Anna Ayu Herawati, Prof Dr Syamsu Yusuf, Ilfiandra, Dr Andi Wahyu Irawan, Ahmad Syafya Habibi
{"title":"Enhancing Athlete Well-being with RED-S: The Potential Role of Virtual Reality for Stress Management.","authors":"Anna Ayu Herawati, Prof Dr Syamsu Yusuf, Ilfiandra, Dr Andi Wahyu Irawan, Ahmad Syafya Habibi","doi":"10.1016/j.jpag.2025.09.006","DOIUrl":"https://doi.org/10.1016/j.jpag.2025.09.006","url":null,"abstract":"","PeriodicalId":16708,"journal":{"name":"Journal of pediatric and adolescent gynecology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dr Om Kumari, Dr Neetu Sharma, Dr Megha Jindal, Dr Kanak Dubey, Dr Latika Chawla
{"title":"\"Bridging the gap between hypothyroidism and precocious puberty: A case report of Von Wyk Grumbach Syndrome\".","authors":"Dr Om Kumari, Dr Neetu Sharma, Dr Megha Jindal, Dr Kanak Dubey, Dr Latika Chawla","doi":"10.1016/j.jpag.2025.09.005","DOIUrl":"https://doi.org/10.1016/j.jpag.2025.09.005","url":null,"abstract":"<p><strong>Introduction: </strong>Von Wyk Grumbach syndrome (VWGS) is a rare clinical entity that presents with the triad of precocious puberty, polycystic ovaries, and severe hypothyroidism. VWGS is an uncommon cause of precocious puberty characterized by dissociation of gonadarche and adrenarche. Unlike other aetiologies of precocious puberty, VWGS is associated with absent growth acceleration and delayed bone maturation due to prolonged, untreated hypothyroidism. The diagnosis is often delayed or overlooked, as the overt or unusual pubertal manifestations may overshadow the subtle signs of hypothyroidism. Failure to identify hypothyroidism as cause of ovarian cyst and precocious puberty may lead to catastrophic ovarian resection and oophorectomy in prepubertal girls and adolescents.</p><p><strong>Case presentation: </strong>We present a case of VWGS in a 07 years old girl presenting with painful abdomen with precocious puberty and menarche .Relevant review of the literature on this uncommon clinical entity is also presented.</p><p><strong>Conclusion: </strong>This study underscores the importance of recognizing the atypical presentation of prolonged hypothyroidism with precocious puberty in young children. It emphasizes the need for clinicians to consider the rare entity of VWGS, which could help prevent delays in appropriate management.</p>","PeriodicalId":16708,"journal":{"name":"Journal of pediatric and adolescent gynecology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicole R Ferrigno-Layton, Carly E Milliren, Sarah Pitts, Amy D DiVasta, Michelle Escovedo, Sarah A Golub, Susan M Coupey, Sofya Maslyanskaya
{"title":"Comparison of Long-Acting Reversible Contraceptive (LARC) Choices by Multiethnic U.S. Adolescents and Young Adults with and without Eating Disorders: A Multicenter Cohort Study.","authors":"Nicole R Ferrigno-Layton, Carly E Milliren, Sarah Pitts, Amy D DiVasta, Michelle Escovedo, Sarah A Golub, Susan M Coupey, Sofya Maslyanskaya","doi":"10.1016/j.jpag.2025.09.003","DOIUrl":"https://doi.org/10.1016/j.jpag.2025.09.003","url":null,"abstract":"<p><strong>Study objective: </strong>Body image concerns may influence contraceptive choices of adolescents and young adults (AYAs) with eating disorders (EDOs). We aimed to compare long-acting reversible contraceptive (LARC) choices and continuation rates for AYAs with and without EDOs.</p><p><strong>Methods: </strong>We used data on LARC insertions from 2017-2021 from four US adolescent medicine practices measuring demographics, menstrual history, reason for LARC device, follow-up and continuation. Additional record search identified participants with EDOs. We examined associations of EDOs and choice of device using adjusted logistic regression and one-year discontinuation using Cox proportional hazards survival analysis.</p><p><strong>Results: </strong>The cohort included 2,346 AYAs; 80 (3%) with EDO; 32% White; 29% Hispanic, 15% Black. Mean age at LARC insertion 18.7±2.4 years (range 12-25). Participants with EDO vs. without had higher odds of choosing intrauterine devices (IUD) over implants (OR=2.18; 95% CI:1.31, 3.61; p=0.003). One-year LARC continuation rates were 77% overall and similar for those with and without EDOs. AYAs with EDOs vs. without had similar likelihood of LARC device removal within one-year. Participants identifying as Black non-Hispanic (OR=0.34;95% CI;0.26, 0.45, p<0.001) and Hispanic (OR=0.34;95% CI;0.26, 0.45, p<0.001) vs White non-Hispanic had lower odds of choosing IUDs over implants. Black non-Hispanic AYAs had higher likelihood than White non-Hispanics for LARC removal within one-year (HR=1.58; 95% CI: 1.11, 2.25; p=0.01).</p><p><strong>Conclusions: </strong>AYAs with EDOs compared to those without EDOs are more likely to choose IUDs over implants and they have similar high one-year LARC continuation rates . AYAs of non-White race/ethnicities independent of EDO diagnosis are less likely to choose IUDs.</p>","PeriodicalId":16708,"journal":{"name":"Journal of pediatric and adolescent gynecology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah H O'Brien, Joseph R Stanek, Adebimpe Adelaja, Andrea E Bonny, Emre Sezgin, Jennifer Chisholm, Natasha S Bala, Sara K Vesely
{"title":"Sustained Engagement and Usability of a Mobile App to Study Menstrual Cycles in Young Adolescents.","authors":"Sarah H O'Brien, Joseph R Stanek, Adebimpe Adelaja, Andrea E Bonny, Emre Sezgin, Jennifer Chisholm, Natasha S Bala, Sara K Vesely","doi":"10.1016/j.jpag.2025.09.004","DOIUrl":"https://doi.org/10.1016/j.jpag.2025.09.004","url":null,"abstract":"<p><strong>Study objective: </strong>To test patient engagement and satisfaction with mobile app menstrual monitoring in young adolescents. We hypothesized at least two-thirds of study participants would demonstrate sustained engagement with menstrual tracking over six months.</p><p><strong>Methods: </strong>The study cohort included menstruating adolescents 10-14 years of age with regular access to a smartphone or tablet. Our study design allowed for a completely remote participant experience, and participants were primarily recruited through electronic platforms. Participants used our HIPAA-compliant Teen-Period (T-Dot) mobile app to track menstrual bleeding and related symptoms over a 6-month timeframe.</p><p><strong>Results: </strong>156 participants were included in data analysis (median age 13 years, IQR 12-14). One hundred participants (64.1%) met the primary outcome of engagement with T-Dot, meaning they entered data for ≥3 menses. Usability of T-Dot was positively rated by study participants, with the majority agreeing or strongly agreeing that T-Dot was easy to use (n=108, 74.5%) and helped to track menses effectively (n=104, 77.2%). Usability scores did not decrease from Week 6 to Month 6, nor did frequency of T-Dot use. Participant engagement did not differ significantly by age, race, body weight, or presence of heavy menstrual bleeding.</p><p><strong>Conclusion: </strong>In this preliminary study of a teen-focused HIPAA-compliant menstrual tracking app, we achieved our enrollment goals and successfully implemented a decentralized prospective cohort study. Our findings demonstrate that menstrual tracking research is possible even in early adolescents.</p>","PeriodicalId":16708,"journal":{"name":"Journal of pediatric and adolescent gynecology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Who You Gonna Trust? Your Doctor or Social Media?","authors":"","doi":"10.1016/j.jpag.2025.09.001","DOIUrl":"10.1016/j.jpag.2025.09.001","url":null,"abstract":"","PeriodicalId":16708,"journal":{"name":"Journal of pediatric and adolescent gynecology","volume":"38 5","pages":"Pages 539-540"},"PeriodicalIF":1.8,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145048182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dr Yuwei Ma, Dr Nan Xiao, Dr Zhewei Fei, Dr Wenjuan Qiu, Dr Yunshu Lu
{"title":"Juvenile gigantomastia with pseudo angiomatous stromal hyperplasia in a 12-year-old female: a case report.","authors":"Dr Yuwei Ma, Dr Nan Xiao, Dr Zhewei Fei, Dr Wenjuan Qiu, Dr Yunshu Lu","doi":"10.1016/j.jpag.2025.08.006","DOIUrl":"https://doi.org/10.1016/j.jpag.2025.08.006","url":null,"abstract":"<p><p>Juvenile gigantomastia is a rare condition showing progressive breast enlargement during puberty. Here, we report a rare case of a 12-year-old female patient who developed rapid bilateral breast hypertrophy following menarche. The patient has complex family history of consanguineous marriage and individual history of suspected Madelung's disease during her infancy. After examinations and muti-department consultation, we did bilateral mastectomy to address the severe breast enlargement, and planned to perform breast reconstruction surgery after complete sexual maturity. The histopathological investigations revealed the presence of pseudo angiomatous stromal hyperplasia (PASH). Genetic analysis was conducted to explore potential hereditary contributions to the condition. During six months of follow-up period, no new breast lumps or enlargement occurred, and the patient had no postoperative complications such as infection and hematoma.</p>","PeriodicalId":16708,"journal":{"name":"Journal of pediatric and adolescent gynecology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dubravka Živanović, Vesna Kesić, Marija Malinić, Jelena Vuković, Martina Bosić, Vesna Reljić
{"title":"Extensive Vulvar Involvement as the Initial Presentation of Granulomatosis with Polyangiitis in a Young Woman.","authors":"Dubravka Živanović, Vesna Kesić, Marija Malinić, Jelena Vuković, Martina Bosić, Vesna Reljić","doi":"10.1016/j.jpag.2025.08.005","DOIUrl":"https://doi.org/10.1016/j.jpag.2025.08.005","url":null,"abstract":"<p><strong>Introduction: </strong>Granulomatosis with polyangiitis (GPA) is a rare systemic vasculitis, rarely affecting the genitourinary tract. Vulvar involvement is extremely uncommon and often misdiagnosed.</p><p><strong>Case presentation: </strong>A 21-year-old female patient presented with a one-month history of necrotic vulvar lesions and skin ulcerations. Markedly elevated PR3-ANCA and histopathological findings supported the diagnosis of GPA. Imaging methods revealed multiple spleen infarctions and pseudo-masses in the kidneys; endocranial MRI showed pansinusitis and otomastoiditis. Initial treatment with systemic corticosteroids and methotrexate was insufficient; however, rituximab achieved significant improvement, resulting in complete healing of both vulvar and skin lesions.</p><p><strong>Conclusion: </strong>Vulvar GPA, though rare, may be the initial sign of systemic vasculitis. Multidisciplinary evaluation is important for early diagnosis and effective immunosuppressive therapy.</p>","PeriodicalId":16708,"journal":{"name":"Journal of pediatric and adolescent gynecology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Liz Abernathey, Morgan E Ryan, Carly E Milliren, Kym Ahrens, Amy D DiVasta, Sarah Pitts, Michelle Escovedo, Sofya Maslyanskayaz, Sarah A Golub
{"title":"Non-Sedated Intrauterine Device Experiences Among Transgender and Cisgender Adolescents and Young Adults in the Outpatient Setting.","authors":"Liz Abernathey, Morgan E Ryan, Carly E Milliren, Kym Ahrens, Amy D DiVasta, Sarah Pitts, Michelle Escovedo, Sofya Maslyanskayaz, Sarah A Golub","doi":"10.1016/j.jpag.2025.08.007","DOIUrl":"https://doi.org/10.1016/j.jpag.2025.08.007","url":null,"abstract":"<p><strong>Study objectives: </strong>This study compares the demographic characteristics and experiences of three different groups of adolescent and young adults (AYAs) seeking non-sedated intrauterine device (IUD) insertion in the outpatient setting: (1) cisgender individuals, (2) transgender and gender diverse (TGD) individuals receiving gender-affirming testosterone therapy, and (3) TGD individuals not receiving gender-affirming testosterone therapy.</p><p><strong>Methods: </strong>This retrospective cohort study included AYAs age 13 to 21 years seeking IUD insertion. Data were obtained from the electronic health record via a pre-existing, multi-institutional shared quality improvement (QI) collaborative. The patient population was characterized by descriptive statistics; inferential statistics compared procedural complications, outcomes and patient-reported side effects. Unadjusted Kaplan-Meier and Cox proportional-hazard modeling assessed continuation rates.</p><p><strong>Results: </strong>Of the 683 participants attempting IUD insertion, 623 were cisgender individuals, 18 were TGD individuals on gender-affirming testosterone, and 54 were TGD individuals not on testosterone. There was no difference in insertion indication (p=0.25). TGD patients on testosterone were more likely to have experienced a procedural adverse event (17%; p=0.04), and to have reported pain beyond expectation (p=0.003), although insertional success did not differ significantly between groups (p=0.22).</p><p><strong>Conclusion: </strong>TGD AYAs had similar reasons as cisgender patients for seeking the IUD. While TGD individuals on testosterone were more likely to have pain or an adverse procedural event, insertional success did not differ. One-year IUD continuation rates were similarly high in all groups.</p>","PeriodicalId":16708,"journal":{"name":"Journal of pediatric and adolescent gynecology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Utilizing Pharmacists as Partners to Expand Access to Adolescent Reproductive Care.","authors":"Kelsey K Schmuhl","doi":"10.1016/j.jpag.2025.08.003","DOIUrl":"https://doi.org/10.1016/j.jpag.2025.08.003","url":null,"abstract":"","PeriodicalId":16708,"journal":{"name":"Journal of pediatric and adolescent gynecology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jacquelyn R Evans, Jennifer M Ladd, Miriam R Conces, Scott E Hickey, Daniel C Koboldt, Y Frances Fei
{"title":"Virilization and hyperandrogenism in Turner syndrome without Y mosaicism: a case report and review of the literature.","authors":"Jacquelyn R Evans, Jennifer M Ladd, Miriam R Conces, Scott E Hickey, Daniel C Koboldt, Y Frances Fei","doi":"10.1016/j.jpag.2025.08.002","DOIUrl":"https://doi.org/10.1016/j.jpag.2025.08.002","url":null,"abstract":"<p><strong>Background: </strong>Up to 10-12% of individuals with Turner Syndrome (TS) have Y chromosome material (e.g. 45,X/46,XY), which can lead to virilization. We present the case of a patient with TS who developed virilization due to ovarian hilus cell (OHC) hyperplasia.</p><p><strong>Clinical case: </strong>An 11-year-old with TS presented with clitoromegaly, hyperandrogenism, and primary ovarian insufficiency (POI). Thorough work up was unable to identify the source of hyperandrogenism. She underwent laparoscopic bilateral gonadectomy and was diagnosed with OHC hyperplasia on pathologic evaluation. Hyperandrogenism resolved post-operatively.</p><p><strong>Conclusion: </strong>OHC hyperplasia is a rare, but important diagnosis to consider. Laparoscopic bilateral gonadectomy is both diagnostic and therapeutic and should be considered a first-line treatment for patients with POI and virilization in the absence of other diagnosed etiology.</p>","PeriodicalId":16708,"journal":{"name":"Journal of pediatric and adolescent gynecology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}