Facta Universitatis, Series: Medicine and Biology最新文献

{"title":"CONSERVATIVE TREATMENT FOR ANAL FISSURE – FOR HOW LONG? – REVIEW OF THE LITERATURE AND PERSONAL EXPERIENCE","authors":"V. Șurlin, S. Scurtu","doi":"10.22190/FUMB190507003S","DOIUrl":"https://doi.org/10.22190/FUMB190507003S","url":null,"abstract":"Anal fissure (AF) is a common proctologic disease and health problem, with potential for chronicity, causing the patient a debilitating suffering. The pathogenesis, in most of the cases consists in a vicious circle of pain-internal anal sphincter (IAS) spasm-decrease blood irrigation of mucosa-delay of healing. Treatment should aim to break this mechanism by cutting or relaxing the IAS and restoring adequate blood flow to promote healing. If anal stretch is becoming history, surgical sphincterotomy has the highest rate of healing and the least percentage of recurrence, but incontinence for flatus and stool may occur so “medical or “chemical” sphincterotomy using calcium channel blockers (CCB), nitric oxide donors, botulinum toxin injection are used with success rates from 50% to over 90%, also in combination with other conservative measures like warm sitz baths, stool softeners, high fiber and more liquid daily ingestion. All of those therapeutic measures are also stated in current guidelines. The question we tried to answer in this paper is for how long we can prolong the conservative, non-operative treatment in AF. Based upon literature research and our personal experience we may state that the earlier institution of medical specific treatment (CCB, nitric oxide donors, botulinum toxin) has more chances to heal the patient and avoid surgery. Success is also dependent on the good communication with the patient, detailed explanation of the purpose of the treatment, how to assess himself the evolution, and employ botulinum toxin earlier if patient is less compliant to topic treatment. Conservative non-operative management should be pushed as long as it is correctly applied and progression is made both from subjective and objective point of view and patient is compliant and content.","PeriodicalId":167216,"journal":{"name":"Facta Universitatis, Series: Medicine and Biology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129732330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PREVALENCE OF METABOLIC SYNDROME IN PATIENTS WITH ARTERIAL HYPERTENSION AND ITS IMPACT ON ASYMPTOMATIC CAROTID ATHEROSCLEROSIS","authors":"S. Kostić, I. Tasic, D. Djordjević, V. Stoičkov, N. Stojanović","doi":"10.22190/FUMB180424009K","DOIUrl":"https://doi.org/10.22190/FUMB180424009K","url":null,"abstract":"The importance of metabolic syndrome (MetSy) lies in the fact that its components are proven risk factors for early blood vessel atherosclerosis and thrombosis.Aim of the paper: Our aim was to establish the prevalence of MetSy in patients with arterial hypertension (AH) and its impact on asymptomatic carotid atherosclerosis. The study involved 391 examinees, divided into two groups. The study group consisted of patients with arterial hypertension (n=342; average age, 66.56 ± 09.52; with 51% of female gender). The presence of cardiovascular (CV) risk factors was established for all involved patients, cardiovascular risk score was determined (SCORE risk), laboratory analyses were performed, as well as anthropometric measurements and color Doppler sonography of the great blood vessels of the neck. The patients with AH were divided into two groups according to the presence of MetSy. Metabolic syndrome was confirmed in 198 patients who comprised group I; there were 144 examinees without MetSy and these comprised group II. Those with MetSy had a greater average number of CV risk factors, a higher SCORE risk score, higher body mass index (p<0.0001), and more frequently had diabetes, hyperlipidemia and obesity. The thickness of the intimal medial complex (IMC) of the carotid arteries was significantly greater in the group with MetSy (p<0.0001) – 51% of examinees had IMC thickness ≥0.90. The patients with MetSy more commonly had one or more carotid plaques (p=0.03), a higher average number of plaques (p=0.01) and percentage of stenosis (p=0.01). As the most important factors associated with early carotid atherosclerosis, multivariant regression analysis singled out the following (for the model R=0.512. R2=0.262. adjusted R2=0.255. standard error of the estimate = 0.174; p<0.0001): age (coefficiant β=0.331. p<0.0001), number of MetSy components (coefficient β=0.158. p=0.002), level of serum uric acid (coefficient β=0.284; p<0.0001). Our results demonstrated a significant association of MetSy and its components with early atherosclerotic changes in the carotid arteries.","PeriodicalId":167216,"journal":{"name":"Facta Universitatis, Series: Medicine and Biology","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124803656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CAMOUFLAGE THERAPY OF HYPOPLASIA OF THE MAXILLA. CASE REPORT","authors":"T. Perović, I. Aleksić, Z. Blažej","doi":"10.22190/FUMB180307002P","DOIUrl":"https://doi.org/10.22190/FUMB180307002P","url":null,"abstract":"Maxillary hypoplasia is one of the forms of class III malocclusion. On average, 60%  class III malocclusions are characterized by maxillary underdevelopment in all three directions. Anomalies in position, size and the shape of facial bones, maxilla in particular, usually appear in childhood, become more pronounced in adolescence until the end of the growth period. The aim of the paper is to show the camouflage treatment of the patient in adolescence with maxillary hypoplasia. Using the RME method in the upper jaw, extraction in the lower jaw and fixed orthodontic devices in both jaws, a satisfactory result was achieved.","PeriodicalId":167216,"journal":{"name":"Facta Universitatis, Series: Medicine and Biology","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114814298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE INFLUENCE OF PROFESSIONAL STRESS IN PERMANENT WORKING CAPABILITY OF WORKERS WITH ARTERIAL HYPERTENSION AND ITS COMPLICATIONS","authors":"J. Jovanović, I. Šarac, J. Jovanović, D. Sokolović, Stevan Jovanović","doi":"10.22190/FUMB180513007J","DOIUrl":"https://doi.org/10.22190/FUMB180513007J","url":null,"abstract":"Arterial hypertension is widespread in the population of workers. Stress at work has a significant impact on the emergence of many psychosomatic diseases including arterial hypertension. The aim of this research is to show the influence of professional stress on the occurrence of arterial hypertension, its complications and the permanent working ability of exposed workers in construction. The survey covered 1900 construction workers. The standardized questionnaire has assessed the level of stress and professional stressors in their workplaces. The survey group consisted of 1350 workers whose level of total professional stress index (OSI) was over 60, and a control group of 550 workers with an OSI level below 60. The prevalence of arterial hypertension and its complications is statistically significantly more frequent in the examined than in the control group.  In the investigated group, a statistically significant number of workers were registered, who, due to their complete loss of working ability, were sent to the disability commission. With an increase in OSI values above 71, the number of workers with complete loss of working capacity is significantly increased in relation to the number of workers who are capable of working. Professional stress is a significant factor that affects the occurrence of arterial hypertension, its complications on vital organs, which lead to a complete permanent loss of working ability of exposed workers in construction.","PeriodicalId":167216,"journal":{"name":"Facta Universitatis, Series: Medicine and Biology","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122134655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STRUCTURE OF RELATIONS BETWEEN THE FREQUENCY OF MICRONUCLEI IN PERIPHERAL BLOOD LYMPHOCYTES AND AGE, GENDER, SMOKING HABITS AND SOCIO-DEMOGRAPHIC FACTORS IN SOUTH-EAST REGION OF SERBIA","authors":"Andjelka N. Hedrih, S. Najman, Vladimir Hedrih, O. Milošević-Djordjević","doi":"10.22190/FUMB180102008H","DOIUrl":"https://doi.org/10.22190/FUMB180102008H","url":null,"abstract":"Frequency of micronuclei (MN) in peripheral blood lymphocytes is a measure of genotoxicity and spontaneous chromosomal instability with many modifying factors. The aim of this work was to examine the relation between results of micronucleus test and set of socio-demographic parameters in healthy population in south-east Serbia using structure equation approach. Cytokinesis–block (CB) technique was used for analysis of MN frequency in peripheral blood lymphocytes on 133 healthy volunteers of various ages. Socio-demographic data was collected through a questionnaire. The mean frequency of MN gradually rose with age from 0.56±0.71 in new-borns to 5.48 ±3.65 in the 61-80 years age group (AG), with a decrease in the 81-92 years AG. MN frequency was positively correlated with age, altitude of birth place, altitude of place of residence, nuclear buds and nucleoplasmatic bridges, and negatively with education level and smoking habits. Linear structural model revealed age to be related to all of the examined variables, and indicates probable existence of another factor, independent of age, influencing all of these except nuclear buds. It can be concluded that the frequency of micronuclei is influenced by age and factor/s resembling socioeconomic status or lifestyle and this influence is independent of age.","PeriodicalId":167216,"journal":{"name":"Facta Universitatis, Series: Medicine and Biology","volume":"225 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121156914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INCIDENCE OF PRENATAL AND POSTNATAL RISK FACTORS FOR CHILDHOOD ASTMA","authors":"M. Jakovljević, D. Mitrović, S. Živanović","doi":"10.22190/FUMB180201011J","DOIUrl":"https://doi.org/10.22190/FUMB180201011J","url":null,"abstract":"Asthma is one of the most frequent chronic diseases of childhood. Its etiology is not fully understood and risk factors for its development are numerous. The aim of this study was to determine the incidence of prenatal and postnatal risk factors in children suffering from asthma. The study was conducted on a sample of 100 patients with a diagnosis of asthma according to Global Initiative for Asthma guidelines. The data was collected using a questionnaire. We have considered prenatal (smoking during pregnancy, hormone and antibiotic therapy, the use of acetaminophen and dietary supplements, maternal blood sugar level, the term of delivery and the method of childbirth) and postnatal risk factors (oxygen and antibiotic therapy during the first year of life, immunization status during the first 6 months of life and presence of the older sibling in the family). In our study group, the most common prenatal risk factors related to asthma were: smoking during pregnancy, hormone therapy, the use of the dietary supplements and delivery via Caesarean section, while the most frequently found postnatal risk factors were: antibiotic therapy during the first year of life and the presence of older child in the family.","PeriodicalId":167216,"journal":{"name":"Facta Universitatis, Series: Medicine and Biology","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128165409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SURGICAL TREATMENT OF COMPLEX CROUZON SYNDROME CRANIOSYNOSTOSIS","authors":"A. Zdravković, Bojana Živković, M. Mićović, L. Rasulić","doi":"10.22190/FUMB181109014Z","DOIUrl":"https://doi.org/10.22190/FUMB181109014Z","url":null,"abstract":"Crouzon syndrome is one of the most common syndromic craniosynostosis. We present complex course of treatment in a child with Crouzon syndrome presented with multisuture craniosynostosis and hydrocephalus. A 3-months-old boy was admitted with clinical signs of hydrocephalus and turribrachycephaly. Firstly, the hydrocephalus was addressed. The ventriculoperitoneal shunt with programmable valve was implanted. Secondly, in May 2017, posterior calvarial remodeling was done. Finally, after the child recovered, anterior calvarial remodeling with fronto-orbital advancement was performed.  This completed the calvarial remodeling in this patient. Child is doing well, so far completing milestones of child development in time. This case presents an extremely complex case of syndromic multisuture craniosynostosis, in which it was necessary to perform the entire calvarial remodeling to correct the deformity and to provide a chance to the brain to grow and develop without constrictions.","PeriodicalId":167216,"journal":{"name":"Facta Universitatis, Series: Medicine and Biology","volume":"124 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133533854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE UNBEARABLE LIGHTNESS OF PRESCRIBING GROWTH HORMONE","authors":"L. Šaranac","doi":"10.22190/FUMB190119001S","DOIUrl":"https://doi.org/10.22190/FUMB190119001S","url":null,"abstract":"Short stature is the most visible and prominent physical characteristic and one of the commonest reason for referral to pediatric endocrinologist. It is assumed as disabling condition with psychosocial consequences that seeks treatment. Behind short stature severe pathology could be hidden, although not necessarily of endocrine origin. Even in the new millennium, many diagnostic pitfalls and dilemmas persist in confirmation of growth hormone deficiency (GHD), the first indication that fits in endocrine paradigm: to replace the missing hormone. In 1985 FDA approved recombinant human GH (hGH) as the treatment of pediatric patients who have growth failure due to inadequate secretion of endogenous GH. Availability of hGH in unlimited amounts enhanced the number of indications of GH use. Pediatric endocrinologist started to promote and to apply use of hGH for height in short, but otherwise healthy children, with hormonal normalcy. Reasonable criticism of such praxis arises in the light of recent safety alerts. The unbearable lightness of prescribing growth hormone to every apparently or really short child is reaching epidemic progress in Serbia. When authorities in this low income country (estimated as developing), approved hGH for use in SGA (small for gestational age) children, use and misuse of hGH exploded. Socially acceptable height, the term applied by some endocrinologists actually means that society does not accept short people. The pharmaceutical companies go even further offering, besides growth acceleration, better and brighter future for potential patients, in whom the self-confidence is measured by centimeters of height. However, benefits of such treatment on quality of life were never confirmed. Children with severe growth failure and documented GHD should be treated undoubtedly, but use of hGH for height, so called cosmetic endocrinology, needs critical appraisal. Children and their parents should be informed about height prediction and long-term consequences.","PeriodicalId":167216,"journal":{"name":"Facta Universitatis, Series: Medicine and Biology","volume":"122 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116273655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE APPLICATION OF STIMULATOR IN THE TREATMENT OF CLEFT LIP AND PALATE IN GOLDENHAR SYNDROME, TRISOMY 13 AND LOBAR HOLOPROSENCEPHALY WITH A MEDIAN CLEFT LIP","authors":"J. Radojicic","doi":"10.22190/FUMB180516003R","DOIUrl":"https://doi.org/10.22190/FUMB180516003R","url":null,"abstract":"The clinical picture of a newborn with a syndromic cleft lip and palate is severe. The orthodontic and surgical treatment of cleft is complex and long-term. It is further complicated by various birth defects which can be life-threatening for a newborn or can make the therapy itself more difficult. The induction of a newborn into total anesthesia with a view to performing the surgery of a cleft is often made difficult or time-limited. This paper presents pre-surgical orthodontic therapy in newborns with three severe types of cleft, UCLP, BCLP and premaxillary agenesis with median cleft lip which occurred within three rare syndromes Goldenhar syndome, lobar holoprosencephaly with a median cleft lip and trisomy 13 (47XX+13). Pre-surgical orthodontic therapy was conducted by means of RBJ stimulators without extra oral fixation, whose construction was conditioned by the type of cleft. With active treatment of RBJ stimulators, the cleft area in all three types of cleft was significantly reduced, as well as the protrusion of the premaxilla in BCLP. By directing the growth of cleft segments of newborn’s upper jaw, the most approximate shape to a healthy newborn’s jaw shape is achieved. All three types of described stimulators used in the therapy of syndromic cleft lip and palate enabled primarily the feeding of newborns, and thus their survival. With their orthopedic treatment they created optimal conditions for successful performing of surgical care of syndromic cleft lip and palate.","PeriodicalId":167216,"journal":{"name":"Facta Universitatis, Series: Medicine and Biology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133349056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PEER VIOLENCE AS PREDICTOR OF CYBERBULLYING AMONG ADOLESCENTS","authors":"Miroljub Ivanović, Uglješa Ivanović","doi":"10.22190/FUMB171026001I","DOIUrl":"https://doi.org/10.22190/FUMB171026001I","url":null,"abstract":"The aim of this cross-sectional study was to examine individual, familial and peer variables as predictors of cyberbullying in early adolescence. The research included (N = 226) male students from Valjevo, aged 15.56  (SD = 0.68). The following measuring instruments were used: Socio-demographic Questionnaire, Violence Among School Children Questionnaire, Parent Behavior Questionnaire. The internal consistency of the questionnaire was examined using Cronbach’s alpha coefficient. The results of correlation analysis have shown minute and statistically significant correlation between the scores of applied variables. Hierarchical regression model has explained 36% of the variance of traditional peer violence and 10% of cyberbullying. All the examined variables have proven to be statistically significant predictors of traditional peer violence, but not cyberbullying. Seeing that the predictor variables of traditional peer violence partly explain cyberbullying, it is necessary to examine other potential determinants such as frequency of use of electronic media, electronic victimization and others, which would contribute to the prediction of the examined criterion. The applied questionnaires are of optimal use in everyday practice in Serbia and can provide relevant information in evaluating traditional peer violence and cyberbullying among preadolescents.","PeriodicalId":167216,"journal":{"name":"Facta Universitatis, Series: Medicine and Biology","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133321256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}