology of Serbia in radiotherapy treatment of malignant tumors in children","authors":"D. Stanić, J. Bokun, M. Nikitović","doi":"10.5937/medist1801007s","DOIUrl":"https://doi.org/10.5937/medist1801007s","url":null,"abstract":"The Institute of Oncology and Radiology of Serbia in Belgrade is an institution in which the implementation of radiotherapy of children and adolescents started 35 years ago. To date, pediatric radiotherapy has been set up and has been following technological possibilities and progress, and a highly specialized multidisciplinary team has been established in the institution with a focus on pediatric oncology and radiotherapy. Purchase of equipment for three-dimensional conformal radiotherapy (3D-CRT) in 2006 enabled qualitative progress in the planning and implementation of pediatric radiotherapy. 60 to 80 patients aged 1 to 18 years are treated annually in our institution. For children aged up to 3 years, and in extremely rare cases older, radiotherapy is carried out in anesthesia, which is emphasized as a significant experience and quality of work of our institution. In the ten-year period from January 2007 to September 2016, 648 children were treated with radiotherapy. In the majority of children, 90.6%, radiotherapy was conducted using 3D conformal technique (3D-CRT) and in small number, 9.4% with conventional radiotherapy (2D-RT). The most frequent patients were children with central nervous system tumors 30.1%, leukemia 16.5%, bone tumors 15.4%, lymphoma 11.9%, soft tissue sarcoma 11.6%, neuroblastoma 6.5%, nephroblastoma 3.6%, retinoblastoma 1.7% and other rare tumors. Besides operative treatment, the majority of children were treated with chemotherapy and radiotherapy, 89.8%. Most of the children treated with radiotherapy were treated with chemotherapy in our institution, 45.8%. In a small number of children, radiotherapy was conducted as the only therapeutic approach, 10.2%. At the Institute for Oncology and Radiology of Serbia, as a central institution for pediatric radiotherapy, 3D-CRT has been fully adopted as a standard in the treatment of children and adolescents. In the past ten years, we have gained our own experiences which will be of great use to us with introduction of advanced techniques that we expect to gain by further purchase of machines and equipment for radiotherapy.","PeriodicalId":167411,"journal":{"name":"Medicinska istrazivanja","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130103993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in diagnostics and treatment of congenital adrenal hyperplasia","authors":"J. Milenkovic, T. Milenković, K. Sedlecki, P. Ilić, V. Kojović, J. Martic, K. Mitrovic, S. Todorović, M. Marjanović, J. Tončev, Sanja Panić-Zarić, D. Pešić, R. Vuković","doi":"10.5937/medi55-41693","DOIUrl":"https://doi.org/10.5937/medi55-41693","url":null,"abstract":"Introduction: Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive diseases caused by a deficiency of enzymes responsible for the steroidogenesis. There are three forms of CAH due to 21-hydroxylase deficiency: the classic form with salt loss, the classic virilizing and the non-classic form. The aim of the paper was to analyze the changes in the diagnosis and treatment of children with CAH during previous 15 years. Material and methods: This retrospective cohort study includes patients who were diagnosed with CAH due to 21-hydroxylase deficiency in the period from 2007 to 2021 in endocrinology department of the Institute for Mother and Child Health Care Institute of Serbia \"Dr Vukan Cupic\". Respondents were divided into two groups - a group whose diagnosis was made in the period between 2007 and 2014 and another group of those whose diagnosis was made in the period between 2015 and 2021. Statistical analysis using Hi-square and Mann Whitney U test was conducted using the software IBM SPSS ver. 22, and p values <0.05 were considered significant. Results: Out of the total of 55 patients included in the study, 46 patients (83.6%) had 46, XX karyotype. The diagnosis was made in all patients on the basis of biochemical analyzes. In the second group the diagnosis was confirmed by genetic analysis in statistically significantly higher number of children (p <0.05). 49 patients (89.1%) received hydrocortisone and 16 patients received fludrocortisone. In patients from the second group a statistically significantly higher frequency of fludrocortisone therapy was noticed in patients with classic CAH. Conclusion: Having in mind the constant advancement in the field, frequent improvements in clinical care of children with CAH are needed.","PeriodicalId":167411,"journal":{"name":"Medicinska istrazivanja","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132708393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The etiology, treatment and outcome of diabetic ketoacidosis and hyperosmolar coma","authors":"D. Melentijević, Teodora Beljić-Živković","doi":"10.5937/medist1501001m","DOIUrl":"https://doi.org/10.5937/medist1501001m","url":null,"abstract":"Diabetic ketoacidosis (DKA) and nonketotic hyperosmolar hyperglycemic state (NHOK) are acute complications of diabetes mellitus (DM). The aim was to investigate precipitating factors, therapy and the result of the treatment of DKA and NHOK. The study included all the people who were admitted to the Clinical Department of Endocrinology, Diabetes and metabolism disease KBC \"Zvezdara\" in the state of DKA and NHOK between 2007 and 2010. During this period we treated 56 people, aged 51.8 ± 18.8 years. DKA was diagnosed in 54 patients, whereas NHOK was diagnosed in two patients. Type 1 DM was present in 26 (46.42%) patients and type 2 in 30 (53.57%) patients. In DKA average values of glucose were 32±8,85mmol / l, HbA1c-11.6±2,52%, pH 6.89±0,17, HCO3-7.40±5,03. In patients with NHOK average glucose was 60.35±15,14mmol / l, HbA1c-11.2±1,7%,pH 7.43±0,1, HCO3-19, 8±5,23. There was a significant difference in the glucose level (t(54) =6.03,p<0.01) as well as in bicarbonate level (t(54)=3.72,p=0.01) between DKA and NHOK. The most common precipitating factors were: infection in 26 (46.42%) cases, inadequate therapy in 24 (42.85%) cases, myocardial infarction and cerebral stroke in 2 (3.57%) cases. All the patients with NHOK and 16 with DKA had previously been on oral antihy-perglycemic drugs, while 29 patients with DKA had previously been on insulin therapy. Upon admission, the previous therapy was not in relation with the level of glucose and pH. Bicarbonate level was significantly higher in the group treated with oral therapy (t (43) = 2.16,p <0.05). The therapy was considered because of rehydration, fractionally giving boluses HM insulin, potassium compensation and treatment precipitating factors. Rehydration was achieved with an average of 5.6±1,65 liters on the first day,4.08±0,87l on the second day, and 3±0,01 liters on the third day of infusion solutions. The total daily dosage of insulin bolus HM on the first day was 81.04±27,97i.j, 59.64±17,60i.j. on the second day and 58.06±19,70i.j. on the third day. Maximum daily supplementation of potassium in the form of 7.4% KCL solution was 61±18,70mmol / l. Upon the end of the treatment, the total of 26 (46.42%) was discharged on basal-bolus human insulin therapy, 18 (32.14%) on the treatment of basal-bolus analogues, 11 (19.64%) on therapy insulin premix and metformin, while two (3.57%) were discharged on oral antihyperglycemic medications. The treatment outcome was successful in 50 people (89.3%), while death occurred in 6 (10.7%) cases. The most common complication was hypokalemia, present in 29 (51.78%) patients. Other complications were acute renal failure (3 people), acute respiratory distress syndrome (2 people), pulmonary edema (2 people) and gastrointestinal bleeding (1 person). Despite education and available medications for diabetes, acute complications of diabetes can still occur and are sometimes accompanied by dangerous complications.","PeriodicalId":167411,"journal":{"name":"Medicinska istrazivanja","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114828236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Students attitudes on learning English for medical academic purposes and adapting the teaching process to their needs","authors":"S. Mićić, D. Sinadinović","doi":"10.5937/medist1301067m","DOIUrl":"https://doi.org/10.5937/medist1301067m","url":null,"abstract":"Since the Faculty of Medicine, University of Belgrade is the institution of long-term tradition of the study and teaching of EMP, the aim of this paper is to investigate the attitudes of students towards these teaching programmes and the teaching material in order to adapt them to the students' real needs. Two questionnaires were used in the research and they were completed by 128 first and second year students of the integrated academic studies and 9 students of the English studies. These questionnaires consisted of open and close questions (the first research) and evaluating statements on Likerttype scale (the second research). The results we got in this small-scale research show that the students are aware of the need to learn this specialized language, that they consider it difficult to master as related to General English (GE), as well as what in their classes they find useful or useless for learning English for Medical Purposes and if they would change anything to their actual needs. As for the teaching material used in classes, the opinions of the limited number of surveyed students are mostly very positive, but a larger-scale research should be conducted to get more relevant results.","PeriodicalId":167411,"journal":{"name":"Medicinska istrazivanja","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116569125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic idiopathic portal vein thrombosis: A case study","authors":"Bojan Mitrović, Z. Gluvić, V. Samardzic, M. Obradović, M. Lačković, Z. Cvetković, A. Pavlović, E. Isenovic","doi":"10.5937/medist1602013m","DOIUrl":"https://doi.org/10.5937/medist1602013m","url":null,"abstract":"Portal vein thrombosis (PVT) is a rare disorder of splanchnic circulation, frequently caused by concomitant presence of local and/or systemic factors. When portal vein thrombosis complicates causative diseases, it will worsen their prognosis, and in such a case, the causative disease and PVT are treated concomitantly. Despite the fact that PVT frequently complicates liver cirrhosis, intraabdominal malignancies, and some hematological diseases, after all causes are excluded, one can define idiopathic portal vein thrombosis. In this study we have described the case of idiopathic chronical portal vein thrombosis.","PeriodicalId":167411,"journal":{"name":"Medicinska istrazivanja","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131864665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary hypothyroidism quality of life assessment by application of different questionnaires and its different processing","authors":"B. Mitrović, Z. Gluvić, M. Obradović, M. Lačković, V. Samardzic, J. Ćirić, E. Isenovic","doi":"10.5937/medist1602001m","DOIUrl":"https://doi.org/10.5937/medist1602001m","url":null,"abstract":"Primary hypothyroidism negatively affects patients' quality of life. Improving the quality of life is expected by establishing eutyreoid state using levothyroxine therapy. The quality of life can be \"assessed\" by applying various questionnaires, such as the general health questionnaire (GHQ12) and thyroid symptom questionnaire (TSQ). The aims of present study were to: sum standard and modified-ranked answers of both questionnaires, rank the scores, test differences in the absolute values of the scores between the groups, classify obtained scores in different clusters (no distress, a minor, and major distress), and test differences in the distribution of frequencies of the respondents among them. Cross-sectional study was conducted in Zemun Clinical Hospital and it included 90 subjects. The subjects were divided into three equal groups (30 subjects per group): hypothyroid without treatment, euthyroid with levothyroxine, and control, euthyroid group without treatment. The subjects answered the questions in the questionnaire, and the answers were then transformed into the ranking of two modelsstandard and modified, and then summarized. Statistical analysis was performed using the SPSS for Windows 18.0. The average level of thyroid stimulating hormone (TSH) in the study population was 1.3 ± 0.3 (1.1-2.2) mU/L. Average TSQm, TSQs, GHQm and GHQs scores were 14±7, 13±6, 11±7 and 11±6 and differed between groups. The lowest scores were registered in the group of levothyroxine-treated, regardless of the ranking models, with the level of TSH that indicates an adequate substitution levothyroxine. Average TSQs/TSQm and GHQs/GHQm scores show a statistical correlation with each other. Scores and scores-defined clusters of both questionnaires are appropriate for clinical presentation shown by specific groups of the population. Considering that the average scores of the questionnaire differ from each other, and that both models rank-transformation of the same questionnaire give a similar score, it is sufficient to use one questionnaire from both categories of instruments for testing the quality of life. The ease of applying these questionnaires, independent of the transformation obtained in response ranges and their application when starting levothyroxine substitution, were used to assess the effectiveness of the therapy.","PeriodicalId":167411,"journal":{"name":"Medicinska istrazivanja","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134251779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypercholesterolemias: Pathogenesis and pathophysiological implications","authors":"D. Vučević, Dragoslav Đorđević, M. Stanojevic, Bojan Jorgačević, Danka Đorović, Đ. Radak, T. Radosavljević","doi":"10.5937/medist1602030v","DOIUrl":"https://doi.org/10.5937/medist1602030v","url":null,"abstract":"In this review, we provide an overview of recent literature data and practical knowledge related to hypercholesterolemias and their pathophysiological implications. Elevated blood lipid levels (hyperlipidaemias) are the most common metabolic disorders in global population. There is consensus regarding hypercholesterolemia, hypertension and cigarette smoking as the three main risk factors for atherothrombosis, with consequences such as cardiovascular and cerebrovascular diseases, being the leading cause of morbidity and mortality worldwide. In relation to this, familial hypercholesterolemia is the most deleterious precursor of coronary artery disease. This severest form of hyperlipidaemia refers to an inherited disorder of cholesterol metabolism due to defects in the receptor for low density lipoprotein (LDL). Besides, numerous factors, including drugs, can influence lipid status and significantly contribute to the development of secondary hypelipidaemias. Thus, inappropriate diet, obesity, diabetes mellitus and alcohol use, in particular, are commonly associated with high blood lipid levels. Therefore, secondary causes of high blood lipids should be considered in each patient with a lipid disorder before lipid-lowering therapy is started. Having in mind the increase of prevalence of lipid metabolism disorders in future, it is necessary to take preventive actions to decrease risk factors (inappropriate diet rich in carbohydrates and saturated fat, obesity, cigarette smoking, sedentary lifestyle and physical inactivity). However, although various studies related to this medical problem have been carried out, scientists are still far from a complete understanding of the molecular basis of this problem.","PeriodicalId":167411,"journal":{"name":"Medicinska istrazivanja","volume":"169 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121711046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between insulin resistance and cardiovascular system disorders","authors":"D. Vučević, Bojan Jorgačević, T. Radosavljević, Đ. Radak, D. Kovačević","doi":"10.5937/medist1503005v","DOIUrl":"https://doi.org/10.5937/medist1503005v","url":null,"abstract":"The metabolic syndrome is a cluster of more or less related metabolic and cardiovascular derangements including visceral obesity, insulin resistance , dislipidemia, hypertension and glucose intolerance. This syndrome is characterized by a primary cellular defect in insulin action due to disorders in insulin signal transduction (insulin is unable adequately to achieve its biological effects). Under these conditions, insulin resistance, in combination with hyperinsulinemia causes a numerous metabolic and cardiovascular disorders, that are leading cause of morbidity and mortality worldwide. From pathophysiological point of view, insulin resistance, as well as adipokines and fatty acids released from metabolically active visceral fat tissue, significantly contributes to development of many chronic diseases (diabetes mellitus /diabetes mellitus/ type 2, hypertension, accelerated atherosclerosis and its cardiovascular and cerebrovascular complications, nonalcoholic fatty liver disease, polycystic ovary syndrome and some malignant diseases / breast cancer, etc./). Having in mind increase of metabolic syndrome prevalence in future, it is necessary to take preventive actions to decrease risk factors (inappropriate diet rich in carbohydrates and saturated fat, obesity, smoking, sedentary lifestyle and physical inactivity). Except to lifestyle changes, usage of hypocaloric diet and increase level of physical activity, in patients with metabolic syndrome it is necessary to apply appropriate medical treatment of some components of the syndrome. Although a numerous studies related to this global medical problem are carrying out, scientists are still far from a complete understanding of the molecular basis of this problem.","PeriodicalId":167411,"journal":{"name":"Medicinska istrazivanja","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123937464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}