Journal of Ophthalmology最新文献

{"title":"Global, Regional, and National Burdens of Refraction Disorders in Children and Adolescents From 2010 to 2021.","authors":"Jiayu Zhao, Lili Sun, Xiao Guo, Lijun Zhang","doi":"10.1155/joph/5159332","DOIUrl":"10.1155/joph/5159332","url":null,"abstract":"<p><strong>Objective: </strong>This analysis investigates the trends in prevalence and disability attributable to refractive disorders among children and adolescents worldwide from 2010 to 2021, using data from the Global Burden of Disease (GBD) 2021 study.</p><p><strong>Materials and methods: </strong>Data on prevalence and years lived with disability (YLDs) were extracted from the GBD 2021 repository. The sociodemographic index (SDI) was derived from World Bank datasets. Analytical methods included the Wilcoxon signed-rank test, Kruskal-Wallis test, and linear regression.</p><p><strong>Results: </strong>Between 2010 and 2021, a modest global decline was observed in both the prevalence and YLD rates of refractive disorders, with estimated annual percentage changes (EAPCs) of -0.193 and -0.191, respectively. The burden was consistently greater in females compared to males. The most pronounced decrease occurred in the 15-19 age cohorts. Contrarily, an upward trend was noted in the majority of nations and regions. Tropical Latin America recorded the highest YLD rates, whereas East Asia experienced the most rapid increase. Regions with middle-high SDI demonstrated a significant rise in both prevalence and YLDs.</p><p><strong>Conclusion: </strong>Although the global burden of refractive disorders diminished over the study period, especially among older adolescents, disparities persisted. Females carried a disproportionately higher burden, and middle-high SDI regions exhibited an increasing trend, underscoring the necessity for targeted public health strategies in vision care.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2026 ","pages":"5159332"},"PeriodicalIF":2.2,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13189494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147988064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Findings in Cataract Surgery Using a Digital Microscope Platform With Infrared Illumination.","authors":"Brady Wortz, Thiago Moulin, Mariam Bakhtyari, Renee C Bondurant, Robert J Weinstock","doi":"10.1155/joph/6715584","DOIUrl":"10.1155/joph/6715584","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the safety and efficacy of infrared (IR) illumination using a digital microscope platform to perform uncomplicated cataract surgery.</p><p><strong>Methods: </strong>A retrospective case series of 39 eyes (33 patients) that underwent cataract surgery under topical anesthesia. Patients were asked to choose between traditional microscope and IR microscope illumination prior to surgery. All cataract procedures were performed by a single surgeon. Primary outcomes were intraoperative complications, surgical time, effective phacoemulsification time (EPT), and patient preferences.</p><p><strong>Results: </strong>The mean patient age was 74.1 ± 9.24 years, with 35.9% male eyes, and 20.5% underwent femtosecond laser-assisted surgery. All patients in this series preferred the IR microscope illumination. Mean surgical time was 8.33 ± 4.02 min, and mean EPT was 1.77 ± 0.84 s. No intraoperative complications were observed.</p><p><strong>Conclusions: </strong>Cataract surgery using IR illumination demonstrated excellent safety and efficacy; patients preferred the IR illumination over a traditional microscope illumination. These preliminary findings support further investigation of IR-based visualization technology in ophthalmic surgeries.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2026 ","pages":"6715584"},"PeriodicalIF":2.2,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13185215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147982055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lacrimal Intubation in the Management of Congenital Nasolacrimal Duct Obstruction: A Prospective Comparative Study.","authors":"Haitham Thabit Rashdan, Mohamed Salah Hamed Korishy, Hany Mahmoud, Alaa Abdalsadek Ahmed Sinjab, Islam Awny","doi":"10.1155/joph/4709302","DOIUrl":"10.1155/joph/4709302","url":null,"abstract":"<p><strong>Background: </strong>Congenital nasolacrimal duct obstruction (CNLDO) is a common cause of epiphora in children. Lacrimal intubation is often performed when probing fails, but the optimal approach remains debated. This study compared the outcomes of nasal endoscopy-guided and blind closed lacrimal intubation in pediatric patients with CNLDO.</p><p><strong>Methods: </strong>This prospective comparative study (single-center retrospectively registered) was conducted on 63 eyes of 39 children under 16 years. Participants were randomly assigned to blind closed intubation (<i>n</i> = 31) or nasal endoscopy-guided intubation (<i>n</i> = 32). Outcomes included operative time, epiphora score, fluorescein dye disappearance test (FDDT), complications, and patient satisfaction.</p><p><strong>Results: </strong>Operation time was significantly lower in the nasal endoscopy-guided group than that in the closed group (<i>p</i> < 0.001). Epiphora score, FDDT, postoperative complications, and satisfaction were comparable. Cut tube occurred in 3.23% of the blind group versus 3.45% of the nasal endoscopy-guided group, while cheese-wiring and persistent tube were observed in 3.23% and 6.9% of the blind cases compared with 6.9% and 6.9% of the nasal endoscopy-guided cases, respectively. Prominent tube and postoperative lacrimation were noted only in the nasal endoscopy-guided group (13.79% and 6.9%), whereas dacryocystitis and recurrence were confined to the blind group (6.45% and 12.9%). Regarding satisfaction, high satisfaction was reported in 70.97% of the blind group versus 59.38% of the nasal endoscopy-guided group, moderate satisfaction in 12.9% versus 31.25%, and no satisfaction in 16.13% versus 9.38%, respectively.</p><p><strong>Conclusions: </strong>Both blind and endoscopic lacrimal intubation achieved high success rates in children with CNLDO. The nasal endoscopy-guided technique shortened operative time and offered better visualization, but overall outcomes and satisfaction were comparable. <b>Trial Registration:</b> Pan African Clinical Trials Registry (PACTR): PACTR202510699342440.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2026 ","pages":"4709302"},"PeriodicalIF":2.2,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147973242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a New Algorithm-Based Approach in Subjective Refraction.","authors":"Imene Salah-Mabed, Vincent Péan, Damien Gatinel","doi":"10.1155/joph/5572620","DOIUrl":"10.1155/joph/5572620","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to evaluate a new algorithm-based approach in subjective refraction by comparing the refractions obtained by a professional expert with those obtained using the SiviewExam Expert system on a large population.</p><p><strong>Methods: </strong>Two subjective refraction methods were compared prospectively on patients visiting Rothschild Foundation between October 2022 and May 2023: (i) A manual refraction performed by an expert using a standardized method and (ii) an automated one with the SiviewExam Expert system. Outcomes of the two subjective refractions were compared using a power vector analysis method. Power vectors are a geometric representation of spherocylindrical refractive errors in 3 fundamental dioptric components: <i>M</i> (<i>M</i> = <i>S</i> + <i>C</i>/2), J0 (J0 = (-<i>C</i>/2) cos (2<i>α</i>) at an axis of <i>α</i> = 0 = 180°), and J45 (J45 = (-<i>C</i>/2) sin (2<i>α</i>) at an axis of <i>α</i> = 45°). At the end of the examination, the SiviewExam Expert system provided a report that has been analyzed as well.</p><p><strong>Results: </strong>A total of 107 patients, with a mean age of 35.7 ± 11.9 years (ranging from 19 to 69 years) were included in the study. The mean SE was -2.10 ± 3.37 D (ranging from -11 D to +7.13 D). The mean differences have shown that there were no bias between the measurements for <i>M</i> (0.01 D, -0.04-0.07 D) and J45 (0.009 D, -0.01-0.03 D) and a clinically negligible bias (0.05 D, -0.08--0.02 D) in the estimation of J0. The limits of agreement were -0.54 D (lower limit: -0.63--0.44) to 0.56 D (upper limit: 0.47-0.65), -0.22 D (lower limit: -0.26 to -0.18) to 0.24 D (upper limit: 0.20-0.27), -0.34 D (lower limit: -0.39 to -0.29) to 0.25 D (upper limit: 0.20 to 0.30) for <i>M</i>, J45, and J0, respectively, and were significantly lower than the expected inter-examiner variability of 0.7 D. Finally, the report provided by the SiviewExam Expert system was found to be accurate according to the expert in 100% of the cases.</p><p><strong>Conclusion: </strong>Our outcomes show that in a large adult population of over 100 patients with a wide range of ametropias, there were no statistically significant differences in the results for <i>M</i>, J0, and J45 between the two refraction methods, indicating that we could reasonably clinically consider the SiviewExam Expert system examination comparable with the one conducted by an expert.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2026 ","pages":"5572620"},"PeriodicalIF":2.2,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13177832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147963846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LncRNA TINCR rs2288947 Polymorphism as a Genetic Susceptibility Factor for Diabetic Retinopathy.","authors":"Jinling Liu, Jing Song, Shasha Han, Yuanyuan Li, Ping Chen, Qian Liu, Na Liu, Min Wu","doi":"10.1155/joph/2631055","DOIUrl":"10.1155/joph/2631055","url":null,"abstract":"<p><strong>Background: </strong>Long noncoding RNAs (lncRNAs) are critically involved in the pathogenesis of diabetic retinopathy (DR). Nevertheless, the role of lncRNA TINCR in DR has not been fully elucidated.</p><p><strong>Objective: </strong>This study aimed to examine the relationship between the lncRNA TINCR polymorphism rs2288947 and DR susceptibility in a Chinese Han population with Type 2 diabetes mellitus (T2DM) and to explore the diagnostic potential of plasma lncRNA TINCR levels.</p><p><strong>Methods: </strong>A case-control study was conducted with 507 participants (255 NPDR patients and 252 T2DM controls). Plasma TINCR expression was measured via qRT-PCR, and rs2288947 genotyping was performed using the TaqMan assay. Multivariate logistic regression and ROC analyses were applied to evaluate diagnostic value and risk associations.</p><p><strong>Results: </strong>LncRNA TINCR expression was significantly elevated and served as an independent risk factor in NPDR patients and exhibited high diagnostic value. The <i>G</i> allele of rs2288947 was associated with increased NPDR risk and higher lncRNA TINCR expression. Carriers of GA/GG genotypes showed upregulated lncRNA TINCR, which correlated with longer diabetes duration, elevated HbA1c, reduced HDL-C, and impaired renal function.</p><p><strong>Conclusion: </strong>Both lncRNA TINCR and the rs2288947 polymorphism contribute to NPDR development and show promise as biomarkers for early screening and risk evaluation.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2026 ","pages":"2631055"},"PeriodicalIF":2.2,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13174572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147963809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Investigations on Pathogenesis, Biomarkers, Epigenetics, and Emerging Therapeutic Strategies to Modulate Multiple Signaling Pathways in Diabetic Retinopathy.","authors":"Zixuan Huang, Jing Wei, Dayong Yang","doi":"10.1155/joph/5539383","DOIUrl":"10.1155/joph/5539383","url":null,"abstract":"<p><strong>Background: </strong>Diabetic retinopathy (DR) is a progressive microvascular complication related to diabetes mellitus and remains a profound cause of vision impairment and blindness globally. In addition to its ocular manifestations, DR is increasingly recognized as a main risk factor for systemic diseases, including cardiovascular and neurodegenerative disorders. Despite advancements in screening and management strategies, challenges persist in evaluating DR progression, identifying reliable biomarkers, and developing targeted therapies. Recent insights into the role of lipoproteins, epigenetics, and systemic inflammatory pathways in DR pathogenesis have opened new avenues for research and therapeutic interventions.</p><p><strong>Objective: </strong>This review aims to provide a comprehensive update on the pathogenesis of DR, highlighting emerging biomarkers and epigenetic factors involved in disease progression. In addition, the efficacy of novel therapeutic approaches targeting key signaling pathways in both preclinical and clinical settings is explored.</p><p><strong>Methods: </strong>A comprehensive literature review was conducted using multiple public databases, including PubMed, Scopus, Google Scholar, and the National Library of Medicine. Relevant studies published in the past decade were analyzed to assess advancements in DR pathophysiology, biomarker discovery, epigenetic implications, and emerging therapeutic strategies. Key findings were synthesized to present an integrated perspective on the evolving landscape of DR research and management.</p><p><strong>Results: </strong>Our analysis reveals that DR pathogenesis involves complex neurovascular interactions, oxidative stress, and hyperglycemia-induced epigenetic modifications. Lipoprotein metabolism and menopausal hormonal changes were found to influence DR progression, emphasizing the need for personalized risk assessments. The review further highlights the role of circulating blood biomarkers, omega-3 fatty acids, microRNAs, and inflammatory cytokines as potential indicators of disease severity. In addition, novel therapeutic approaches, including anti-VEGF agents, neuroprotective strategies, and epigenetic modulators, have shown promising results in preclinical and early clinical studies. Targeting multiple signaling pathways, including VEGF, Wnt/β-catenin, and inflammatory cascades, holds significant potential for improving DR outcomes.</p><p><strong>Conclusion: </strong>Advancements in biomarker research and epigenetic regulation provide significant avenues pertinent to DR pathogenesis and progression. The integration of molecular and clinical approaches is essential for developing targeted therapies that address both ocular and systemic implications of DR. Future research should focus on translating these findings into personalized treatment strategies to enhance patient outcomes and prevent vision loss.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2026 ","pages":"5539383"},"PeriodicalIF":2.2,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13168869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147941791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Association Study Between Refractive Error-Related Genes and High Myopia in the Chinese Han Population.","authors":"Jianxin Liu, Weijiang Liao, Chunbao Xie, Xinyu Wang, Yukai Gong, Chunchun Yang, Fang Hao, Yin Yang, Liang Zou, Yi Shi, Jiayu Meng, Lingxi Jiang","doi":"10.1155/joph/8363695","DOIUrl":"10.1155/joph/8363695","url":null,"abstract":"<p><strong>Background: </strong>Refractive errors are the leading cause of visual impairment and blindness globally. High myopia (HM) poses significant risks of severe ocular complications and blindness. 12 SNPs, including rs580839, have been associated with refractive errors in European and Asian populations, but their roles in Chinese cohorts remain unexplored. Their genetic association with HM is investigated in this study.</p><p><strong>Methods: </strong>Genotyping of specific SNPs was conducted using multiplexed SNP/exome capture sequencing in a cohort consisting of HM patients and emmetropic individuals. The 3DSNP and GTEx databases were used to identify the causal association between SNPs and regulated genes. In addition, a mouse form-deprivation myopia (FDM) model was established, and retinal protein levels were quantified by the western blot analysis.</p><p><strong>Results: </strong>Our study revealed that the heterozygous genotype of <i>GJD2</i>-rs580839 (G/A) was associated with HM in both the heterozygous (GA vs. GG: <i>p</i> = 0.021, OR = 1.433) and dominant (GA + AA vs. GG: <i>p</i> = 0.026, OR = 1.388) inheritance models. GTEx database indicates that the aforementioned risk genotypes (rs580839-AG and rs580839-AG + AA) are associated with the regulation of <i>GJD2</i> gene expression. In the FDM mouse model, a significant downregulation of C × 36 protein expression was observed.</p><p><strong>Conclusions: </strong>This study showed a statistically suggestive association between rs580839 (<i>GJD2</i>) and HM among the Han Chinese population. In addition, rs580839 may influence the pathogenesis of HM through the C × 36-mediated pathway. However, further in vivo studies are required to elucidate the complex mechanisms that underlie HM development.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2026 ","pages":"8363695"},"PeriodicalIF":2.2,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13172293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147963758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Clinical Significance of Imaging Biomarkers Discoverable by Anomaly Detection Methods in Retinal Diseases: A Review.","authors":"Anna M Wittmann, Philipp Seeböck, Katharina A Heger, Daniel Egger, Georg Langs, Sebastian M Waldstein","doi":"10.1155/joph/9792133","DOIUrl":"10.1155/joph/9792133","url":null,"abstract":"<p><strong>Introduction: </strong>The increasing prevalence of vision-threatening retinal diseases poses a growing challenge on healthcare systems worldwide, underscoring the need for effective strategies in disease diagnosis and management. Unsupervised artificial intelligence (AI) approaches, such as anomaly detection, offer the potential to identify established and novel retinal imaging biomarkers. They reduce reliance on expert-driven annotations, mitigate bias, and overcome the limitations of predefined disease categories. Moreover, when integrated into clinical workflows, they have the potential to enhance practical applicability by supporting efficient screening, longitudinal disease monitoring, and objective assessment of treatment response.</p><p><strong>Areas covered: </strong>This review examines the role of anomaly detection for discovering clinically relevant retinal imaging biomarkers, by categorizing biomarkers according to their underlying pathophysiology, summarizing the spectrum of anomaly detection methods applied in the field, and highlighting biomarkers that have been identified through these approaches.</p><p><strong>Critical appraisal: </strong>Current anomaly detection methods favor the identification of established biomarkers characterized by strong intensity contrasts and well-defined structural boundaries, while more subtle abnormalities remain difficult to capture. Future research should prioritize integrating large language models (LLMs), foundation methods, multimodality, and few-shot anomaly detection, and increase explainability to advance the clinical application of anomaly detection for retinal imaging biomarker discovery in ophthalmology.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2026 ","pages":"9792133"},"PeriodicalIF":2.2,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Outcomes of Pars Plana Vitrectomy With and Without Adjunct Laser Photocoagulation in Optic Disc Pit Maculopathy.","authors":"Mehmet Sahin Sevim, Semra Sevim","doi":"10.1155/joph/3889015","DOIUrl":"10.1155/joph/3889015","url":null,"abstract":"<p><strong>Purpose: </strong>Optic disc pit maculopathy (ODP-M) is a rare condition that can lead to progressive visual impairment. Although pars plana vitrectomy (PPV) has become the mainstay of treatment, the additional benefit of adjunct peripapillary laser photocoagulation remains controversial. We hypothesized that adjunct laser photocoagulation does not provide additional anatomical or functional benefit when combined with PPV and gas tamponade. This study aimed to compare the anatomical and functional outcomes of PPV with and without adjunct peripapillary endolaser photocoagulation in the management of ODP-M.</p><p><strong>Methods: </strong>This retrospective comparative study included 19 eyes of 17 patients who underwent PPV with gas tamponade for ODP-M between January 2013 and August 2024. Patients were divided into two groups according to whether endolaser photocoagulation was applied to the temporal margin of the optic disc during surgery. Pre- and postoperative best-corrected visual acuity (BCVA), central retinal thickness (CRT), and anatomical outcomes were compared between groups. Anatomical success was defined as complete resolution of subretinal and/or intraretinal fluid on spectral-domain optical coherence tomography (SD-OCT).</p><p><strong>Results: </strong>The mean postoperative follow-up duration was 20 months (range, 12-36 months). Anatomical success was achieved in 9 of 10 eyes (90%) in the laser group and 8 of 9 eyes (89%) in the nonlaser group (<i>p</i> = 1.00). The mean postoperative BCVA was 0.40 ± 0.27 logMAR and 0.41 ± 0.24 logMAR, respectively (<i>p</i> = 0.82). Both groups showed significant visual improvement compared to baseline, but there were no intergroup differences in BCVA or CRT changes. No intraoperative or postoperative complications such as retinal detachment, macular hole formation, or endophthalmitis were observed.</p><p><strong>Conclusion: </strong>PPV with gas tamponade provides favorable anatomical and functional outcomes in ODP-M. The addition of endolaser photocoagulation does not yield further benefit and may be unnecessary in standard PPV-based management.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2026 ","pages":"3889015"},"PeriodicalIF":2.2,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13139903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the Coronavirus Disease 2019 Pandemic on Retinal Artery Occlusion.","authors":"Tetsuya Muto, Shigeki Machida, Shinichiro Imaizumi, Tetsuju Sekiryu","doi":"10.1155/joph/5740618","DOIUrl":"10.1155/joph/5740618","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the prevalence and clinical characteristics of retinal artery occlusion (RAO), including branch RAO (BRAO) and central RAO (CRAO), among new patients before and after the declaration of a state of emergency due to coronavirus disease 2019 (April 7, 2020) in Japan.</p><p><strong>Methods: </strong>New patients and patients with newly diagnosed RAO were categorized into \"Before\" and \"After\" groups based on the initial visit. The prevalence, sex ratio, and age of patients newly diagnosed with RAO were compared between the groups. The rates of patients newly diagnosed with rhegmatogenous retinal detachment (RRD) and pseudoexfoliation glaucoma (PEX) were also examined in the Before and After groups.</p><p><strong>Results: </strong>This study included 53 and 31 patients with BRAO and 55 and 40 patients with CRAO in the Before and After groups, respectively. There were no significant differences in prevalence of RAOs among newly diagnosed patients (BRAO: <i>p</i> = 0.449; CRAO: <i>p</i> = 0.060), patients with RRD (BRAO: <i>p</i> = 0.425; CRAO: <i>p</i> = 0.082), or patients with PEX (BRAO: <i>p</i> = 0.317; CRAO: <i>p</i> = 0.072), as well as in sex ratio and age. Although initial best-corrected visual acuity (BRAO: <i>p</i> = 0.303; CRAO: <i>p</i> = 0.291) of RAOs showed no significant differences, the final best-corrected visual acuity in BRAO significantly worsened in the After group (<i>p</i> = 0.002).</p><p><strong>Conclusions: </strong>Although the coronavirus disease 2019 pandemic did not affect the prevalence of RAOs among new patients compared with that of RRD and PEX, it may have affected its pathophysiology.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":"2026 ","pages":"5740618"},"PeriodicalIF":2.2,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13141676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}