Journal of periodontal research最新文献

{"title":"Does Computer-Assisted Surgery Improve the Accuracy of Immediate Implant Placement? A Systematic Review and Network Meta-Analysis.","authors":"Lucia Schiavon, Leonardo Mancini, Eugenia Settecase, Ronald E Jung, Tim Joda","doi":"10.1111/jre.70010","DOIUrl":"https://doi.org/10.1111/jre.70010","url":null,"abstract":"<p><strong>Aim: </strong>This systematic review and network meta-analysis aimed to answer the PICO question: In patients undergoing immediate implant placement (IIP) [P], does Computer-Assisted Implant Surgery (CAIS) [I] lead to higher accuracy [O] compared to free-hand (FH) [C] implant placement?</p><p><strong>Methods: </strong>A systematic search of MEDLINE, Scopus, and Cochrane databases was conducted for randomized clinical trials (RCTs) published between January 2014 and September 2024, comparing accuracy of CAIS and FH for IIP. Two reviewers screened the studies and extracted data for a network meta-analysis.</p><p><strong>Results: </strong>Of 2064 records screened, 7 RCTs (338 implants and 291 patients) met the inclusion criteria. These RCTs evaluated FH and dynamic, full static, and partial static CAIS for single or partial implant placement. No RCTs analyzing robotic-assisted implant surgery (RAIS) were found. In 71.4% of the studies, IIP was performed in the anterior maxilla using a flapless approach. Accuracy was assessed by angular, cervical, and apical deviations between planned and real implant positions. All CAIS methods demonstrated significantly higher accuracy than FH (p < 0.05), but no significant differences were observed between CAIS approaches.</p><p><strong>Conclusions: </strong>CAIS significantly improves IIP accuracy, enhancing 3D implant positioning and prosthetic outcomes. All CAIS techniques revealed comparable accuracy, allowing clinicians to select the most suitable approach for each patient.</p><p><strong>Trial registration: </strong>PROSPERO identification number: CRD42024554241.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors of Periodontitis: Evidence From Two-Sample Mendelian Randomization and Meta-Analysis.","authors":"Lingjun Yan, Zilin Liu, Bingqin Xie, Yu Huang, Yuxuan Wu, Baochang He, Yanfen Li, Lan Luo, Fuhua Yan, Fa Chen","doi":"10.1111/jre.70001","DOIUrl":"https://doi.org/10.1111/jre.70001","url":null,"abstract":"<p><strong>Aim: </strong>Mendelian randomization is a more appropriate tool for causal inference, as the main suspected risk factors for periodontitis are difficult to test by randomized controlled trials due to ethical or feasibility issues. This study aimed to evaluate potential causal relationships between 50 known and suspected factors and periodontitis risk by a two-sample Mendelian randomization study and meta-analysis.</p><p><strong>Methods: </strong>By utilizing the databases of the Gene-Lifestyle Interactions at Dental Endpoints (GLIDE) consortium and the Finnish Genetics (FinnGen) consortium, 25 obesity-related indicators (BMI, birth weight, weight, height, waist-hip ratio, waist circumference, hip circumference, 18 body fat percentage or fat-free mass factors), eight hormone-related indicators (estradiol levels, total testosterone levels, sex hormone-binding globulin, age at menarche, age at menopause, three bone mineral density factors), five lifestyle factors (smoking, alcohol drinking, sleep duration, morning/evening chronotype, years of schooling), three dietary factors (coffee, tea, fruit), six blood biomarkers (fasting glucose, high-density lipoprotein cholesterol [HDL cholesterol], low-density lipoprotein cholesterol [LDL cholesterol], total cholesterol, serum 25-hydroxyvitamin D levels, hemoglobin A1c [HbA1c]), and three diseases (hypertension, type 2 diabetes, COVID-19). The odds ratios (ORs) and 95% confidence intervals (CIs) associated with the risk of periodontitis were estimated for each trait using the inverse variance weighting (IVW) method. A meta-analysis was conducted to analyze the causal associations from these databases.</p><p><strong>Results: </strong>Among the 50 potential risk factors, the IVW analyses revealed significant associations with the risk of periodontitis for 22 and two traits (FDR-corrected p < 0.05) in the GLIDE database as well as the FinnGen database, respectively. The meta-analyses revealed that 23 traits maintained statistically significant associations with periodontitis risk. Noteworthy associations included 20 obesity-related indicators with ORs ranging from 1.11 to 1.25, smoking (OR = 1.74), and hemoglobin A1c (OR = 1.07), which were associated with an increased risk of periodontitis. Conversely, increased years of education (OR = 0.81) were identified as potential mitigators of periodontitis risk. The sensitivity analyses utilizing five additional methods further bolstered the robustness of these findings.</p><p><strong>Conclusions: </strong>This comprehensive study provides evidence for the potential causal association of several modifiable risk factors with periodontitis, highlighting the importance of addressing these factors in preventive strategies for periodontal health.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell Therapy for Periodontal, Soft-Tissue, and Craniofacial Regeneration.","authors":"Kamal Mustafa, Shuntaro Yamada, Nerea Sanchez, Magdalena Mayol, Cecilie Gjerde, Mariano Sanz","doi":"10.1111/jre.70011","DOIUrl":"https://doi.org/10.1111/jre.70011","url":null,"abstract":"<p><p>Periodontal and craniofacial regeneration presents significant challenges owing to the complex tissue architecture, inadequate vascularization, and diminished stem cell populations within damaged tissues. Traditionally, autologous bone grafts or alternative bone substitute materials have been employed to address these conditions; however, these approaches are constrained by donor site morbidity, limited availability, and suboptimal regenerative efficacy. The advancement of mesenchymal stem/stromal cell (MSC) biology has accelerated the development of cell-based therapies in modern dentistry, which now focuses on biologically driven approaches to regenerate tissues. MSC-based therapies currently under investigation, both preclinically and clinically, show promise for improving tissue integration and healing processes of both soft and hard tissues, attributable to their multipotent nature, immunomodulatory properties, and paracrine signaling capabilities. Nevertheless, obstacles persist, including inconsistent standardization, limited scalability, regulatory hurdles, a paucity of controlled studies, and restricted biomaterial options. This review evaluates MSC-based treatments for periodontal and craniofacial reconstruction by discussing recent research findings and existing obstacles. This review also examines future prospects, such as advanced biofabrication methods, including 3D printing and bioprinting, which have the potential to improve personalized cell therapy for periodontal and craniofacial regeneration.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining Success in Implant Dentistry: Beyond Mere Implant Placement.","authors":"Marcel F Kunrath, Christer Dahlin","doi":"10.1111/jre.70009","DOIUrl":"https://doi.org/10.1111/jre.70009","url":null,"abstract":"","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Salivary Circular RNAs Expression and Periodontal Disease Status.","authors":"Pingping Han, Kexin Jiao, Peter Mark Bartold, Andrew Liaw, Wei Wei, Sašo Ivanovski","doi":"10.1111/jre.70004","DOIUrl":"https://doi.org/10.1111/jre.70004","url":null,"abstract":"<p><p>Salivary circular RNAs, particularly hsa_circ_0003563 (circRUNX2) and hsa_circ_0001161 (circMMP9), show strong potential as non-invasive biomarkers for diagnosing periodontitis and distinguishing the rate of disease progression, offering promising tools for improved periodontal diagnostics.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tunnel Versus Coronally Advanced Flap for the Treatment of Localized Gingival Recessions: A Randomized Clinical Trial.","authors":"Samuel Batista Borges, Lidya Nara Marques de Araújo, Gabriela Ellen Gomes, Rebeca Confessor Silva, Bruno César de Vasconcelos Gurgel","doi":"10.1111/jre.70006","DOIUrl":"https://doi.org/10.1111/jre.70006","url":null,"abstract":"<p><p>This study shows that using subepithelial connective tissue graft (SeCTG) with either the coronally-advanced flap (CAF) or the tunnel technique (TT) results in similar outcomes for root coverage and patient-reported measures, offering effective treatment options for localized type-1 gingival recessions.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical Factors Affecting Root Coverage Outcomes in Mandibular Incisors: A 3-Year Prospective Clinical Study.","authors":"Giovanna Laura Di Domenico, Sofia Aroca, Silvia Rizzuto, Davide Guglielmi, Massimo de Sanctis","doi":"10.1111/jre.70008","DOIUrl":"https://doi.org/10.1111/jre.70008","url":null,"abstract":"<p><strong>Aims: </strong>The primary objective was to evaluate the 3-year outcomes of a coronally advanced flap with connective tissue graft (CAF + CTG) for treating gingival recession defects affecting lower incisors. Additionally, the study aimed to investigate whether anatomical factors related to mandibular incisors influence gingival margin stability 3 years post-surgery.</p><p><strong>Methods: </strong>A prospective study was conducted on 30 patients with single gingival recession affecting mandibular incisors, treated with a trapezoidal CAF + CTG at San Raffaele Hospital (Milan, Italy) between January and May 2021. Clinical parameters, including recession depth (REC), keratinized tissue width (KTW), and marginal tissue thickness (MTT), were recorded at baseline and at the 1-year and 3-year follow-ups. Cone Beam Computed Tomography (CBCT) scans were also utilized to assess bucco-lingual inclination, apical root position, vestibular bone dehiscence, and root prominence.</p><p><strong>Results: </strong>At the 3-year follow-up, complete root coverage (CRC) was achieved in 52% of treated sites. A statistically significant reduction in REC was observed over the evaluation period. However, no significant differences were found in clinical parameters (REC, KTW, and MTT) between the 1-year and 3-year follow-ups. REC at 3 years was significantly and positively correlated with baseline REC, whereas it was inversely correlated with apical root position. Factors associated with mRC at 3 years were KTW baseline, root prominence, and apical root position.</p><p><strong>Conclusion: </strong>The findings of this study highlight key site-specific anatomical factors that may negatively influence root coverage outcomes in mandibular incisors, providing valuable insights for predicting treatment success.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lip and Oral Cancer, Caries and Other Oral Conditions: Estimates From the 2021 Global Burden of Disease Study and Projections up to 2050","authors":"Silas Alves-Costa,&nbsp;Mario Romandini,&nbsp;Gustavo G. Nascimento","doi":"10.1111/jre.13421","DOIUrl":"10.1111/jre.13421","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To (i) assess the prevalence, incidence, and burden of lip and oral cavity cancer, untreated caries, and “other oral conditions” (a group that includes temporomandibular disorders, malocclusion, and dental trauma, among others) in 2021; and (ii) forecast their estimates in 2050. Aggregate estimates for overall oral conditions (comprising caries, periodontitis, and edentulism, but excluding cancer) were also evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Prevalence, incidence, Years Lived with Disability (YLDs), Years of Life Lost (YLLs), Disability-Adjusted Life Years (DALYs), and deaths were reported for lip and oral cavity cancer. Untreated caries and “other oral conditions” were described as prevalence and YLDs, with incidence included only for caries. Aggregate estimates for overall oral conditions encompassed prevalence, incidence, and YLDs. Data were gathered globally, covering 204 countries, seven super-regions, and 21 regions from the Global Burden of Disease (GBD) study in 2021, with projections up to 2050 using mixed-effects models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In 2021, over 1.54 million (95% UI 1.44; 1.63) people worldwide were affected by lip and oral cavity cancer, with a global age-standardized prevalence of 0.02%. The burden included 1.28 YLDs per 100 000 (0.97; 1.59), 65.86 YLLs per 100 000 (59.53; 71.00), 67.71 DALYs per 100 000 (61.32; 73.17), and 2.42 deaths per 100 000 (2.21; 2.60). By 2050, prevalence and incidence are projected to increase by +68.7% and + 82.6%, respectively. By that time, lip and oral cavity cancer is expected to rank 119th in terms of YLDs. In 2021, 7.55% (6.29–8.78) of children had untreated caries in deciduous teeth, 27.54% (23.98–32.02) of the adult population had caries in permanent teeth, and 1.86% (1.78–1.93) were affected by “other oral conditions”, with 45.91% (42.26–49.78) of the global population experiencing at least one oral condition. By 2050, the prevalence of deciduous caries is projected to decrease by −15.80%, while permanent caries is predicted to rise by +23.77%, and “other oral conditions” will increase by +22.28%. Overall oral conditions (including periodontitis and edentulism, but excluding cancer) are projected to affect 46.17% (42.52–49.95) of the global population in 2050, ranking as the 10th leading cause of YLDs, surpassing conditions such as stroke and Alzheimer's disease.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Lip and oral cavity cancer, along with oral conditions aggregated (caries, periodontitis, edentulism, ","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":"60 6","pages":"544-558"},"PeriodicalIF":3.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jre.13421","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Membranes for Periodontal and Bone Regeneration: Everything You Need to Know.","authors":"Marcel F Kunrath, Gabriel L Magrin, Candida S Zorzo, Ingrid Rigotto, Hanna Aludden, Christer Dahlin","doi":"10.1111/jre.70005","DOIUrl":"https://doi.org/10.1111/jre.70005","url":null,"abstract":"<p><p>Implant dentistry and periodontology have shown an increasing demand for regenerative procedures associated with biomaterials targeting successful clinical outcomes and predictable long-term results. Membranes applied in oral regeneration have proved to be essential in regenerative procedures, increasing the quality, volume, and stability of the regenerated tissues. This review depicts and explores the past, present, and future of membranes used in periodontal and bone regeneration. Historical concepts and early studies using pioneering membranes are reviewed; physio-chemical and biological membrane properties (e.g., wettability, roughness, biocompatibility, porosity, and mechanical characteristics) are discussed, as well as, the future directions of innovative membranes in the developing stage; and as a central focus, a summary of the clinical techniques and scientific evidence in which membrane application is significantly relevant is exposed. Today, a wide option of membranes is available on the market for clinicians to select and use in regenerative procedures according to the surgical level and desired tissue to be regenerated. For instance, non-resorbable membranes (d-PTFE, e-PTFE, and Ti-reinforced PTFE); resorbable membranes (synthetic and collagen-based); and autologous membranes. Clinical and preclinical results in regenerative procedures using membranes such as horizontal and vertical bone augmentation, sinus lift, immediate implant placement, have shown strong positive evidence compared to spontaneous healing, meanwhile, the current use of membranes in periodontal regeneration, periimplantitis treatment, and alveolar ridge preservation has revealed reduced scientific data, suggesting the need for further investigation. Concluding, the use of membranes is predictable and relevant in oral regeneration. Nevertheless, still there is space for evolution and clinical progress in the use of membranes in oral regeneration aiming to surpass current limitations, eliminate possible contaminations, and promote faster regeneration.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis.","authors":"Groeger Sabine Elisabeth, Zhou Yuxi, Yong Jiawen, Wang Lei, Ruf Sabine, Meyle Joerg","doi":"10.1111/jre.70003","DOIUrl":"https://doi.org/10.1111/jre.70003","url":null,"abstract":"<p><p>Periodontitis, a chronic inflammatory condition, affects approximately 20%-50% of the world's population. It is usually characterized by progressive destruction of the periodontal soft and hard tissues, clinically manifested as gingival inflammation combined with attachment loss (CAL), radiographically detectable alveolar bone resorption, periodontal pockets, and bleeding on probing, as well as tooth mobility and potential tooth loss in advanced stages. These processes are moderated by the interplay between a dysbiotic microbiota and aberrant immune reactions within the gingival and periodontal tissues and can be modified by numerous internal or external influences. A number of studies discovered the importance of a variety of these impacting factors in periodontitis, including systemic, lifestyle, and environmental factors. Regarding the evidence level, these factors can be classified as predisposing factors, risk indicators, or risk factors. Predisposing factors include age, physical activity, dietary habits, alcohol consumption, and socioeconomic status. As risk indicators, obesity, osteoporosis, cardiovascular diseases, mental health disorders, poor diet, stress, and sleep disorders can be regarded Well-known risk factors for periodontitis are smoking/tobacco use and diabetes mellitus. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long-standing knowledge of the progression of the disease.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}