Keimyung Medical Journal最新文献_第3页

Confined Blood Chimerism in Monochorionic Diamniotic Dizygotic Twin 单绒毛膜双血异卵双胞胎的限制性血液嵌合

Keimyung Medical Journal Pub Date : 2023-03-22 DOI: 10.46308/kmj.2023.00010

Do-Hoon Kim

引用次数: 0

Cardiac Arrest as the Initial Presentation of Leigh Syndrome Associated with Novel NDUFS1 Mutation 心脏骤停是与新型NDUFS1突变相关的Leigh综合征的初始表现

Keimyung Medical Journal Pub Date : 2023-03-20 DOI: 10.46308/kmj.2023.00017

Na Hyun Lee, Do-Hoon Kim, J. Byun

引用次数: 0

Retinal and Choroidal Vasculature Before and After Patch Occlusion Treatment Using Optical Coherence Tomography Angiography in Patients with Amblyopia 光学相干断层扫描血管造影术治疗弱视前后视网膜和脉络膜血管

Keimyung Medical Journal Pub Date : 2023-03-17 DOI: 10.46308/kmj.2022.00241

Jae-Gon Kim, Se Youp Lee, Dong Cheol Lee

引用次数: 0

Knowledge and Attitude about Alternative Treatment in Cancer Patient 癌症患者对替代治疗的认识与态度

Keimyung Medical Journal Pub Date : 2023-02-22 DOI: 10.46308/kmj.2022.00248

Jee Weon Lee, Deog-Young Lee, DaeHyun Kim

引用次数: 0

Post-recovery Stigma in Early and Late COVID-19 Epidemic COVID-19流行早期和晚期的康复后病耻感

Keimyung Medical Journal Pub Date : 2022-12-15 DOI: 10.46308/kmj.2022.00171

Daehyun Kim

{"title":"Post-recovery Stigma in Early and Late COVID-19 Epidemic","authors":"Daehyun Kim","doi":"10.46308/kmj.2022.00171","DOIUrl":"https://doi.org/10.46308/kmj.2022.00171","url":null,"abstract":"People who recover from the novel coronavirus diseases 2019 (COVID-19) complain of psychological symptoms such as stress, anxiety, and depression by psycho-stress due to social stigma in the early stage of the epidemic. To assess the psychological stigma of early and late epidemic periods, stigma scale was compared between the first epidemic period (February-May 2020, n = 20) and the fifth epidemic period (February-May 2022, n = 21) post-recovery COVID-19 patients in outpatient clinic. The average total stigma score was significantly higher (79.6 ± 18.16) in post-recovery COVID-19 patients of the early (first) epidemic period compared to late (5th) epidemic period patients (37.5 ±10.99). Four subscales were significantly higher in early epidemic period compared to late epidemic period (enacted stigma 27.5 ± 7.25 vs. 13.0±4.18, disclosure concerns 19.5 ± 9.38 vs. 9.4 ± 2.99, negative self-image 16.2 ± 8.10 vs. 8.1±2.47, concern with public attitudes 16.6 ± 6.95 vs. 7.0 ± 2.01). In those who recovered from the early COVID-19 epidemic period, patients experienced significantly higher social stigma stress compared to the late epidemic period. In the early period of novel virus epidemics, the risk of personal stigmatization and stress should be prevented in public policy. Socio-psychological assessment and treatment should be considered for the patient in addition to physical symptoms.","PeriodicalId":166951,"journal":{"name":"Keimyung Medical Journal","volume":"108 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115627366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-adipogenic Effect and Mechanism in 3T3-L1 Preadipocyte Differentiation by Salvianolic Acid B 丹酚酸B在3T3-L1前脂肪细胞分化中的抗脂肪作用及机制

Keimyung Medical Journal Pub Date : 2022-12-15 DOI: 10.46308/kmj.2022.00213

Hyo-Shin Kwon, B. Jang

{"title":"Anti-adipogenic Effect and Mechanism in 3T3-L1 Preadipocyte Differentiation by Salvianolic Acid B","authors":"Hyo-Shin Kwon, B. Jang","doi":"10.46308/kmj.2022.00213","DOIUrl":"https://doi.org/10.46308/kmj.2022.00213","url":null,"abstract":"Salvianolic acid B (Sal B) is one of the most active hydrophilic compounds extracted from Salvia miltiorrhiza root. Previous in vitro and in vivo studies demonstrate the ability of Sal B to modulate adipocyte differentiation. However, the lipid-modulating effect and mechanism of Sal B in adipocytes remain controversial. Here we investigated the regulatory effect and mode of action of Sal B on lipid accumulation in 3T3-L1 preadipocyte differentiation. Lipid droplet (LD) accumulation and triglyceride (TG) content during 3T3-L1 preadipocyte differentiation were measured by Oil Red O staining and AdipoRed assay. The growth inhibition during 3T3-L1 preadipocyte differentiation was measured by cell count analysis. Western blotting and real-time qPCR analysis were utilized to determine the protein and mRNA expression in the preadipocyte differentiation. Notably, in 3T3-L1 preadipocyte differentiation, treatment with Sal B at 100 M led to a marked decrease in LD accumulation and TG content without influencing cell growth. Sal B treatment (100 M) further reduced the expression and phosphorylation levels of adipogenic transcription factors, including CCAAT/enhancer-binding protein- (C/EBP-), peroxisome proliferator-activated receptor-gamma (PPAR)-, and signal transducer and activator of transcription (STAT)-3/5. Treatment with Sal B (100 M) also reduced the expression and phosphorylation levels of fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC), two lipogenic enzymes and perilipin A, an LD-binding and stabilizing protein. These results collectively demonstrate that Sal B at 100 M strongly inhibits lipid accumulation in 3T3-L1 preadipocyte differentiation, mediated through regulation of the expression and phosphorylation levels of C/EBP-, PPAR-, STAT-3/5, FAS, ACC, and perilipin.","PeriodicalId":166951,"journal":{"name":"Keimyung Medical Journal","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126111348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health Behaviors in Combustible Cigarette, Heated Tobacco Users and Quitters 可燃香烟、加热烟草使用者和戒烟者的健康行为

Keimyung Medical Journal Pub Date : 2022-12-15 DOI: 10.46308/kmj.2022.00157

B. Youn, S. Hong, Dae-Wook Kim

{"title":"Health Behaviors in Combustible Cigarette, Heated Tobacco Users and Quitters","authors":"B. Youn, S. Hong, Dae-Wook Kim","doi":"10.46308/kmj.2022.00157","DOIUrl":"https://doi.org/10.46308/kmj.2022.00157","url":null,"abstract":"Smoking can be changed by health behavior education on the fact that unhealthy behaviors can cause chronic diseases and cancer and that it is important to identify health behaviors in smoking. We try to compare the health behaviors of combustible cigarette (CC), heated tobacco (HT) users, and quitters. Smoking behaviors were divided into three groups (CC, HT users, and quitters). The HT user group (n = 100) was selected among those who underwent a health examination in 2021-2022. CC smokers cohort group (n = 100) and quitters cohort (n = 100) were randomly selected from the same groups (age ± 2) who underwent a health examination in the same period. Sleep-related problems (snoring and sleep apnea), alcohol consumption, and exercise were compared in the CC group, HT group, and quitters group, respectively. Snoring was more common in the quitters group (27%) than in the CC users group (19%) and HT users group (18%). It can be related to weight gain during quitting tobacco use. Nondrinkers were more common in the CC users group (21%) than the HT users group (8%) and quitters group (10%). CC users seem to be more concerned about the health effects of drinking compared to HT users and quitters. Anaerobic exercise was different among groups, and aerobic exercise was not. HT users group did more aerobic exercise than CC users and quitters group. Differences in healthy behaviors among CC and HC users and quitters can be useful information for health education to smokers. Understanding smokers’ health behavior is important to smoking cessation counseling in clinical practice.","PeriodicalId":166951,"journal":{"name":"Keimyung Medical Journal","volume":"219 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132646832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2-Aryl Propionic Acid Amide Modification of Naproxen and Ibuprofen Dimers for Anti-neuroinflammatory Activity in BV2 mouse Microglial Cells 萘普生和布洛芬二聚体的2-芳基丙酸酰胺修饰对BV2小鼠小胶质细胞抗神经炎活性的影响

Keimyung Medical Journal Pub Date : 2022-12-15 DOI: 10.46308/kmj.2022.00199

H. Ju, Shailashree Pachhapure, Amila Mufida, A-Reum Kim, D. Elmaleh, Sungwoong Choi, B. Jang

{"title":"2-Aryl Propionic Acid Amide Modification of Naproxen and Ibuprofen Dimers for Anti-neuroinflammatory Activity in BV2 mouse Microglial Cells","authors":"H. Ju, Shailashree Pachhapure, Amila Mufida, A-Reum Kim, D. Elmaleh, Sungwoong Choi, B. Jang","doi":"10.46308/kmj.2022.00199","DOIUrl":"https://doi.org/10.46308/kmj.2022.00199","url":null,"abstract":"Inflammation is a common link in the pathophysiology of many neurological illnesses, including Alzheimer’s disease. Activated glial cells contribute to neuroinflammation by producing pro-inflammatory mediators. Naproxen and ibuprofen are nonsteroidal anti-inflammatory drugs with 2-aryl(s) propionic acid as a common pharmacophore. Here we designed a small series of naproxen and ibuprofen amide dimers and tested their effects on the expression of inducible nitric oxide synthase (iNOS), a neuroinflammatory enzyme in lipopolysaccharide (LPS)-stimulated BV2 mouse microglial cells. Of note, treatment with CNU 019, 020, 021, 023, 024, and 027 at 10 M markedly inhibited the LPS-induced iNOS expression in BV2 cells. CNU 024 was tested further at different concentrations to regulate the LPS-induced iNOS expression in BV2 cells. Treatment with CNU 024 at 5, 10, or 20 M dose-dependently suppressed the LPS-induced iNOS protein and mRNA expression levels in BV2 cells, in which maximal inhibition was seen at 20 M. CNU 024 treatment at doses tested further led to a concentration-dependent inhibition of the LPS-induced phosphorylation (activation) of p38 mitogen-activated protein kinase (MAPK) without influencing its total protein expression in BV2 cells, but it did not affect the LPS-induced activation of c-jun N-terminal kinase-1/2 and extracellular signal-regulated kinases-1/2 in these cells. In summary, our results demonstrate that CNU 024 inhibits the LPS-induced iNOS expression in BV2 cells, partly mediated by the inhibition of p38 MAPK. This work shows that CNU 024 could be a valuable ligand for further development as a potential drug candidate for treating neuroinflammatory pathologies.","PeriodicalId":166951,"journal":{"name":"Keimyung Medical Journal","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117058600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and Management Status of Anatomical Labs in Medical Schools 医学院校解剖实验室的安全与管理现状

Keimyung Medical Journal Pub Date : 2022-12-15 DOI: 10.46308/kmj.2022.00150

Jae-Hee Park, Kwangrak Park, Anna Bae, Han-Gyu Jeong, Jae-ho Lee

{"title":"Safety and Management Status of Anatomical Labs in Medical Schools","authors":"Jae-Hee Park, Kwangrak Park, Anna Bae, Han-Gyu Jeong, Jae-ho Lee","doi":"10.46308/kmj.2022.00150","DOIUrl":"https://doi.org/10.46308/kmj.2022.00150","url":null,"abstract":"It is necessary to install ventilation facilities in the laboratory and to regularly monitor harmful gases including formalin for safe environment of the dissection laboratory. However, there are no indicators that can identify the current status of ventilation facilities, safety equipment, and protective equipment in the dissection laboratory. In this study, the status of safety management of anatomical lab at domestic medical, dental, and oriental medical universities are investigated through an online questionnaire. Of the total 32 universities, 7 universities (21.8%) regularly monitor harmful gases such as formalin in the dissection lab, 13 universities (40.6%) do it on an irregular basis, and 12 do not do it at all. Seven universities (21.8%) are using the exhaust-type dissection table, 24 universities (75%) are not using it. Regarding the need for standards for manpower and facilities in the management of the anatomy lab, 7 universities (21.8%) are mediocre, 21 universities are necessary (65.6%), and 4 universities (12.5%) are very necessary. The responsibility for anatomy lab is 27 universities (84.3%) of the schools that responded as head professors of the department of anatomy, 3 universities (9.3%) of technicians, and 2 universities (6.2%) of the dean of the medical school. Regarding the need for standards for the anatomical lab, 7 universities (21.8%) are very necessary, 21 universities (65.6%) are necessary, and 4 universities (12.5%) are mediocre. Based on this data, the standard for the quality improvement and safety of anatomical education should be prepared.","PeriodicalId":166951,"journal":{"name":"Keimyung Medical Journal","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117286250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Succinate Induces Liver Damage and Hepatic Fibrosis in a Mouse Model 琥珀酸钠诱导小鼠肝损伤和肝纤维化

Keimyung Medical Journal Pub Date : 2022-12-15 DOI: 10.46308/kmj.2022.00143

Cong Thuc Le, Giang Nguyen, H. Dong, So young Park, Y. Cho, Daehee Choi, Won Sun Park, Yoojin Lee, Ji-Young Lee, Eun-Hee Cho

{"title":"Succinate Induces Liver Damage and Hepatic Fibrosis in a Mouse Model","authors":"Cong Thuc Le, Giang Nguyen, H. Dong, So young Park, Y. Cho, Daehee Choi, Won Sun Park, Yoojin Lee, Ji-Young Lee, Eun-Hee Cho","doi":"10.46308/kmj.2022.00143","DOIUrl":"https://doi.org/10.46308/kmj.2022.00143","url":null,"abstract":"Hepatic stellate cells (HSCs) play a key role in liver fibrosis. Succinate and succinate receptor (GPR91) signaling pathway are involved in the activation, proliferation, and migration of HSCs. We investigated whether succinate may induce hepatic fibrosis. The mice were randomly divided into 2 groups —the control group (chow diet-fed mice, n = 26) and sodium succinate group (2% sodium succinate + chow diet, n = 38). Each diet was provided for 16 weeks. Mice administered an oral diet of 2% sodium succinate for sixteen weeks lost body weight and had increased serum alanine transaminase and hepatic triglyceride contents compared to those in the control mice. Moreover, mice fed with sodium succinate showed increased expression of the alpha smooth muscle actin protein and gene in the liver at 8 weeks of feeding and increased fibrosis in their histology at 16 weeks of feeding. However, the expression of the GPR91 protein and mRNA increased at 4 weeks of feeding, but decreased at 8 and 16 weeks of feeding. These results suggest that an oral succinate diet could induce liver damage and liver fibrosis in mice and that GPR91 signaling might be an early marker or sensor of hepatic fibrosis development.","PeriodicalId":166951,"journal":{"name":"Keimyung Medical Journal","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133416064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1