Diet-related diseases mediate the effect of masticatory function on premature death in older adults.

IF 3.4 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Xindi Wei, Xiaomeng Zhang, Ruiying Chen, Xiao Zhang, Suru Liu, Hongchang Lai, Junyu Shi
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引用次数: 0

Abstract

Aim: Although poor oral health has been a potentially modifiable risk for mortality, the precise association between functional tooth units (FTUs) and premature death as well as the underlying mechanisms remains unclear.

Methods: This study used data from the National Health and Nutrition Examination Survey (NHANES) 2009-2018. Mortality details were obtained from the National Death Index (NDI). The number of FTUs was defined as pairs of opposing natural and artificial teeth in the premolar and molar area. Weighted logistic regression models were employed to assess the relationship between FTU and premature death. Demographic characteristics, lifestyle habits, and disease histories were adjusted as confounding factors. The propensity score matching (PSM) was conducted to further assess the association between FTU and premature death. Mediation analyses were conducted to assess the role of diet-related diseases in the association between FTU and premature death.

Results: The analysis included 4169 individuals aged between 60 and 74 years. Participants with 0 ≤ FTUs ≤ 3 had a significantly higher odds of premature death compared to the 10 ≤ FTUs ≤ 12 group (OR = 2.142, 95% CI 1.091-4.208). After missing data imputation, 0 ≤ FTUs ≤ 3 was still significantly associated with increased odds of premature death (OR = 2.115, 95% CI 1.125-3.975). The relationship between 0 ≤ FTUs ≤ 3 and reference group persisted (OR = 2.196, 95% CI 1.296-3.721) after PSM analyses. For mechanism, mediation analysis showed that diet-related diseases, including diabetes and hypertension, partially mediated the association between FTU and premature death with proportions of 5.089% and 8.437%, respectively.

Conclusion: The findings revealed a link between impairment of masticatory function and a heightened odds of premature death among older adults. Notably, 0 ≤ FTUs ≤ 3 is significantly correlated to premature death among this demographic, with diabetes and hypertension partially mediating the effect of FTU on premature death. Further longitudinal studies are required to validate the findings.

咀嚼功能对老年人过早死亡的影响与饮食相关。
目的:尽管口腔健康状况不佳一直是一种潜在的可改变的死亡风险,但功能性牙齿单位(FTU)与过早死亡之间的确切关联及其内在机制仍不清楚:本研究使用了 2009-2018 年美国国家健康与营养调查(NHANES)的数据。死亡率详情来自国家死亡指数(NDI)。FTU的数量被定义为前磨牙和臼齿区域的对生天然牙和人工牙。采用加权逻辑回归模型评估 FTU 与过早死亡之间的关系。人口统计学特征、生活习惯和疾病史作为混杂因素进行了调整。为了进一步评估 FTU 与过早死亡之间的关系,还进行了倾向得分匹配(PSM)。此外,还进行了中介分析,以评估饮食相关疾病在工伤保险与过早死亡之间的关联中的作用:分析对象包括 4169 名年龄在 60 至 74 岁之间的人。与 10≤FTU≤12 组相比,0≤FTU≤3 组的参与者过早死亡的几率明显更高(OR = 2.142,95% CI 1.091-4.208)。在对缺失数据进行估算后,0 ≤ FTU ≤ 3 仍与过早死亡几率增加显著相关(OR = 2.115,95% CI 1.125-3.975)。经过 PSM 分析,0 ≤ FTUs ≤ 3 与参照组之间的关系仍然存在(OR = 2.196,95% CI 1.296-3.721)。在机制方面,中介分析表明,饮食相关疾病(包括糖尿病和高血压)部分中介了FTU与过早死亡之间的关系,中介比例分别为5.089%和8.437%:研究结果表明,咀嚼功能受损与老年人过早死亡的几率增加之间存在联系。值得注意的是,0 ≤ FTU ≤ 3 与该人群的过早死亡显著相关,而糖尿病和高血压在一定程度上介导了 FTU 对过早死亡的影响。需要进一步的纵向研究来验证这些发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of periodontal research
Journal of periodontal research 医学-牙科与口腔外科
CiteScore
6.90
自引率
5.70%
发文量
103
审稿时长
6-12 weeks
期刊介绍: The Journal of Periodontal Research is an international research periodical the purpose of which is to publish original clinical and basic investigations and review articles concerned with every aspect of periodontology and related sciences. Brief communications (1-3 journal pages) are also accepted and a special effort is made to ensure their rapid publication. Reports of scientific meetings in periodontology and related fields are also published. One volume of six issues is published annually.
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