Local delivery of pamidronate with collagen matrix mitigates buccal bone resorption following immediate implant placement - An experimental in vivo study.

IF 3.4 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Inpyo Hong, Jeung-Min Joo, Yoon-Hee Kwon, David T Wu, Mariano Sanz, Ui-Won Jung, Jae-Kook Cha
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引用次数: 0

Abstract

Aims: The aim of this experimental in vivo pilot study was to evaluate the effect of the local delivery of pamidronate within a collagen membrane on the changes in the buccal soft and hard tissue dimensions at the time of immediate implant placement and whether this effect was influenced by the placement of bone substitutes.

Methods: In six beagle dogs, the distal roots of the third and fourth premolars were extracted, and immediate implants were placed. Treatment groups were randomly allocated to each socket: (i) covering the buccal bone with pamidronate-soaked collagen membrane (BP group), (ii) filling the gap defect with synthetic bone substitute (BS group), (iii) filling the gap defect with synthetic bone substitute and covering the buccal bone with pamidronate soaked collagen membrane (BP/BS group), (iv) no treatment (control group). Intraoral scanning was performed immediately after the surgery and at 20 weeks. Histomorphometric and micro-computed tomography (CT) outcomes were evaluated at 20 weeks.

Results: The micro CT analysis demonstrated that the BP group showed no apparent difference in vertical bone level with residual mesial root area, while control group showed significant buccal bone resorption at the implant site. The histomorphometric analysis demonstrated that the vertical bone level of buccal plate was significantly differed between the BP and control group (0.34 ± 0.93 and 1.27 ± 0.56 mm, respectively; p = .041). There was no statistically significant difference in the horizontal ridge width (HRW 1, 2, 3) among the groups. Also, the thickness, height and buccal contours of the soft tissue did not reveal significant changes among the groups.

Conclusion: The local delivery of pamidronate to the outer surface of the buccal wall at the time of immediate implant placement effectively limits buccal bone resorption. The results from the present investigation should be interpreted with caution, as well as its clinical translatability. Further investigation is needed to understand the pamidronate binding and releasing kinetic, as well as the ideal carrier of this drug for its topical application.

帕米膦酸钠与胶原基质的局部给药可减轻即刻植入种植体后的颊骨吸收--一项体内实验研究。
目的:这项体内试验性研究旨在评估在胶原膜内局部给药帕米膦酸钠对即刻种植体植入时颊面软、硬组织尺寸变化的影响,以及这种影响是否受骨替代物植入的影响:方法:在六只猎犬中拔除第三和第四前臼齿的远端牙根,并植入即刻种植体。在每个牙槽窝随机分配治疗组:(i) 用帕米膦酸盐浸泡的胶原膜覆盖颊骨(BP 组),(ii) 用合成骨替代物填充间隙缺损(BS 组),(iii) 用合成骨替代物填充间隙缺损并用帕米膦酸盐浸泡的胶原膜覆盖颊骨(BP/BS 组),(iv) 不进行治疗(对照组)。术后即刻和 20 周时进行口内扫描。20 周时对组织形态学和显微计算机断层扫描(CT)结果进行评估:显微 CT 分析表明,BP 组的垂直骨水平与残余中牙根区域无明显差异,而对照组则显示种植部位有明显的颊骨吸收。组织形态计量分析表明,BP 组和对照组的颊板垂直骨水平有显著差异(分别为 0.34 ± 0.93 毫米和 1.27 ± 0.56 毫米;P = 0.041)。各组之间的水平脊宽度(HRW 1、2、3)差异无统计学意义。此外,各组软组织的厚度、高度和颊面轮廓也没有明显变化:结论:在即刻种植体植入时向颊壁外表面局部施用帕米膦酸钠能有效限制颊骨吸收。对本研究结果的解释应谨慎,同时也要考虑其临床转化性。要了解帕米膦酸钠的结合和释放动力学,以及该药物局部应用的理想载体,还需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of periodontal research
Journal of periodontal research 医学-牙科与口腔外科
CiteScore
6.90
自引率
5.70%
发文量
103
审稿时长
6-12 weeks
期刊介绍: The Journal of Periodontal Research is an international research periodical the purpose of which is to publish original clinical and basic investigations and review articles concerned with every aspect of periodontology and related sciences. Brief communications (1-3 journal pages) are also accepted and a special effort is made to ensure their rapid publication. Reports of scientific meetings in periodontology and related fields are also published. One volume of six issues is published annually.
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