Facta Universitatis, Series: Medicine and Biology最新文献_第2页

OVERCOMING FEAR AVOIDANCE BEHAVIORS AND KINESIOPHOBIA IN PATIENTS WITH CHRONIC LOW BACK PAIN 克服慢性腰痛患者的恐惧回避行为和运动恐惧症

Facta Universitatis, Series: Medicine and Biology Pub Date : 2022-09-30 DOI: 10.22190/fumb220719005s

A. Stanković, O. Zikic, M. Kocić, D. Zlatanovic, I. Stanković

{"title":"OVERCOMING FEAR AVOIDANCE BEHAVIORS AND KINESIOPHOBIA IN PATIENTS WITH CHRONIC LOW BACK PAIN","authors":"A. Stanković, O. Zikic, M. Kocić, D. Zlatanovic, I. Stanković","doi":"10.22190/fumb220719005s","DOIUrl":"https://doi.org/10.22190/fumb220719005s","url":null,"abstract":"Chronic low back pain (CLBP) is a very complex medical, social and economic problem. Long duration and variability of symptoms can be frustrating for patients and lead to various psychological and behavioral changes, which can be expressed as an over-powering fear of movement and lead to avoidance behavior. The aim of this study was to highlight the importance of individually designed exercises (IDE) and cognitive-behavioral treatment (CBT) in the treatment of patients with CLBP who have signs of fear-avoidance behavior and kinesiophobia. One hundred and thirty patients were included in a prospective randomized study. Group 1 (G1; n = 35) had a combined IDE and CBT program. Group 2 (G2; n = 35) had IDE, without CBT. Group 3 (G3; n = 30) had standard group exercises for CLBP. Group 4 (G4; n = 30) was a control, patients did not have IDE or CBT. Waddel's Fear Avoidance Beliefs Questionnaire (FABQ) and Tampa Scale of Kinesiophobia (TSK), were used for monitoring and evaluation. Patients completed them at the beginning, at the end of the therapy, and also after 3 months. After therapy and three months later, a statistically significant reduction in symptoms in G1 and G2 was recorded, with better results in G1: FABQph = 4.77±3.83/5.51±4.02; FABQw = 2.31±3.69/2.94±4.19; TSK = 5.63±4.56/5.69 ± 4.55. (p <0.001). The combination of IDE and CBT is an effective therapy for CLBP patients with fear avoidance behaviour and kinesiophobia.","PeriodicalId":167216,"journal":{"name":"Facta Universitatis, Series: Medicine and Biology","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133425334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

USE OF BISPECTRAL INDEX (BIS) FOR MONITORING OF SEDATION AND TOTAL INTRAVENOUS ANESTHESIA (TIVA) IN PEDIATRIC PATIENTS UNDERGOING COLONOSCOPY 应用双谱指数(bis)监测小儿结肠镜检查患者的镇静和全静脉麻醉(tiva)

Facta Universitatis, Series: Medicine and Biology Pub Date : 2022-07-12 DOI: 10.22190/fumb220413003b

I. Budic, Z. Djurić, V. Marjanovic, Ivona Djordjevic, M. Stevic, D. Simić

{"title":"USE OF BISPECTRAL INDEX (BIS) FOR MONITORING OF SEDATION AND TOTAL INTRAVENOUS ANESTHESIA (TIVA) IN PEDIATRIC PATIENTS UNDERGOING COLONOSCOPY","authors":"I. Budic, Z. Djurić, V. Marjanovic, Ivona Djordjevic, M. Stevic, D. Simić","doi":"10.22190/fumb220413003b","DOIUrl":"https://doi.org/10.22190/fumb220413003b","url":null,"abstract":"The objectives of this study were to determine whether there was a correlation between bispectral index (BIS) and Ramsey Sedation Scale (RSS) in regard to the type of sedation and total intravenous anesthesia (TIVA) during colonoscopy procedures in children, and to assess the utility of ketamine and propofol combination (ketofol) for this kind of procedures at children’s age. In our prospective study, 40 ASA I-II patients, 3 to 17 years of age, were randomly divided into two groups of 20 patients each. After premedication with atropine and midazolam, sedation was induced with propofol and fentanyl in Group PF, whereas in Group PK propofol and ketamine were used for induction. Both groups were further divided into two subgroups depending on whether anesthesia was maintained with intermittent doses or continuous infusion of propofol. Ketamine and/or fentanyl were administered as bolus doses. Heart rate (HR), peripheral oxygen saturation (SpO2), RSS and BIS values of all patients were recorded every 5 minutes throughout the colonoscopy procedures. The strongest degree of correlation between RSS and BIS existed when sedation or TIVA was maintained by the boluses of propofol and fentanyl. The use of ketamine significantly reduced the doses of propofol and fentanyl. BIS can be monitored in all pediatric patients in whom sedation and TIVA are administered during colonoscopy, but the effect of different anesthetics on the EEG signal should be considered in order to adequately assess the depth of sedation and anesthesia.Key words: awareness, monitoring, child, anesthetics, endoscopy","PeriodicalId":167216,"journal":{"name":"Facta Universitatis, Series: Medicine and Biology","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115060160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NONSTEROIDAL ANTI-INFLAMMATORY DRUGS AS THERAPEUTIC ALLIES OF THE GUT MICROBIOME ON CHRONIC INFLAMMATION 非甾体抗炎药作为肠道微生物群治疗慢性炎症的盟友

Facta Universitatis, Series: Medicine and Biology Pub Date : 2020-01-27 DOI: 10.22190/FUMB201222013M

Fabian Mermans, Evelien Heiremans, M. V. Belleghem, Axelle Meersschaut, E. Hernandez-Sanabria

{"title":"NONSTEROIDAL ANTI-INFLAMMATORY DRUGS AS THERAPEUTIC ALLIES OF THE GUT MICROBIOME ON CHRONIC INFLAMMATION","authors":"Fabian Mermans, Evelien Heiremans, M. V. Belleghem, Axelle Meersschaut, E. Hernandez-Sanabria","doi":"10.22190/FUMB201222013M","DOIUrl":"https://doi.org/10.22190/FUMB201222013M","url":null,"abstract":"Our gut harbours around 1014 bacteria of more than 1000 species, accounting for approximately 2 kg of biomass. The gut microbiome plays several vital functions in processes such as the development of the immune system, food digestion and protection against pathogens. For these functions to be beneficial for both host and microbiome, interactions are tightly regulated. Gut and immune cells continuously interact to distinguish among commensal microbiota, harmless foodstuff, and pathogens. A fine balance between inflammatory and anti-inflammatory state is fundamental to protect intestinal homeostasis. Nonsteroidal anti-inflammatories (NSAIDs) are a class of drugs used for management of pain and inflammation. These compounds have heterologous structures but similar therapeutic activities. The target of all NSAIDs are the isoforms of cyclooxygenase enzymes (COX): the primarily constitutive form COX-1, and the inducible from COX-2. Both isoforms catalyse the conversion of arachidonic acid to PGH2, the immediate substrate for specific prostaglandin and thromboxane synthesis. The gut microbiota plays a role in drug metabolism, resulting in altered bioavailability of these compounds. Additionally, complex host-microbiome interactions lead to modified xenobiotic metabolism and altered expression of genes involved in drug metabolism. These effects can be at gut tissue-level, or distant, including in the liver. Besides the gut microbiome influencing drug metabolism, drugs also impact the microbial communities in the gut. As different drugs exert selective pressures on the gut microbiome, understanding this bidirectional relationship is crucial for developing effective therapies for managing chronic inflammation.","PeriodicalId":167216,"journal":{"name":"Facta Universitatis, Series: Medicine and Biology","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133895044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

THE INFLUENCE OF VARIOUS MICROENVIRONMENTAL FACTORS ON BIOMECHANICAL FEATURES OF DIFFERENT SUTURE MATERIALS USED IN HEPATO-PANCREATO-BILIARY SURGERY 各种微环境因素对肝胰胆手术中不同缝合材料生物力学特性的影响

Facta Universitatis, Series: Medicine and Biology Pub Date : 2020-01-27 DOI: 10.22190/FUMB190625015R

M. Radojković, M. Stojković, I. Golubović, D. Sokolović

引用次数: 1

THE INFLUENCE OF THE SAGITTAL DENTOSKELETAL PATTERN ON THE VALUE OF THE SOFT TISSUE PROFILE ANGLES - A CEPHALOMETRIC STUDY 矢状齿骨模式对软组织轮廓角值的影响-一项头侧测量研究

Facta Universitatis, Series: Medicine and Biology Pub Date : 2019-10-12 DOI: 10.22190/FUMB190514011P

T. Perović, M. Blažej, I. Jovanovic

{"title":"THE INFLUENCE OF THE SAGITTAL DENTOSKELETAL PATTERN ON THE VALUE OF THE SOFT TISSUE PROFILE ANGLES - A CEPHALOMETRIC STUDY","authors":"T. Perović, M. Blažej, I. Jovanovic","doi":"10.22190/FUMB190514011P","DOIUrl":"https://doi.org/10.22190/FUMB190514011P","url":null,"abstract":"The aim of this study has been to establish the values of soft tissue profile angles in subjects with dentoskeletal Class I, Class II Division 1, Class II Division 2, and Class III pattern, in order to examine the influence of sagittal dentoskeletal relation on the value of angular profile parameters. This comparative cephalometric study included the examination and the analysis by lateral cephalograms to evaluate soft tissue profile angles for 120 adult Caucasian subjects (60 women and 60 men) from the mid Balkan region divided into four groups towards ANB angle and incisors inclination. The following angles were examined: angle of facial convexity, facial convexity angle for the lower face and the angle of total facial convexity. By investigating the influence of the sagittal dentoskeletal pattern on the value of facial convexity angles, significant differences have been established between subjects with Class I and Class II Division 1 and 2 for all examined angles (p<0.001; p=0.011), while the differences between Class I and Class III are only significant for the facial convexity angle and facial convexity angle for the lower face, while the differences in the overall facial convexity angle are not significant (p=0.067). There are significant differences between subjects for all examined angles except the total facial convexity angle between Class I and Class III.","PeriodicalId":167216,"journal":{"name":"Facta Universitatis, Series: Medicine and Biology","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116180659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IMMUNOHISTOCHEMICAL IDENTIFICATION AND DISTRIBUTION OF GLUTAMATERGIC NMDA AND mGlu1 RECEPTORS IN THE PONTINE INTERTRIGEMINAL REGION IN RATS 大鼠脑桥三叉间区谷氨酸能NMDA和mGlu1受体的免疫组织化学鉴定和分布

Facta Universitatis, Series: Medicine and Biology Pub Date : 2019-10-12 DOI: 10.22190/FUMB180205001S

M. Stoiljkovic

{"title":"IMMUNOHISTOCHEMICAL IDENTIFICATION AND DISTRIBUTION OF GLUTAMATERGIC NMDA AND mGlu1 RECEPTORS IN THE PONTINE INTERTRIGEMINAL REGION IN RATS","authors":"M. Stoiljkovic","doi":"10.22190/FUMB180205001S","DOIUrl":"https://doi.org/10.22190/FUMB180205001S","url":null,"abstract":"Local glutamate simulation of intertrigeminal region (ITR) in the lateral pons evoked immediate cardiovascular and respiratory effects proposing its role in central cardiorespiratory control. Since pharmacological studies provided only functional evidence for the existence of glutamate receptors in the ITR and thereby specifying putative neurochemical substrate involved in this control, here we employed immunohistochemistry to examine expression and distribution of NMDA and mGlu1 receptors in this structure. Thirty adult male Sprague-Dawley rats were perfuse-fixed, their brains frozen and cut into sequential series of 20 µm thick sections through the ITR. Immunohistochemistry was performed using polyclonal antibodies against NMDA-NR1, NMDA-NR2A and mGlu1 receptors. Labeled neurons in the ITR were analyzed using light microscope and computerized image analysis system for quantification of relative immunoreactivity as the mean of integrated optical density (IOD), and counting the immunopositive cells. Light microscopic analyses demonstrated NMDA-NR1-immunoreactivity mainly localized in the neuronal cell bodies with sparse distribution on primary dendrites, while NMDA-NR2A-immunoreactivity was basically somatically distributed. The mGlu1-immunoreactivity was moderate and observed both in neuronal bodies and primary dendrites or extracellular matrix suggesting somatodendritic localization. Quantitative analyses of IOD showed very strong expression of NMDA-NR1, weak of NMDA-NR2A and strong-to-moderate expression of mGluR1, with differences in immunostaining signal distribution over rostro-caudal span of the ITR. Counting of immunopositive cells followed similar expression profile. Our data directly confirm the presence of glutamatergic NMDA and mGlu1 receptors in the ITR apparently involved in signaling pathways by which this region modulates cardiorespiratory functions such as blood pressure, heart rate and breathing.","PeriodicalId":167216,"journal":{"name":"Facta Universitatis, Series: Medicine and Biology","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132397488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ACNE VULGARIS – ADEQUATE AND TIMELY THERAPY AS AN EARLY PREVENTION OF PSYCHOSOCIAL DISTURBANCES 寻常痤疮-适当和及时的治疗作为早期预防心理社会障碍

Facta Universitatis, Series: Medicine and Biology Pub Date : 2019-10-12 DOI: 10.22190/FUMB180427012P

M. Paravina, M. Stepanović, P. Štilet, Danica Janjić Spasić

{"title":"ACNE VULGARIS – ADEQUATE AND TIMELY THERAPY AS AN EARLY PREVENTION OF PSYCHOSOCIAL DISTURBANCES","authors":"M. Paravina, M. Stepanović, P. Štilet, Danica Janjić Spasić","doi":"10.22190/FUMB180427012P","DOIUrl":"https://doi.org/10.22190/FUMB180427012P","url":null,"abstract":"Acne is a polyetiological chronic disease of pilosebaceous units that affects 80% to 90% of teenagers and adolescents. It is manifested as mild, moderate, or severe form. Since adolescence is time of psychological, emotional and social personality development, the appearance of acne, most frequently on face, demands long-term treatment, significantly affects psychologic and emotional state, creating the feeling of being marked and leading to depression, anxiety, social isolation and negative effect on the quality of life. Timely education, with general information on the causes, duration of the disease and adequate treatment can significantly affect patients’ relation to the disease and reduction of psycho-social problems. The analysis included 220, 39 (55%) males and 60 (45%) females, 14 to 30 years of age (or more), most frequently 16 to 20 years old with moderate form of the disease. Therapy was applied according to valid protocols. Each patient was given full attention with the explanation of the nature and course of the disease. The largest number of patients had the expected results, which was mutually appreciated. It was concluded that individual approach and cooperation during the treatment of each patient were necessary.","PeriodicalId":167216,"journal":{"name":"Facta Universitatis, Series: Medicine and Biology","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121966360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

SOME GUIDELINES FOR WRITING A LETTER TO THE EDITOR 给编辑写信的一些指导原则

Facta Universitatis, Series: Medicine and Biology Pub Date : 2019-10-12 DOI: 10.22190/FUMB190520012A

Zorica Antić

引用次数: 0

ANALYSIS OF PATIENTS’ NONADHERENCE TO STATIN THERAPY FROM CARDIOVASCULAR EVENT TO CARDIOVASCULAR REHABILITATION 他汀类药物治疗从心血管事件到心血管康复的不依从分析

Facta Universitatis, Series: Medicine and Biology Pub Date : 2019-10-12 DOI: 10.22190/FUMB171213010D

D. Djordjevic, I. Tasic, B. Stamenkovic, S. Kostić, M. Lovic

{"title":"ANALYSIS OF PATIENTS’ NONADHERENCE TO STATIN THERAPY FROM CARDIOVASCULAR EVENT TO CARDIOVASCULAR REHABILITATION","authors":"D. Djordjevic, I. Tasic, B. Stamenkovic, S. Kostić, M. Lovic","doi":"10.22190/FUMB171213010D","DOIUrl":"https://doi.org/10.22190/FUMB171213010D","url":null,"abstract":"Numerous studies have pointed to low adherence to statin, which decreases as time period from acute cardiovascular event elapses. The aim was to analyze the cause of not taking statin by patients who were referred to rehabilitation after coronary event. Study population and methods. The research included the total of 573 patients, average age 60.3, while 305 (53.1%) of them were patients who experienced the first cardiovascular event. The stated research was conducted by means of a questionnaire and implied active participation of the researchers in terms of monitoring the possession and use of medication during rehabilitation. On arrival to rehabilitation, 98 (17.1%) patients did not have statin. They stated that they had never used statins before or that they stopped using them shortly after the event. This subgroup had significantly unfavorable values of lipid parameters (p<0.001), abdominal obesity (p<0.01), physical inactivity (p<0.01), more comorbidities (p<0.001), more prescribed medications on daily level (p<0.05), lower education degree level (p<0.01) and lower monthly income (p<0.001). Independent factors for not taking statin were: female gender, low monthly income and large number of comorbidities (R = 0.291, R2 = 0.85, adjusted R2 = 0.80, std. error of the estimate = 0.36151; p < 0.001). The patients themselves stated that the first reason for not taking statin was lack of financial funds (45.9%), while the second reason was normalization of laboratory results (21.4%). Three months after acute coronary event, 17.1% of patients in Serbia stopped taking statin. Lower adherence to statin closely correlates with female gender, low financial income and multiple comorbidities.","PeriodicalId":167216,"journal":{"name":"Facta Universitatis, Series: Medicine and Biology","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121790078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

POPULATION PHARMACOKINETICS OF 2-OXO-CLOPIDOGREL IN PATIENTS WITH ACUTE CORONARY SYNDROME 2-氧-氯吡格雷在急性冠脉综合征患者中的人群药代动力学

Facta Universitatis, Series: Medicine and Biology Pub Date : 2019-10-12 DOI: 10.22190/FUMB181224015N

V. Nikolić, S. Janković, D. Stokanović, S. Konstantinović, J. Zvezdanović, N. Stefanović, Jelena Lilić, S. Apostolovic, T. Jevtović-Stoimenov, J. Milovanović

{"title":"POPULATION PHARMACOKINETICS OF 2-OXO-CLOPIDOGREL IN PATIENTS WITH ACUTE CORONARY SYNDROME","authors":"V. Nikolić, S. Janković, D. Stokanović, S. Konstantinović, J. Zvezdanović, N. Stefanović, Jelena Lilić, S. Apostolovic, T. Jevtović-Stoimenov, J. Milovanović","doi":"10.22190/FUMB181224015N","DOIUrl":"https://doi.org/10.22190/FUMB181224015N","url":null,"abstract":"The aim of the study was to develop a population pharmacokinetic (PK) model for clearance of 2-oxo-clopidogrel in patients with acute coronary syndrome (ACS). Population pharmacokinetic analysis was performed by using 72 plasma concentrations from the same number of patients (mean age of 60.82±10.76 years; total body weight (TBW) of 73.63±9.67 kg) with ACS using non-linear mixed-effect modeling (NONMEM). Validation of the final PPK model was carried out through the bootstrap analysis with 200 runs and it was used to estimate the predictive performance of the pharmacokinetic model. The typical mean value for 2-oxo-clopidogrel clearance (CL), estimated by the base model (without covariates), in our population was 39.2 l h−1.The value of aspartate transaminase and co-medication with digoxin were determinants of a derived population model. The final regression model for the clearance of 2-oxo-clopidogrel was the following: CL (lh-1) = 1.7 + 1.31*AST + 115*DIGOXIN. The derived PK model describes the clearance of 2-oxo-clopidogrel in patients with ACS, showing that the value of aspartate transaminase and co-medication with digoxin are the most important covariate. This finding will provide the basis for future PK studies.","PeriodicalId":167216,"journal":{"name":"Facta Universitatis, Series: Medicine and Biology","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125815939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0