Journal of pediatric and adolescent gynecology最新文献

{"title":"Exploring the Association Between Sleep Quality and Menstrual Abnormalities in Adolescents","authors":"Jessica N. Zhang BS ,&nbsp;Grace K. Sarris BS ,&nbsp;Daniela G. Fernandez-Bergnes BS ,&nbsp;Tatiana M. Salloum BS ,&nbsp;Katherine M. Hofmann BS ,&nbsp;Edith Duncan BA ,&nbsp;Judith S. Simms-Cendan MD","doi":"10.1016/j.jpag.2025.08.001","DOIUrl":"10.1016/j.jpag.2025.08.001","url":null,"abstract":"<div><h3>Study Objective</h3><div>This study aims to assess the association between sleep quality and menstrual cycle abnormalities in adolescent females in the United States (U.S.). In doing so, we address the gap in adolescent menstrual health by providing baseline data that can inform future sleep and menstrual health interventions.</div></div><div><h3>Methods</h3><div>An Institutional Review Board (IRB) approved, anonymous survey was distributed to new patients at an academic pediatric gynecology clinic. Exclusion criteria included age over 21, hormonal contraceptive use, prior chemotherapy, or reproductive disorders. Electronic consent was obtained. The survey included the Pittsburgh Sleep Quality Index (PSQI), menstrual cycle data, comorbidities, and demographic data. Continuous variables were analyzed using linear regression and categorical variables using chi-square (with <em>P &lt; .</em>05 considered significant). Odds ratios (OR) were reported with 95% confidence intervals (CI).</div></div><div><h3>Results</h3><div>Among the 100 analyzed responses, 84.0% identified as Hispanic, with over one-third (37.0%) being born outside of the U.S. Sixty-three had poor sleep quality (PSQI &gt; 5), and 64 had abnormal menses. Higher PSQI scores were significantly associated with abnormal menses (OR = 1.15, CI = 1.01, 1.32, <em>P = .</em>04). Poor sleep correlated with prior anxiety (χ² = 6.84, <em>P = .</em>01) and depression diagnoses (χ² = 3.89, <em>P = .</em>05).</div></div><div><h3>Conclusion</h3><div>Our findings suggest a significant relationship between poor sleep quality and menstrual abnormalities, emphasizing the need to evaluate sleep when managing adolescent menstrual health. Future research is needed to gain deeper insights into the mechanistic link between the two and the broader implications of this association.</div></div>","PeriodicalId":16708,"journal":{"name":"Journal of pediatric and adolescent gynecology","volume":"38 6","pages":"Pages 681-686"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144847099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing Pharmacists as Partners to Expand Access to Adolescent Reproductive Care","authors":"Kelsey K. Schmuhl PharmD","doi":"10.1016/j.jpag.2025.08.003","DOIUrl":"10.1016/j.jpag.2025.08.003","url":null,"abstract":"","PeriodicalId":16708,"journal":{"name":"Journal of pediatric and adolescent gynecology","volume":"38 6","pages":"Pages 647-648"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Hormone Replacement Therapy and Bleeding Patterns among Adolescents and Young Adult Females with Prader–Willi Syndrome","authors":"Julie C. Friedman MD ,&nbsp;Kendra Hutchens PhD ,&nbsp;Hava Starkman MD ,&nbsp;Laurel E. Beaty MS ,&nbsp;Mary D. Sammel ScD ,&nbsp;Erin Finn MD ,&nbsp;Leslie C. Appiah MD ,&nbsp;Veronica I. Alaniz MD ,&nbsp;Christine L. Chan MD","doi":"10.1016/j.jpag.2025.07.011","DOIUrl":"10.1016/j.jpag.2025.07.011","url":null,"abstract":"<div><h3>Introduction</h3><div>Prader–Willi syndrome (PWS) is associated with hypogonadism. Limited data exist on guidelines for sex hormone replacement therapy (HRT) in females with PWS. We aimed to characterize pubertal timing, vaginal bleeding patterns, and HRT practices in adolescent and young adult females with PWS.</div></div><div><h3>Methods</h3><div>We conducted a retrospective review of females ages 5-25 years, diagnosed with PWS, at a single institution (01/2013-09/2023). Demographic and clinical data were abstracted from electronic medical records and analyzed with descriptive statistics. Patients were classified as having complete hypogonadotropic hypogonadism (HH) (luteinizing hormone [LH] &lt;0.3 mIU/mL or lack of thelarche by 13 years) or partial hypogonadism (PH) (LH &gt;0.3 mIU/mL and estradiol &lt;20 pg/mL or amenorrhea by 15 years).</div></div><div><h3>Results</h3><div>Fifty-one patients met inclusion criteria; 21 (41%) were diagnosed with hypogonadism and were included in the final analysis. Of these patients, 8 (38.1%) had HH and 13 (61.9%) PH. Delayed puberty was diagnosed at a median of 13.5 years (range: 10-15) in the HH cohort and at 14.5 years (range: 13-18) in the PH cohort. Six patients (28.6%) reported spontaneous vaginal bleeding, median age of 14.0 (range: 10-16) years. Eighteen patients (85.7%) were prescribed HRT at a median of 14.0 (range: 12-21) years, of which 8 (44.4%) discontinued HRT, with half reporting breakthrough bleeding.</div></div><div><h3>Discussion</h3><div>Hypogonadism is common among adolescent and young adult females with PWS. We found high rates of HRT discontinuation primarily due to breakthrough bleeding. These findings highlight the need to tailor HRT regimens and identify strategies to encourage HRT adherence to optimize long-term outcomes.</div></div>","PeriodicalId":16708,"journal":{"name":"Journal of pediatric and adolescent gynecology","volume":"38 6","pages":"Pages 724-730"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and Prevalence of Polycystic Ovary Syndrome in Adolescent and Young Adult US Military Dependents From 2018 to 2022","authors":"Megan N. Parker PhD ,&nbsp;Shelby P. Wiggins MD ,&nbsp;Jennifer A. Thornton PhD ,&nbsp;Kevin W. Sunderland PhD ,&nbsp;Rick Brydum ,&nbsp;Wendy Funk MS ,&nbsp;Veronika Pav MS ,&nbsp;David A. Klein MD, MPH","doi":"10.1016/j.jpag.2025.06.008","DOIUrl":"10.1016/j.jpag.2025.06.008","url":null,"abstract":"<div><h3>Study Objective</h3><div>Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among people who menstruate. Adolescent and young adult (AYA) military dependents, a large, diverse subset of the United States population, have not been represented in prior reports of PCOS. This study estimated the incidence and prevalence of possible-PCOS (PCOS symptoms in the absence of a documented PCOS diagnosis) and PCOS in AYA military dependents, and described the length of time between possible-PCOS and first documented PCOS diagnosis for people who met both during the surveillance period.</div></div><div><h3>Methods</h3><div>This retrospective cohort study reviewed military electronic medical records and TRICARE insurance claims from the US Military Health System from 2018 to 2022. We identified female dependents aged 15-21 years with PCOS (International Classification of Diseases, 10^th edition (ICD-10); code E28.2x) or possible-PCOS (i.e., having both androgen excess and a amenorrhea or oligomenorrhea ICD-10 code within a 12-month period) who received care through TRICARE due to insurance sponsor’s military service.</div></div><div><h3>Results</h3><div>A total of 8385 AYA military dependents had PCOS or possible-PCOS. Across the 5-year period, the average yearly incidence was 59/10,000 people (range 54-64). The average yearly prevalence was 182/10,000 people (range 159-195) and was lowest among Black (139/10,000 people) and Asian (132/10,000 people) AYA.</div></div><div><h3>Conclusion</h3><div>Rates of PCOS in AYA military dependents are comparable to rates estimated from medical record data in US civilian populations. Identifying barriers to PCOS detection could facilitate earlier treatment access for military dependents.</div></div>","PeriodicalId":16708,"journal":{"name":"Journal of pediatric and adolescent gynecology","volume":"38 6","pages":"Pages 693-699"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Juvenile gigantomastia with pseudo angiomatous stromal hyperplasia in a 12-year-old female: A case report","authors":"Yuwei Ma MD ,&nbsp;Nan Xiao MD ,&nbsp;Zhewei Fei MD ,&nbsp;Wenjuan Qiu MD ,&nbsp;Yunshu Lu MD","doi":"10.1016/j.jpag.2025.08.006","DOIUrl":"10.1016/j.jpag.2025.08.006","url":null,"abstract":"<div><div>Juvenile gigantomastia is a rare condition showing progressive breast enlargement during puberty. Here, we report a rare case of a 12-year-old female patient who developed rapid bilateral breast hypertrophy following menarche. The patient has complex family history of consanguineous marriage and individual history of suspected Madelung’s disease during her infancy. After examinations and muti-department consultation, we did bilateral mastectomy to address the severe breast enlargement, and planned to perform breast reconstruction surgery after complete sexual maturity. The histopathological investigations revealed the presence of pseudo angiomatous stromal hyperplasia (PASH). Genetic analysis was conducted to explore potential hereditary contributions to the condition. During six months of follow-up period, no new breast lumps or enlargement occurred, and the patient had no postoperative complications such as infection and hematoma.</div></div>","PeriodicalId":16708,"journal":{"name":"Journal of pediatric and adolescent gynecology","volume":"38 6","pages":"Pages 762-765"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustained Engagement and Usability of a Mobile App to Study Menstrual Cycles in Young Adolescents","authors":"Sarah H. O’Brien MD ,&nbsp;Joseph R. Stanek MS ,&nbsp;Adebimpe Adelaja MPH ,&nbsp;Andrea E. Bonny MD ,&nbsp;Emre Sezgin PhD ,&nbsp;Jennifer C. Chisholm MBBS ,&nbsp;Natasha S. Bala MD ,&nbsp;Sara K. Vesely PhD","doi":"10.1016/j.jpag.2025.09.004","DOIUrl":"10.1016/j.jpag.2025.09.004","url":null,"abstract":"<div><h3>Study Objective</h3><div>To test patient engagement and satisfaction with mobile app menstrual monitoring in young adolescents. We hypothesized that at least two-thirds of study participants would demonstrate sustained engagement with menstrual tracking over 6 months.</div></div><div><h3>Methods</h3><div>The study cohort included menstruating adolescents 10-14 years of age with regular access to a smartphone or tablet. Our study design allowed for a completely remote participant experience, and participants were primarily recruited through electronic platforms. Participants used our HIPAA-compliant Teen-Period (T-Dot) mobile app to track menstrual bleeding and related symptoms over a 6-month timeframe.</div></div><div><h3>Results</h3><div>A total of 156 participants were included in the data analysis (median age 13 years, IQR 12-14). One hundred participants (64.1%) met the primary outcome of engagement with T-Dot, meaning they entered data for ≥3 menses. Usability of T-Dot was positively rated by study participants, with the majority agreeing or strongly agreeing that T-Dot was easy to use (n = 108, 74.5%) and helped to track menses effectively (n = 104, 77.2%). Usability scores did not decrease from Week 6 to Month 6, nor did the frequency of T-Dot use. Participant engagement did not differ significantly by age, race, body weight, or presence of heavy menstrual bleeding.</div></div><div><h3>Conclusion</h3><div>In this preliminary study of a teen-focused HIPAA-compliant menstrual tracking app, we achieved our enrollment goals and successfully implemented a decentralized prospective cohort study. Our findings demonstrate that menstrual tracking research is possible even in early adolescents.</div></div>","PeriodicalId":16708,"journal":{"name":"Journal of pediatric and adolescent gynecology","volume":"38 6","pages":"Pages 674-680"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Athlete Well-being with RED-S: The Potential Role of Virtual Reality for Stress Management","authors":"Anna Ayu Herawati MPd ,&nbsp;Syamsu Yusuf LN MPd ,&nbsp;Ilfiandra MPd ,&nbsp;Andi Wahyu Irawan MPd ,&nbsp;Ahmad Syaf Ya Habibi MPd","doi":"10.1016/j.jpag.2025.09.006","DOIUrl":"10.1016/j.jpag.2025.09.006","url":null,"abstract":"","PeriodicalId":16708,"journal":{"name":"Journal of pediatric and adolescent gynecology","volume":"38 6","pages":"Pages 769-770"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FIGIJ Advocacy Statement on Female Genital Mutilation/Cutting FGM/C, Endorsed by NASPAG","authors":"Anastasia Vatopoulou MD, PhD ,&nbsp;Judith Simms-Cendan MD ,&nbsp;Daniela Ivanova Panova MD, PhD ,&nbsp;Clara Di Nunzio MD ,&nbsp;Mariela Orti MD ,&nbsp;Ellen Rome MD, MPH ,&nbsp;Angela Aguilar MD, MSc, MBA ,&nbsp;Michalina Drejza MD, MSc, PhD ,&nbsp;Marisa Labovsky MD ,&nbsp;Yasmin Jayasinghe MBBS, PhD","doi":"10.1016/j.jpag.2025.06.009","DOIUrl":"10.1016/j.jpag.2025.06.009","url":null,"abstract":"<div><div>Female genital mutilation/cutting (FGM/C) is a global problem affecting millions of girls and women. It involves cutting or removing parts of the external genitalia for no medical reason, often without consent, and has no health benefits. It is deeply rooted in tradition and often undertaken by lay practitioners. It is known to have immediate risks (of hemorrhage, infection, death) and long-term sexual, gynecological, obstetric, urological, and mental health sequelae including post-traumatic stress disorder. Health professionals worldwide need to be aware that girls and women from high-prevalence regions, including migrants, might have been subjected to FGM/C. FIGIJ and NASPAG strongly oppose the harmful practice of FGM/C as it is a form of gender-based violence and child abuse. FIGIJ and NASPAG call upon governments to ban the practice, and health professionals to develop culturally sensitive patient-centered clinical practice guidelines, and to respectfully cooperate with community leaders in order to co-design solutions that will eliminate the practice.</div></div>","PeriodicalId":16708,"journal":{"name":"Journal of pediatric and adolescent gynecology","volume":"38 6","pages":"Pages 649-652"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144618678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of COVID-19 Vaccination on Menstrual Cycles of Adolescents and Young Adults: A Systematic Review and Meta-analysis","authors":"B.M. Milne MPH, PhD(c) ,&nbsp;E.M. Mallett BScH ,&nbsp;S.B. Brogly PhD","doi":"10.1016/j.jpag.2025.06.010","DOIUrl":"10.1016/j.jpag.2025.06.010","url":null,"abstract":"<div><h3>Background and Study Objective</h3><div>The binding of the SARS-CoV-2 spike protein from vaccination can affect the menstrual cycle. Most studies have focused on women of reproductive age, with less attention given to adolescent and young women, despite their increased risk of heightened responses to vaccines. Thus, we consolidated evidence on menstrual changes after COVID-19 vaccination for adolescent and young women.</div></div><div><h3>Methods</h3><div>The OVID MEDLINE, EMBASE, and CINAHL databases were searched (January 2020-December 2024) for peer-reviewed studies on COVID-19 vaccination in menstruating people &lt;25 years old. Of 80 articles identified, 15 met the inclusion criteria after review by 2 independent reviewers. We estimated risk ratios (RRs) and mean differences (MDs) when data permitted. We assessed publication bias with funnel plots and evaluated heterogeneity using Cochran’s Q, Galbraith plots, and the <em>I</em>² statistic. Outcomes included any measured or perceived changes in menstrual cycles, bleeding length, and cycle length (ie, length between the first day of bleeding of 2 periods).</div></div><div><h3>Results</h3><div>Among the 15 studies, 24,647 adolescents and young adults aged 12-25 were included. The summary effect measure showed no effect of vaccination on any menstrual change (RR = 1.09; 95% CI, 0.84-1.42) and significant heterogeneity across studies (<em>I</em>² = 69%). There was, however, a greater risk of longer cycle length after vaccination (RR = 1.17; 95% CI, 1.08-1.27) and no heterogeneity between 2 studies (<em>I</em>² = 0%); however, when assessed continuously, there was a nonsignificant increase in cycle length (MD = 0.24 days; 95% CI, –0.34 to 0.82). No studies assessed menses bleeding length in adolescent and young women. Funnel plots suggested no publication bias.</div></div><div><h3>Conclusion</h3><div>Although few studies were included, the available data suggest that there may be an increased risk of a longer menstrual cycle length in adolescents and young women, but no other changes were identified. Further data are needed.</div></div>","PeriodicalId":16708,"journal":{"name":"Journal of pediatric and adolescent gynecology","volume":"38 6","pages":"Pages 653-660"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virilization and Hyperandrogenism in Turner Syndrome without Y Mosaicism: A Case Report and Review of the Literature","authors":"Jacquelyn R. Evans DO ,&nbsp;Jennifer M. Ladd MD, MSc ,&nbsp;Miriam R. Conces MD ,&nbsp;Scott E. Hickey MD ,&nbsp;Daniel C. Koboldt MS ,&nbsp;Yueyang Frances Fei MD","doi":"10.1016/j.jpag.2025.08.002","DOIUrl":"10.1016/j.jpag.2025.08.002","url":null,"abstract":"<div><h3>Background</h3><div>Up to 10%-12% of individuals with Turner syndrome (TS) have Y chromosome material (eg, 45,X/46,XY), which can lead to virilization. We present the case of a patient with TS who developed virilization due to ovarian hilus cell (OHC) hyperplasia.</div></div><div><h3>Clinical Case</h3><div>An 11-year-old with TS presented with clitoromegaly, hyperandrogenism, and primary ovarian insufficiency (POI). Thorough workup was unable to identify the source of hyperandrogenism. She underwent laparoscopic bilateral gonadectomy and was diagnosed with OHC hyperplasia on pathologic evaluation. Hyperandrogenism resolved postoperatively.</div></div><div><h3>Conclusion</h3><div>OHC hyperplasia is a rare but important diagnosis to consider. Laparoscopic bilateral gonadectomy is both diagnostic and therapeutic and should be considered a first-line treatment for patients with POI and virilization in the absence of other diagnosed etiology.</div></div>","PeriodicalId":16708,"journal":{"name":"Journal of pediatric and adolescent gynecology","volume":"38 6","pages":"Pages 754-758"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}