Journal of periodontal research最新文献

{"title":"Use of Platelet-Rich Fibrin (PRF) on Palatal Wound Healing: A Narrative Review With Clinical Recommendations.","authors":"Nima Farshidfar, Paras Ahmad, Nathan Estrin, Yufeng Zhang, Richard J Miron","doi":"10.1111/jre.13413","DOIUrl":"https://doi.org/10.1111/jre.13413","url":null,"abstract":"<p><p>This clinical narrative review aimed to comprehensively evaluate the effects of platelet-rich fibrin (PRF) on clinically related and patient-reported outcomes during palatal wound healing following autologous palatal graft harvesting. To gather all available evidence, a comprehensive literature search was conducted in PubMed, Scopus, Web of Science, and Google Scholar, along with a manual search of reference lists from eligible studies, up to November 22, 2024. A total of 28 clinical comparative studies were identified, including 21 randomized clinical trials (RCTs), two non-RCTs, and five case series. Most studies investigated the application of PRF following free gingival grafts (FGG) rather than subepithelial connective tissue grafts (SCTG), with the majority also using solid PRF as opposed to liquid PRF. For FGG harvesting sites, PRF demonstrated positive outcomes in enhancing wound healing-related outcomes, reducing postoperative pain and other complications, lowering analgesic consumption, and improving quality of life (QoL). For SCTG harvesting sites, PRF also showed beneficial effects in promoting wound healing, reducing postoperative pain, and eliminating the need for analgesics. Based on the current findings, PRF application following either FGG and SCTG harvesting appears to be a promising approach for enhancing wound healing, minimizing postoperative complications, reducing analgesic consumption, and improving patient satisfaction. Clinical recommendations, along with step-by-step protocols, are also provided in this review article to guide clinicians in optimized efficiency for use of PRF for palatal wound healing following FGG and SCTG harvesting. A recommended simplified use of solid PRF prepared using horizontal centrifugation, in combination with a palatal stent, is suggested. The addition of sutures alongside the stent may provide enhanced stabilization of PRF in place for larger graft sites. Nevertheless, further well-designed RCTs with standardized methods and larger sample sizes are needed to strengthen the evidence base and confirm the therapeutic advantages of PRF in palatal wound healing.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Repeated Abutment Changes on Peri-Implant Tissue Stability and Keratinised Tissue on Peri-Implant Health: 12-Year Post-Loading Results From a Multicentre Randomised Controlled Trial.","authors":"Eriberto Bressan, Maria Gabriella Grusovin, Riccardo Federico Visconti, Giuseppe Luongo, Pasquale Piombino, Katia Greco, Jacopo Buti, Luca Sbricoli, Marco Esposito","doi":"10.1111/jre.13418","DOIUrl":"https://doi.org/10.1111/jre.13418","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Aims: &lt;/strong&gt;To evaluate the influence of at least three abutment disconnections in conventionally loaded implants against placement of a definitive abutment in immediately non-occlusal loaded implants on hard and soft tissue changes. A secondary aim was to evaluate whether the presence of less than 2 mm of keratinised mucosa is associated with increased peri-implant marginal bone loss and soft tissue recessions.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Sixty patients requiring one single crown or one fixed partial prosthesis supported by a maximum of three implants were randomised, after implants were placed with a torque superior to 35 Ncm, according to a parallel group design to receive definitive abutments which were loaded immediately (definitive abutment group) or transmucosal abutments which were delayed loaded after 3 months and were removed at least three times (repeated disconnection group). Patients were treated in three centres, and each patient contributed to the study with only one prosthesis followed for 12 years after initial loading. Outcome measures were: prosthesis failures, implant failures, complications, pink esthetic score (PES), buccal recessions, patient satisfaction, peri-implant marginal bone level changes, and height of the keratinised mucosa.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Thirty patients were randomly allocated to each group according to a parallel group design. Six patients dropped out or died from the definitive abutment group and seven from the repeated disconnection group. At 12 years post-loading, no patient in the definitive abutment group had implant failures versus three patients who lost five implants in the repeated disconnection group (difference = 13.04%; 95% CI: -6.7 to 26.8 to; p = 0.109; Fisher's exact test). No patient in the definitive abutment group had a prosthesis failure versus four patients of the repeated disconnection group. The difference was statistically significant (difference = 17.39%; 95% CI: 1.9 to 32.9; p = 0.049; Fisher's exact test). Four patients from the definitive abutment group versus seven patients from the repeated disconnection group were affected by complications (difference = 13.77%; 95% CI: -37.8 to 10.2; p = 0.318; Fisher's exact test), the difference not being statistically significant. PES scores did not show any statistically significant differences between the two groups: 10.84 ± 1.95 for the definitive abutment group and 10.31 ± 2.57 for the repeated abutment changes group (difference = -0.53; 95% CI: -1.14 to 2.20; p = 0.505). Buccal recessions amounted to 0.30 ± 0.98 mm for the definitive abutment group and 0.15 ± 0.54 mm for the repeated abutment changes group with no statistically significant differences between the two groups (difference = -0.14; 95% CI: -0.69 to 0.41; p = 0.592). All patients were declared to be very satisfied with the function and aesthetics of the prostheses and would undergo the same procedure again. Mean peri-implant marginal bone loss ","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microgravity Exacerbates Periodontitis In Vivo.","authors":"Ahmed Bakri, Asmaa Ismail, Alaa Mansour, Xavier Struillou, Iman M Talaat, Adel B Elmoselhi, Zahi Badran","doi":"10.1111/jre.70000","DOIUrl":"https://doi.org/10.1111/jre.70000","url":null,"abstract":"<p><p>This is the first study to examine induced periodontitis under simulated microgravity in vivo. Microgravity significantly increased alveolar bone loss, elevated GCF alkaline phosphatase levels, and caused severe periodontal destruction with notable immune cell infiltration. Understanding the underlying molecular pathways may guide future treatments for periodontitis in space and on Earth.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence in Periodontology: The Past, the Present, the Future","authors":"William V. Giannobile","doi":"10.1111/jre.13420","DOIUrl":"10.1111/jre.13420","url":null,"abstract":"","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":"60 5","pages":"395-397"},"PeriodicalIF":3.4,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Disease Detection in Dental Settings-Development and External Validation of a Nomogram (PerioCARD).","authors":"John Rong Hao Tay, Huihua Li, Mario Romandini, Gustavo G Nascimento","doi":"10.1111/jre.13401","DOIUrl":"https://doi.org/10.1111/jre.13401","url":null,"abstract":"<p><strong>Aim: </strong>Cardiovascular disease (CVD) is a leading cause of mortality and morbidity worldwide. Since many people visit their dentists regularly, assessing CVD in dental settings offers valuable opportunities for its early detection. This study aims to identify easily accessible indicators in dental settings that are associated with CVD in adults and to develop a nomogram, providing a practical tool to integrate CVD case detection into routine dental care.</p><p><strong>Methods: </strong>Demographic (age and sex), self-reported history (smoking, high cholesterol, diabetes, and use of hypertension medications), and periodontal data from the 2009 to 2010 National Health and Nutrition Examination Survey (NHANES) were utilized as candidate predictors for model training, targeting self-reported history of CVD as the reference standard. Multivariable logistic regression models were assessed using receiver operating characteristic analysis and calibration curves. The nomogram was internally validated with bootstrapping and externally validated (NHANES 2011-2012; 2013-2014) and assessed for discrimination and calibration.</p><p><strong>Results: </strong>Two thousand eight hundred and ninety participants were selected for training and 7416 for external validation. The final model, PerioCARD (Periodontal-based Cardiovascular Assessment and Recognition of Disease), included age, sex, smoking, high cholesterol, use of hypertensive medications, and periodontal status. The nomogram model achieved an area under the curve (AUC) of 0.82 (95% CI: 0.80-0.84) for identifying CVD, with an area under the precision-recall curve (AUPRC) of 0.38 (95% CI: 0.34-0.43). The external validation set had an AUC of 0.82 (95% CI: 0.81-0.84) and AUPRC of 0.32 (95% CI: 0.30-0.36), with good calibration and clinical net benefits in decision curve analysis.</p><p><strong>Conclusion: </strong>The PerioCARD nomogram was developed and validated using accessible parameters in the dental chair. This may have practical implications for rapid case detection of individuals with CVD by dental professionals.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Education in Periodontology: The Past, the Present, and the Future","authors":"Mariano Sanz,&nbsp;Elena Figuero,&nbsp;David Herrera","doi":"10.1111/jre.13417","DOIUrl":"10.1111/jre.13417","url":null,"abstract":"&lt;p&gt;The harmonization of dental education in Europe occurred alongside the broader process of European convergence in higher education initiated by the La Sorbonne Declaration in 1998 and the signing of the Bologna Declaration in 1999. This declaration emphasized the importance of achieving coherence within the European higher education area while maintaining diversity. It established a two-tier structure consisting of undergraduate and postgraduate cycles [&lt;span&gt;1&lt;/span&gt;]. Additionally, it introduced a common credit system known as the European Credit Transfer and Accumulation System or ECTS. It promoted curricular development, inter-institutional collaboration, and the integration of studies, training, and research to enhance mobility and ensure comparable criteria and methodologies. With this aim, the Association for Dental Education in Europe (ADEE) and the “DentEd” thematic network secured funding from the European Commission for a third Network Project, “DentEd III” (2004–2007), to create a curricular model in dentistry that fully complies with the principles of the Bologna Declaration [&lt;span&gt;2&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;The first step in this challenge was to agree on a professional profile with a defined set of general and specific competencies. Despite the need for graduates equipped to undertake independent dental practice safely, the educational and training programs varied significantly, with each school and country adopting different approaches shaped by their structures, cultures, and resources. Nevertheless, there was a common aspiration to achieve the highest possible standards in educational outcomes and relevant clinical competencies, enabling graduates to move freely and practice anywhere in Europe [&lt;span&gt;3&lt;/span&gt;]. The profile of the dentist was defined in the European Union by a directive on the recognition of professional qualifications, which stated: “&lt;i&gt;All Member States must recognize the profession of dental practitioner, equipped with the skills needed for the prevention, diagnosis, and treatment of diseases related to the teeth, mouth, jaws, and associated tissues&lt;/i&gt;.” It was further emphasized that dental training should consist of at least five years of full-time theoretical and practical training.&lt;/p&gt;&lt;p&gt;Based on these legal provisions, the proposed ADEE Dental Curricular structure was organized into modules according to the ECTS and aligned with the profile, domains, and competencies approved by ADEE. This framework defines competencies as a combination of knowledge, skills, and attitudes relevant to the dental education process, with a minimum acceptable level of performance for graduating dentists, emphasizing speed and accuracy that is consistent with patient well-being rather than performance at the highest possible level. Competencies were organized into seven domains representing the broad categories of professional activity and dimensions that occur in the general practice of dentistry: (I) professionalism, (II) communic","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":"60 4","pages":"291-299"},"PeriodicalIF":3.4,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jre.13417","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chlorhexidine 0.12% Mouthwash With or Without Bioflavonoids as an Adjunct to Non-Surgical Periodontal Therapy: A Randomized Clinical Trial.","authors":"Margherita Giorgia Liguori, Franz Josef Strauss, Francesco Tarallo, Davide Simeone, Alessandro Crea, Enrico Marchetti","doi":"10.1111/jre.13423","DOIUrl":"https://doi.org/10.1111/jre.13423","url":null,"abstract":"<p><p>This randomized clinical trial evaluated the adjunctive use of bioflavonoids in a 0.12% chlorhexidine mouthwash during non-surgical periodontal therapy. The addition of bioflavonoids resulted in clinical and patient-reported outcomes comparable to chlorhexidine alone, with both groups showing improvement over time and good overall treatment tolerance.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinol-Augmented PRF Versus PRF Alone in Periodontal Regeneration: A Randomized Clinical Trial","authors":"Abdallah Hassan,&nbsp;Weam Elbattawy,&nbsp;Dalia Sanaa,&nbsp;Alaa Nawwar,&nbsp;Sameh Magdeldin,&nbsp;Maha Mokhtar,&nbsp;Taghreed Khaled Abdelmoneim,&nbsp;Karim Fawzy El-Sayed","doi":"10.1111/jre.13404","DOIUrl":"10.1111/jre.13404","url":null,"abstract":"<p>VitA/i-PRF and i-PRF alone improved clinical and radiographic outcomes of M-MIST in periodontal intraosseous defects of patients with stage-III grade B periodontitis. VitA/i-PRF showed a minor, clinically non-significant advantage in defect depth reduction and bone fill at 6 months, with effects diminishing by 9 months in patients with stage-III grade B periodontitis.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":"60 8","pages":"847-849"},"PeriodicalIF":3.4,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jre.13404","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Porphyromonas gingivalis Outer Membrane Vesicles Promote Gingival Fibroblasts Senescence via IL21R-AS1.","authors":"Zirui Li, Yijing Xiao, Jiahui Ma, Xu Chen, Yi Zhou, Huiqing Gou, Yan Xu","doi":"10.1111/jre.13419","DOIUrl":"https://doi.org/10.1111/jre.13419","url":null,"abstract":"<p><strong>Aims: </strong>Periodontitis, a chronic inflammatory disease, is associated with accelerated cellular senescence. This study aims to explore how Porphyromonas gingivalis (P. gingivalis) outer membrane vesicles (OMVs) induce senescence and senescence-associated secretory phenotype (SASP) in human gingival fibroblasts (HGFs), focusing on the role of lncRNAs in promoting periodontitis progression.</p><p><strong>Methods: </strong>In vivo, gingival senescence was assessed via immunohistochemistry while bone loss was evaluated using micro-CT, HE and TRAP staining. In vitro, HGFs senescence was validated using CCK-8, SA-β-gal staining, western blot and immunofluorescence assays. IL21R-AS1 was transfected with targeted siRNAs and overexpression plasmids to verify its function. Dual-luciferase reporter assays and rescue experiments were conducted to elucidate the competing endogenous RNA (ceRNA) mechanism of IL21R-AS1. Upstream transcription factors of IL21R-AS1 were validated by CUT&Tag-qPCR and western blot.</p><p><strong>Results: </strong>P. gingivalis OMVs induced gingival tissue senescence and alveolar bone loss in vivo. In vitro, P. gingivalis OMVs promoted HGFs senescence and SASP via IL21R-AS1. IL21R-AS1 acted as a ceRNA by sponging miR-500a-3p, thereby enhancing the regulation of FBXW7. Moreover, P. gingivalis OMVs activated TLR4 and increased PAX5 expression, leading to elevated IL21R-AS1 levels.</p><p><strong>Conclusions: </strong>P. gingivalis OMVs promote HGFs senescence SASP by the upregulation of IL21R-AS1, which acts as a ceRNA, mediating the miR-500a-3p/FBXW7 axis and contributes to the progression of periodontitis. These findings offer novel insights into the molecular mechanisms of OMVs-induced senescence and periodontitis.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Do Patients Prefer in Periodontal and Implant Therapy? A Scoping Review.","authors":"Sarah Gomulinski, Vianney Gandillot, Fabien Valet, Kevimy Agossa, Olivier Huck, Stéphane Kerner, Philippe Bouchard, Maria Clotilde Carra","doi":"10.1111/jre.13412","DOIUrl":"https://doi.org/10.1111/jre.13412","url":null,"abstract":"<p><strong>Aims: </strong>Understanding and integrating patients' preferences into clinical practice can enhance personalized care, improve patient's adherence to treatment, and lead to better therapeutic outcomes. The aim of this scoping review was to map the existing literature investigating patients' preferences in periodontal and implant therapy while identifying key areas for future research and development.</p><p><strong>Methods: </strong>Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Reviews (PRISMA-ScR) guidelines, an electronic search was conducted in four databases (PubMed, Google Scholar, Cochrane Library, and ScienceDirect) in July 2024 to identify studies evaluating patients' preferences for periodontal and implant therapy.</p><p><strong>Results: </strong>The literature search yielded 384 studies, of which eight articles met the inclusion criteria. These studies were conducted between 2003 and 2019 in Brazil, China, Austria, Italy, Germany, Canada, USA, Chile, France, Spain, and Portugal. A total of 1642 patients were included. Preferences were assessed using various quantitative and mixed methodologies. Results indicate a strong preference for treatments aimed at preserving teeth, favoring conservative approaches. When teeth cannot be restored, most patients prefer an implant-supported fixed partial denture to avoid damaging adjacent teeth with a conventional tooth-supported fixed partial denture. In this context, treatment predictability is ranked as the most important factor. While no sociodemographic factors appeared to be associated with preferences in periodontal treatments, several predictors were identified for dental implant therapy. Younger patients, women, individuals with higher education levels, and those with high perceived dental health showed a higher willingness to pay for dental implants.</p><p><strong>Conclusion: </strong>The literature on patients' preferences in periodontal and implant therapies is scarce. Several trends are identified but further longitudinal studies are needed to explore patients' preferences over time and the role of sociodemographic and cultural segmentation criteria.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}