Has the COVID-19 pandemic affected Vulvovaginitis in Prepuberty and Adolescent Females in China? A retrospective study of 4 644 cases during 2018-2021.

IF 1.7 4区 医学 Q3 OBSTETRICS & GYNECOLOGY
Huihui Gao, Sunyi Wang, Mingming Zhou, Yuchen Zhang, Charleen Cheung, Symphorosa S C Chan, Changzheng Yuan, Liying Sun
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引用次数: 0

Abstract

Objective: Vulvovaginitis (VV) is one of the most common gynecologic complaints in prepubertal and adolescent girls. However, data on the impact of the COVID-19 pandemic on VV in this population are limited. This study aimed to explore changes in the epidemiology, pathogenic patterns, and antibiotic susceptibility of VV in girls before and during the COVID-19 pandemic in China.

Methods: A retrospective study was conducted in girls aged 0-18 years who were diagnosed with VV from January 2018 to December 2021.

Results: A total of 4 644 cases of VV were identified, including 2 427 cases from 2018-2019 (before the COVID-19 pandemic) and 2 217 cases from 2020-2021 (during the COVID-19 pandemic). The proportion of VV cases in the 0-6-year age group decreased significantly from 40.2% to 31.3%, whereas the proportion in the 10-18-year age group increased from 30.1% to 39.6%. The major pathogens identified from 2020-2021 were similar to those detected from 2018-2019. The detection rates of Haemophilus influenzae, Streptococcus pyogenes, and Streptococcus pneumoniae decreased during the COVID-19 pandemic. In contrast, the detection rates of Escherichia coli, Klebsiella pneumoniae, and Candida albicans increased. Antibiotic susceptibility testing revealed that the sensitivity of Haemophilus influenzae to ampicillin/sulbactam and amoxicillin/clavulanate increased by 5.6% and 13.4%, respectively, after the pandemic. In contrast, levofloxacin sensitivity in Escherichia coli decreased by 20.3% after the pandemic.

Conclusion: Our findings provide evidence-based guidance for appropriate antibiotic use and facilitate the optimization of therapeutic strategies and lifestyle recommendations for prepubertal and adolescent girls with VV.

新冠肺炎疫情对中国青春期前和青春期女性外阴阴道炎有影响吗?回顾性研究2018-2021年4 644例病例。
目的:外阴阴道炎(VV)是青春期前和青春期女孩最常见的妇科疾病之一。然而,关于COVID-19大流行对这一人群VV影响的数据有限。本研究旨在探讨2019冠状病毒病(COVID-19)大流行前和期间中国女孩VV流行病学、致病模式和抗生素敏感性的变化。方法:对2018年1月至2021年12月诊断为VV的0-18岁女孩进行回顾性研究。结果:共发现VV病例4 644例,其中2018-2019年(COVID-19大流行前)2 427例,2020-2021年(COVID-19大流行期间)2 217例。0 ~ 6岁年龄组VV病例比例由40.2%下降至31.3%,10 ~ 18岁年龄组VV病例比例由30.1%上升至39.6%。2020-2021年发现的主要病原体与2018-2019年发现的主要病原体相似。新冠肺炎大流行期间,流感嗜血杆菌、化脓性链球菌和肺炎链球菌的检出率下降。而大肠杆菌、肺炎克雷伯菌和白色念珠菌的检出率则有所上升。抗生素敏感性试验显示,流感嗜血杆菌对氨苄西林/舒巴坦和阿莫西林/克拉维酸盐的敏感性在大流行后分别增加了5.6%和13.4%。相比之下,大流行后大肠杆菌对左氧氟沙星的敏感性下降了20.3%。结论:本研究结果为合理使用抗生素提供了循证指导,并有助于优化青春期前和青春期少女VV的治疗策略和生活方式建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.90
自引率
11.10%
发文量
251
审稿时长
57 days
期刊介绍: Journal of Pediatric and Adolescent Gynecology includes all aspects of clinical and basic science research in pediatric and adolescent gynecology. The Journal draws on expertise from a variety of disciplines including pediatrics, obstetrics and gynecology, reproduction and gynecology, reproductive and pediatric endocrinology, genetics, and molecular biology. The Journal of Pediatric and Adolescent Gynecology features original studies, review articles, book and literature reviews, letters to the editor, and communications in brief. It is an essential resource for the libraries of OB/GYN specialists, as well as pediatricians and primary care physicians.
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