Journal of periodontal research最新文献

{"title":"Peri-Implantitis and Soft Tissue Dehiscence in a Turkish Population: Risk Indicators, Diagnostic Parameters and Biomarkers Discovery.","authors":"Sila Cagri Isler, Gulcin Akca, Berrin Unsal, Georgios Romanos, Anton Sculean, Mario Romandini","doi":"10.1111/jre.13422","DOIUrl":"https://doi.org/10.1111/jre.13422","url":null,"abstract":"<p><strong>Aim: </strong>To assess (i) the risk indicators of peri-implantitis and peri-implant soft-tissue dehiscence (PISTD), and (ii) the accuracy of clinical parameters and peri-implant crevicular fluid (PICF) immunological markers in diagnosing peri-implantitis, within a Turkish university population.</p><p><strong>Methods: </strong>A total of 324 implants in 112 patients were included. The outcomes for the risk indicators analysis were the presence of peri-implantitis and PISTD, with peri-implantitis also serving as the reference standard for the diagnostic accuracy analysis. Several potential risk indicators-including demographic, medical, and dental history, clinical and radiographic parameters, and dental chart data-were assessed using multilevel logistic regressions. The diagnostic performance of clinical parameters and PICF immunological markers was evaluated using logistic regressions and reporting sensitivity, specificity, positive/negative predictive values, and area under the curve (AUC) values.</p><p><strong>Results: </strong>In the final multilevel logistic regression, the following indicators were associated with peri-implantitis: stage III-IV periodontitis (OR = 5.67), irregular maintenance (SPIC) compliance (OR = 7.71), history of implant loss (OR = 14.44), implant system, absence of keratinized mucosa (KM) (OR = 8.41), and clinical attachment loss in adjacent teeth (OR = 3.75). Risk indicators for PISTD included: mandibular location (OR = 0.22), implant system, absence of KM (OR = 5.95), and mucosal thickness < 2 mm (OR = 197.01). Peri-implant bleeding on probing (BoP) at 2 or more sites had the highest sensitivity for peri-implantitis (98.0%), while the highest specificity was observed for BoP severity (modified Bleeding Index 2-3 = 96.4%). The highest AUC was found for peri-implant probing pocket depth (PPD) ≥ 6 mm (0.88). Among PICF immunological markers, IL-2 and IL-10 exhibited the highest sensitivity (100.0%), while TNF-α had the highest specificity (92.9%). IL-8 and TNF-α had the highest AUC values (0.80).</p><p><strong>Conclusion: </strong>In this Turkish university cohort, several risk indicators were identified for peri-implantitis and PISTD. Among clinical parameters, only PPD ≥ 6 mm demonstrated strong diagnostic accuracy for peri-implantitis. Several PICF immunological markers, particularly IL-8 and TNF-α, showed promising diagnostic potential.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontal Prognosis: The Past, the Present, the Future","authors":"Jack G. Caton","doi":"10.1111/jre.70020","DOIUrl":"10.1111/jre.70020","url":null,"abstract":"","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":"60 7","pages":"631-632"},"PeriodicalIF":3.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Keratinized Mucosa on the Risk of Peri-Implant Diseases and Soft Tissue Dehiscence in the Posterior Mandible-A 20-Year Prospective Cohort Study.","authors":"Andrea Roccuzzo, Jean-Claude Imber, Alexandra Stähli, Mario Romandini, Anton Sculean, Giovanni E Salvi, Mario Roccuzzo","doi":"10.1111/jre.70018","DOIUrl":"https://doi.org/10.1111/jre.70018","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the 20-year outcomes of tissue-level implants placed in the posterior mandible, comparing implants surrounded by keratinized tissue (KT) or alveolar mucosa (AM).</p><p><strong>Methods: </strong>At baseline, 128 patients (128 implants) were rehabilitated with implant-supported fixed dental prostheses in the posterior mandible and enrolled in a supportive periodontal/peri-implant care (SPC) program. Patients were categorized based on the presence (KT) or absence (AM) of keratinized mucosa. During the first 10 years of SPC, 11 AM patients underwent free gingival grafting (FGG), identifying a third group (AM + FGG). At the 20-year follow-up, peri-implant health status and soft-tissue dehiscence were assessed according to the 2018 Case Definitions. The need for additional treatment between the 10- and 20-year examinations was also recorded.</p><p><strong>Results: </strong>Of the 98 patients evaluated at the 10-year follow-up, 64 (KT = 42; AM = 16; AM + FGG = 6; drop-out rate: 35%) attended the 20-year examination. Additional treatment was required in 11 AM patients (50%) versus 2 KT patients (5%) (p < 0.01). AM implants exhibited significantly greater marginal bone loss, bleeding on probing, and soft tissue recession compared to KT implants (p < 0.01). The application of an FGG (AM + FGG = 6) had a protective effect on peri-implant health status at 20 years. Peri-implantitis was diagnosed in 4.2% of implants surrounded by keratinized mucosa (KT or AM + FGG) versus 25% in the AM group (OR = 6.67; 95% CI: 1.09-40.9; p = 0.041).</p><p><strong>Conclusion: </strong>Tissue level implants placed in the posterior mandible without KT showed greater marginal bone loss, bleeding on probing, soft tissue recession, and peri-implant diseases compared to implants with KT at 20 years.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential.","authors":"Karim M Fawzy El-Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A El-Rashidy, Marwa M S Abbass, Christof E Dörfer","doi":"10.1111/jre.70015","DOIUrl":"https://doi.org/10.1111/jre.70015","url":null,"abstract":"<p><p>The dental pulp and the periodontal tissues are crucial for maintaining oral health through supporting the structure, function, and integrity of teeth and surrounding tissues. The potential to regenerate these tissues (in case of their damage) represents a significant advancement in dental medicine. A functional regeneration could profoundly impact the quality of life for individuals with dental and periodontal diseases through offering new solutions to tissue loss and dental functional impairment, beyond what conventional dental therapies would provide. Studies on tissue engineering-based dentin-pulpal and periodontal regeneration have demonstrated promising results, using mesenchymal stromal cells (MSCs) from sources like bone marrow, adipose tissue, and cord blood. Nevertheless, MSCs derived directly from dental and periodontal tissues exhibit unique biological properties, with the potential to specifically address dental and periodontal regeneration, holding distinctive regenerative and immunomodulatory properties that may allow them to become valuable tools in clinical regenerative procedures. Their use in therapies could greatly benefit patients with oral and periodontal diseases, potentially enhancing life quality. Despite these promising findings, the distinct regenerative capacity of these cells, their mechanisms, and their potential clinical translational applications remain not fully elucidated. This review article aims to consolidate current knowledge about the biological characteristics and regenerative capabilities of dental and periodontal MSCs. By exploring the biology, isolation, and functional capacities of these cells, this work seeks to offer a deeper understanding of their potential and limitations, guiding future research and clinical strategies.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Oxidative Stress in Periodontitis.","authors":"Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino","doi":"10.1111/jre.70016","DOIUrl":"https://doi.org/10.1111/jre.70016","url":null,"abstract":"<p><p>Periodontitis and noncommunicable diseases share an overall inflammatory state often sustained by concomitant oxidative stress as one of the main processes involved. A huge amount of literature supports such a main pathogenic process, which is also considered the therapeutic target. The attempt to control inflammation by acting on oxidative stress has given largely unsatisfactory results, either as preventive or as treatment approaches. To propose new ideas that will help in this field, the paper reviewed all physiological processes involved in oxidative stress in periodontitis. The discussion considers all of them, considering whether they come from endogenous sources, that is, all the intracellular physiological devices and/or processes that are involved in oxidative stress, such as mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, or from exogenous sources, that is, the external factors that affect oxidative stress, such as nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs. The most important conclusion is that all of them should be taken into consideration in future research since we need to address oxidative stress as part of a specific biological and metabolic cellular state in a multicellular organism. To understand the cellular physiology that underlies oxidative stress and consider this point in treating each of our periodontal patients according to a specific oxidative state could be called personalized/precise oxidative stress therapy (POST) and should include the following points: (1) environmental conditions, (2) individual characteristics, and (3) oxidative state of different intracellular organelles.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Versus Non-Surgical Treatment of Periodontitis: The Past, the Present, the Future","authors":"Bruce L. Pihlstrom","doi":"10.1111/jre.70017","DOIUrl":"10.1111/jre.70017","url":null,"abstract":"&lt;p&gt;Overall, the goal of periodontal therapy is to maintain the natural dentition in health, comfort, and function. For decades, dentists have considered, discussed, and debated the fundamental question of whether to use surgical or non-surgical therapy to treat periodontitis [&lt;span&gt;1, 2&lt;/span&gt;]. Historically, decisions for or against using various treatments were based on anecdotal evidence and clinical experience. Over the last 50 years or so, clinical research has provided objective data to support both methods of therapy. This led to the current management of periodontitis, which involves a combination of both non-surgical and surgical interventions. One of the main questions facing clinicians today is how to monitor the stability of periodontitis following treatment so they can intervene to prevent or reverse further loss of periodontal support. While future treatment strategies cannot be predicted, advances in periodontal diagnosis, new technology, cost-effectiveness, precision care, artificial intelligence, and new ways to control periodontal inflammation are likely to influence future methods of periodontal treatment.&lt;/p&gt;&lt;p&gt;It should be noted that these studies used practitioner-measured outcomes of probing depth and CAL rather than the patient-centered outcome of tooth retention. This was necessary because tooth loss from periodontitis occurs over many years, making it impractical to use as an outcome measure in shorter studies. However, CAL is generally accepted as a valid measure of periodontal support and, importantly, CAL loss ≥ 2 mm has been validated as an informative surrogate for tooth loss in a large 26-year population study [&lt;span&gt;20&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;In the past, surgical and non-surgical treatment for periodontitis were often viewed as distinct and separate treatment strategies. Today there is more emphasis on integrating non-surgical and surgical treatment into a continuum of therapy. Depending on specific diagnoses, systemic health, risk factors, and other considerations, both are frequently used and have been endorsed by the American Academy of Periodontology [&lt;span&gt;23&lt;/span&gt;] and the European Federation of Periodontology [&lt;span&gt;24&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;It is impossible to predict the future of any discipline, but current trends can provide some insight into what may transpire in coming years. Regardless of future treatment methods, controlling periodontal inflammation and the oral biofilm will remain essential for successful surgical and non-surgical periodontal therapy. New developments in helping patients improve oral hygiene and comply with supportive care and new ways to change harmful behaviors such as substance and tobacco use could have profound effects on periodontal treatment methods. Rather than using a periodontal probe and laborious methods of physical clinical measurement (i.e., CAL, probing depth, BOP), future clinicians will likely use improved diagnostic methods and biomarkers that will allow precise identification o","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":"60 6","pages":"519-523"},"PeriodicalIF":3.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jre.70017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sixty Years of Osseointegration: The Past, the Present, the Future.","authors":"Tomas Albrektsson","doi":"10.1111/jre.13397","DOIUrl":"https://doi.org/10.1111/jre.13397","url":null,"abstract":"","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontitis: Microbial Dysbiosis, Non-Resolving Inflammation, or Both?","authors":"Thomas E Van Dyke, Giacomo Baima, Mario Romandini","doi":"10.1111/jre.13424","DOIUrl":"https://doi.org/10.1111/jre.13424","url":null,"abstract":"<p><p>The central question addressed in this review revisits the historical chicken-and-egg debate: \"In periodontitis, does microbial dysbiosis drive inflammation, or does inflammation shape the subgingival microbiome?\" This question is reframed through the lens of inflammation resolution. Specialized pro-resolving mediators (SPMs) provide a mechanistic framework for understanding how inflammation intersects with microbial dysbiosis. Derived from omega-3 and omega-6 fatty acids, SPMs actively promote the resolution of inflammation through binding of specific cell surface receptors rather than nonspecifically suppressing it, highlighting their therapeutic potential as side-effect-free host modulators, with implications beyond periodontitis to other chronic inflammatory diseases. The evidence reviewed shows how SPMs can: (1) control inflammation by resolution rather than inhibition, (2) reverse microbial dysbiosis as a consequence of inflammation control, and (3) promote tissue regeneration through diverse biological pathways. Whether the primary dysregulation in periodontitis lies solely in resolution failure or involves additional-possibly still unidentified-mechanisms, remains unclear. All individuals harbor periodontal pathobionts, yet only a subset develop severe disease. Why do some individuals with significant biofilm accumulation maintain attachment levels, while others with reasonable plaque control become edentulous? This remains one of the most significant unanswered questions in periodontology. What is evident, however, is the need for a paradigm shift. While bacteria initiate the inflammatory process in all individuals, it is the host response that ultimately determines the progression to periodontitis.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Susceptibility to Periodontitis.","authors":"Gesa M Richter, Arne S Schaefer","doi":"10.1111/jre.70002","DOIUrl":"https://doi.org/10.1111/jre.70002","url":null,"abstract":"<p><p>Periodontitis is a widespread inflammatory disease of the oral cavity that is influenced by genetic and environmental factors. Periodontitis has a high heritability, and particularly severe periodontitis often manifests before the age of 40, suggesting a strong genetic component. Genetic research has identified genetic variants associated with susceptibility to periodontitis that provide insights into the underlying mechanisms, which may improve future diagnostic and treatment strategies. We screened potential risk single-nucleotide variants (SNVs) identified in genetic association studies on periodontitis using the following selection criteria: genome-wide significance (p ≤ 5 × 10^-8) or suggestive significance (p ≤ 5 × 10^-6) with replication in ≥ 1 independent study. Additionally, we included SNVs with p < 5 × 10^-4 and ≥ 2 independent replications and functional validation. Due to the polygenic nature of periodontitis, we prioritized common variants with a minor allele frequency ≥ 1% and included rare variants (MAF ≤ 0.001) identified in whole-exome sequencing studies of severe cases with early onset. These criteria increased the reliability of identifying true genetic risk factors. The identified genetic risk loci for periodontitis can be primarily attributed to two biological functions: immune response and tissue integrity including regeneration. Genes such as SIGLEC5, DEFA1, FCERG1, PPBP/CXCL5/PF4, CDKN2B-AS1, and CTSC have a known function in neutrophil activity, antimicrobial defense, and mediation of the immune response. In particular, SIGLEC5, PLG, RSPO4, ROBO2, HMCN2, and CTSC appear to contribute to wound healing, extracellular matrix remodeling, and hemostasis. In particular, SIGLEC5, PLG, and PPBP/PF4 interact at the interface of immune function and tissue repair. In conclusion, risk genes for periodontitis point to the importance of the interplay between immune response and tissue homeostasis in the etiology of periodontitis. Future large-scale genome-wide association studies, whole-exome sequencing, and functional studies will likely uncover additional risk genes and refine our understanding of genetic contributions to periodontitis and help to develop potential therapeutic targets.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications.","authors":"Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber","doi":"10.1111/jre.70007","DOIUrl":"https://doi.org/10.1111/jre.70007","url":null,"abstract":"<p><p>Although tissue engineering and cell therapy have been widely investigated as promising regenerative modalities, their clinical translation has partly been limited by a lack of standardization, high costs, and regulatory barriers. Recently, cell-free therapies (CFT) in the form of cell secretomes [conditioned media (CM)] and extracellular vesicles (EVs) have emerged as viable alternatives to cell therapies. However, much of the evidence is based on preclinical studies. This scoping review aimed to summarize the current evidence for using human-derived CFT, with a focus on EVs, for craniofacial regeneration. Based on predefined inclusion criteria and a systematic search covering three electronic databases (MEDLINE, EMBASE, Web of Science), 122 animal studies (n = 27 CM, n = 95 EVs), and 4 clinical studies (n = 2 CM, n = 2 EVs), mostly reporting on bone and periodontal regeneration, were included. The use of oral-derived CFT, particularly from the periodontal ligament, dental pulp, and gingiva, was frequently reported. A wide range of pre-conditioning strategies, dosages, and delivery methods were tested. The preclinical data revealed a clear adjunctive benefit of CFT with biomaterial scaffolds versus scaffolds alone for bone and periodontal regeneration. Limited clinical data based on small patient groups confirmed the safety and feasibility of CFT, although robust evidence for efficacy is lacking. Finally, several issues related to the clinical translation of CFT have been highlighted for future consideration.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}