Journal of periodontal research最新文献

{"title":"Three-Dimensional Scaffolds for Bone, Soft Tissue, and Periodontal Regeneration.","authors":"Reuben Staples, Jamil Alayan, Raghavendra Vamsi Anegundi, Marisca Pereira, Saraswat Basu, Sašo Ivanovski","doi":"10.1111/jre.70176","DOIUrl":"10.1111/jre.70176","url":null,"abstract":"<p><p>The oral cavity presents three distinct regenerative challenges: restoration of alveolar bone volume and stability, augmentation of soft mucogingival tissues, and regeneration of the tooth-supporting periodontium. In each of these clinical contexts, conventional approaches remain limited by the morbidity associated with autologous tissue harvesting and by the difficulty in predictably reconstructing the complex architecture and functional integration required for the long-term stability of these distinct tissues. Although currently available biomaterials have demonstrated clinical effectiveness, many provide limited spatial control and tissue-specific functionality, which may constrain their capacity to support coordinated regeneration of complex oral tissues. Recent advances in manufacturing technologies have enabled the development of highly precise three-dimensional scaffold systems with tailored porosity, chemistry, architecture, and degradation profiles. This review examines recent progress in three-dimensional scaffold technologies for bone, soft tissue, and periodontal regeneration. Conventional and emerging engineered scaffold systems are critically appraised to illustrate how advances in material science, scaffold architecture, fabrication technologies, and biological functionalisation are shaping contemporary regenerative strategies. Despite these advances, important challenges remain before scaffold-based therapies can consistently achieve predictable clinical outcomes across all indications. Future research should focus on optimising scaffold design, strengthening biological performance, and generating robust clinical evidence to support routine clinical implementation and improve long-term outcomes.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontitis and Neuropsychiatric Disorders: Epidemiological and Mechanistic Evidence.","authors":"Julia Ríos-Barbero, María Martínez, Nagore Ambrosio, Borja García-Bueno, David Fraguas, Juan Carlos Leza, Mariano Sanz, Elena Figuero","doi":"10.1111/jre.70172","DOIUrl":"https://doi.org/10.1111/jre.70172","url":null,"abstract":"<p><p>This review aims to critically analyze the epidemiological evidence and mechanistic insights linking periodontitis with the onset, progression, or severity of neuropsychiatric disorders. From an epidemiological perspective, eligible evidence was identified regarding disorders related to trauma, stress, anxiety, depressive, and bipolar disorders, whereas no studies meeting the predefined inclusion criteria were found for the remaining considered disorders. The strongest epidemiological evidence was observed for depressive disorders and anxiety- and stress-related conditions. However, the predominance of cross-sectional studies, together with substantial methodological heterogeneity, limits conclusions regarding temporality and causality. From a mechanistic perspective, the available evidence regarding the association between periodontitis and neuropsychiatric disorders predominantly supports as mechanisms (1) microbial pathways (microbial translocation and functional dysregulation of the oral microbiome), (2) inflammatory and immune pathways (systemic (meta)inflammation and trafficking of immune players systemic), and (3) shared underlying vulnerabilities (behavioral factors, medication-related effects, lifestyle and systemic health factors, and genetic mechanisms). Periodontitis may promote a persistent low-grade systemic inflammatory state through the release of bacterial products and inflammatory mediators into the circulation, thereby influencing immune, neuroendocrine, and vascular pathways relevant to neuropsychiatric vulnerability. Moreover, the hematogenous dissemination or swallowing of periodontal bacteria and their virulence factors may contribute to microbial remodeling at distant sites, including the gut, supporting the concept of an oral-gut-brain axis. Overall, the evidence analyzed supports periodontitis as a potential modifiable contributor within a broader biopsychosocial network linking oral and mental health, while highlighting the need for longitudinal studies and interventional trials to clarify causality and clinical relevance.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontitis, Psoriasis and Other Skin Disorders: Epidemiological and Mechanistic Evidence.","authors":"Crystal Marruganti, Francesco D'Aiuto","doi":"10.1111/jre.70175","DOIUrl":"https://doi.org/10.1111/jre.70175","url":null,"abstract":"<p><p>Periodontitis is a highly prevalent chronic inflammatory disease characterized by a dysbiotic biofilm-induced host immune dysregulation and sustained low-grade systemic inflammation. Psoriasis and other inflammatory skin disorders, including atopic dermatitis and alopecia, are immune-mediated conditions driven by complex interactions between genetic susceptibility, environmental triggers, microbial factors, and cytokine network activation. Mounting epidemiological and experimental evidence suggests a consistent association between periodontitis and psoriasis, with emerging links to other skin disorders. This narrative review critically appraised the current available evidence regarding the epidemiological association between periodontitis and inflammatory skin disorders, explored the shared pathogenic mechanisms underpinning a potential oral-skin axis, and evaluated the impact of periodontal therapy on dermatological outcomes. Epidemiological and meta-analytical data suggest a positive association between periodontitis and psoriasis across diverse populations, although direct causality remains unclear. Mechanistically, overlapping pathways include systemic dissemination of pro-inflammatory cytokines (e.g., IL-6, TNF-α, IL-17), Th17-driven immune responses, neutrophil priming and NETosis, microbial translocation, and shared lifestyle-related determinants within the multimorbidity framework. Preclinical and clinical randomized controlled trials suggest that non-surgical periodontal therapy may reduce psoriasis severity and extent over the short term (8-10 weeks), potentially acting as a relevant adjunct to dermatologic medications. While heterogeneity and residual confounding limit definitive conclusions, the convergence of epidemiological, mechanistic, and interventional evidence supports the plausibility of a bidirectional interaction between periodontal and skin inflammation and the potential existence of an oral-skin axis. Interdisciplinary clinical strategies integrating periodontal and dermatologic care should be implemented for the early diagnosis and management of both periodontal and skin diseases and conditions.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological Targets for Periodontitis: A Systematic Review of Drug-Target Mendelian Randomisation Studies.","authors":"Luigi Nibali, Jing Kang, Simon Haworth, Alessandro Polizzi, Gaetano Isola","doi":"10.1111/jre.70168","DOIUrl":"https://doi.org/10.1111/jre.70168","url":null,"abstract":"<p><strong>Aim: </strong>Drug-target Mendelian randomisation (MR) studies investigate whether genetically proxied modulation of druggable proteins affects the risk of periodontitis, thereby identifying potential pharmacological targets.</p><p><strong>Methods: </strong>A systematic review was conducted following PRISMA 2020 guidelines. Three electronic databases (MEDLINE/Pubmed, Scopus, Web of Science) were searched. Eligible studies applied MR to evaluate causal relationships between druggable targets and periodontitis. Data on study design, population, exposure, and outcomes were extracted; risk of bias was assessed qualitatively. Supplementary searches of Google Scholar, reference lists, and medRxiv were also undertaken.</p><p><strong>Results: </strong>Fifteen MR studies published between 2023 and 2026 were included. Underlying data on periodontal outcomes were derived from a limited number of studies. Identified targets spanned inflammatory cytokines (e.g., IL6R), complement components (C3 and C5), immune regulators (CXCL10 and CXCR4), calcium-binding proteins (S100A8/A9/A12), and proteins involved in angiogenesis, apoptosis, cell-cycle regulation, and extracellular-matrix remodelling, including VEGFA, CASP3, CCND1, and MMP25. Several studies integrated multi-omics, colocalization, and single-cell approaches. However, the therapeutic relevance of these targets remains to be established through independent replication and experimental or clinical validation.</p><p><strong>Conclusion: </strong>Drug-target MR provides a platform for investigating host molecular traits linked to periodontal disease and highlights multiple targets for possible drug repurposing in the future. Methodological and data constraints currently limit the validity of these findings and their potential clinical applications.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saliva Liquid Biopsy for Detection of Oral and Systemic Diseases.","authors":"Irene Choi, Aaron Zander, Bradley Chan, Leila Syedmoradi, Dev Trivedi, Karolina Elżbieta Kaczor-Urbanowicz, Fang Wei, Neeti Swarup, Trinity Chan, Mario Romandini, David T W Wong","doi":"10.1111/jre.70152","DOIUrl":"https://doi.org/10.1111/jre.70152","url":null,"abstract":"<p><p>Saliva has emerged as a compelling liquid biopsy for the non-invasive diagnosis and monitoring of both oral and systemic diseases. Secreted by major and minor salivary glands and enriched by gingival crevicular fluid, epithelial turnover, immune mediators, microbial products, and plasma-derived constituents, saliva reflects a biologically integrated interface between local oral environments and systemic physiology. This dual origin enables detection of disease-associated signals across multiple molecular layers, including extracellular RNA, cell-free DNA, genomic and epigenetic material, proteins, metabolites, microbial signatures, and hormones. Advances in high-throughput sequencing, mass spectrometry, and ultrasensitive immunoassays have revealed that salivary analytes can capture dynamic pathological processes ranging from periodontal inflammation and dental caries to oral and head and neck cancers, as well as systemic conditions such as non-oral cancers and autoimmune, cardiometabolic, infectious, endocrine, and neurodegenerative diseases. In particular, extracellular vesicle-encapsulated RNA, cfDNA fragmentomics, and methylation patterns have expanded the diagnostic reach of saliva beyond conventional protein-based biomarkers, while integrated multi-omics approaches increasingly improve diagnostic performance. Despite this progress, clinical translation remains constrained by biological complexity, including variable glandular contributions, oral microbiome interactions, and pre-analytical variability in collection and processing. Emerging point-of-care technologies, microfluidic platforms, and artificial intelligence-driven multi-omic integration are beginning to address these limitations, enabling higher analytical sensitivity and improved disease stratification. Regulatory pathways, including in vitro diagnostic frameworks and laboratory-developed test structures, are progressively accommodating salivary assays, as demonstrated during the COVID-19 pandemic. However, widespread clinical adoption will require rigorous standardization, large-scale validation, and demonstration of clinical utility. Together, saliva-based liquid biopsy represents a rapidly evolving diagnostic paradigm with the potential to shift disease detection towards earlier, minimally invasive, and data-rich precision medicine approaches across dentistry and systemic healthcare.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of AI Chatbots in Providing EFP S3-Level Guideline-Based Information for Stage IV Periodontitis.","authors":"Alessandro Polizzi, Luigi Nibali, Pasquale Santamaria, Pietro Venezia, Gianluca Tartaglia, Gaetano Isola","doi":"10.1111/jre.70166","DOIUrl":"https://doi.org/10.1111/jre.70166","url":null,"abstract":"<p><p>Benchmarking AI chatbots using structured questions derived from the EFP S3-level guideline for stage IV periodontitis showed high clarity but variable guideline alignment and source reporting. Apparent chatbot rankings were attenuated after excluding Sources, and chatbot identity was not associated with total QAMAI score after adjustment. Rankings may therefore be influenced by retrieval and source-reporting features rather than reflecting intrinsic model capability. All outputs require clinician verification.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tunnel Technique With Connective Tissue Graft Versus Free Gingival Graft for Multiple Gingival Recessions in the Anterior Mandible: A Randomized Clinical Trial.","authors":"Marcela Iunes da Silveira, Jovânia Alves Oliveira, Roberta de Oliveira Alves, Gabriel Marques Araújo, Guilherme José Pimentel Lopes de Oliveira, Suzane Cristina Pigossi","doi":"10.1111/jre.70170","DOIUrl":"https://doi.org/10.1111/jre.70170","url":null,"abstract":"<p><p>Both techniques were effective in treating multiple mandibular gingival recessions, resulting in a significant reduction in recession depth after 12 months. Free gingival graft showed a more predictable approach for keratinized tissue gain. In contrast, the tunnel technique was superior in healing outcomes.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Oral-Hepatic Axis: Epidemiological and Mechanistic Links Between Periodontal and Liver Diseases.","authors":"Sinem Esra Sahingur, Kinga Grzech-Leśniak, Samuel F Suslavich, Janina Golob Deeb","doi":"10.1111/jre.70159","DOIUrl":"https://doi.org/10.1111/jre.70159","url":null,"abstract":"<p><p>Chronic liver diseases and periodontitis are prevalent inflammatory disorders that impose substantial global health and economic burdens. Increasing evidence supports an oral-hepatic axis through which periodontal dysbiosis and chronic oral inflammation may influence hepatic homeostasis and disease progression. Epidemiologic studies have linked periodontitis with metabolic dysfunction-associated steatotic liver disease (MASLD), nonalcoholic fatty liver disease (NAFLD), viral hepatitis, cirrhosis, and hepatocellular carcinoma. Although many associations persist after adjustment for shared risk factors, including obesity, diabetes, smoking, nutritional status, and socioeconomic factors, the independent contribution of periodontitis to liver disease remains unclear. Experimental and translational studies indicate that periodontal pathogens and their virulence factors promote systemic inflammation, endotoxemia, microbial translocation, immune dysregulation, and alterations in gut microbial ecology. Nutritional factors may further influence these interactions through their effects on host immunity, inflammation, and microbial communities. Together, these mechanisms converge along the oral-gut-liver axis to activate hepatic inflammatory, oxidative stress and profibrotic pathways that contribute to steatosis, immune activation, and fibrogenesis. Emerging evidence suggests that trained immunity, driven by metabolic and epigenetic reprogramming, may represent an additional mechanism linking periodontitis and liver disease warranting future studies. Preliminary studies indicate that periodontal therapy may reduce systemic inflammatory burden and improve hepatic biomarkers; however, evidence for an effect on liver disease progression or clinical outcomes remains limited. Similarly, hepatic dysfunction may exacerbate immune dysregulation and periodontal breakdown, reinforcing an inflammatory loop. However, overall causal relationships remain to be established. This review summarizes current epidemiological, clinical, and mechanistic evidence linking periodontitis and chronic liver diseases, highlighting the oral-gut-liver axis, shared immunometabolic and nutritional pathways. Understanding these interactions shows the significance of integrated dental-medical care and opens new avenues for prevention and adjunctive therapy to sustain oral and hepatic health.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Dual Face of Fusobacterium nucleatum in Cancer: Foe, Friend or Both?","authors":"Anjali Chander, Huile Lim, Gilad Bachrach, Miguel Reis Ferreira","doi":"10.1111/jre.70165","DOIUrl":"https://doi.org/10.1111/jre.70165","url":null,"abstract":"<p><p>Fusobacterium is a genus of anaerobic Gram-negative bacteria that has been increasingly implicated in a range of diseases, including periodontitis and cancer. This review critically evaluates the reported role of Fusobacterium nucleatum in cancer, highlighting new findings that suggest a more nuanced cross-talk with the disease. We contextualise current evidence on the interactions with the wider tumour micro-environment, including the roles of polymicrobial communities, microbial metabolites and taxonomic heterogeneity. Collectively, the evidence suggests that Fusobacterium nucleatum should not be regarded as universally pathogenic or oncogenic. Rather, its behaviour is likely context-dependent and shaped by its surrounding microenvironment. Notably, opposing pro- and anti-tumoural mechanisms can coexist within the same cancer type. For example, in colorectal cancer, F. nucleatum is predominantly associated with poorer outcomes by promoting immune evasion (e.g., suppression of cytotoxic T cell responses) and oncogenic signalling (e.g., via the E-cadherin/β-catenin pathway), yet it also displays oncosuppressive activity through promotion of neutrophil-mediated anti-tumoural cytotoxicity and butyrate-driven cytotoxic T cell activation and potentiation of immunotherapy. In head and neck cancer, by contrast, F. nucleatum detection is associated with improved survival across independent cohorts, potentially reflecting a different balance of these same competing mechanisms. We suggest implications for its proposed use as a biomarker and as a target in cancer therapy. Lingering questions are also laid out to help investigators shape future research to better capture the complexity of the TME and elucidate the overall impact of Fusobacterium nucleatum in cancer.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148759720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macrophage Phenotype Alterations in Treated Periodontitis Patients Suggest a Pro-Inflammatory Bias","authors":"Mariane Cristina Sloniak,&nbsp;Josiane Betim de Assis,&nbsp;Luciana Saraiva,&nbsp;Cláudio Mendes Pannuti,&nbsp;Ana Paula Lepique,&nbsp;Cristina Cunha Villar","doi":"10.1111/jre.70098","DOIUrl":"10.1111/jre.70098","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Understanding macrophage polarization in periodontitis is critical for elucidating the underlying disease mechanisms. This exploratory study aimed to characterize phenotypic features of monocyte-derived macrophages (MDMs) from treated periodontitis patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Peripheral blood mononuclear cells were isolated from 30 individuals classified into three groups: periodontal healthy (H) and patients with treated stage III, grade B (PIII-B) or grade C (PIII-C) periodontitis. Monocytes were differentiated into macrophages and cultured under non-polarizing (M0), M1-polarizing (LPS + IFN-γ), or M2-polarizing (IL-4 + IL-13) conditions. MDM polarization was evaluated by immunophenotyping and cytokine secretion profiling.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Under M0 conditions, the percentage of M1 MDMs decreased in the H group but remained stable in both periodontitis groups, particularly in PIII-C, which exhibited a higher M1/M2 ratio. Following M1 stimulation, no significant differences in M1/M2 ratios were observed among groups. However, H MDMs increased VEGF and IL-10 secretion compared with those from PIII-B. Under M2 stimulation, PIII-C MDMs exhibited a higher proportion of M1 cells and increased IL-6 secretion, while PIII-B MDMs demonstrated an elevated M1/M2 ratio and lower IL-10 response, suggesting a shift toward a more pro-inflammatory profile.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In this exploratory study, MDMs from individuals with successfully treated stage III, grade B or C periodontitis exhibited a tendency toward a M1-like phenotype across different polarization conditions, indicating the possible persistence of a pro-inflammatory immune trait that requires confirmation in longitudinal and mechanistic studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":"61 6","pages":"705-715"},"PeriodicalIF":5.4,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jre.70098","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147433545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}