Journal of periodontal research最新文献

{"title":"Periodontitis and Quality of Life: A Systematic Review and Meta-Analyses.","authors":"Gustavo G Nascimento, John Rong Hao Tay, Ethan Ng, Dian Yi Chow, Marco A Peres, Fabio R M Leite","doi":"10.1111/jre.70122","DOIUrl":"https://doi.org/10.1111/jre.70122","url":null,"abstract":"<p><strong>Aim: </strong>To systematically review and meta-analyze population-based epidemiological evidence on the association between periodontitis and quality of life.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were conducted in accordance with PRISMA guidelines and registered in PROSPERO (CRD420251130194). Embase, MEDLINE, PubMed, and Scopus were searched without date restrictions, supplemented by gray literature and reference screening. Population-based studies of adults (≥ 18 years) with representative sampling frames were eligible. Periodontitis was assessed using clinical measures, self-reports, or established classification systems, and compared with the absence of periodontitis. The primary outcome was oral health-related quality of life (OHRQoL) measured using validated instruments; general quality of life (QoL) was a secondary outcome. Random-effects meta-analyses were conducted using standardized and instrument-specific effect measures. Risk of bias was assessed using the Newcastle-Ottawa Scale for longitudinal studies, and its adaptation (NOS-xs) for cross-sectional studies.</p><p><strong>Results: </strong>Twenty-three studies met the inclusion criteria, and 15 were included in the quantitative synthesis. Severe periodontitis was consistently associated with poorer OHRQoL across effect measures, including pooled standardized mean differences (SMDs) (0.29; 95% CI: 0.06-0.52; I² 89.1%), adjusted odds ratios (ORs) (1.58; 95% CI: 1.26-1.96; I² 3.2%), and mean ratios (MRs) (1.24; 95% CI: 1.07-1.44), although heterogeneity was substantial in several analyses. OHIP-14 mean differences indicated higher scores among individuals with severe periodontitis (2.51; 95% CI: 0.15-4.86; I² 92.6%). Associations for moderate periodontitis were weaker and less consistent, with several estimates crossing the null. Evidence on general QoL was limited and methodologically heterogeneous.</p><p><strong>Conclusion: </strong>In representative population-based studies, severe periodontitis is consistently associated with poorer OHRQoL, whereas associations for moderate disease were less robust and consistent and should be interpreted with greater caution. These findings indicate that the population-level quality-of-life burden of periodontitis is driven primarily by advanced disease.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147963923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoporosis and Periodontitis: Two-Way Epidemiological and Mechanistic Evidence.","authors":"Jia Chang, Geeta Madhuri Bhuvanagiri, Megan Dulkanchainun, Cunyu Wang","doi":"10.1111/jre.70125","DOIUrl":"10.1111/jre.70125","url":null,"abstract":"<p><p>Osteoporosis and periodontitis are highly prevalent, chronic inflammatory diseases that constitute a major global health burden. Strong epidemiological evidence shows an association between the two diseases, in which osteoporosis patients have an increased risk of periodontitis, specifically in postmenopausal women. Osteoporosis and periodontitis are linked by bidirectional relationships through shared inflammatory and bone-resorptive pathways. Such a connection is explained by shared osteo-immunologic pathways, particularly as highlighted by recent breakthrough findings in the field. In this review, we comprehensively examined the seven links between osteoporosis and periodontitis across microbial translocation, systemic meta-inflammation, maladaptive myelopoiesis, immune cell trafficking, masticatory dysfunction-diet interactions, underlying vulnerabilities, and functional alterations of the oral microbiome, drawing on current biological findings and clinical evidence. This bidirectional relationship underscores the importance of integrated medical and dental screening and management strategies to improve patient outcomes for both conditions.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147963906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tooth Loss and Edentulism Are Associated With Poorer Quality of Life: A Systematic Review and Meta-Analyses.","authors":"Fabio R M Leite, John Rong Hao Tay, Dian Yi Chow, Ethan Ng, Gustavo G Nascimento, Marco A Peres","doi":"10.1111/jre.70121","DOIUrl":"https://doi.org/10.1111/jre.70121","url":null,"abstract":"<p><strong>Aim: </strong>Tooth loss and edentulism are common consequences of oral diseases and may compromise quality of life, yet population-level evidence remains heterogeneous. This systematic review and meta-analysis evaluated the association between tooth loss, edentulism, and quality of life outcomes in adults using population-based epidemiological studies.</p><p><strong>Methods: </strong>MEDLINE, Embase, Scopus, and CENTRAL were searched for observational studies of representative adult populations assessing associations between tooth loss or edentulism and oral health-related quality of life (OHRQoL) or general quality of life (QoL), measured using validated instruments. Risk of bias was assessed using the Newcastle-Ottawa Scale (including adaptations for cross-sectional studies), and certainty of evidence was evaluated using GRADE. Random-effects meta-analyses were conducted for comparable adjusted effect estimates, stratified by estimand and exposure definition. For binary OHRQoL outcomes, pooling was based on study-specific dichotomizations reported by the original studies.</p><p><strong>Results: </strong>Fifty articles comprising 55 population-based cohorts (287 750 participants from 37 countries) were included. Among these, four were prospective cohort studies, and the remaining had cross-sectional designs. Thirteen articles contributed to the quantitative synthesis. Individuals with nonfunctional dentition had approximately twice the odds of impaired OHRQoL compared with those with functional dentition [pooled adjusted odds ratio (OR) = 2.08; 95% CI 1.72-2.52; I² = 70.6%]. This association remained robust in analyses restricted to studies using the OHIP-14 instrument (OR = 2.03; 95% CI 1.65-2.50; I² = 65.9%). Overall associations between edentulism and impaired OHRQoL were heterogeneous; however, when restricted to OHIP-14-based studies, edentulism was associated with impaired OHRQoL (OR = 3.99; 95% CI 2.62-6.10; I² = 0.0%). Reduced posterior occlusal support was also associated with worse OHRQoL, although the supporting evidence remains limited. Certainty of evidence for OHRQoL outcomes was rated as moderate.</p><p><strong>Conclusion: </strong>In population-based adult samples, tooth loss, particularly when resulting in nonfunctional dentition or reduced occlusal support, is consistently associated with poorer OHRQoL. Associations with general QoL are less consistent, reflecting broader determinants and instrument sensitivity. Preserving functional dentition and access to effective prosthetic rehabilitation may yield meaningful quality-of-life benefits at the population level.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147930672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontal Medicine and the Limitations of Linear Causality: Time for a Cybernetic Framework.","authors":"Tom Lonsdale","doi":"10.1111/jre.70118","DOIUrl":"https://doi.org/10.1111/jre.70118","url":null,"abstract":"","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet-Rich Fibrins as Local Drug-Delivery Carriers.","authors":"Karim M Fawzy El-Sayed, Christof E Dörfer","doi":"10.1111/jre.70114","DOIUrl":"https://doi.org/10.1111/jre.70114","url":null,"abstract":"<p><p>The present review article explores the emerging evidence on the use of autologous platelet concentrates (APCs) as sustained release vehicles for a variety of drugs, including antibiotics, antifungals, antidiabetic drugs, exosomes, and vitamins for localized delivery approaches. The incorporation of such bioactive agents into APCs could enhance their therapeutic efficacy, support antimicrobial effects, wound healing and regeneration, and potentially reduce the need for systemic therapy. Although platelet-rich plasma (PRP) has also been studied as a carrier of bioactive agents, the rapid degranulation of platelets and lack of a cohesive fibrin network in PRP lead to a short-lived burst-type release profile. On the other hand, platelet-rich fibrin (PRF) has a three-dimensional scaffold of fibrin in which the growth factors and drug agents are retained, characteristics which make PRF-based APCs advantageous over PRP in the field of drug-delivery systems. However, a major challenge remains to be the absence of standardized drug-loaded APCs preparation protocols, with variations in centrifugation parameters, tube composition, and biomolecules' loading techniques, thereby influencing the APCs' structural integrity and release kinetics. The present review further highlights key findings on optimal loading strategies and the interactions between incorporated agents and the carrying APCs. It further highlights the level of current evidence for each of these drug-loaded APCs under investigation, their strength of recommendation, and possible knowledge gaps. Future work should focus on further developing and standardizing preparation protocols, advancing controlled release technologies, and validating efficacy through large scale clinical trials. Overall, bioactive drug-loaded APCs could represent a promising platform for targeted antimicrobial, antifungal, and regenerative therapies, bridging infection management with precision-guided tissue healing.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Oral-Gut Axis: Bidirectional Interactions Between Microbiome and Diseases.","authors":"Shinya Ebihara, Nobuhiko Kamada","doi":"10.1111/jre.70116","DOIUrl":"10.1111/jre.70116","url":null,"abstract":"<p><p>Increased colonization of typically oral microorganisms is frequently observed in the gut mucosa or lumen of individuals with gastrointestinal disorders, including patients with inflammatory bowel disease and colorectal cancer. Accumulating clinical and experimental evidence indicates that this phenomenon, known as \"gut oralization,\" plays an important role in the pathogenesis of these diseases. Although several physiological barriers normally restrict the translocation and ectopic colonization of microorganisms from the oral cavity to the gut, certain oral pathobionts-often enriched in individuals with oral diseases such as periodontitis-have evolved specialized strategies to overcome these defenses. This review examines the bidirectional interactions through which bacterial traits, including unique adhesion systems and metabolic adaptations, support colonization and expansion within the gastrointestinal tract, as well as how disease-associated alterations in the gut environment and increased host vulnerability facilitate ectopic colonization by bacteria of oral origin. By integrating clinical and mechanistic evidence, this review highlights the potential of targeting the oral-gut microbial axis as a therapeutic approach for preventing and treating chronic gastrointestinal disorders.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":"61 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148067689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":"61 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148067688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Augmented and Virtual Reality in Dental Medicine Updated: A Systematic Review and Meta-Analysis.","authors":"Sofya Sadilina, Syed Majeed Quadri, Ronald E Jung, Eugenia Settecase, Marc Balmer, Tim Joda","doi":"10.1111/jre.70115","DOIUrl":"https://doi.org/10.1111/jre.70115","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;This updated systematic review aimed to synthesize and evaluate the available evidence on the use of augmented reality (AR), mixed reality (MR), and virtual reality (VR) technologies in dental medicine and education. Both qualitative synthesis and quantitative analysis through pairwise meta-analysis, where applicable, were performed to assess their effectiveness and potential applications in clinical and educational settings.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A systematic electronic search was conducted, incorporating an updated search strategy from the original publication to reflect updated terminology, for articles published between January 1, 2019, and July 14, 2025. Articles reporting the use of AR, MR, or VR in clinical treatment or dental education were eligible for inclusion. Data on study characteristics, target population, dental discipline, application concept, type of reality, primary and secondary outcomes were extracted. Pairwise frequentist meta-analysis was conducted on randomized controlled trials (RCTs) assessing VR and objective stress-related clinical parameters such as heart rate. Study quality was appraised using the corresponding scale according to the study design.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 110 studies, reporting the use of AR, MR or VR, encompassing 8573 participants, were included. VR was the most frequently investigated technology (n = 94), followed by AR (n = 11) and MR (n = 2). Most studies evaluated multiple applications: clinical or patient-centered applications were evaluated in 71 trials, operator- or clinician-orientated applications in 33, and educational applications in 132 studies. Among primary outcomes, patient-reported (n = 30) and educational outcomes (n = 57) predominated, whereas clinical, clinician-, and operator-related outcomes were less frequently assessed. Results from the pairwise meta-analyses of RCTs showed that VR significantly reduced anxiety levels in children patients when compared to tell-show-do techniques (SMD = -1.32, 95% CI -1.93 to -0.72); meanwhile, there was a borderline significant reduction in heart rate levels of children patients under the VR technique compared to tell-show-do technique (MD = -3.26, 95% CI -6.51 to -0.00). On the other hand, no significant differences were found in terms of physiological and reported outcomes in adult patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;AR, MR and VR are increasingly used in dental medicine and education, mainly in undergraduate and postgraduate training. Current evidence supports the effectiveness of immersive technologies, particularly VR, in enhancing learning outcomes for students and improving patient experience, especially in anxiety and pain management. However, conclusions are limited by heterogeneity and a small number of high-quality studies, with overall low to moderate certainty of evidence.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Trial registration: &lt;/strong&gt;PROSPERO number: CDR42023403360 and date of registrati","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":"61 4","pages":"329-331"},"PeriodicalIF":3.4,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148086786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}