S. Arsic, M. Trandafilović, Sonja Janković, D. Ilić, Bojan Nedović, N. Vitković, M. Stojković, Milica Tufegdzic, J. Mitic, M. Trajanovic
{"title":"ANALYSIS OF THE HUMAN CEPHALOMETRIC PARAMETERS IMPORTANT FOR DENTAL PRACTICE","authors":"S. Arsic, M. Trandafilović, Sonja Janković, D. Ilić, Bojan Nedović, N. Vitković, M. Stojković, Milica Tufegdzic, J. Mitic, M. Trajanovic","doi":"10.22190/FUMB180912002A","DOIUrl":"https://doi.org/10.22190/FUMB180912002A","url":null,"abstract":"Cephalometry is a measurement of the head by imaging, also taking into account the layer which consists of all the soft tissues of the head. Following the introduction of computed tomography (CT), 3D reconstruction of the head and neck structures and 3D analysis of angular and linear cephalometric parameters was enabled. This study aimed to determine the characteristic cephalometric parameters, using the 2D reconstruction of the multi-slice CT (MSCT) images, which are essential for computer designing of the parametric-geometric-mathematical model (PGMM) of the human skull. We conducted the study on 20 CT scans of adult patients (12 males and 8 females), taken from the radiology archive of the Clinical Center in Niš. Measurements were done on 2D reconstruction images of preselected 3D images of the human head created using MSCT. The values of 29 linear cephalometric parameters (LCP) and 20 angular cephalometric parameters (ACP) were determined. Statistically significant differences between males and females were noted for the distance between the points Sella and Supraorbitale and for the distance between the points Subspinale and Labium superius. Mean values of cephalometric parameters obtained by measurements on 2D CT images can be used to generate normative parameters which represent values used to generate 3D PGMM of the human skull. This PGMM of the skull may allow a more accurate diagnosis, better selection of treatment methods and more accurate prognosis for healing in orthodontics, implantology, oral and maxillofacial surgery.","PeriodicalId":167216,"journal":{"name":"Facta Universitatis, Series: Medicine and Biology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131772684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Kutlesic, R. Kutlesic, T. Ilić-Mostić, D. Stanišić
{"title":"THE EFFECT OF REMIFENTANIL ON INTUBATION CONDITIONS IN PATIENTS UNDERGOING CAESAREAN DELIVERY UNDER GENERAL ANESTHESIA: COMPARISON OF TWO DOSING REGIMENS","authors":"M. Kutlesic, R. Kutlesic, T. Ilić-Mostić, D. Stanišić","doi":"10.22190/FUMB180602005K","DOIUrl":"https://doi.org/10.22190/FUMB180602005K","url":null,"abstract":"The objective of our study was to compare the effects of two remifentanil dosing regimens, used during induction-delivery period of cesarean section, and of remifentanil-free control on maternal intubating conditions and hemodynamic response to endotracheal intubation as well as on neonatal outcome. Seventy seven ASA physical status I-II women with singleton term pregnancy, who were scheduled for elective cesarean section in general anesthesia and have given written informed consent, were enrolled in this prospective, randomized controlled study and divided in three groups: A - 31 patient received 1 µg/kg remifentanil bolus before the induction of anesthesia, followed by 0.15 µg/kg/min remifentanil infusion that was stopped after the skin incision; B - 27 patients received only 1 µg/kg remifentanil bolus; C - 19 patients did not receive remifentanil until the delivery of the baby. Intubating conditions were qualified as excellent, good or poor. Group A had significantly higher number of patients with excellent intubating conditions (p = 0.011); majority of patients with good intubating conditions were in group C (p = 0.017). Systolic, diastolic, main arterial pressure and heart rate raised significantly in group C compared to A and B (p < 0.001). Neonatal outcome did not differ between groups – all neonates were vital with first minute Apgar scores ≥ 8. In conclusion, our dosing regimen of remifentanil 1µg/kg bolus given immediately before the induction followed by 0.15 µg/kg/min interrupted after skin incision provided the best compromise between the achievement of excellent intubating conditions, attenuation of maternal hemodynamic stress response to endotracheal intubation and avoidance of neonatal respiratory depression.","PeriodicalId":167216,"journal":{"name":"Facta Universitatis, Series: Medicine and Biology","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115358707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Nestorović, V. Pecić, B. Brankovic, D. Mihajlović, D. Petrović, L. Jeremić, I. Pešić, N. Ignjatovic, Marko Gmijović, Z. Krivokapic, G. Stanojevic
{"title":"PILONIDAL DISEASE","authors":"M. Nestorović, V. Pecić, B. Brankovic, D. Mihajlović, D. Petrović, L. Jeremić, I. Pešić, N. Ignjatovic, Marko Gmijović, Z. Krivokapic, G. Stanojevic","doi":"10.22190/fumb190507002n","DOIUrl":"https://doi.org/10.22190/fumb190507002n","url":null,"abstract":"Pilonidal disease is a common and well-recognized medical condition. It affects people in reproductive age, especially men and in combination with in-patient and outpatient treatment and absence from work it causes a considerable socioeconomic loss. This fact led to a renewed interest in understanding of the disease and search for the ideal method of treatment. The purpose of this review was to provide update on therapeutic options for patients with pilonidal disease. In case of chronic or recurrent pilonidal disease various treatment options exist, addressing different measures of surgical outcome. Like for many conditions, there is increase in the use of minimally invasive techniques in the treatment, which could be alternative to surgical excisions for pilonidal disease. Procedures for treatment of pilonidal disease can be divided in two large groups: minimally invasive treatment and excisional procedures. Although various treatment options exist nowadays, surgery is still preferred as definitive treatment. The optimal closure of the wound following an excision is still under debate since outcome measures depend mostly on type of closure selected. Most of the procedures fail to achieve the goals altogether. The final decision on treatment should be made based on surgeon and the patient’ preference.","PeriodicalId":167216,"journal":{"name":"Facta Universitatis, Series: Medicine and Biology","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130872401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Brankovic, M. Nestorović, G. Stanojevic, D. Petrović, D. Mihajlović, I. Golubović
{"title":"PATIENTS' CONTENTMENT WITH TRANSANAL HEMORRHOIDAL DEARTERIALISATION","authors":"B. Brankovic, M. Nestorović, G. Stanojevic, D. Petrović, D. Mihajlović, I. Golubović","doi":"10.22190/FUMB190507007B","DOIUrl":"https://doi.org/10.22190/FUMB190507007B","url":null,"abstract":"Hemorrhoidectomy was the method of choice for treating grade 3 and 4 hemorrhoids. Due to a large number of complications, a new surgical treatment called transanal hemorrhoidal dearterialization (THD) was introduced. The aim of the study was to evaluate the effect of treatment with THD in patients with hemorrhoids. This study included 70 patients, 48 males and 22 females, who were hospitalized at the Clinical Center Nis in the period from September 2016 to September 2018. Fifteen patients had grade 4 hemorrhoids, 54 were with grade 3, one patient with grade 2. The average duration of the operation was 33.33 minutes, and patients were hospitalized for 1-2 days. We recorded: sex, age, stage, type of anesthesia, duration of surgery, length of stay, patient satisfaction, combinations of THD with other procedures, and surgical complications. In 46 patients, surgery was performed under general anesthesia, in 18 patients in spinal and in 6 patients in local anesthesia with analgesia. In 37 subjects we used THD only, and in 33 we used THD in combination with other methods. We observed the development of complications in 9 patients. Bleeding occurred in 2 patients, pain in 2, and urinary retention in 4, and abscess in 1. The majority of the patients (62.9%) were satisfied with this method, 27.1% were partially satisfied and 10% were unsatisfied. This method provides a shorter stay in the hospital, low complications rate and is a safe, fast and simple initial surgical option.","PeriodicalId":167216,"journal":{"name":"Facta Universitatis, Series: Medicine and Biology","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114483218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Pešić, M. Nestorović, V. Pecić, M. Radojković, Lidija Đorđević, Miodrag Đorđević, Toplica Bojić
{"title":"ESTIMATION OF RISK FACTORS OF EARLY POSTOPERATIVE MORTALITY IN ELDERLY PATIENTS WHO ARE SUBJECTED TO GASTRIC SURGICAL PROCEDURES","authors":"I. Pešić, M. Nestorović, V. Pecić, M. Radojković, Lidija Đorđević, Miodrag Đorđević, Toplica Bojić","doi":"10.22190/FUMB190507008P","DOIUrl":"https://doi.org/10.22190/FUMB190507008P","url":null,"abstract":"The use of screening programms in elderly population (age ≥65 years) comprises an increasing proportion of patients undergoing emergency general surgery (EGS) procedures nowadays. The aim was to determine the intra-hospital mortality rate in elderly patients undergoing gastric surgical procedures. 108 elderly patients (≥65 years old) were examined, divided into two groups: deceased and surviving surgical patients, treated for diseases (benign and malignant) of the stomach. The patients were divided into four age groups and five ASA groups, taking into account the presence of chronic diseases, the values of some laboratory parameters, administered transfusion and the occurrence of surgical complications during hospitalization. The mortality rate among elderly patients was 28.7%. The significant risk factors for mortality were: emergency surgery (p < 0.001), bleeding gastric ulcer operations (p = 0.042), lung (p = 0.003), kidney (p < 0.001), heart (p = 0.025) diseases, ASA score of 4 or higher (p < 0.001), serum levels (higher after two times measurement) of creatinine, haemoglobin, CRP, PCT and glycemia (p < 0.001). In order to improve medical treatment, the determination of independent validated risk indicators for mortality in elderly patients might lead to developing a dedicated scoring system.","PeriodicalId":167216,"journal":{"name":"Facta Universitatis, Series: Medicine and Biology","volume":"460 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124490769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"FISTULOTOMY FOR THE SURGICAL TREATMENT OF PERIANAL FISTULA OF CRYPTOGLANDULAR ORIGIN","authors":"E. Xynos","doi":"10.22190/FUMB190507005X","DOIUrl":"https://doi.org/10.22190/FUMB190507005X","url":null,"abstract":"Perianal fistula usually results from a non-specific infection of the cryptic glands located at the anal dentate line. Identification of the exact course of a perianal fistula and the extent of anal sphincteric complex involvement are of paramount importance, in order to design the therapeutic and interventional approach and achieve the best results without impairment of the anorectal function. Several interventional methods are in use for the surgical treatment of CPF, including fistulotomy, insertion of cutting “seton”, core fistulectomy, ligation of the intersphincteric fistulous track (LIFT), rectal advancement flap, injection of fibrin glue at the fistulous track, insertion of fistulous plug, and obliteration of the fistulous track with the use of Laser. In clinical practice a combination of the aforementioned methods can be used, in particular for the complex-high or recurrent fistulae.","PeriodicalId":167216,"journal":{"name":"Facta Universitatis, Series: Medicine and Biology","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132020218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SPECIFIC ASPECTS OF ANESTHESIA IN PROCTOLOGY","authors":"R. Jankovic, M. Stosic","doi":"10.22190/FUMB190507006J","DOIUrl":"https://doi.org/10.22190/FUMB190507006J","url":null,"abstract":"Proctology, as a domain of abdominal surgery, deals with the treatment of diseases affecting the end part of the large bowel, it’s terminal 20 cm, to which anus anatomically belongs as well. In view of the physiological role of this part of the digestive tract (stool control), all the diseases and disorders in the region cause patient discomfort and produce significant problems in everyday life. On account of that, diagnostic management should be performed promptly in order that effective treatments could be introduced as soon as possible. The most commonly used techniques of anesthesia in proctology are local anesthesia, independent or in combination with intravenous analgosedation, regional anesthesia (spinal and epidural), and general anesthesia. Local anesthesia combined with analgosedation has been the preferred approach in recent studies, since it is able to provide adequate settings for the planned surgery, patient comfort and minimization of side effects. An adequate anesthesia technique reduces metabolic response to surgical stress and length of hospitalization, which markedly affects cost-effectiveness of the treatment.","PeriodicalId":167216,"journal":{"name":"Facta Universitatis, Series: Medicine and Biology","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130147195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Ignjatovic, G. Stanojevic, M. Stojanović, L. Jeremić, M. Nestorović, Vesna Brzački, D. Stojanov, M. Djordjevic, M. Marinkovic
{"title":"SURGICAL TREATMENT OF ADVANCED GASTRIC CANCER","authors":"N. Ignjatovic, G. Stanojevic, M. Stojanović, L. Jeremić, M. Nestorović, Vesna Brzački, D. Stojanov, M. Djordjevic, M. Marinkovic","doi":"10.22190/FUMB190507004I","DOIUrl":"https://doi.org/10.22190/FUMB190507004I","url":null,"abstract":"Patients with advanced gastric cancer generally have poor overall prognosis as well as survival rate. Unfortunately, in the West, gastric cancer typically occurs at an advanced stage and many of these patients have tumor invasion into adjacent structures (International Union Against Cancer [UICC]/American Joint Committee on Cancer [AJCC] Stage T4). Although T4 gastric cancer patients often have peritoneal dissemination or distant metastasis, many do not have M1 disease and are therefore candidates for surgery with the curative intent. A multivisceral resection (MVR) or gastrectomy with resection of adjacent organs is needed in T4 gastric cancer patients to achieve an R0 resection that is one of the most powerful forecasters of gastric cancer surgery results. Spleen, distal pancreas, liver, and large intestine (mostly transverse colon) were the most commonly resected organs. The therapeutic choice with acceptable postoperative morbidity and mortality rates in locally advanced patients with gastric cancer should be gastrectomy with MVR, where complete resection could be realistically obtained and where metastatic involvement of the lymph node is not evident. MVR is done with a curative R0 resection to provide advanced gastric cancer patients with the best survival chance. It was found that resections involving the pancreas, transverse colon and liver were associated with increased survival rate in comparison to MVR with resection of other structures. It was shown that survival rate significantly decreased in patients who had undergone MVR without complete resection compared to those who had an R0 resection. Nevertheless, the extent of the surgical resection required and further advantages of MVR are disputable.","PeriodicalId":167216,"journal":{"name":"Facta Universitatis, Series: Medicine and Biology","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132362038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marko Gmijović, L. Savić, M. Nestorović, V. Pecić, B. Brankovic, M. Djordjevic, T. Stoimenov, M. Stojanović, M. Radojković, M. Stojanović
{"title":"MOLECULAR MECHANISMS OF ISCHEMIC-REPERFUSION INJURY DURING LIVER RESECTION FOR COLORECTAL CANCER METASTASES- STUDY PROTOCOL","authors":"Marko Gmijović, L. Savić, M. Nestorović, V. Pecić, B. Brankovic, M. Djordjevic, T. Stoimenov, M. Stojanović, M. Radojković, M. Stojanović","doi":"10.22190/FUMB190507009G","DOIUrl":"https://doi.org/10.22190/FUMB190507009G","url":null,"abstract":"Bleeding during liver resection is a significant threat to the clinical outcome. Portal triad occlusion with complete ischemia of the liver flow of hepatoduodenal ligament is a well-documented, safe and useful way to reduce this problem. Although the technique is efficient in limiting blood loss, there is still controversy concerning potential disadvantages and subsequent reperfusion liver injury. A prospective analysis will include at least 30 patients 18-75 years old, who are undergoing liver resection due to metastases of the colorectal carcinoma. After signing the informed consent, the parameters will be analyzed in three phases, pre-, intra- and postoperatively. During surgery (indicated by a surgical/oncological team of doctors not related to our study) liver tissue samples will be taken of the “healthy liver” (not involved in the tumor process) in which after tissue homogenization, analysis of parameters will be done responsible for the development of liver injury. This research will not affect the clinical practice, course and outcome of the treatment in patients who are included. The study may be useful for future patients who will undergo liver resections. The application of modern research methods with scientific validity of statistical processing of data and the use of appropriate literature, significant data will be obtained about the character, i.e. intensity of damage of the liver tissue in patients undergoing liver resections.","PeriodicalId":167216,"journal":{"name":"Facta Universitatis, Series: Medicine and Biology","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131223986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Pecić, M. Nestorović, Ivan Pesic, D. Mihajlović, L. Jeremić, Marko Gmijović, D. Petrović, B. Brankovic
{"title":"PERINEAL HERNIA AFTER ABDOMINOPERINEAL LAPAROSCOPIC RESECTION – CASE REPORT","authors":"V. Pecić, M. Nestorović, Ivan Pesic, D. Mihajlović, L. Jeremić, Marko Gmijović, D. Petrović, B. Brankovic","doi":"10.22190/FUMB190507010P","DOIUrl":"https://doi.org/10.22190/FUMB190507010P","url":null,"abstract":"A perineal hernia can severely affect everyday activities. We represent a case of a sixty-five-year-old with perineal hernia after abdominoperineal resection for rectal cancer. Bulging in the perineum appeared 24 months following operation with uneventful postoperative course. She felt pain and difficulty while sitting. At physical examination the defect in perineum was approximately 3x3 cm. After cancer recurrence had been excluded, hernioplasty was planned. A 10x15 cm composite mesh was used for pelvic floor reconstruction. The mesh was sutured through urogenital diaphragm. Postoperative course was uneventful. Three years after surgery, there was no recurrence of cancer or hernia. Repair of perineal hernia is challenging, with limitation regarding guidelines in literature.","PeriodicalId":167216,"journal":{"name":"Facta Universitatis, Series: Medicine and Biology","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133486562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}