原发性甲状腺功能减退症的生活质量评价:不同问卷的应用及其不同的处理

B. Mitrović, Z. Gluvić, M. Obradović, M. Lačković, V. Samardzic, J. Ćirić, E. Isenovic
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引用次数: 0

摘要

原发性甲状腺功能减退会对患者的生活质量产生负面影响。通过左旋甲状腺素治疗建立纯甲状腺状态,期望改善生活质量。生活质量可以通过应用各种问卷进行“评估”,如一般健康问卷(GHQ12)和甲状腺症状问卷(TSQ)。本研究的目的是:对两种问卷的标准答案和修正排序答案进行求和,对得分进行排序,检验两组之间得分绝对值的差异,对不同类别(无痛苦、轻微痛苦和严重痛苦)的得分进行分类,并检验其中被调查者频率分布的差异。横断面研究在泽门临床医院进行,共纳入90例受试者。将受试者平均分为三组(每组30例):未经治疗的甲状腺功能减退组、经左甲状腺素治疗的甲状腺功能正常组和未经治疗的对照组。被试回答问卷中的问题,然后将答案转化为两个模型的排名标准和修改,然后总结。采用SPSS for Windows 18.0进行统计学分析。研究人群中促甲状腺激素(TSH)平均水平为1.3±0.3 (1.1-2.2)mU/L。TSQm、TSQs、GHQm和GHQs平均得分分别为14±7、13±6、11±7和11±6,组间差异有统计学意义。无论排名模型如何,在左旋甲状腺素治疗组中,TSH水平最低,表明左旋甲状腺素替代足够。TSQs/TSQm平均分与GHQs/GHQm平均分之间存在统计学相关性。两份问卷的分数和分数定义的聚类适用于特定人群的临床表现。考虑到问卷的平均得分不同,并且同一份问卷的两种模型的秩变换给出的分数相似,因此使用两类工具中的一份问卷来测试生活质量就足够了。应用这些问卷的难易程度,独立于在应答范围内获得的转化以及在开始左甲状腺素替代时的应用,被用来评估治疗的有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Primary hypothyroidism quality of life assessment by application of different questionnaires and its different processing
Primary hypothyroidism negatively affects patients' quality of life. Improving the quality of life is expected by establishing eutyreoid state using levothyroxine therapy. The quality of life can be "assessed" by applying various questionnaires, such as the general health questionnaire (GHQ12) and thyroid symptom questionnaire (TSQ). The aims of present study were to: sum standard and modified-ranked answers of both questionnaires, rank the scores, test differences in the absolute values of the scores between the groups, classify obtained scores in different clusters (no distress, a minor, and major distress), and test differences in the distribution of frequencies of the respondents among them. Cross-sectional study was conducted in Zemun Clinical Hospital and it included 90 subjects. The subjects were divided into three equal groups (30 subjects per group): hypothyroid without treatment, euthyroid with levothyroxine, and control, euthyroid group without treatment. The subjects answered the questions in the questionnaire, and the answers were then transformed into the ranking of two modelsstandard and modified, and then summarized. Statistical analysis was performed using the SPSS for Windows 18.0. The average level of thyroid stimulating hormone (TSH) in the study population was 1.3 ± 0.3 (1.1-2.2) mU/L. Average TSQm, TSQs, GHQm and GHQs scores were 14±7, 13±6, 11±7 and 11±6 and differed between groups. The lowest scores were registered in the group of levothyroxine-treated, regardless of the ranking models, with the level of TSH that indicates an adequate substitution levothyroxine. Average TSQs/TSQm and GHQs/GHQm scores show a statistical correlation with each other. Scores and scores-defined clusters of both questionnaires are appropriate for clinical presentation shown by specific groups of the population. Considering that the average scores of the questionnaire differ from each other, and that both models rank-transformation of the same questionnaire give a similar score, it is sufficient to use one questionnaire from both categories of instruments for testing the quality of life. The ease of applying these questionnaires, independent of the transformation obtained in response ranges and their application when starting levothyroxine substitution, were used to assess the effectiveness of the therapy.
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